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P79996

- MK09_CHICK

UniProt

P79996 - MK09_CHICK

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Protein
Mitogen-activated protein kinase 9
Gene
MAPK9, JNK2
Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity By similarity. May play a role in the development of the central nervous system during embryogenesis.By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Cofactori

Magnesium By similarity.By similarity

Enzyme regulationi

Activated by threonine and tyrosine phosphorylation By similarity.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei55 – 551ATP By similarityBy similarity
Active sitei151 – 1511Proton acceptor By similarityBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi33 – 386ATP By similarityBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. MAP kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. JNK cascade Source: UniProtKB
  2. MyD88-dependent toll-like receptor signaling pathway Source: Reactome
  3. activation of MAPK activity involved in innate immune response Source: Reactome
  4. embryo development Source: UniProtKB
  5. innate immune response Source: Reactome
  6. positive regulation of apoptotic signaling pathway Source: Ensembl
  7. positive regulation of gene expression Source: Ensembl
  8. positive regulation of macrophage derived foam cell differentiation Source: Ensembl
  9. response to cadmium ion Source: Ensembl
  10. toll-like receptor 15 signaling pathway Source: Reactome
  11. toll-like receptor 2 signaling pathway Source: Reactome
  12. toll-like receptor 21 signaling pathway Source: Reactome
  13. toll-like receptor 3 signaling pathway Source: Reactome
  14. toll-like receptor 4 signaling pathway Source: Reactome
  15. toll-like receptor 5 signaling pathway Source: Reactome
  16. toll-like receptor 7 signaling pathway Source: Reactome
  17. toll-like receptor signaling pathway Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_194397. FCERI mediated MAPK activation.
REACT_194991. Oxidative Stress Induced Senescence.
REACT_25273. Activated TAK1 mediates Jun kinases (JNK) phosphorylation and activation.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitogen-activated protein kinase 9 (EC:2.7.11.24)
Short name:
MAP kinase 9
Short name:
MAPK 9
Alternative name(s):
Stress-activated protein kinase JNK2
c-Jun N-terminal kinase 2
Gene namesi
Name:MAPK9
Synonyms:JNK2
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Chromosome 13

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: Ensembl
  2. mitochondrion Source: Ensembl
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 382382Mitogen-activated protein kinase 9
PRO_0000186276Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei183 – 1831Phosphothreonine By similarityBy similarity
Modified residuei185 – 1851Phosphotyrosine By similarityBy similarity

Post-translational modificationi

Dually phosphorylated on Thr-183 and Tyr-185, which activates the enzyme By similarity.

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP79996.
PRIDEiP79996.

Expressioni

Tissue specificityi

Expressed in the neuroepithelium of developing brain at stages 16 to 26.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000022313.

Structurei

3D structure databases

ProteinModelPortaliP79996.
SMRiP79996. Positions 7-362.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini26 – 321296Protein kinaseBy similarity
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi183 – 1853TXY

Domaini

The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00550000074271.
HOGENOMiHOG000233024.
HOVERGENiHBG014652.
InParanoidiP79996.
KOiK04440.
OMAiSSMSTEH.
OrthoDBiEOG7PCJGV.
PhylomeDBiP79996.
TreeFamiTF105100.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR003527. MAP_kinase_CS.
IPR008351. MAPK_JNK.
IPR000719. Prot_kinase_dom.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
PRINTSiPR01772. JNKMAPKINASE.
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS01351. MAPK. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P79996-1 [UniParc]FASTAAdd to Basket

« Hide

MSDSKCDSQF YSVQVADSTF TVLKRYQQLK PIGSGAQGIV CAAFDTVLGI    50
NVAVKKLSRP FQNQTHAKRA YRELVLLKCV NHKNIISLLN VFTPQKSLEE 100
FQDVYLVMEL MDANLCQVIH MELDHERMSY LLYQMLCGIK HLHSAGIIHR 150
DLKPSNIVVK SDCTLKILDF GLARTACTNF MMTPYVVTRY YRAPEVILGM 200
GYKENVDIWS VGCIMGELVK GCVIFQGTDH IDQWNKVIEQ LGTPSAEFMK 250
KLQPTVRNYV ENRPKYPGIK FEELFPDWIF PSESDRDKLK TSQARDLLSK 300
MLVVDPDKRI SVDEALRHPY ITVWYDPAEA EAPPPQIYDA QLEEREHAIE 350
EWKELIYKEV MDWEERSKNG VVKDQPSAQM QQ 382
Length:382
Mass (Da):44,009
Last modified:May 1, 1997 - v1
Checksum:i9A737C925465E54C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB000807 mRNA. Translation: BAA19188.1.
PIRiJC5531.
RefSeqiNP_990426.1. NM_205095.1.
UniGeneiGga.3651.

Genome annotation databases

EnsembliENSGALT00000022353; ENSGALP00000022313; ENSGALG00000013761.
GeneIDi395983.
KEGGigga:395983.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB000807 mRNA. Translation: BAA19188.1 .
PIRi JC5531.
RefSeqi NP_990426.1. NM_205095.1.
UniGenei Gga.3651.

3D structure databases

ProteinModelPortali P79996.
SMRi P79996. Positions 7-362.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9031.ENSGALP00000022313.

Proteomic databases

PaxDbi P79996.
PRIDEi P79996.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSGALT00000022353 ; ENSGALP00000022313 ; ENSGALG00000013761 .
GeneIDi 395983.
KEGGi gga:395983.

Organism-specific databases

CTDi 5601.

Phylogenomic databases

eggNOGi COG0515.
GeneTreei ENSGT00550000074271.
HOGENOMi HOG000233024.
HOVERGENi HBG014652.
InParanoidi P79996.
KOi K04440.
OMAi SSMSTEH.
OrthoDBi EOG7PCJGV.
PhylomeDBi P79996.
TreeFami TF105100.

Enzyme and pathway databases

Reactomei REACT_194397. FCERI mediated MAPK activation.
REACT_194991. Oxidative Stress Induced Senescence.
REACT_25273. Activated TAK1 mediates Jun kinases (JNK) phosphorylation and activation.

Miscellaneous databases

NextBioi 20816047.
PROi P79996.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR003527. MAP_kinase_CS.
IPR008351. MAPK_JNK.
IPR000719. Prot_kinase_dom.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
PRINTSi PR01772. JNKMAPKINASE.
SMARTi SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS01351. MAPK. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Embryo.
  2. Erratum
    Ishikawa T., Nakada-Moriya Y., Ando C., Tanda N., Nishida S., Minatogawa Y., Nohno T.
    Biochem. Biophys. Res. Commun. 236:538-538(1997)

Entry informationi

Entry nameiMK09_CHICK
AccessioniPrimary (citable) accession number: P79996
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 30, 2003
Last sequence update: May 1, 1997
Last modified: September 3, 2014
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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