P80003 (PA2A2_HELSU) Reviewed, UniProtKB/Swiss-Prot
Last modified
May 1, 2013.
Version 76.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Acidic phospholipase A2 PA4 Short name=PLA2 EC=3.1.1.4 Alternative name(s): Phosphatidylcholine 2-acylhydrolase Cleaved into the following chain: |
| Organism | Heloderma suspectum (Gila monster) |
| Taxonomic identifier | 8554 [NCBI] |
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Lepidosauria › Squamata › Scleroglossa › Anguimorpha › Helodermatidae › Heloderma![]() |
Protein attributes
| Sequence length | 142 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Function | PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. |
| Catalytic activity | Phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate. |
| Cofactor | Binds 1 calcium ion per subunit By similarity. |
| Subcellular location | |
| Tissue specificity | Expressed by the venom gland. |
| Sequence similarities | Belongs to the phospholipase A2 family. Group III subfamily. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Lipid degradation Lipid metabolism |
| Cellular component | Secreted |
| Ligand | Calcium Metal-binding |
| Molecular function | Hydrolase |
| PTM | Disulfide bond |
| Technical term | Direct protein sequencing |
| Gene Ontology (GO) | |
| Biological_process | lipid catabolic process Inferred from electronic annotation. Source: UniProtKB-KW phospholipid metabolic processInferred from electronic annotation. Source: InterPro |
| Cellular_component | extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular_function | calcium ion binding Inferred from electronic annotation. Source: InterPro phospholipase A2 activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||
Molecule processing | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 142 | 142 | Acidic phospholipase A2 PA4 | PRO_0000045885 | |||||||
| Chain | 1 – 141 | 141 | Acidic phospholipase A2 PA2 | PRO_0000045886 | |||||||
Sites | |||||||||||
| Active site | 36 | 1 | By similarity | ||||||||
| Metal binding | 10 | 1 | Calcium; via carbonyl oxygen By similarity | ||||||||
| Metal binding | 12 | 1 | Calcium; via carbonyl oxygen By similarity | ||||||||
| Metal binding | 14 | 1 | Calcium; via carbonyl oxygen By similarity | ||||||||
| Metal binding | 37 | 1 | Calcium By similarity | ||||||||
Amino acid modifications | |||||||||||
| Disulfide bond | 11 ↔ 33 | By similarity | |||||||||
| Disulfide bond | 32 ↔ 72 | By similarity | |||||||||
| Disulfide bond | 39 ↔ 65 | By similarity | |||||||||
Sequences
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References
| [1] | "Differences in primary structure among five phospholipases A2 from Heloderma suspectum." Vandermeers A., Vandermeers-Piret M.-C., Vigneron L., Rathe J., Stievenart M., Christophe J. Eur. J. Biochem. 196:537-544(1991) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE. Tissue: Venom. |
Cross-references
Sequence databases | |
|---|---|
| PIR | S25093. |
3D structure databases | |
| ProteinModelPortal | P80003. |
| ModBase | Search... |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Phylogenomic databases | |
| HOVERGEN | HBG008138. |
Family and domain databases | |
| Gene3D | 1.20.90.10. 1 hit. |
| InterPro | IPR001211. PLipase_A2. IPR013090. PLipase_A2_AS. IPR016090. PLipase_A2_dom. [Graphical view] |
| PANTHER | PTHR12253. PTHR12253. 1 hit. |
| Pfam | PF05826. Phospholip_A2_2. 1 hit. [Graphical view] |
| SMART | SM00085. PA2c. 1 hit. [Graphical view] |
| SUPFAM | SSF48619. PhospholipaseA2. 1 hit. |
| PROSITE | PS00119. PA2_ASP. False negative. PS00118. PA2_HIS. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | PA2A2_HELSU | ||||||||
| Accession | Primary (citable) accession number: P80003 Secondary accession number(s): P80006 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
Relevant documents
| SIMILARITY comments Index of protein domains and families |

Clusters with
