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P80007 (CRA2_HOMGA) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Crustacyanin-A2 subunit
OrganismHomarus gammarus (European lobster) (Homarus vulgaris)
Taxonomic identifier6707 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaCrustaceaMalacostracaEumalacostracaEucaridaDecapodaPleocyemataAstacideaNephropoideaNephropidaeHomarus

Protein attributes

Sequence length174 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Binds the carotenoid astaxanthin (AXT) which provides the blue coloration to the carapace of the lobster.

Subunit structure

Oligomer; Can form dimers (beta-crustacyanin); or complexes of 16 subunits (alpha-crustacyanin). There are five types of subunits: A1, A2, A3, C1 and C2.

Subcellular location

Secretedextracellular space.

Tissue specificity

Found in the carapace.

Sequence similarities

Belongs to the calycin superfamily. Lipocalin family.

Ontologies

Keywords
   Biological processTransport
   Cellular componentSecreted
   LigandPigment
   PTMDisulfide bond
   Technical term3D-structure
Direct protein sequencing
Gene Ontology (GO)
   Biological_processtransport

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentextracellular space

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionpigment binding

Inferred from electronic annotation. Source: UniProtKB-KW

small molecule binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 174174Crustacyanin-A2 subunit
PRO_0000201010

Amino acid modifications

Disulfide bond12 ↔ 119 Ref.2
Disulfide bond46 ↔ 170 Ref.2

Secondary structure

................................ 174
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P80007 [UniParc].

Last modified May 1, 1991. Version 1.
Checksum: AC47FAA650C5E44E

FASTA17419,670
        10         20         30         40         50         60 
DGIPSFVTAG KCASVANQDN FDLRRYAGRW YQTHIIENAY QPVTRCIHSN YEYSTNDYGF 

        70         80         90        100        110        120 
KVTTAGFNPN DEYLKIDFKV YPTKEFPAAH MLIDAPSVFA APYEVIETDY ETYSCVYSCI 

       130        140        150        160        170 
TTDNYKSEFA FVFSRTPQTS GPAVEKTAAV FNKNGVEFSK FVPVSHTAEC VYRA 

« Hide

References

[1]"Complete sequence and model for the A2 subunit of the carotenoid pigment complex, crustacyanin."
Keen J.N., Caceres I., Eliopoulos E.E., Zagalsky P.F., Findlay J.B.C.
Eur. J. Biochem. 197:407-417(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE.
[2]"The molecular basis of the coloration mechanism in lobster shell: beta-crustacyanin at 3.2-A resolution."
Cianci M., Rizkallah P.J., Olczak A., Raftery J., Chayen N.E., Zagalsky P.F., Helliwell J.R.
Proc. Natl. Acad. Sci. U.S.A. 99:9795-9800(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (3.23 ANGSTROMS) OF HETERODIMER OF A1 AND A3 IN COMPLEX WITH ASTAXANTHIN, DISULFIDE BONDS.

Web resources

Protein Spotlight

Squeeze me - Issue 26 of September 2002

Cross-references

Sequence databases

PIRS15391.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1GKAX-ray3.23B1-174[»]
ProteinModelPortalP80007.
SMRP80007. Positions 1-174.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

MINTMINT-242150.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D2.40.128.20. 1 hit.
InterProIPR012674. Calycin.
IPR011038. Calycin-like.
IPR003057. Invtbrt_color.
IPR002345. Lipocalin.
IPR022271. Lipocalin_ApoD.
IPR022272. Lipocalin_CS.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
[Graphical view]
PfamPF00061. Lipocalin. 1 hit.
[Graphical view]
PIRSFPIRSF036893. Lipocalin_ApoD. 1 hit.
PRINTSPR01273. INVTBRTCOLOR.
PR00179. LIPOCALIN.
SUPFAMSSF50814. SSF50814. 1 hit.
PROSITEPS00213. LIPOCALIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP80007.

Entry information

Entry nameCRA2_HOMGA
AccessionPrimary (citable) accession number: P80007
Entry history
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: May 1, 1991
Last modified: February 19, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Protein Spotlight

Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries

PDB cross-references

Index of Protein Data Bank (PDB) cross-references