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Protein

High-affinity lysophosphatidic acid receptor

Gene
N/A
Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Highly selective receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
High-affinity lysophosphatidic acid receptor
Alternative name(s):
PSP24
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-1009032. gpr45.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3838ExtracellularSequence analysisAdd
BLAST
Transmembranei39 – 5921Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini60 – 8021CytoplasmicSequence analysisAdd
BLAST
Transmembranei81 – 10121Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini102 – 1087ExtracellularSequence analysis
Transmembranei109 – 12921Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini130 – 14920CytoplasmicSequence analysisAdd
BLAST
Transmembranei150 – 17021Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini171 – 19828ExtracellularSequence analysisAdd
BLAST
Transmembranei199 – 21921Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini220 – 26849CytoplasmicSequence analysisAdd
BLAST
Transmembranei269 – 28921Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini290 – 30112ExtracellularSequence analysisAdd
BLAST
Transmembranei302 – 32423Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini325 – 37248CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 372372High-affinity lysophosphatidic acid receptorPRO_0000070086Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi4 – 41N-linked (GlcNAc...)Sequence analysis
Glycosylationi15 – 151N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Expressioni

Tissue specificityi

Ubiquitously expressed.

Structurei

3D structure databases

ProteinModelPortaliP79945.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG051812.
KOiK08409.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P79945-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGCNNTALDN CMLPNLSIAT APLDLRFAFS TPLRMLLAII MILMIAIAFL
60 70 80 90 100
GNAIVCLIVY QKPAMRSAIN LLLATLAFSD IMLSLFCMPF TAVTIITGSW
110 120 130 140 150
LFGTQFCQIS AMLYWFFVLE GVAILLIISV DRFLIIVQRQ DKLNPHRAKI
160 170 180 190 200
MIAASWVLSF CISLPSVVGW TLVEVPTRAP QCVLGYTEFS ADRVYAVMLI
210 220 230 240 250
VAVFFIPFSV MLYSYLCILN TVRRNAVRIH THADSLCLSQ VSKLGLMGLQ
260 270 280 290 300
RPHQMNVDMS FKTRAFTTIL ILFIGFSLCW LPHSVFSLLS VFSRTFYYSS
310 320 330 340 350
SFYSISTCTL WLTYLKSVFN PVIYCWRIKK FREACLEFMP KTFKILPNVR
360 370
GRTRRRIRPS TIYVCGEHQS AV
Length:372
Mass (Da):42,254
Last modified:May 1, 1997 - v1
Checksum:i888FFA4105D592C9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U76385 mRNA. Translation: AAB37322.1.
RefSeqiNP_001079283.1. NM_001085814.1.
UniGeneiXl.70.

Genome annotation databases

GeneIDi378570.
KEGGixla:378570.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U76385 mRNA. Translation: AAB37322.1.
RefSeqiNP_001079283.1. NM_001085814.1.
UniGeneiXl.70.

3D structure databases

ProteinModelPortaliP79945.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

GPCRDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi378570.
KEGGixla:378570.

Organism-specific databases

CTDi11250.
XenbaseiXB-GENE-1009032. gpr45.

Phylogenomic databases

HOVERGENiHBG051812.
KOiK08409.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPSP24_XENLA
AccessioniPrimary (citable) accession number: P79945
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2002
Last sequence update: May 1, 1997
Last modified: January 7, 2015
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.