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Protein

Guanylate cyclase

Gene

gucy2c

Organism
Xenopus laevis (African clawed frog)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

GTP = 3',5'-cyclic GMP + diphosphate.UniRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotationSAAS annotationImported

Keywords - Biological processi

cGMP biosynthesisUniRule annotationSAAS annotation

Keywords - Ligandi

Nucleotide-bindingSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Guanylate cyclaseUniRule annotationSAAS annotation (EC:4.6.1.2UniRule annotationSAAS annotation)
Gene namesi
Name:gucy2cImported
OrganismiXenopus laevis (African clawed frog)Imported
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-952211. gucy2c.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei424 – 44724HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence analysisAdd
BLAST
Chaini23 – 10651043Guanylate cyclaseSequence analysisPRO_5004161729Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP79991.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini484 – 741258Protein kinaseInterPro annotationAdd
BLAST
Domaini816 – 946131Guanylate cyclaseInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.UniRule annotationSAAS annotation
Contains guanylate cyclase domain.SAAS annotation
Contains protein kinase domain.SAAS annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

HOVERGENiHBG106967.
KOiK12320.

Family and domain databases

Gene3Di3.30.70.1230. 1 hit.
InterProiIPR001054. A/G_cyclase.
IPR018297. A/G_cyclase_CS.
IPR001828. ANF_lig-bd_rcpt.
IPR011009. Kinase-like_dom.
IPR029787. Nucleotide_cyclase.
IPR028082. Peripla_BP_I.
IPR000719. Prot_kinase_dom.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF01094. ANF_receptor. 1 hit.
PF00211. Guanylate_cyc. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
SMARTiSM00044. CYCc. 1 hit.
[Graphical view]
SUPFAMiSSF53822. SSF53822. 1 hit.
SSF55073. SSF55073. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00452. GUANYLATE_CYCLASE_1. 1 hit.
PS50125. GUANYLATE_CYCLASE_2. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P79991-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRKEHTWLCL QIILWLTDLL EANCMSGSLT MNVIMLNDSM TEWNIKAVQE
60 70 80 90 100
AVSIGMHVVT KDLEREGIKV TINADFQTFN TDLYATPGCV SSGCEGVEKL
110 120 130 140 150
KNLRHTRRLG CVILGPTCTY ATYQMLSLKN TFGVPLISAG SFGLSCDYHR
160 170 180 190 200
SLARMLLPAR KITYFFKEFW QYEDFIKPKK WQSVYIYKWD GNTESCFWYI
210 220 230 240 250
NALESGVSYF NNALKFKEIL RTEGELMKVL QENNHKSNVI LMCGTPNDIW
260 270 280 290 300
NLHNKVAIPQ DKVLILLDIF NTVYYDNKSS PYYMENVLVV TQRPSNMSKI
310 320 330 340 350
SNQTGIAKLL EDNYAAGYLD GVLLFGHILK KFLGSVDINQ TFSFIDQFRN
360 370 380 390 400
ISIIGALGPL ILDAAGDREL NLTLLYSSTA TNNYTELIQF DTSTNQTTVM
410 420 430 440 450
DTSPNFIWKN HRLPSDVPQS GPHILTIAVF TLIVVVILVL IIGLLVFRRY
460 470 480 490 500
RLENELRQKK WSHISAEKIL PLNMTETSHV SLKIDDDKRR DSGPRLQIRK
510 520 530 540 550
YDKKVVILKD LKHDENFTEK QKMELNKLLQ IDYYNLTKFY GTVKLDNMIY
560 570 580 590 600
AVIEYCDKGS LRDVLNDNIS YPDGTFMDWE FKISVMYDIA KGMSYLHASK
610 620 630 640 650
CEVHGHLKST NCVVDGRMVV KITDFFGKSI LSPEKDLWTA PEHLHQEGFS
660 670 680 690 700
QKGDVYSYGV IAQEIILRQE TFYTEQCDDT KEKISRVQNN KGECPFRPDL
710 720 730 740 750
NLDSANEREI EVYVLVKSCW EEDPERRPDF KKIENTLSKI FSNFHSQTTE
760 770 780 790 800
SYMDTLIRRL QLYSKNLEHL VEERTQLYKA ERDRADRLNY LLLPGPVVMS
810 820 830 840 850
LKETGRVEPE FFEEVTIYFS DIVGFTTICK YSAPMEVVDM LNDMYKNFDH
860 870 880 890 900
ILDHHDVYKV ETIGDAYMVV SGLPNRNGNN HAVDISRMAL DILCFMGSFE
910 920 930 940 950
LRHLPGLPVW IRIGIHSGPC AAGVVGIKMP RYCLFGDTVN TTSRMESTGL
960 970 980 990 1000
PLRIHVNKST ISILRRTDCE FQYEVRGETY LKGKGPEITY WLTGETEQKY
1010 1020 1030 1040 1050
NIPTPPSVEN QQRLQSDFAE MIMESLQRKE ADGDKKKMPT RVASYRNGTL
1060
EYLQLGTSDQ SSTYF
Length:1,065
Mass (Da):122,522
Last modified:May 1, 1997 - v1
Checksum:iE301336E41A3AD4B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D49837 mRNA. Translation: BAA08638.1.
RefSeqiNP_001079334.1. NM_001085865.1.
UniGeneiXl.1206.

Genome annotation databases

GeneIDi378662.
KEGGixla:378662.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D49837 mRNA. Translation: BAA08638.1.
RefSeqiNP_001079334.1. NM_001085865.1.
UniGeneiXl.1206.

3D structure databases

ProteinModelPortaliP79991.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi378662.
KEGGixla:378662.

Organism-specific databases

CTDi2984.
XenbaseiXB-GENE-952211. gucy2c.

Phylogenomic databases

HOVERGENiHBG106967.
KOiK12320.

Family and domain databases

Gene3Di3.30.70.1230. 1 hit.
InterProiIPR001054. A/G_cyclase.
IPR018297. A/G_cyclase_CS.
IPR001828. ANF_lig-bd_rcpt.
IPR011009. Kinase-like_dom.
IPR029787. Nucleotide_cyclase.
IPR028082. Peripla_BP_I.
IPR000719. Prot_kinase_dom.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF01094. ANF_receptor. 1 hit.
PF00211. Guanylate_cyc. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
SMARTiSM00044. CYCc. 1 hit.
[Graphical view]
SUPFAMiSSF53822. SSF53822. 1 hit.
SSF55073. SSF55073. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00452. GUANYLATE_CYCLASE_1. 1 hit.
PS50125. GUANYLATE_CYCLASE_2. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Xenopus laevis mRNA for guanylyl cyclase C."
    MacFARLAND R.T.
    Submitted (MAR-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: IntestineImported.

Entry informationi

Entry nameiP79991_XENLA
AccessioniPrimary (citable) accession number: P79991
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 1997
Last sequence update: May 1, 1997
Last modified: May 11, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.