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Protein

High-affinity lysophosphatidic acid receptor

Gene
N/A
Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Highly selective receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities.

GO - Molecular functioni

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
High-affinity lysophosphatidic acid receptor
Alternative name(s):
PSP24
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-1009032. gpr45.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 38ExtracellularSequence analysisAdd BLAST38
Transmembranei39 – 59Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini60 – 80CytoplasmicSequence analysisAdd BLAST21
Transmembranei81 – 101Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini102 – 108ExtracellularSequence analysis7
Transmembranei109 – 129Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini130 – 149CytoplasmicSequence analysisAdd BLAST20
Transmembranei150 – 170Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini171 – 198ExtracellularSequence analysisAdd BLAST28
Transmembranei199 – 219Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini220 – 268CytoplasmicSequence analysisAdd BLAST49
Transmembranei269 – 289Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini290 – 301ExtracellularSequence analysisAdd BLAST12
Transmembranei302 – 324Helical; Name=7Sequence analysisAdd BLAST23
Topological domaini325 – 372CytoplasmicSequence analysisAdd BLAST48

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000700861 – 372High-affinity lysophosphatidic acid receptorAdd BLAST372

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi4N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi15N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Expressioni

Tissue specificityi

Ubiquitously expressed.

Structurei

3D structure databases

ProteinModelPortaliP79945.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG051812.
KOiK08409.

Family and domain databases

InterProiView protein in InterPro
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
PfamiView protein in Pfam
PF00001. 7tm_1. 1 hit.
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiView protein in PROSITE
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P79945-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGCNNTALDN CMLPNLSIAT APLDLRFAFS TPLRMLLAII MILMIAIAFL
60 70 80 90 100
GNAIVCLIVY QKPAMRSAIN LLLATLAFSD IMLSLFCMPF TAVTIITGSW
110 120 130 140 150
LFGTQFCQIS AMLYWFFVLE GVAILLIISV DRFLIIVQRQ DKLNPHRAKI
160 170 180 190 200
MIAASWVLSF CISLPSVVGW TLVEVPTRAP QCVLGYTEFS ADRVYAVMLI
210 220 230 240 250
VAVFFIPFSV MLYSYLCILN TVRRNAVRIH THADSLCLSQ VSKLGLMGLQ
260 270 280 290 300
RPHQMNVDMS FKTRAFTTIL ILFIGFSLCW LPHSVFSLLS VFSRTFYYSS
310 320 330 340 350
SFYSISTCTL WLTYLKSVFN PVIYCWRIKK FREACLEFMP KTFKILPNVR
360 370
GRTRRRIRPS TIYVCGEHQS AV
Length:372
Mass (Da):42,254
Last modified:May 1, 1997 - v1
Checksum:i888FFA4105D592C9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U76385 mRNA. Translation: AAB37322.1.
RefSeqiNP_001079283.1. NM_001085814.1.
UniGeneiXl.70.

Genome annotation databases

GeneIDi378570.
KEGGixla:378570.

Similar proteinsi

Entry informationi

Entry nameiPSP24_XENLA
AccessioniPrimary (citable) accession number: P79945
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2002
Last sequence update: May 1, 1997
Last modified: August 30, 2017
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families