Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Hepatocyte nuclear factor 4-beta

Gene

hnf4b

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Transcription factor; binds and activates the promoter for the HNF1-alpha gene. Seems to have a lower DNA binding activity than HNF4-alpha and is a weaker transactivator than the alpha isoform.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi47 – 12276Nuclear receptorPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri50 – 7021NR C4-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri86 – 11025NR C4-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator, Receptor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Hepatocyte nuclear factor 4-beta
Short name:
HNF-4-beta
Alternative name(s):
Nuclear receptor subfamily 2 group A member 3
Gene namesi
Name:hnf4b
Synonyms:nr2a3
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 446446Hepatocyte nuclear factor 4-betaPRO_0000053564Add
BLAST

Expressioni

Tissue specificityi

Expressed in liver, kidney, stomach, intestine, lung, ovary, and testis. Not expressed in fat, muscle and brain.

Developmental stagei

Maternal protein which is distributed within an animal-to-vegetal gradient in the embryo. Present from the egg stage onward and throughout the entire development.

Interactioni

Subunit structurei

Homodimerization is required for HNF4-alpha to bind to its recognition site.By similarity

Structurei

3D structure databases

ProteinModelPortaliP79926.
SMRiP79926. Positions 49-124, 141-366.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 nuclear receptor DNA-binding domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri50 – 7021NR C4-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri86 – 11025NR C4-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

HOVERGENiHBG005606.

Family and domain databases

Gene3Di1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProiIPR000536. Nucl_hrmn_rcpt_lig-bd.
IPR001723. Nuclear_hrmn_rcpt.
IPR000003. Retinoid-X_rcpt/HNF4.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR00545. RETINOIDXR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P79926-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDMPDYTETL DSSYTMLEFD SIRVLPSNTE IITVETASPG LLNNGINSFC
60 70 80 90 100
AICGDRATGK HYGASSCDGC KGFFRRSVRK NHVYACRFSR QCIVDKDKRN
110 120 130 140 150
QCRYCRLRKC FRAGMKKEAV QNERDRISMR RSSYEDNGSL SINVLTQAEA
160 170 180 190 200
MVHQYSPVSP VHSSDISMKK VASISDVCES MKQQLLLLVE WAKYIPAFCE
210 220 230 240 250
LPLDDQVALL RAHAGAHLLL GVAKRSLPYK DFLLLGNDFI MPMHCPELEI
260 270 280 290 300
ARVPCRILDE LVKPLREIQI DDNEYVCLKA IIFFDPDCKG LSDQTKVKNM
310 320 330 340 350
RFQVQVNLED YINDRQFDSR GRFSDILLLL PPLQSITWQM IEQVQFAKLF
360 370 380 390 400
GVARIDSLLQ ELLLGGTTMD GGQYINSGHS SLNLDLLPGP TVHSHNLHSV
410 420 430 440
IHTVSSLSPE TSPPTNSTSE DYKMNTATVS SIPLMQRTVI AKKEIL
Length:446
Mass (Da):50,257
Last modified:May 1, 1997 - v1
Checksum:i854FF260834DF18D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49827 mRNA. Translation: CAA89991.1.
UniGeneiXl.1216.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49827 mRNA. Translation: CAA89991.1.
UniGeneiXl.1216.

3D structure databases

ProteinModelPortaliP79926.
SMRiP79926. Positions 49-124, 141-366.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG005606.

Family and domain databases

Gene3Di1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProiIPR000536. Nucl_hrmn_rcpt_lig-bd.
IPR001723. Nuclear_hrmn_rcpt.
IPR000003. Retinoid-X_rcpt/HNF4.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR00545. RETINOIDXR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHNF4B_XENLA
AccessioniPrimary (citable) accession number: P79926
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: May 1, 1997
Last modified: April 13, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.