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P79996 (MK09_CHICK) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 108. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Mitogen-activated protein kinase 9

Short name=MAP kinase 9
Short name=MAPK 9
EC=2.7.11.24
Alternative name(s):
Stress-activated protein kinase JNK2
c-Jun N-terminal kinase 2
Gene names
Name:MAPK9
Synonyms:JNK2
OrganismGallus gallus (Chicken) [Reference proteome]
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus

Protein attributes

Sequence length382 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity By similarity. May play a role in the development of the central nervous system during embryogenesis. UniProtKB P45984

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Cofactor

Magnesium By similarity. UniProtKB P45984

Enzyme regulation

Activated by threonine and tyrosine phosphorylation By similarity. UniProtKB P45984

Tissue specificity

Expressed in the neuroepithelium of developing brain at stages 16 to 26. Ref.1

Domain

The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.

Post-translational modification

Dually phosphorylated on Thr-183 and Tyr-185, which activates the enzyme By similarity.

Sequence similarities

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.

Contains 1 protein kinase domain.

Ontologies

Keywords
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Serine/threonine-protein kinase
Transferase
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processJNK cascade

Inferred from sequence or structural similarity. Source: UniProtKB

MyD88-dependent toll-like receptor signaling pathway

Traceable author statement. Source: Reactome

activation of MAPK activity involved in innate immune response

Traceable author statement. Source: Reactome

embryo development

Inferred from direct assay Ref.1. Source: UniProtKB

innate immune response

Traceable author statement. Source: Reactome

positive regulation of apoptotic signaling pathway

Inferred from electronic annotation. Source: Ensembl

positive regulation of gene expression

Inferred from electronic annotation. Source: Ensembl

positive regulation of macrophage derived foam cell differentiation

Inferred from electronic annotation. Source: Ensembl

response to cadmium ion

Inferred from electronic annotation. Source: Ensembl

toll-like receptor 15 signaling pathway

Traceable author statement. Source: Reactome

toll-like receptor 2 signaling pathway

Traceable author statement. Source: Reactome

toll-like receptor 21 signaling pathway

Traceable author statement. Source: Reactome

toll-like receptor 3 signaling pathway

Traceable author statement. Source: Reactome

toll-like receptor 4 signaling pathway

Traceable author statement. Source: Reactome

toll-like receptor 5 signaling pathway

Traceable author statement. Source: Reactome

toll-like receptor 7 signaling pathway

Traceable author statement. Source: Reactome

toll-like receptor signaling pathway

Traceable author statement. Source: Reactome

   Cellular_componentcytosol

Inferred from electronic annotation. Source: Ensembl

mitochondrion

Inferred from electronic annotation. Source: Ensembl

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

MAP kinase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 382382Mitogen-activated protein kinase 9
PRO_0000186276

Regions

Domain26 – 321296Protein kinase UniProtKB P53779
Nucleotide binding33 – 386ATP By similarity UniProtKB P53779
Motif183 – 1853TXY

Sites

Active site1511Proton acceptor By similarity UniProtKB P53779
Binding site551ATP By similarity UniProtKB P53779

Amino acid modifications

Modified residue1831Phosphothreonine By similarity UniProtKB P53779
Modified residue1851Phosphotyrosine By similarity UniProtKB P53779

Sequences

Sequence LengthMass (Da)Tools
P79996 [UniParc].

Last modified May 1, 1997. Version 1.
Checksum: 9A737C925465E54C

FASTA38244,009
        10         20         30         40         50         60 
MSDSKCDSQF YSVQVADSTF TVLKRYQQLK PIGSGAQGIV CAAFDTVLGI NVAVKKLSRP 

        70         80         90        100        110        120 
FQNQTHAKRA YRELVLLKCV NHKNIISLLN VFTPQKSLEE FQDVYLVMEL MDANLCQVIH 

       130        140        150        160        170        180 
MELDHERMSY LLYQMLCGIK HLHSAGIIHR DLKPSNIVVK SDCTLKILDF GLARTACTNF 

       190        200        210        220        230        240 
MMTPYVVTRY YRAPEVILGM GYKENVDIWS VGCIMGELVK GCVIFQGTDH IDQWNKVIEQ 

       250        260        270        280        290        300 
LGTPSAEFMK KLQPTVRNYV ENRPKYPGIK FEELFPDWIF PSESDRDKLK TSQARDLLSK 

       310        320        330        340        350        360 
MLVVDPDKRI SVDEALRHPY ITVWYDPAEA EAPPPQIYDA QLEEREHAIE EWKELIYKEV 

       370        380 
MDWEERSKNG VVKDQPSAQM QQ 

« Hide

References

[1]"Expression of the JNK2-alpha1 gene in the developing chick brain."
Ishikawa T., Nakada-Moriya Y., Ando C., Tanda N., Nishida S., Minatogawa Y., Nohno T.
Biochem. Biophys. Res. Commun. 234:489-492(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
Tissue: Embryo.
[2]Erratum
Ishikawa T., Nakada-Moriya Y., Ando C., Tanda N., Nishida S., Minatogawa Y., Nohno T.
Biochem. Biophys. Res. Commun. 236:538-538(1997)

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB000807 mRNA. Translation: BAA19188.1.
PIRJC5531.
RefSeqNP_990426.1. NM_205095.1.
UniGeneGga.3651.

3D structure databases

ProteinModelPortalP79996.
SMRP79996. Positions 7-362.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9031.ENSGALP00000022313.

Proteomic databases

PaxDbP79996.
PRIDEP79996.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSGALT00000022353; ENSGALP00000022313; ENSGALG00000013761.
GeneID395983.
KEGGgga:395983.

Organism-specific databases

CTD5601.

Phylogenomic databases

eggNOGCOG0515.
GeneTreeENSGT00550000074271.
HOGENOMHOG000233024.
HOVERGENHBG014652.
InParanoidP79996.
KOK04440.
OMASSMSTEH.
OrthoDBEOG7PCJGV.
PhylomeDBP79996.
TreeFamTF105100.

Enzyme and pathway databases

ReactomeREACT_147795. Innate Immune System.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR003527. MAP_kinase_CS.
IPR008351. MAPK_JNK.
IPR000719. Prot_kinase_dom.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
PRINTSPR01772. JNKMAPKINASE.
SMARTSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS01351. MAPK. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20816047.
PROP79996.

Entry information

Entry nameMK09_CHICK
AccessionPrimary (citable) accession number: P79996
Entry history
Integrated into UniProtKB/Swiss-Prot: April 30, 2003
Last sequence update: May 1, 1997
Last modified: May 14, 2014
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families