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P80007

- CRA2_HOMGA

UniProt

P80007 - CRA2_HOMGA

Protein

Crustacyanin-A2 subunit

Gene
N/A
Organism
Homarus gammarus (European lobster) (Homarus vulgaris)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Binds the carotenoid astaxanthin (AXT) which provides the blue coloration to the carapace of the lobster.

    GO - Molecular functioni

    1. pigment binding Source: UniProtKB-KW
    2. small molecule binding Source: InterPro

    GO - Biological processi

    1. transport Source: UniProtKB-KW

    Keywords - Biological processi

    Transport

    Keywords - Ligandi

    Pigment

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Crustacyanin-A2 subunit
    OrganismiHomarus gammarus (European lobster) (Homarus vulgaris)
    Taxonomic identifieri6707 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaCrustaceaMalacostracaEumalacostracaEucaridaDecapodaPleocyemataAstacideaNephropoideaNephropidaeHomarus

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 174174Crustacyanin-A2 subunitPRO_0000201010Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi12 ↔ 1191 Publication
    Disulfide bondi46 ↔ 1701 Publication

    Keywords - PTMi

    Disulfide bond

    Expressioni

    Tissue specificityi

    Found in the carapace.

    Interactioni

    Subunit structurei

    Oligomer; Can form dimers (beta-crustacyanin); or complexes of 16 subunits (alpha-crustacyanin). There are five types of subunits: A1, A2, A3, C1 and C2.1 Publication

    Protein-protein interaction databases

    MINTiMINT-242150.

    Structurei

    Secondary structure

    1
    174
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi7 – 104
    Turni23 – 264
    Beta strandi28 – 358
    Beta strandi45 – 5410
    Turni55 – 584
    Beta strandi59 – 679
    Beta strandi69 – 713
    Beta strandi73 – 764
    Beta strandi79 – 813
    Beta strandi90 – 945
    Beta strandi96 – 983
    Beta strandi101 – 1088
    Beta strandi110 – 12112
    Beta strandi123 – 13614
    Beta strandi139 – 1413
    Helixi142 – 15413
    Helixi158 – 1603

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1GKAX-ray3.23B1-174[»]
    ProteinModelPortaliP80007.
    SMRiP80007. Positions 1-174.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP80007.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the calycin superfamily. Lipocalin family.Curated

    Family and domain databases

    Gene3Di2.40.128.20. 1 hit.
    InterProiIPR012674. Calycin.
    IPR011038. Calycin-like.
    IPR003057. Invtbrt_color.
    IPR002345. Lipocalin.
    IPR022271. Lipocalin_ApoD.
    IPR022272. Lipocalin_CS.
    IPR000566. Lipocln_cytosolic_FA-bd_dom.
    [Graphical view]
    PfamiPF00061. Lipocalin. 1 hit.
    [Graphical view]
    PIRSFiPIRSF036893. Lipocalin_ApoD. 1 hit.
    PRINTSiPR01273. INVTBRTCOLOR.
    PR00179. LIPOCALIN.
    SUPFAMiSSF50814. SSF50814. 1 hit.
    PROSITEiPS00213. LIPOCALIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P80007-1 [UniParc]FASTAAdd to Basket

    « Hide

    DGIPSFVTAG KCASVANQDN FDLRRYAGRW YQTHIIENAY QPVTRCIHSN    50
    YEYSTNDYGF KVTTAGFNPN DEYLKIDFKV YPTKEFPAAH MLIDAPSVFA 100
    APYEVIETDY ETYSCVYSCI TTDNYKSEFA FVFSRTPQTS GPAVEKTAAV 150
    FNKNGVEFSK FVPVSHTAEC VYRA 174
    Length:174
    Mass (Da):19,670
    Last modified:May 1, 1991 - v1
    Checksum:iAC47FAA650C5E44E
    GO

    Sequence databases

    PIRiS15391.

    Cross-referencesi

    Web resourcesi

    Protein Spotlight

    Squeeze me - Issue 26 of September 2002

    Sequence databases

    PIRi S15391.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1GKA X-ray 3.23 B 1-174 [» ]
    ProteinModelPortali P80007.
    SMRi P80007. Positions 1-174.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-242150.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Miscellaneous databases

    EvolutionaryTracei P80007.

    Family and domain databases

    Gene3Di 2.40.128.20. 1 hit.
    InterProi IPR012674. Calycin.
    IPR011038. Calycin-like.
    IPR003057. Invtbrt_color.
    IPR002345. Lipocalin.
    IPR022271. Lipocalin_ApoD.
    IPR022272. Lipocalin_CS.
    IPR000566. Lipocln_cytosolic_FA-bd_dom.
    [Graphical view ]
    Pfami PF00061. Lipocalin. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF036893. Lipocalin_ApoD. 1 hit.
    PRINTSi PR01273. INVTBRTCOLOR.
    PR00179. LIPOCALIN.
    SUPFAMi SSF50814. SSF50814. 1 hit.
    PROSITEi PS00213. LIPOCALIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence and model for the A2 subunit of the carotenoid pigment complex, crustacyanin."
      Keen J.N., Caceres I., Eliopoulos E.E., Zagalsky P.F., Findlay J.B.C.
      Eur. J. Biochem. 197:407-417(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE.
    2. "The molecular basis of the coloration mechanism in lobster shell: beta-crustacyanin at 3.2-A resolution."
      Cianci M., Rizkallah P.J., Olczak A., Raftery J., Chayen N.E., Zagalsky P.F., Helliwell J.R.
      Proc. Natl. Acad. Sci. U.S.A. 99:9795-9800(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.23 ANGSTROMS) OF HETERODIMER OF A1 AND A3 IN COMPLEX WITH ASTAXANTHIN, DISULFIDE BONDS.

    Entry informationi

    Entry nameiCRA2_HOMGA
    AccessioniPrimary (citable) accession number: P80007
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 1991
    Last sequence update: May 1, 1991
    Last modified: October 1, 2014
    This is version 86 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Direct protein sequencing

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. Protein Spotlight
      Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3