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Protein

Guanylyl cyclase-activating protein 1

Gene

GUCA1A

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Stimulates retinal guanylyl cyclase when free calcium ions concentration is low and inhibits guanylyl cyclase when free calcium ions concentration is elevated. This Ca2+-sensitive regulation of retinal guanylyl cyclase is a key event in recovery of the dark state of rod photoreceptors following light exposure.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi63 – 7411 PublicationAdd BLAST12
Calcium bindingi99 – 11021 PublicationAdd BLAST12
Calcium bindingi142 – 15331 PublicationAdd BLAST12

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processSensory transduction, Vision
LigandCalcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-GGA-2514859 Inactivation, recovery and regulation of the phototransduction cascade

Names & Taxonomyi

Protein namesi
Recommended name:
Guanylyl cyclase-activating protein 1
Short name:
GCAP 1
Alternative name(s):
Guanylate cyclase activator 1A
Gene namesi
Name:GUCA1A
Synonyms:GCAP1
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 26

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved
ChainiPRO_00000738052 – 199Guanylyl cyclase-activating protein 1Add BLAST198

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycine1 Publication1
Modified residuei3Deamidated asparagineSequence analysis1

Keywords - PTMi

Lipoprotein, Myristate

Proteomic databases

PaxDbiP79880
PRIDEiP79880

PTM databases

iPTMnetiP79880

Expressioni

Tissue specificityi

Retina, in rod and cone outer segments, and pineal gland.

Gene expression databases

BgeeiENSGALG00000001431

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000002177

Structurei

Secondary structure

1199
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi6 – 13Combined sources8
Helixi17 – 27Combined sources11
Beta strandi31 – 33Combined sources3
Helixi35 – 42Combined sources8
Helixi49 – 62Combined sources14
Helixi72 – 82Combined sources11
Helixi87 – 98Combined sources12
Helixi108 – 117Combined sources10
Helixi120 – 123Combined sources4
Beta strandi124 – 126Combined sources3
Helixi130 – 141Combined sources12
Beta strandi146 – 149Combined sources4
Helixi151 – 158Combined sources8
Helixi162 – 169Combined sources8
Helixi174 – 181Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2R2IX-ray2.00A2-199[»]
ProteinModelPortaliP79880
SMRiP79880
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP79880

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini13 – 48EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini50 – 85EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini86 – 121EF-hand 3PROSITE-ProRule annotationAdd BLAST36
Domaini129 – 164EF-hand 4PROSITE-ProRule annotationAdd BLAST36

Domaini

Binds three calcium ions (via EF-hands 2, 3 and 4) when calcium levels are high (PubMed:17997965). Binds Mg2+ when calcium levels are low.By similarity1 Publication

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0044 Eukaryota
COG5126 LUCA
GeneTreeiENSGT00760000118820
HOGENOMiHOG000233019
HOVERGENiHBG108179
InParanoidiP79880
KOiK08328
OMAiINPCSDS
OrthoDBiEOG091G0LKQ
PhylomeDBiP79880
TreeFamiTF333971

Family and domain databases

CDDicd00051 EFh, 2 hits
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR033022 GUCA1A
PANTHERiPTHR23055:SF13 PTHR23055:SF13, 1 hit
PfamiView protein in Pfam
PF00036 EF-hand_1, 1 hit
PF13499 EF-hand_7, 1 hit
SMARTiView protein in SMART
SM00054 EFh, 3 hits
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 3 hits
PS50222 EF_HAND_2, 4 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P79880-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGNMDGKAVE ELSATECHQW YKKFMTECPS GQLTLYEFKQ FFGLKNLSPS
60 70 80 90 100
ANKYVEQMFE TFDFNKDGYI DFMEYVAALS LVLKGKVDQK LRWYFKLYDV
110 120 130 140 150
DGNGCIDRGE LLNIIKAIRA INRCNEAMTA EEFTNMVFDK IDINGDGELS
160 170 180 190
LEEFMEGVQK DEVLLDILTR SLDLTHIVKL IQNDGKNPHA PEEAEEAAQ
Length:199
Mass (Da):22,808
Last modified:January 23, 2007 - v3
Checksum:i2F4ED65CF471F9F6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S82199 mRNA Translation: AAB47111.1
AF172707 Genomic DNA Translation: AAD47879.1
PIRiS68838
RefSeqiNP_989651.1, NM_204320.2
UniGeneiGga.625

Genome annotation databases

EnsembliENSGALT00000002179; ENSGALP00000002177; ENSGALG00000001431
GeneIDi374216
KEGGigga:374216

Similar proteinsi

Entry informationi

Entry nameiGUC1A_CHICK
AccessioniPrimary (citable) accession number: P79880
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 129 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health