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Protein

Cadherin-4

Gene

cdh4

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Probably contributes in early embryos to cell-type non-specific cell adhesion, but in post-neurula embryos may be responsible for the development and/or maintenance of anterior neural tissues, and may be used in adult frog for the development and/or maintenance of neural, endodermal and reproductive organs.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cadherin-4
Alternative name(s):
Maternally-expressed neural cadherin
XmN-cadherin
Gene namesi
Name:cdh4
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-6500246. cdh4.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini25 – 740ExtracellularSequence analysisAdd BLAST716
Transmembranei741 – 761HelicalSequence analysisAdd BLAST21
Topological domaini762 – 922CytoplasmicSequence analysisAdd BLAST161

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000004278425 – 922Cadherin-4Add BLAST898

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi33N-linked (GlcNAc...)Sequence analysis1
Glycosylationi137N-linked (GlcNAc...)Sequence analysis1
Glycosylationi236N-linked (GlcNAc...)Sequence analysis1
Glycosylationi289N-linked (GlcNAc...)Sequence analysis1
Glycosylationi314N-linked (GlcNAc...)Sequence analysis1
Glycosylationi418N-linked (GlcNAc...)Sequence analysis1
Glycosylationi563N-linked (GlcNAc...)Sequence analysis1
Glycosylationi638N-linked (GlcNAc...)Sequence analysis1
Glycosylationi667N-linked (GlcNAc...)Sequence analysis1
Glycosylationi708N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Expressioni

Tissue specificityi

Expressed strongly in ovary, testis, brain, eye and kidney, and weakly in stomach and intestine.1 Publication

Developmental stagei

In the egg, the mRNA occurred as a maternal mRNA at a relatively high level, and its level became very low by the neurula stage, then increased steadily thereafter.1 Publication

Structurei

3D structure databases

ProteinModelPortaliP79883.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini176 – 283Cadherin 1PROSITE-ProRule annotationAdd BLAST108
Domaini284 – 398Cadherin 2PROSITE-ProRule annotationAdd BLAST115
Domaini399 – 513Cadherin 3PROSITE-ProRule annotationAdd BLAST115
Domaini514 – 621Cadherin 4PROSITE-ProRule annotationAdd BLAST108
Domaini620 – 728Cadherin 5PROSITE-ProRule annotationAdd BLAST109

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi891 – 894Poly-Ser4

Domaini

Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.By similarity

Sequence similaritiesi

Contains 5 cadherin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG106438.

Family and domain databases

Gene3Di2.60.40.60. 6 hits.
4.10.900.10. 1 hit.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR000233. Cadherin_cytoplasmic-dom.
IPR014868. Cadherin_pro_dom.
IPR027397. Catenin_binding_dom.
[Graphical view]
PfamiPF00028. Cadherin. 4 hits.
PF01049. Cadherin_C. 1 hit.
PF08758. Cadherin_pro. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 5 hits.
SM01055. Cadherin_pro. 1 hit.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 7 hits.
PROSITEiPS00232. CADHERIN_1. 3 hits.
PS50268. CADHERIN_2. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P79883-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTGGPGSSPL FLLLLTGALS GARSRALGAY DGNASVSSAC TPGFSADGYT
60 70 80 90 100
ALVSPNIMEG QKLLKVKFNG CSSGAQGIWY ETNNPDFKVG ADGAVYTARE
110 120 130 140 150
VQIPAKQAKF IVAAWDHETP EKWEAAIQLF VEETPLNQSQ YQTGSQSQES
160 170 180 190 200
EQEQSQSGTL LPWRQHHKGL RRQKRDWVIP PVNVPENSRG PFPQQLVLIR
210 220 230 240 250
SDKDRDDTIR YSITGVGADQ PPMAIFNIDP IFGRMNVTRP LDREERSSYH
260 270 280 290 300
LRAHAVDING NKVENPIDLS IYVIDMNDNR PEFSSPIFNG SVDEASKPGT
310 320 330 340 350
YVMTVTAHDA DDINTSNGIV MYRIMDQSPQ SPSHDMFVIH SKTGVINTVA
360 370 380 390 400
AGLDREKVQQ YTVVIQATDM EGNLNHGLSN TATAIITVAD VNDNPPEFTR
410 420 430 440 450
KMFIGEVPEN HVDVVVANLT VVDRDQPYTS NWNAVFKIIS GDPDGHFTIK
460 470 480 490 500
TDPVTNEGIV TVSKPVDYEM SKVFPLIVMV TNQAPLASGI QMSLQSTAAV
510 520 530 540 550
TVSVNDVNEA PYFPNRNEPI RKLEGESAGR LLITFSAVDP DHSMQQVLRY
560 570 580 590 600
SKISDPANWL AINTTNGQVS TTAVLDRESP FVKDDLYQAK FLATDNGNPP
610 620 630 640 650
ASGTGTLLIQ LIDINDNAPE LLPKDAQICE RPNGNGINIT AIDVDRKPSA
660 670 680 690 700
DPFVFELPSV PYTIRRNWTI HRINSIYARL SLQIGYLESG MYDVPVIVTD
710 720 730 740 750
SGNPPLYNTS IIKVKVCPCD NNGDCTTIGA VAAAGLGTGA IISILICIII
760 770 780 790 800
LLSMVLLFVM WMKRREKERH TKQLLIDPED DVRDNILKYD EEGGGEEDQD
810 820 830 840 850
YDLSQLQQPE TLDHVLNKVA GVRRVDERPV GAEHQYPIRP VIPHPGDIGD
860 870 880 890 900
FITEGLRAAD NDPTAPPYDS LLVFDYEGSG STAGSVSSLN SSSSEDQDFD
910 920
YLNDWGPRFK KLADMYGGAD ED
Length:922
Mass (Da):101,173
Last modified:May 1, 1997 - v1
Checksum:iFEA7A95CBAF1B640
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S82457 mRNA. Translation: AAB37685.2.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S82457 mRNA. Translation: AAB37685.2.

3D structure databases

ProteinModelPortaliP79883.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

XenbaseiXB-GENE-6500246. cdh4.

Phylogenomic databases

HOVERGENiHBG106438.

Family and domain databases

Gene3Di2.60.40.60. 6 hits.
4.10.900.10. 1 hit.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR000233. Cadherin_cytoplasmic-dom.
IPR014868. Cadherin_pro_dom.
IPR027397. Catenin_binding_dom.
[Graphical view]
PfamiPF00028. Cadherin. 4 hits.
PF01049. Cadherin_C. 1 hit.
PF08758. Cadherin_pro. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 5 hits.
SM01055. Cadherin_pro. 1 hit.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 7 hits.
PROSITEiPS00232. CADHERIN_1. 3 hits.
PS50268. CADHERIN_2. 5 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCADH4_XENLA
AccessioniPrimary (citable) accession number: P79883
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: May 1, 1997
Last modified: October 5, 2016
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.