P80018 (GLBC_CAUAR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Globin C, coelomic
Organism	Caudina arenicola (Sea cucumber) (Molpadia arenicola)
Taxonomic identifier	7698 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Echinodermata › Eleutherozoa › Echinozoa › Holothuroidea › Apodacea › Molpadiida › Caudinidae › Caudina

Protein attributes

Sequence length	159 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Subunit structure	Monomer.
Miscellaneous	Caudina arenicola coelomocytes contain four hemoglobin chains labeled A, B, C, D.
Sequence similarities	Belongs to the globin family.

Ontologies

Keywords
Biological process	Oxygen transport Transport
Ligand	Heme Iron Metal-binding
PTM	Acetylation
Technical term	3D-structure Direct protein sequencing
Gene Ontology (GO)
Cellular_component	extracellular region Inferred from electronic annotation. Source: InterPro hemoglobin complex Inferred from electronic annotation. Source: InterPro
Molecular_function	heme binding Inferred from electronic annotation. Source: InterPro iron ion binding Inferred from electronic annotation. Source: InterPro oxygen binding Inferred from electronic annotation. Source: InterPro oxygen transporter activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Initiator methionine

1

1

Removed Ref.1 Ref.2

Chain

2 – 159

158

Globin C, coelomic

PRO_0000052496

Sites

Metal binding

74

1

Iron (heme distal ligand)

Metal binding

105

1

Iron (heme proximal ligand)

Amino acid modifications

Modified residue

2

1

N-acetylglycine

Experimental info

Sequence conflict

3

1

Missing AA sequence Ref.1

Sequence conflict

133

1

D → A AA sequence Ref.1

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

159

Helix Strand Turn

Details...

Helix

15 – 31

17

Helix

35 – 46

12

Helix

49 – 52

4

Helix

55 – 57

3

Helix

62 – 65

4

Helix

69 – 86

18

Helix

94 – 97

4

Helix

99 – 107

9

Helix

112 – 130

19

Helix

137 – 151

15

Sequences

	Sequence		Length	Mass (Da)
	P80018 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: B98B4EDD76AB8F84	FASTA	159	17,780
	10 20 30 40 50 60 MGGTLAIQAQ GDLTLAQKKI VRKTWHQLMR NKTSFVTDVF IRIFAYDPSA QNKFPQMAGM 70 80 90 100 110 120 SASQLRSSRQ MQAHAIRVSS IMSEYVEELD SDILPELLAT LARTHDLNKV GADHYNLFAK 130 140 150 VLMEALQAEL GSDFNEKTRD AWAKAFSVVQ AVLLVKHGN

References

[1]	"Amino acid sequence of the coelomic C globin from the sea cucumber Caudina (Molpadia) arenicola." McDonald G.D., Davidson L., Kitto G.B. J. Protein Chem. 11:29-37(1992) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 2-159. Tissue: Coelomic fluid.
[2]	Thomas P.W. Thesis (1994), University of Texas / Austin, United States Cited for: PROTEIN SEQUENCE OF 2-159.
[3]	"Three-dimensional structure of a hemichrome hemoglobin from Caudina arenicola." Mitchell D.T., Ernst S.R., Wu W.X., Hackert M.L. Acta Crystallogr. D 51:647-653(1995) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS).
+	Additional computationally mapped references.

Cross-references

Sequence databases

PIR

A53881.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1HLB	X-ray	2.50	A	2-157	[»]

ProteinModelPortal

P80018.

SMR

P80018. Positions 2-158.

ModBase

Search...

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Family and domain databases

Gene3D

1.10.490.10. 1 hit.

InterPro

IPR002336. Erythrocruorin.
IPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin_dom.
[Graphical view]

Pfam

PF00042. Globin. 1 hit.
[Graphical view]

PRINTS

PR00611. ERYTHCRUORIN.

SUPFAM

SSF46458. Globin_like. 1 hit.

PROSITE

PS01033. GLOBIN. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

P80018.

Entry information

Entry name

GLBC_CAUAR

Accession

Primary (citable) accession number: P80018

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 1, 1991
Last sequence update:	January 23, 2007
Last modified:	April 3, 2013
This is version 77 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)