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Protein

Guanylyl cyclase-activating protein 2

Gene

GUCA1B

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Stimulates synthesis of cGMP in photoreceptors. Thought to mediate Ca2+-sensitive regulation of guanylyl cyclase (GC), a key event in recovery of the dark state of rod photoreceptors following light exposure (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi65 – 76121PROSITE-ProRule annotationAdd
BLAST
Calcium bindingi101 – 112122PROSITE-ProRule annotationAdd
BLAST
Calcium bindingi152 – 163123PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Sensory transduction, Vision

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-GGA-2514859. Inactivation, recovery and regulation of the phototransduction cascade.

Names & Taxonomyi

Protein namesi
Recommended name:
Guanylyl cyclase-activating protein 2
Short name:
GCAP 2
Alternative name(s):
Guanylate cyclase activator 1B
Gene namesi
Name:GUCA1B
Synonyms:GCAP2
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 26

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedSequence analysis
Chaini2 – 198197Guanylyl cyclase-activating protein 2PRO_0000073810Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi2 – 21N-myristoyl glycineSequence analysis

Keywords - PTMi

Lipoprotein, Myristate

Proteomic databases

PaxDbiP79881.

Expressioni

Tissue specificityi

Retina and pineal gland.

Interactioni

Subunit structurei

Undergoes dimerization at low calcium ions concentration, while the presence of calcium ions inhibits its dimerization. Dimerization correlates with its ability to activate GC.

Protein-protein interaction databases

STRINGi9031.ENSGALP00000002158.

Structurei

3D structure databases

ProteinModelPortaliP79881.
SMRiP79881. Positions 2-184.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini16 – 5136EF-hand 1PROSITE-ProRule annotationAdd
BLAST
Domaini52 – 8736EF-hand 2PROSITE-ProRule annotationAdd
BLAST
Domaini88 – 12336EF-hand 3PROSITE-ProRule annotationAdd
BLAST
Domaini139 – 17436EF-hand 4PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 4 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0044. Eukaryota.
COG5126. LUCA.
GeneTreeiENSGT00760000118820.
HOGENOMiHOG000233019.
HOVERGENiHBG108179.
InParanoidiP79881.
KOiK08328.
OMAiQFSWEEA.
PhylomeDBiP79881.
TreeFamiTF333971.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR015756. GCAP-2.
IPR028846. Recoverin.
[Graphical view]
PANTHERiPTHR23055. PTHR23055. 1 hit.
PTHR23055:SF11. PTHR23055:SF11. 1 hit.
PfamiPF00036. EF-hand_1. 1 hit.
PF13499. EF-hand_7. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 3 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 3 hits.
PS50222. EF_HAND_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P79881-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGQQFTNAEG EQTEIDVAEL QEWYKKFVVE CPSGTLFMHE FKRFFGVQDN
60 70 80 90 100
HEAAEYIENM FRAFDKNGDN TIDFLEYVAA LNLVLRGKLE HKLRWTFKVY
110 120 130 140 150
DKDGNGCIDK PELLEIVESI YKLKKVCRSE VEERTPLLTP EEVVDRIFQL
160 170 180 190
VDENGDGQLS LDEFIDGARK DKWVMKMLQM DVNPGGWISE QRRKSALF
Length:198
Mass (Da):23,128
Last modified:January 23, 2007 - v3
Checksum:i7A2B475FCD34964F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S82200 mRNA. Translation: AAB47112.1.
AF172708 Genomic DNA. Translation: AAD47880.1.
PIRiS68839.
RefSeqiNP_001007882.1. NM_001007881.2.
UniGeneiGga.624.

Genome annotation databases

EnsembliENSGALT00000035145; ENSGALP00000034499; ENSGALG00000001418.
GeneIDi419864.
KEGGigga:419864.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S82200 mRNA. Translation: AAB47112.1.
AF172708 Genomic DNA. Translation: AAD47880.1.
PIRiS68839.
RefSeqiNP_001007882.1. NM_001007881.2.
UniGeneiGga.624.

3D structure databases

ProteinModelPortaliP79881.
SMRiP79881. Positions 2-184.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000002158.

Proteomic databases

PaxDbiP79881.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000035145; ENSGALP00000034499; ENSGALG00000001418.
GeneIDi419864.
KEGGigga:419864.

Organism-specific databases

CTDi2979.

Phylogenomic databases

eggNOGiKOG0044. Eukaryota.
COG5126. LUCA.
GeneTreeiENSGT00760000118820.
HOGENOMiHOG000233019.
HOVERGENiHBG108179.
InParanoidiP79881.
KOiK08328.
OMAiQFSWEEA.
PhylomeDBiP79881.
TreeFamiTF333971.

Enzyme and pathway databases

ReactomeiR-GGA-2514859. Inactivation, recovery and regulation of the phototransduction cascade.

Miscellaneous databases

PROiP79881.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR015756. GCAP-2.
IPR028846. Recoverin.
[Graphical view]
PANTHERiPTHR23055. PTHR23055. 1 hit.
PTHR23055:SF11. PTHR23055:SF11. 1 hit.
PfamiPF00036. EF-hand_1. 1 hit.
PF13499. EF-hand_7. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 3 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 3 hits.
PS50222. EF_HAND_2. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Expression of GCAP1 and GCAP2 in the retinal degeneration (rd) mutant chicken retina."
    Semple-Rowland S.L., Gorczyca W.A., Buczylko J., Helekar B.S., Ruiz C.C., Subbaraya I., Palczewski K., Baehr W.
    FEBS Lett. 385:47-52(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Retina.
  2. "Characterization of the chicken GCAP gene array and analyses of GCAP1, GCAP2, and GC1 gene expression in normal and rd chicken pineal."
    Semple-Rowland S.L., Larkin P., Bronson J.D., Nykamp K., Streit W.J., Baehr W.
    Mol. Vis. 5:14-14(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: White leghorn.
    Tissue: Liver.

Entry informationi

Entry nameiGUC1B_CHICK
AccessioniPrimary (citable) accession number: P79881
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 23, 2007
Last modified: June 8, 2016
This is version 116 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Binds three calcium ions.By similarity

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.