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Protein
Submitted name:

DNA topoisomerase I

Gene
N/A
Organism
Gallus gallus (Chicken)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • chromatin binding Source: AgBase
  • DNA binding Source: UniProtKB
  • DNA topoisomerase type I activity Source: AgBase
  • DNA topoisomerase type II (ATP-hydrolyzing) activity Source: InterPro
  • double-stranded DNA binding Source: AgBase

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

IsomeraseImported

Enzyme and pathway databases

ReactomeiR-GGA-4615885. SUMOylation of DNA replication proteins.

Names & Taxonomyi

Protein namesi
Submitted name:
DNA topoisomerase IImported
OrganismiGallus gallus (Chicken)Imported
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Proteomic databases

PaxDbiP79994.
PRIDEiP79994.

Expressioni

Gene expression databases

BgeeiENSGALG00000003681.
ExpressionAtlasiP79994. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000005822.

Structurei

3D structure databases

ProteinModelPortaliP79994.
SMRiP79994. Positions 200-766.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini361 – 738378TOPEUcInterPro annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili154 – 18330Sequence analysisAdd
BLAST
Coiled coili311 – 33828Sequence analysisAdd
BLAST
Coiled coili645 – 67935Sequence analysisAdd
BLAST
Coiled coili685 – 71228Sequence analysisAdd
BLAST

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG0981. Eukaryota.
COG3569. LUCA.
HOGENOMiHOG000105469.
HOVERGENiHBG007988.
KOiK03163.
PhylomeDBiP79994.

Family and domain databases

Gene3Di1.10.10.41. 1 hit.
1.10.132.10. 1 hit.
2.170.11.10. 2 hits.
3.90.15.10. 1 hit.
InterProiIPR011010. DNA_brk_join_enz.
IPR013034. DNA_topo_domain1.
IPR001631. TopoI.
IPR018521. TopoI_AS.
IPR025834. TopoI_C_dom.
IPR014711. TopoI_cat_a-hlx-sub_euk.
IPR014727. TopoI_cat_a/b-sub_euk.
IPR013500. TopoI_cat_euk.
IPR008336. TopoI_DNA-bd_euk.
IPR013030. TopoI_DNA-bd_mixed-a/b_euk.
IPR013499. TopoI_euk.
[Graphical view]
PfamiPF14370. Topo_C_assoc. 1 hit.
PF01028. Topoisom_I. 1 hit.
PF02919. Topoisom_I_N. 1 hit.
[Graphical view]
PRINTSiPR00416. EUTPISMRASEI.
SMARTiSM00435. TOPEUc. 1 hit.
[Graphical view]
SUPFAMiSSF56349. SSF56349. 2 hits.
SSF56741. SSF56741. 1 hit.
PROSITEiPS00176. TOPOISOMERASE_I_EUK. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P79994-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGDQLHNDS QIEADFRAND SHKHKDKHKD REHRHKEHKK DKEKDREKSK
60 70 80 90 100
HSNSEHKDSS EKKHKDKEKT KHKDGSSEKH KDKHKDKDKE KRKEEKIKLS
110 120 130 140 150
SGDIKIKKEK ENGFSSPPRI KDEPDDDGFY ASPKEDSKPL KRPREDDDAD
160 170 180 190 200
YKPKKIKTED VKKAKKRKQE EEEDSKAKKA KNKDKKSPEA DKRKKPKKEE
210 220 230 240 250
EQKWKWWEEE RYPEGIKWKF LEHKGPVFAP PYEPLPENVK FYYDGKVMKL
260 270 280 290 300
STKAEEVATF FAKMLDHEYT TKEIFRKNFF KDWRKEMTSE EKSTITSLSK
310 320 330 340 350
CDFTHMSQYF KAQTEARKQM SKEEKQKIKE ENERLLKEYG YCVMDNHKER
360 370 380 390 400
IANFKIEPPG LFRGRGNHPK MGMLKRRIMP EDIIINCSKD SKVPPPPPGH
410 420 430 440 450
KWKEVRHDNK VTWLVSWTEN IQGSIKYIML NPSSRIKGEK DWQKYETARR
460 470 480 490 500
LKKCVDKIRN QYREDWKSKE MKVRQRAVAL YFIDKLALRA GNEKEEGETA
510 520 530 540 550
DTVGCCSLRV EHIKLHPELD GQEYVVEFDF LGKDSIRYYN KVPVEKRVFK
560 570 580 590 600
NLQLFMENKQ PEDDLFDRLN TSILNKHLQD LMEGLTAKVF RTYNASITLQ
610 620 630 640 650
QQLKELTNPD DNIPAKILSY NRANRAVAIL CNHQRAPPKT FEKSMMNLQS
660 670 680 690 700
KIDAKKEQLA DARRELKSAK ADAKVRRDEK SKKAVESKKK AVQRIEEQLM
710 720 730 740 750
KLEVQATDRE ENKQIALSTS KLNYLDPRIS VAWCKKWGIP IEKIYNKTQR
760
EKFAWAIDMA EEDYEF
Length:766
Mass (Da):90,796
Last modified:May 1, 1997 - v1
Checksum:iB724A2338F56FB9B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB000407 mRNA. Translation: BAA19101.1.
RefSeqiNP_990441.1. NM_205110.1.
UniGeneiGga.37721.

Genome annotation databases

GeneIDi396004.
KEGGigga:396004.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB000407 mRNA. Translation: BAA19101.1.
RefSeqiNP_990441.1. NM_205110.1.
UniGeneiGga.37721.

3D structure databases

ProteinModelPortaliP79994.
SMRiP79994. Positions 200-766.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000005822.

Proteomic databases

PaxDbiP79994.
PRIDEiP79994.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi396004.
KEGGigga:396004.

Organism-specific databases

CTDi7150.

Phylogenomic databases

eggNOGiKOG0981. Eukaryota.
COG3569. LUCA.
HOGENOMiHOG000105469.
HOVERGENiHBG007988.
KOiK03163.
PhylomeDBiP79994.

Enzyme and pathway databases

ReactomeiR-GGA-4615885. SUMOylation of DNA replication proteins.

Gene expression databases

BgeeiENSGALG00000003681.
ExpressionAtlasiP79994. baseline and differential.

Family and domain databases

Gene3Di1.10.10.41. 1 hit.
1.10.132.10. 1 hit.
2.170.11.10. 2 hits.
3.90.15.10. 1 hit.
InterProiIPR011010. DNA_brk_join_enz.
IPR013034. DNA_topo_domain1.
IPR001631. TopoI.
IPR018521. TopoI_AS.
IPR025834. TopoI_C_dom.
IPR014711. TopoI_cat_a-hlx-sub_euk.
IPR014727. TopoI_cat_a/b-sub_euk.
IPR013500. TopoI_cat_euk.
IPR008336. TopoI_DNA-bd_euk.
IPR013030. TopoI_DNA-bd_mixed-a/b_euk.
IPR013499. TopoI_euk.
[Graphical view]
PfamiPF14370. Topo_C_assoc. 1 hit.
PF01028. Topoisom_I. 1 hit.
PF02919. Topoisom_I_N. 1 hit.
[Graphical view]
PRINTSiPR00416. EUTPISMRASEI.
SMARTiSM00435. TOPEUc. 1 hit.
[Graphical view]
SUPFAMiSSF56349. SSF56349. 2 hits.
SSF56741. SSF56741. 1 hit.
PROSITEiPS00176. TOPOISOMERASE_I_EUK. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiP79994_CHICK
AccessioniPrimary (citable) accession number: P79994
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 1997
Last sequence update: May 1, 1997
Last modified: September 7, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.