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P80018

- GLBC_CAUAR

UniProt

P80018 - GLBC_CAUAR

Protein

Globin C, coelomic

Gene
N/A
Organism
Caudina arenicola (Sea cucumber) (Molpadia arenicola)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi74 – 741Iron (heme distal ligand)
    Metal bindingi105 – 1051Iron (heme proximal ligand)

    GO - Molecular functioni

    1. heme binding Source: InterPro
    2. iron ion binding Source: InterPro
    3. oxygen binding Source: InterPro
    4. oxygen transporter activity Source: UniProtKB-KW

    Keywords - Biological processi

    Oxygen transport, Transport

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Globin C, coelomic
    OrganismiCaudina arenicola (Sea cucumber) (Molpadia arenicola)
    Taxonomic identifieri7698 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEchinodermataEleutherozoaEchinozoaHolothuroideaApodaceaMolpadiidaCaudinidaeCaudina

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: InterPro
    2. hemoglobin complex Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed2 Publications
    Chaini2 – 159158Globin C, coelomicPRO_0000052496Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylglycine

    Keywords - PTMi

    Acetylation

    Interactioni

    Subunit structurei

    Monomer.

    Structurei

    Secondary structure

    1
    159
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi15 – 3117
    Helixi35 – 4612
    Helixi49 – 524
    Helixi55 – 573
    Helixi62 – 654
    Helixi69 – 8618
    Helixi94 – 974
    Helixi99 – 1079
    Helixi112 – 13019
    Helixi137 – 15115

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1HLBX-ray2.50A2-158[»]
    ProteinModelPortaliP80018.
    SMRiP80018. Positions 2-158.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP80018.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the globin family.PROSITE-ProRule annotation

    Family and domain databases

    Gene3Di1.10.490.10. 1 hit.
    InterProiIPR002336. Erythrocruorin.
    IPR000971. Globin.
    IPR009050. Globin-like.
    IPR012292. Globin_dom.
    [Graphical view]
    PfamiPF00042. Globin. 1 hit.
    [Graphical view]
    PRINTSiPR00611. ERYTHCRUORIN.
    SUPFAMiSSF46458. SSF46458. 1 hit.
    PROSITEiPS01033. GLOBIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P80018-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGGTLAIQAQ GDLTLAQKKI VRKTWHQLMR NKTSFVTDVF IRIFAYDPSA    50
    QNKFPQMAGM SASQLRSSRQ MQAHAIRVSS IMSEYVEELD SDILPELLAT 100
    LARTHDLNKV GADHYNLFAK VLMEALQAEL GSDFNEKTRD AWAKAFSVVQ 150
    AVLLVKHGN 159
    Length:159
    Mass (Da):17,780
    Last modified:January 23, 2007 - v3
    Checksum:iB98B4EDD76AB8F84
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti3 – 31Missing AA sequence (PubMed:1515032)Curated
    Sequence conflicti133 – 1331D → A AA sequence (PubMed:1515032)Curated

    Sequence databases

    PIRiA53881.

    Cross-referencesi

    Sequence databases

    PIRi A53881.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1HLB X-ray 2.50 A 2-158 [» ]
    ProteinModelPortali P80018.
    SMRi P80018. Positions 2-158.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Miscellaneous databases

    EvolutionaryTracei P80018.

    Family and domain databases

    Gene3Di 1.10.490.10. 1 hit.
    InterProi IPR002336. Erythrocruorin.
    IPR000971. Globin.
    IPR009050. Globin-like.
    IPR012292. Globin_dom.
    [Graphical view ]
    Pfami PF00042. Globin. 1 hit.
    [Graphical view ]
    PRINTSi PR00611. ERYTHCRUORIN.
    SUPFAMi SSF46458. SSF46458. 1 hit.
    PROSITEi PS01033. GLOBIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Amino acid sequence of the coelomic C globin from the sea cucumber Caudina (Molpadia) arenicola."
      McDonald G.D., Davidson L., Kitto G.B.
      J. Protein Chem. 11:29-37(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 2-159.
      Tissue: Coelomic fluid.
    2. Thomas P.W.
      Thesis (1994), University of Texas / Austin, United States
      Cited for: PROTEIN SEQUENCE OF 2-159.
    3. "Three-dimensional structure of a hemichrome hemoglobin from Caudina arenicola."
      Mitchell D.T., Ernst S.R., Wu W.X., Hackert M.L.
      Acta Crystallogr. D 51:647-653(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS).

    Entry informationi

    Entry nameiGLBC_CAUAR
    AccessioniPrimary (citable) accession number: P80018
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 1991
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 80 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Miscellaneous

    Caudina arenicola coelomocytes contain four hemoglobin chains labeled A, B, C, D.

    Keywords - Technical termi

    3D-structure, Direct protein sequencing

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3