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P79996

- MK09_CHICK

UniProt

P79996 - MK09_CHICK

Protein

Mitogen-activated protein kinase 9

Gene

MAPK9

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 110 (01 Oct 2014)
      Sequence version 1 (01 May 1997)
      Previous versions | rss
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    Functioni

    Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity By similarity. May play a role in the development of the central nervous system during embryogenesis.By similarity

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Cofactori

    Magnesium.By similarity

    Enzyme regulationi

    Activated by threonine and tyrosine phosphorylation.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei55 – 551ATPPROSITE-ProRule annotation
    Active sitei151 – 1511Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi33 – 386ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. MAP kinase activity Source: UniProtKB-EC

    GO - Biological processi

    1. activation of MAPK activity involved in innate immune response Source: Reactome
    2. embryo development Source: UniProtKB
    3. innate immune response Source: Reactome
    4. JNK cascade Source: UniProtKB
    5. MyD88-dependent toll-like receptor signaling pathway Source: Reactome
    6. positive regulation of apoptotic signaling pathway Source: Ensembl
    7. positive regulation of gene expression Source: Ensembl
    8. positive regulation of macrophage derived foam cell differentiation Source: Ensembl
    9. response to cadmium ion Source: Ensembl
    10. toll-like receptor 15 signaling pathway Source: Reactome
    11. toll-like receptor 21 signaling pathway Source: Reactome
    12. toll-like receptor 2 signaling pathway Source: Reactome
    13. toll-like receptor 3 signaling pathway Source: Reactome
    14. toll-like receptor 4 signaling pathway Source: Reactome
    15. toll-like receptor 5 signaling pathway Source: Reactome
    16. toll-like receptor 7 signaling pathway Source: Reactome
    17. toll-like receptor signaling pathway Source: Reactome

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_194397. FCERI mediated MAPK activation.
    REACT_194991. Oxidative Stress Induced Senescence.
    REACT_25273. Activated TAK1 mediates Jun kinases (JNK) phosphorylation and activation.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mitogen-activated protein kinase 9 (EC:2.7.11.24)
    Short name:
    MAP kinase 9
    Short name:
    MAPK 9
    Alternative name(s):
    Stress-activated protein kinase JNK2
    c-Jun N-terminal kinase 2
    Gene namesi
    Name:MAPK9
    Synonyms:JNK2
    OrganismiGallus gallus (Chicken)Imported
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Chromosome 13

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: Ensembl
    2. mitochondrion Source: Ensembl

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 382382Mitogen-activated protein kinase 9PRO_0000186276Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei183 – 1831PhosphothreonineBy similarity
    Modified residuei185 – 1851PhosphotyrosineBy similarity

    Post-translational modificationi

    Dually phosphorylated on Thr-183 and Tyr-185, which activates the enzyme.By similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiP79996.
    PRIDEiP79996.

    Expressioni

    Tissue specificityi

    Expressed in the neuroepithelium of developing brain at stages 16 to 26.1 Publication

    Interactioni

    Protein-protein interaction databases

    STRINGi9031.ENSGALP00000022313.

    Structurei

    3D structure databases

    ProteinModelPortaliP79996.
    SMRiP79996. Positions 7-362.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini26 – 321296Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi183 – 1853TXY

    Domaini

    The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.

    Sequence similaritiesi

    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0515.
    GeneTreeiENSGT00550000074271.
    HOGENOMiHOG000233024.
    HOVERGENiHBG014652.
    InParanoidiP79996.
    KOiK04440.
    OMAiSSMSTEH.
    OrthoDBiEOG7PCJGV.
    PhylomeDBiP79996.
    TreeFamiTF105100.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR003527. MAP_kinase_CS.
    IPR008351. MAPK_JNK.
    IPR000719. Prot_kinase_dom.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    PRINTSiPR01772. JNKMAPKINASE.
    SMARTiSM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS01351. MAPK. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P79996-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSDSKCDSQF YSVQVADSTF TVLKRYQQLK PIGSGAQGIV CAAFDTVLGI    50
    NVAVKKLSRP FQNQTHAKRA YRELVLLKCV NHKNIISLLN VFTPQKSLEE 100
    FQDVYLVMEL MDANLCQVIH MELDHERMSY LLYQMLCGIK HLHSAGIIHR 150
    DLKPSNIVVK SDCTLKILDF GLARTACTNF MMTPYVVTRY YRAPEVILGM 200
    GYKENVDIWS VGCIMGELVK GCVIFQGTDH IDQWNKVIEQ LGTPSAEFMK 250
    KLQPTVRNYV ENRPKYPGIK FEELFPDWIF PSESDRDKLK TSQARDLLSK 300
    MLVVDPDKRI SVDEALRHPY ITVWYDPAEA EAPPPQIYDA QLEEREHAIE 350
    EWKELIYKEV MDWEERSKNG VVKDQPSAQM QQ 382
    Length:382
    Mass (Da):44,009
    Last modified:May 1, 1997 - v1
    Checksum:i9A737C925465E54C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB000807 mRNA. Translation: BAA19188.1.
    PIRiJC5531.
    RefSeqiNP_990426.1. NM_205095.1.
    UniGeneiGga.3651.

    Genome annotation databases

    EnsembliENSGALT00000022353; ENSGALP00000022313; ENSGALG00000013761.
    GeneIDi395983.
    KEGGigga:395983.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB000807 mRNA. Translation: BAA19188.1 .
    PIRi JC5531.
    RefSeqi NP_990426.1. NM_205095.1.
    UniGenei Gga.3651.

    3D structure databases

    ProteinModelPortali P79996.
    SMRi P79996. Positions 7-362.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9031.ENSGALP00000022313.

    Proteomic databases

    PaxDbi P79996.
    PRIDEi P79996.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSGALT00000022353 ; ENSGALP00000022313 ; ENSGALG00000013761 .
    GeneIDi 395983.
    KEGGi gga:395983.

    Organism-specific databases

    CTDi 5601.

    Phylogenomic databases

    eggNOGi COG0515.
    GeneTreei ENSGT00550000074271.
    HOGENOMi HOG000233024.
    HOVERGENi HBG014652.
    InParanoidi P79996.
    KOi K04440.
    OMAi SSMSTEH.
    OrthoDBi EOG7PCJGV.
    PhylomeDBi P79996.
    TreeFami TF105100.

    Enzyme and pathway databases

    Reactomei REACT_194397. FCERI mediated MAPK activation.
    REACT_194991. Oxidative Stress Induced Senescence.
    REACT_25273. Activated TAK1 mediates Jun kinases (JNK) phosphorylation and activation.

    Miscellaneous databases

    NextBioi 20816047.
    PROi P79996.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR003527. MAP_kinase_CS.
    IPR008351. MAPK_JNK.
    IPR000719. Prot_kinase_dom.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    PRINTSi PR01772. JNKMAPKINASE.
    SMARTi SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS01351. MAPK. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
      Tissue: Embryo.
    2. Erratum
      Ishikawa T., Nakada-Moriya Y., Ando C., Tanda N., Nishida S., Minatogawa Y., Nohno T.
      Biochem. Biophys. Res. Commun. 236:538-538(1997)

    Entry informationi

    Entry nameiMK09_CHICK
    AccessioniPrimary (citable) accession number: P79996
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 30, 2003
    Last sequence update: May 1, 1997
    Last modified: October 1, 2014
    This is version 110 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3