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Protein

Guanylyl cyclase-activating protein 1

Gene

GUCA1A

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Stimulates retinal guanylyl cyclase when free calcium ions concentration is low and inhibits guanylyl cyclase when free calcium ions concentration is elevated. This Ca2+-sensitive regulation of retinal guanylyl cyclase is a key event in recovery of the dark state of rod photoreceptors following light exposure.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi63 – 7411 PublicationAdd BLAST12
Calcium bindingi99 – 11021 PublicationAdd BLAST12
Calcium bindingi142 – 15331 PublicationAdd BLAST12

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Sensory transduction, Vision

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-GGA-2514859. Inactivation, recovery and regulation of the phototransduction cascade.

Names & Taxonomyi

Protein namesi
Recommended name:
Guanylyl cyclase-activating protein 1
Short name:
GCAP 1
Alternative name(s):
Guanylate cyclase activator 1A
Gene namesi
Name:GUCA1A
Synonyms:GCAP1
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 26

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved
ChainiPRO_00000738052 – 199Guanylyl cyclase-activating protein 1Add BLAST198

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycine1 Publication1
Modified residuei3Deamidated asparagineSequence analysis1

Keywords - PTMi

Lipoprotein, Myristate

Proteomic databases

PaxDbiP79880.

Expressioni

Tissue specificityi

Retina, in rod and cone outer segments, and pineal gland.

Gene expression databases

BgeeiENSGALG00000001431.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000002177.

Structurei

Secondary structure

1199
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi6 – 13Combined sources8
Helixi17 – 27Combined sources11
Beta strandi31 – 33Combined sources3
Helixi35 – 42Combined sources8
Helixi49 – 62Combined sources14
Helixi72 – 82Combined sources11
Helixi87 – 98Combined sources12
Helixi108 – 117Combined sources10
Helixi120 – 123Combined sources4
Beta strandi124 – 126Combined sources3
Helixi130 – 141Combined sources12
Beta strandi146 – 149Combined sources4
Helixi151 – 158Combined sources8
Helixi162 – 169Combined sources8
Helixi174 – 181Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2R2IX-ray2.00A2-199[»]
ProteinModelPortaliP79880.
SMRiP79880.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP79880.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini13 – 48EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini50 – 85EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini86 – 121EF-hand 3PROSITE-ProRule annotationAdd BLAST36
Domaini129 – 164EF-hand 4PROSITE-ProRule annotationAdd BLAST36

Domaini

Binds three calcium ions (via EF-hands 2, 3 and 4) when calcium levels are high (PubMed:17997965). Binds Mg2+ when calcium levels are low.By similarity1 Publication

Sequence similaritiesi

Contains 4 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0044. Eukaryota.
COG5126. LUCA.
GeneTreeiENSGT00760000118820.
HOGENOMiHOG000233019.
HOVERGENiHBG108179.
InParanoidiP79880.
KOiK08328.
OMAiINPCSDS.
OrthoDBiEOG091G0LKQ.
PhylomeDBiP79880.
TreeFamiTF333971.

Family and domain databases

CDDicd00051. EFh. 2 hits.
Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR033022. GUCA1A.
IPR028846. Recoverin.
[Graphical view]
PANTHERiPTHR23055. PTHR23055. 1 hit.
PTHR23055:SF13. PTHR23055:SF13. 1 hit.
PfamiPF00036. EF-hand_1. 1 hit.
PF13499. EF-hand_7. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 3 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 3 hits.
PS50222. EF_HAND_2. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P79880-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGNMDGKAVE ELSATECHQW YKKFMTECPS GQLTLYEFKQ FFGLKNLSPS
60 70 80 90 100
ANKYVEQMFE TFDFNKDGYI DFMEYVAALS LVLKGKVDQK LRWYFKLYDV
110 120 130 140 150
DGNGCIDRGE LLNIIKAIRA INRCNEAMTA EEFTNMVFDK IDINGDGELS
160 170 180 190
LEEFMEGVQK DEVLLDILTR SLDLTHIVKL IQNDGKNPHA PEEAEEAAQ
Length:199
Mass (Da):22,808
Last modified:January 23, 2007 - v3
Checksum:i2F4ED65CF471F9F6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S82199 mRNA. Translation: AAB47111.1.
AF172707 Genomic DNA. Translation: AAD47879.1.
PIRiS68838.
RefSeqiNP_989651.1. NM_204320.2.
UniGeneiGga.625.

Genome annotation databases

EnsembliENSGALT00000002179; ENSGALP00000002177; ENSGALG00000001431.
GeneIDi374216.
KEGGigga:374216.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S82199 mRNA. Translation: AAB47111.1.
AF172707 Genomic DNA. Translation: AAD47879.1.
PIRiS68838.
RefSeqiNP_989651.1. NM_204320.2.
UniGeneiGga.625.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2R2IX-ray2.00A2-199[»]
ProteinModelPortaliP79880.
SMRiP79880.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000002177.

Proteomic databases

PaxDbiP79880.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000002179; ENSGALP00000002177; ENSGALG00000001431.
GeneIDi374216.
KEGGigga:374216.

Organism-specific databases

CTDi2978.

Phylogenomic databases

eggNOGiKOG0044. Eukaryota.
COG5126. LUCA.
GeneTreeiENSGT00760000118820.
HOGENOMiHOG000233019.
HOVERGENiHBG108179.
InParanoidiP79880.
KOiK08328.
OMAiINPCSDS.
OrthoDBiEOG091G0LKQ.
PhylomeDBiP79880.
TreeFamiTF333971.

Enzyme and pathway databases

ReactomeiR-GGA-2514859. Inactivation, recovery and regulation of the phototransduction cascade.

Miscellaneous databases

EvolutionaryTraceiP79880.
PROiP79880.

Gene expression databases

BgeeiENSGALG00000001431.

Family and domain databases

CDDicd00051. EFh. 2 hits.
Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR033022. GUCA1A.
IPR028846. Recoverin.
[Graphical view]
PANTHERiPTHR23055. PTHR23055. 1 hit.
PTHR23055:SF13. PTHR23055:SF13. 1 hit.
PfamiPF00036. EF-hand_1. 1 hit.
PF13499. EF-hand_7. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 3 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 3 hits.
PS50222. EF_HAND_2. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGUC1A_CHICK
AccessioniPrimary (citable) accession number: P79880
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 23, 2007
Last modified: November 30, 2016
This is version 123 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.