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Protein

Gastrotropin

Gene

Fabp6

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binds to bile acids and is involved in enterohepatic bile acid metabolism. Required for efficient apical to basolateral transport of conjugated bile acids in ileal enterocytes (By similarity). Stimulates gastric acid and pepsinogen secretion (By similarity).By similarity1 Publication

GO - Molecular functioni

  • bile acid binding Source: InterPro
  • fatty acid binding Source: RGD
  • transporter activity Source: InterPro

GO - Biological processi

  • bile acid metabolic process Source: InterPro
  • lipid transport Source: UniProtKB-KW
  • steroid metabolic process Source: RGD
Complete GO annotation...

Keywords - Biological processi

Lipid transport, Transport

Keywords - Ligandi

Lipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Gastrotropin
Short name:
GT
Alternative name(s):
14 kDa bile acid-binding protein
Fatty acid-binding protein 6
I-BABP
Ileal lipid-binding protein
Short name:
ILBP
Intestinal 15 kDa protein
Short name:
I-15P
Gene namesi
Name:Fabp6
Synonyms:Ilbp, Illbp
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi2592. Fabp6.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: RGD
  • membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemoved1 Publication
Chaini2 – 128127GastrotropinPRO_0000067384Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP80020.

Expressioni

Tissue specificityi

Predominantly expressed in ileum; also expressed in ovary.2 Publications

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000005205.

Structurei

3D structure databases

ProteinModelPortaliP80020.
SMRiP80020. Positions 2-128.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior. Can bind at least two ligands per molecule, however, the stoichiometry is debated.By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG4015. Eukaryota.
ENOG4111US8. LUCA.
HOGENOMiHOG000004830.
HOVERGENiHBG005633.
InParanoidiP80020.
KOiK08755.
PhylomeDBiP80020.

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiIPR012674. Calycin.
IPR011038. Calycin-like.
IPR000463. Fatty_acid-bd.
IPR031257. Gastrotropin.
IPR031259. iLBP.
[Graphical view]
PANTHERiPTHR11955. PTHR11955. 1 hit.
PTHR11955:SF69. PTHR11955:SF69. 1 hit.
PRINTSiPR00178. FATTYACIDBP.
SUPFAMiSSF50814. SSF50814. 1 hit.
PROSITEiPS00214. FABP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P80020-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFTGKYEFE SEKNYDEFMK RLGLPDEVIE RGRNFKIITE VQQDGENFTW
60 70 80 90 100
SQSYSGGNIM SNKFTIGKEC EMQTMGGKKF KATVKMEGGK VVADFPNYHQ
110 120
TSEVVGDKLV EISTIGDVTY ERVSKRVA
Length:128
Mass (Da):14,544
Last modified:January 23, 2007 - v3
Checksum:i66580FC781DE4B3D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti16 – 172DE → ED AA sequence (PubMed:2029905).Curated
Sequence conflicti26 – 272DE → ED in AAB24948 (PubMed:8197128).Curated
Sequence conflicti26 – 272DE → ED in AAA57155 (PubMed:8197128).Curated
Sequence conflicti26 – 272DE → GD AA sequence (PubMed:2059206).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S52878 mRNA. Translation: AAB24948.1.
L22788 mRNA. Translation: AAA57155.1.
PIRiJC1413.
RefSeqiNP_058794.1. NM_017098.1.
UniGeneiRn.10008.

Genome annotation databases

GeneIDi25440.
KEGGirno:25440.
UCSCiRGD:2592. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S52878 mRNA. Translation: AAB24948.1.
L22788 mRNA. Translation: AAA57155.1.
PIRiJC1413.
RefSeqiNP_058794.1. NM_017098.1.
UniGeneiRn.10008.

3D structure databases

ProteinModelPortaliP80020.
SMRiP80020. Positions 2-128.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000005205.

Proteomic databases

PaxDbiP80020.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi25440.
KEGGirno:25440.
UCSCiRGD:2592. rat.

Organism-specific databases

CTDi2172.
RGDi2592. Fabp6.

Phylogenomic databases

eggNOGiKOG4015. Eukaryota.
ENOG4111US8. LUCA.
HOGENOMiHOG000004830.
HOVERGENiHBG005633.
InParanoidiP80020.
KOiK08755.
PhylomeDBiP80020.

Miscellaneous databases

PROiP80020.

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiIPR012674. Calycin.
IPR011038. Calycin-like.
IPR000463. Fatty_acid-bd.
IPR031257. Gastrotropin.
IPR031259. iLBP.
[Graphical view]
PANTHERiPTHR11955. PTHR11955. 1 hit.
PTHR11955:SF69. PTHR11955:SF69. 1 hit.
PRINTSiPR00178. FATTYACIDBP.
SUPFAMiSSF50814. SSF50814. 1 hit.
PROSITEiPS00214. FABP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning of a cDNA encoding rat intestinal 15 kDa protein and its tissue distribution."
    Fujii H., Nomura M., Kanda T., Amano O., Iseki S., Hatakeyama K., Ono T.
    Biochem. Biophys. Res. Commun. 190:175-180(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Molecular cloning, tissue distribution, and expression of a 14-kDa bile acid-binding protein from rat ileal cytosol."
    Gong Y.Z., Everett E.T., Schwartz D.A., Norris J.S., Wilson F.A.
    Proc. Natl. Acad. Sci. U.S.A. 91:4741-4745(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], BILE ACID-BINDING, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Strain: Sprague-Dawley.
    Tissue: Ileum.
  3. "Primary structure of a 15-kDa protein from rat intestinal epithelium. Sequence similarity to fatty-acid-binding proteins."
    Kanda T., Odani S., Tomoi M., Matsubara Y., Ono T.
    Eur. J. Biochem. 197:759-768(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-128, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT ALA-2, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Strain: Sprague-Dawley.
    Tissue: Intestinal mucosa.
  4. "Identification of the 14 kDa bile acid transport protein of rat ileal cytosol as gastrotropin."
    Vodenlich A.D. Jr., Gong Y.-Z., Geoghegan K.F., Lin M.C., Lanzetti A.J., Wilson F.A.
    Biochem. Biophys. Res. Commun. 177:1147-1154(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 21-31; 88-103 AND 109-128.
    Tissue: Ileum.

Entry informationi

Entry nameiFABP6_RAT
AccessioniPrimary (citable) accession number: P80020
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: January 23, 2007
Last modified: July 6, 2016
This is version 119 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.