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Protein

Receptor protein serine/threonine kinase

Gene

bmpr2

Organism
Xenopus laevis (African clawed frog)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.SAAS annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Kinase, ReceptorSAAS annotationImported, Serine/threonine-protein kinaseSAAS annotation, Transferase

Keywords - Ligandi

ATP-bindingSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor protein serine/threonine kinaseSAAS annotation (EC:2.7.11.30SAAS annotation)
Gene namesi
Name:bmpr2Imported
Synonyms:XBMPR-IIImported
OrganismiXenopus laevis (African clawed frog)Imported
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-865330. bmpr2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei173 – 19624HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Structurei

3D structure databases

ProteinModelPortaliP79954.
SMRiP79954. Positions 53-152.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini227 – 528302Protein kinaseInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.SAAS annotation
Contains protein kinase domain.SAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

HOVERGENiHBG050705.
KOiK04671.

Family and domain databases

InterProiIPR000472. Activin_recp.
IPR015770. BMPR2.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR000333. TGFB_receptor.
[Graphical view]
PANTHERiPTHR23255. PTHR23255. 1 hit.
PTHR23255:SF63. PTHR23255:SF63. 1 hit.
PfamiPF01064. Activin_recp. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P79954-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVFLLIPFAP SLFQFYWKFQ DMASNRTLVL LILGLHSTFL LATASAAQSE
60 70 80 90 100
ERLCAYKDPN YQDQGVSESQ VSLENGTVKC TKGNICFGLW EKTREGEINL
110 120 130 140 150
VRQGCWSHVG DPHDCYNDEC VVTTPPPVIQ NGTYRFCCCI KDMCNVNFTE
160 170 180 190 200
NFTPSDPTSA SPYSPTGWLH REMTIIIALA SVSVLAVLIV VFFFGYRIFG
210 220 230 240 250
GDRKQGLHSM NVLEAATSEP SLDLDNLKLL ELIGRGRYGS VYKGSLEERP
260 270 280 290 300
VAVKVFSFNN RQNFVNERSI YRTPLLEHDN IAHFIAADER VTSDGRLEYL
310 320 330 340 350
LVMEYYANGS LCKYLNVHSN DWLNSCRLAH SVTKGLAYMH TELLRGDQYK
360 370 380 390 400
SAISHRDLNS RNVLVKSDGT CVISDFGLSM RLTGNRLVRP GDEDNAAISE
410 420 430 440 450
VGTIRYMAPE VLEGAVNLRD CESALKQVDM YSLGLIYWEI FMRCTDLFPG
460 470 480 490 500
ESVPEYQMVF QTEAGNHPTF EDMQVLVSRE KQRPKFPEAW KENSLAVRSL
510 520 530 540 550
KETIDDCWDQ DAEARLTAQC AEERMAELMM IWERNKSVSP TINPTSTTVQ
560 570 580 590 600
NERNLSQNRR VPKIGPYPDF SSSSYIEDSV HNTDNIVKNI SSETSMSSTP
610 620 630 640 650
LTTGEKNRNS INYERQQAQA RLPSPETSVT SLSTTAGLTP STGMTTISEV
660 670 680 690 700
QYSDDTMHSV QNIGPTPVCL QLTEEDLETN KLDPKEVDKN LKESSDENLM
710 720 730 740 750
EHSLKQFSGP DPLSSTSSNL FYPLIKLAVE STGQQDFNQA ANGQACIVQD
760 770 780 790 800
VHAAQLYPLP KQQNLPKRPT SLPLNTKNSG KESRLKFSSK HKSNLKHVET
810 820 830 840 850
GVAKMNTVTA AEPHVVTVTT ASASGRTGYV NSQGPAAQFS STSAVQSSNS
860 870 880 890 900
RAHSGQEMLE NQFRGEDSRL NINSSPDENE PLLRRDEQAG QDESVLDRLV
910 920 930 940 950
DRREHPAENS RVNSNNNNNS SQCVLQDTAS QSAPVETRQR QTRRAQRPNS
960 970 980 990 1000
LDLSSSSIMD NCSTQCETLS DSRSGSGDKI KKRVKTPYSL KRWRPSTWAI
1010 1020 1030 1040
PTERQDCEVN NNGSSETFSH SKSSTAVYLI DGGTSTSTLS KEANMSCL
Length:1,048
Mass (Da):116,788
Last modified:May 1, 1997 - v1
Checksum:i7D305088BFF126FD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U81958 mRNA. Translation: AAB39883.1.
RefSeqiNP_001081659.1. NM_001088190.1.
UniGeneiXl.88.

Genome annotation databases

GeneIDi397981.
KEGGixla:397981.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U81958 mRNA. Translation: AAB39883.1.
RefSeqiNP_001081659.1. NM_001088190.1.
UniGeneiXl.88.

3D structure databases

ProteinModelPortaliP79954.
SMRiP79954. Positions 53-152.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi397981.
KEGGixla:397981.

Organism-specific databases

CTDi659.
XenbaseiXB-GENE-865330. bmpr2.

Phylogenomic databases

HOVERGENiHBG050705.
KOiK04671.

Family and domain databases

InterProiIPR000472. Activin_recp.
IPR015770. BMPR2.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR000333. TGFB_receptor.
[Graphical view]
PANTHERiPTHR23255. PTHR23255. 1 hit.
PTHR23255:SF63. PTHR23255:SF63. 1 hit.
PfamiPF01064. Activin_recp. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiP79954_XENLA
AccessioniPrimary (citable) accession number: P79954
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 1997
Last sequence update: May 1, 1997
Last modified: September 7, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.