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Protein

Globin C, coelomic

Gene
N/A
Organism
Caudina arenicola (Sea cucumber) (Molpadia arenicola)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi74 – 741Iron (heme distal ligand)
Metal bindingi105 – 1051Iron (heme proximal ligand)

GO - Molecular functioni

  1. heme binding Source: InterPro
  2. iron ion binding Source: InterPro
  3. oxygen binding Source: InterPro
  4. oxygen transporter activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Oxygen transport, Transport

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Globin C, coelomic
OrganismiCaudina arenicola (Sea cucumber) (Molpadia arenicola)
Taxonomic identifieri7698 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEchinodermataEleutherozoaEchinozoaHolothuroideaApodaceaMolpadiidaCaudinidaeCaudina

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: InterPro
  2. hemoglobin complex Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed2 Publications
Chaini2 – 159158Globin C, coelomicPRO_0000052496Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylglycine

Keywords - PTMi

Acetylation

Interactioni

Subunit structurei

Monomer.

Structurei

Secondary structure

1
159
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi15 – 3117Combined sources
Helixi35 – 4612Combined sources
Helixi49 – 524Combined sources
Helixi55 – 573Combined sources
Helixi62 – 654Combined sources
Helixi69 – 8618Combined sources
Helixi94 – 974Combined sources
Helixi99 – 1079Combined sources
Helixi112 – 13019Combined sources
Helixi137 – 15115Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1HLBX-ray2.50A2-158[»]
SMRiP80018. Positions 2-158.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP80018.

Family & Domainsi

Sequence similaritiesi

Belongs to the globin family.PROSITE-ProRule annotation

Family and domain databases

Gene3Di1.10.490.10. 1 hit.
InterProiIPR002336. Erythrocruorin.
IPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin_dom.
[Graphical view]
PfamiPF00042. Globin. 1 hit.
[Graphical view]
PRINTSiPR00611. ERYTHCRUORIN.
SUPFAMiSSF46458. SSF46458. 1 hit.
PROSITEiPS01033. GLOBIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P80018-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGGTLAIQAQ GDLTLAQKKI VRKTWHQLMR NKTSFVTDVF IRIFAYDPSA
60 70 80 90 100
QNKFPQMAGM SASQLRSSRQ MQAHAIRVSS IMSEYVEELD SDILPELLAT
110 120 130 140 150
LARTHDLNKV GADHYNLFAK VLMEALQAEL GSDFNEKTRD AWAKAFSVVQ

AVLLVKHGN
Length:159
Mass (Da):17,780
Last modified:January 23, 2007 - v3
Checksum:iB98B4EDD76AB8F84
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti3 – 31Missing AA sequence (PubMed:1515032).Curated
Sequence conflicti133 – 1331D → A AA sequence (PubMed:1515032).Curated

Sequence databases

PIRiA53881.

Cross-referencesi

Sequence databases

PIRiA53881.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1HLBX-ray2.50A2-158[»]
SMRiP80018. Positions 2-158.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP80018.

Family and domain databases

Gene3Di1.10.490.10. 1 hit.
InterProiIPR002336. Erythrocruorin.
IPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin_dom.
[Graphical view]
PfamiPF00042. Globin. 1 hit.
[Graphical view]
PRINTSiPR00611. ERYTHCRUORIN.
SUPFAMiSSF46458. SSF46458. 1 hit.
PROSITEiPS01033. GLOBIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Amino acid sequence of the coelomic C globin from the sea cucumber Caudina (Molpadia) arenicola."
    McDonald G.D., Davidson L., Kitto G.B.
    J. Protein Chem. 11:29-37(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-159.
    Tissue: Coelomic fluid.
  2. Thomas P.W.
    Thesis (1994), University of Texas / Austin, United States
    Cited for: PROTEIN SEQUENCE OF 2-159.
  3. "Three-dimensional structure of a hemichrome hemoglobin from Caudina arenicola."
    Mitchell D.T., Ernst S.R., Wu W.X., Hackert M.L.
    Acta Crystallogr. D 51:647-653(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS).

Entry informationi

Entry nameiGLBC_CAUAR
AccessioniPrimary (citable) accession number: P80018
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: January 23, 2007
Last modified: April 1, 2015
This is version 82 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Miscellaneous

Caudina arenicola coelomocytes contain four hemoglobin chains labeled A, B, C, D.

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.