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Protein

Homeobox protein Meis1

Gene

meis1

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Induces expression of a number of neural crest marker genes as part of a heterodimer with isoform b of pbx1, to specify neural crest cell fate. Binds to a highly conserved region in the promoter of the neural crest marker gene zic3.3 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi272 – 33463Homeobox; TALE-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • sequence-specific DNA binding Source: UniProtKB

GO - Biological processi

  • neural crest cell fate specification Source: UniProtKB
  • positive regulation of transcription, DNA-templated Source: UniProtKB
  • positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator, Developmental protein

Keywords - Biological processi

Transcription

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Meis1
Short name:
XMeis1
Gene namesi
Name:meis1
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-479443. meis1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • nucleus Source: UniProtKB
  • transcription factor complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 390390Homeobox protein Meis1PRO_0000049107Add
BLAST

Expressioni

Tissue specificityi

In the embryo, displays a broad expression pattern with high levels observed in tissues of neural cell fate such as midbrain, hindbrain, dorsal portion of the neural tube, and neural crest-derived branchial arches. Widely expressed in the adult with highest levels in brain and spleen.1 Publication

Developmental stagei

Levels of isoform 1 decrease slightly during gastrulation but show a marked increase during neurulation and throughout embryogenesis. Expression of isoform 2 is low during early embryogenesis but increases after tailbud stages.1 Publication

Interactioni

Subunit structurei

Interacts with pbx1 isoform b.1 Publication

Structurei

3D structure databases

ProteinModelPortaliP79937.
SMRiP79937. Positions 272-332.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi194 – 24047Ser/Thr-richAdd
BLAST
Compositional biasi242 – 26928Asp/Glu-rich (acidic)Add
BLAST
Compositional biasi262 – 2676Poly-Asp

Sequence similaritiesi

Belongs to the TALE/MEIS homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

HOVERGENiHBG055193.
KOiK15613.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR001356. Homeobox_dom.
IPR008422. Homeobox_KN_domain.
IPR009057. Homeodomain-like.
IPR032453. PKNOX/Meis_N.
[Graphical view]
PfamiPF05920. Homeobox_KN. 1 hit.
PF16493. Meis_PKNOX_N. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Additional isoforms seem to exist.
Isoform 1 (identifier: P79937-1) [UniParc]FASTAAdd to basket
Also known as: XMeis1-1, a

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAQRYDDLPH YGGMDGVGLP SSMYGDPHAA RSMKSVHHLN HGPPLHPHQY
60 70 80 90 100
PHSAHTNAMP PSMGSSVNDA LKRDKDSIYG HPLFPLLALI FEKCELATCT
110 120 130 140 150
PREPGVAGGD VCSSESFNED IAVFSKQIRA EKPLFSSNPE LDNLMIQAIQ
160 170 180 190 200
VLRFHLLELE KVHELCDNFC HRYISCLEGK MPIDLVIDDR DGGSKSDSED
210 220 230 240 250
LTRSAPLTDQ PSWSRDHDDA ASIRSGGTPG PSSGGHTSHS GDNSSEQGDG
260 270 280 290 300
LDNSIASPST GDDDDPDKEK KRNKGRGIFP KVATNIMRAW LFQHLTHPYP
310 320 330 340 350
SEEQKKQLAQ DTGLTILQVN NWFINARRRI VQPMIDQSNR AVSQGTPYNP
360 370 380 390
DGQPIGGFVM DGQQHMGIRA PGPMSGMGMN MGMEGQWHYM
Length:390
Mass (Da):42,887
Last modified:May 1, 1997 - v1
Checksum:iD0D98637D08CF32F
GO
Isoform 2 (identifier: P79937-2) [UniParc]FASTAAdd to basket
Also known as: XMeis1-2, b

The sequence of this isoform differs from the canonical sequence as follows:
     373-390: PMSGMGMNMGMEGQWHYM → LQGMPGSYIS...SGHVMNIHAQ

Show »
Length:465
Mass (Da):50,625
Checksum:iE3C19A61106C4E37
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti34 – 341K → Q.
Natural varianti91 – 911F → L.
Natural varianti178 – 1781E → K.
Natural varianti273 – 2731N → H.
Natural varianti275 – 2751G → K.
Natural varianti315 – 3151Missing .

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei373 – 39018PMSGM…QWHYM → LQGMPGSYISPSGPMGMSMA QPSYTTSQMPLHHAQLRHGT SVHTYIPGHHHHPAMMMHGG PPQPGMPISASSPSVLNTGD PSMSGHVMNIHAQ in isoform 2. 1 PublicationVSP_002241Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U68386 mRNA. Translation: AAB19196.1.
U68387 mRNA. Translation: AAB19197.1.
RefSeqiNP_001084104.1. NM_001090635.1.
UniGeneiXl.607.

Genome annotation databases

GeneIDi399305.
KEGGixla:399305.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U68386 mRNA. Translation: AAB19196.1.
U68387 mRNA. Translation: AAB19197.1.
RefSeqiNP_001084104.1. NM_001090635.1.
UniGeneiXl.607.

3D structure databases

ProteinModelPortaliP79937.
SMRiP79937. Positions 272-332.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi399305.
KEGGixla:399305.

Organism-specific databases

CTDi4211.
XenbaseiXB-GENE-479443. meis1.

Phylogenomic databases

HOVERGENiHBG055193.
KOiK15613.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR001356. Homeobox_dom.
IPR008422. Homeobox_KN_domain.
IPR009057. Homeodomain-like.
IPR032453. PKNOX/Meis_N.
[Graphical view]
PfamiPF05920. Homeobox_KN. 1 hit.
PF16493. Meis_PKNOX_N. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMEIS1_XENLA
AccessioniPrimary (citable) accession number: P79937
Secondary accession number(s): P79938
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 1, 1997
Last modified: November 11, 2015
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.