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Protein

von Willebrand factor

Gene

VWF

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei410 – 4101Factor XIIIa-binding
Sitei414 – 4141Factor XIIIa-binding
Sitei605 – 6051Factor XIIIa-binding

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Blood coagulation, Cell adhesion, Hemostasis

Protein family/group databases

MEROPSiI08.954.

Names & Taxonomyi

Protein namesi
Recommended name:
von Willebrand factor
Short name:
vWF
Gene namesi
Name:VWF
Synonyms:F8VWF
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence analysisAdd
BLAST
Propeptidei23 – 762740By similarityPRO_0000022678Add
BLAST
Chaini763 – ›937›175von Willebrand factorPRO_0000022679Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi99 – 991N-linked (GlcNAc...)Sequence analysis
Glycosylationi156 – 1561N-linked (GlcNAc...)Sequence analysis
Glycosylationi211 – 2111N-linked (GlcNAc...)Sequence analysis
Glycosylationi665 – 6651N-linked (GlcNAc...)Sequence analysis
Disulfide bondi766 ↔ 807By similarity
Disulfide bondi775 ↔ 803By similarity
Glycosylationi856 – 8561N-linked (GlcNAc...)Sequence analysis
Disulfide bondi913 ↔ 920By similarity

Post-translational modificationi

All cysteine residues are involved in intrachain or interchain disulfide bonds.By similarity
N- and O-glycosylated.By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP80012.
PRIDEiP80012.

Expressioni

Tissue specificityi

Plasma.

Interactioni

Subunit structurei

Multimeric. Interacts with F8 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000016273.

Structurei

3D structure databases

ProteinModelPortaliP80012.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini34 – 239206VWFD 1PROSITE-ProRule annotationAdd
BLAST
Domaini294 – 34754TIL 1Add
BLAST
Domaini386 – 597212VWFD 2PROSITE-ProRule annotationAdd
BLAST
Domaini651 – 70656TIL 2Add
BLAST
Domaini865 – ›937›73VWFD 3PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni763 – 78624Amino-terminalAdd
BLAST
Regioni787 – 83246E1Add
BLAST
Regioni825 – 85228CXAdd
BLAST

Domaini

The propeptide is required for multimerization of vWF and for its targeting to storage granules.By similarity

Sequence similaritiesi

Contains at least 3 VWFD domains.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410KDA7. Eukaryota.
ENOG41100RZ. LUCA.
InParanoidiP80012.
KOiK03900.

Family and domain databases

InterProiIPR002919. TIL_dom.
IPR014853. Unchr_dom_Cys-rich.
IPR012011. VWF.
IPR001007. VWF_dom.
IPR001846. VWF_type-D.
[Graphical view]
PANTHERiPTHR11339:SF259. PTHR11339:SF259. 2 hits.
PfamiPF08742. C8. 2 hits.
PF01826. TIL. 2 hits.
PF00094. VWD. 3 hits.
[Graphical view]
SMARTiSM00832. C8. 2 hits.
SM00215. VWC_out. 2 hits.
SM00216. VWD. 2 hits.
[Graphical view]
SUPFAMiSSF57567. SSF57567. 3 hits.
PROSITEiPS51233. VWFD. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Sequence processingi: The displayed sequence is further processed into a mature form.

P80012-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFPTRLARLL LAVALTLPGA LCGEGALGKS SMARCSLFGA DFINTFDESM
60 70 80 90 100
YSFSGDCSYL LAGDCKTHSF SIVGDFQGGR RMGLSVYLGE FFDIHVFVNG
110 120 130 140 150
TVLQGGQHVS MPYATRGLYL ETEVGHHKLS SESYGFVARI DGSGNFQILL
160 170 180 190 200
SDRHFNKTCG LCGDFNIFAE DDFRTQEGTL TSDPYDFANS WALSSEEQRC
210 220 230 240 250
PRVSPPSSSC NVSSELQKGL WEKCQLLKTA SVFARCHALV DPEPFVALCE
260 270 280 290 300
RMLCACAQGL RCPCPVLLEY ARACAKQGML LYGWADHSSC RPDCPTGMEY
310 320 330 340 350
KECVSPCHRT CRSLSITEVC REQCVDGCSC PEGQLLDEGR CVESTECPCV
360 370 380 390 400
HAGKPYPPGA SLSRDCNTCI CRNSQWVCSN EDCPGECLIT GQSHFKSFDD
410 420 430 440 450
RHFTFSGVCQ YLLAQDCQDH SFSVVIETVQ CADDPDAVCT RSVTVRLPSP
460 470 480 490 500
HHGLLKLKHG GGVALDGQDV QIPLLQGDLR IQHTVTASLQ LNFGEDLQID
510 520 530 540 550
WDGRGRLLLK LSPVYAGRTC GLCGNYNGNQ RDDFLTPAGL VEPLVEHFGN
560 570 580 590 600
SWKLRADCED LQEQPSDPCS LNPRLTKFAD QACAILTSPK FEACHSAVSP
610 620 630 640 650
LPYLRNCRYD VCACSDGRDC LCDAVANYAA ACARRGVHVG WREPSFCALS
660 670 680 690 700
CPHGQVYQQC GTPCNLTCRS LSHPDEECTE VCLEGCFCPP GLFLDETGSC
710 720 730 740 750
VPKAQCPCYY DGEIFQPEDI FSDHHTMCYC EDGFMHSATS GAPGSLLPEA
760 770 780 790 800
VLSSPLSHRS KRSLSCRPPM VKVVCPADNP RAEGLECTKT CQNYDLECMS
810 820 830 840 850
TGCVSGCLPA PGMVRHENRC VALERCPCFH QGREYAPGDR VKVDCNSCVC
860 870 880 890 900
QDRKWNCTDH VCDASCSALG LAHYFTFDGL KYLFPGECQY VLVQDHCGSN
910 920 930
PGTFRVLVGN EGCSVPSLKC RKRITILVEG GEIELFD
Length:937
Mass (Da):102,599
Last modified:January 11, 2001 - v2
Checksum:i9BF4C94A254A5629
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti330 – 3301Missing AA sequence (PubMed:1707363).Curated
Sequence conflicti523 – 5231Missing AA sequence (PubMed:7588715).Curated
Sequence conflicti528 – 5281G → Q AA sequence (PubMed:7588715).Curated
Non-terminal residuei937 – 9371

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y09353 mRNA. Translation: CAA70525.1.
U28147 mRNA. Translation: AAA96953.1.
RefSeqiNP_001192237.1. NM_001205308.1.
UniGeneiBt.35003.

Genome annotation databases

GeneIDi280958.
KEGGibta:280958.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y09353 mRNA. Translation: CAA70525.1.
U28147 mRNA. Translation: AAA96953.1.
RefSeqiNP_001192237.1. NM_001205308.1.
UniGeneiBt.35003.

3D structure databases

ProteinModelPortaliP80012.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000016273.

Protein family/group databases

MEROPSiI08.954.

Proteomic databases

PaxDbiP80012.
PRIDEiP80012.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi280958.
KEGGibta:280958.

Organism-specific databases

CTDi7450.

Phylogenomic databases

eggNOGiENOG410KDA7. Eukaryota.
ENOG41100RZ. LUCA.
InParanoidiP80012.
KOiK03900.

Family and domain databases

InterProiIPR002919. TIL_dom.
IPR014853. Unchr_dom_Cys-rich.
IPR012011. VWF.
IPR001007. VWF_dom.
IPR001846. VWF_type-D.
[Graphical view]
PANTHERiPTHR11339:SF259. PTHR11339:SF259. 2 hits.
PfamiPF08742. C8. 2 hits.
PF01826. TIL. 2 hits.
PF00094. VWD. 3 hits.
[Graphical view]
SMARTiSM00832. C8. 2 hits.
SM00215. VWC_out. 2 hits.
SM00216. VWD. 2 hits.
[Graphical view]
SUPFAMiSSF57567. SSF57567. 3 hits.
PROSITEiPS51233. VWFD. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiVWF_BOVIN
AccessioniPrimary (citable) accession number: P80012
Secondary accession number(s): Q28011
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: January 11, 2001
Last modified: June 8, 2016
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.