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P80018

- GLBC_CAUAR

UniProt

P80018 - GLBC_CAUAR

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Protein

Globin C, coelomic

Gene
N/A
Organism
Caudina arenicola (Sea cucumber) (Molpadia arenicola)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi74 – 741Iron (heme distal ligand)
Metal bindingi105 – 1051Iron (heme proximal ligand)

GO - Molecular functioni

  1. heme binding Source: InterPro
  2. iron ion binding Source: InterPro
  3. oxygen binding Source: InterPro
  4. oxygen transporter activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Oxygen transport, Transport

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Globin C, coelomic
OrganismiCaudina arenicola (Sea cucumber) (Molpadia arenicola)
Taxonomic identifieri7698 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEchinodermataEleutherozoaEchinozoaHolothuroideaApodaceaMolpadiidaCaudinidaeCaudina

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: InterPro
  2. hemoglobin complex Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed2 Publications
Chaini2 – 159158Globin C, coelomicPRO_0000052496Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylglycine

Keywords - PTMi

Acetylation

Interactioni

Subunit structurei

Monomer.

Structurei

Secondary structure

1
159
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi15 – 3117
Helixi35 – 4612
Helixi49 – 524
Helixi55 – 573
Helixi62 – 654
Helixi69 – 8618
Helixi94 – 974
Helixi99 – 1079
Helixi112 – 13019
Helixi137 – 15115

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1HLBX-ray2.50A2-158[»]
ProteinModelPortaliP80018.
SMRiP80018. Positions 2-158.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP80018.

Family & Domainsi

Sequence similaritiesi

Belongs to the globin family.PROSITE-ProRule annotation

Family and domain databases

Gene3Di1.10.490.10. 1 hit.
InterProiIPR002336. Erythrocruorin.
IPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin_dom.
[Graphical view]
PfamiPF00042. Globin. 1 hit.
[Graphical view]
PRINTSiPR00611. ERYTHCRUORIN.
SUPFAMiSSF46458. SSF46458. 1 hit.
PROSITEiPS01033. GLOBIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P80018-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGGTLAIQAQ GDLTLAQKKI VRKTWHQLMR NKTSFVTDVF IRIFAYDPSA
60 70 80 90 100
QNKFPQMAGM SASQLRSSRQ MQAHAIRVSS IMSEYVEELD SDILPELLAT
110 120 130 140 150
LARTHDLNKV GADHYNLFAK VLMEALQAEL GSDFNEKTRD AWAKAFSVVQ

AVLLVKHGN
Length:159
Mass (Da):17,780
Last modified:January 23, 2007 - v3
Checksum:iB98B4EDD76AB8F84
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti3 – 31Missing AA sequence (PubMed:1515032)Curated
Sequence conflicti133 – 1331D → A AA sequence (PubMed:1515032)Curated

Sequence databases

PIRiA53881.

Cross-referencesi

Sequence databases

PIRi A53881.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1HLB X-ray 2.50 A 2-158 [» ]
ProteinModelPortali P80018.
SMRi P80018. Positions 2-158.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Miscellaneous databases

EvolutionaryTracei P80018.

Family and domain databases

Gene3Di 1.10.490.10. 1 hit.
InterProi IPR002336. Erythrocruorin.
IPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin_dom.
[Graphical view ]
Pfami PF00042. Globin. 1 hit.
[Graphical view ]
PRINTSi PR00611. ERYTHCRUORIN.
SUPFAMi SSF46458. SSF46458. 1 hit.
PROSITEi PS01033. GLOBIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Amino acid sequence of the coelomic C globin from the sea cucumber Caudina (Molpadia) arenicola."
    McDonald G.D., Davidson L., Kitto G.B.
    J. Protein Chem. 11:29-37(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-159.
    Tissue: Coelomic fluid.
  2. Thomas P.W.
    Thesis (1994), University of Texas / Austin, United States
    Cited for: PROTEIN SEQUENCE OF 2-159.
  3. "Three-dimensional structure of a hemichrome hemoglobin from Caudina arenicola."
    Mitchell D.T., Ernst S.R., Wu W.X., Hackert M.L.
    Acta Crystallogr. D 51:647-653(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS).

Entry informationi

Entry nameiGLBC_CAUAR
AccessioniPrimary (citable) accession number: P80018
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: January 23, 2007
Last modified: October 1, 2014
This is version 80 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Miscellaneous

Caudina arenicola coelomocytes contain four hemoglobin chains labeled A, B, C, D.

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3