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Protein

Cellular tumor antigen p53

Gene

tp53

Organism
Oryzias latipes (Japanese rice fish) (Japanese killifish)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity).By similarity

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi161ZincBy similarity1
Metal bindingi164ZincBy similarity1
Metal bindingi220ZincBy similarity1
Metal bindingi224ZincBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi87 – 273By similarityAdd BLAST187

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processApoptosis, Cell cycle, Transcription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Cellular tumor antigen p53
Alternative name(s):
Tumor suppressor p53
Gene namesi
Name:tp53
Synonyms:p53
OrganismiOryzias latipes (Japanese rice fish) (Japanese killifish)
Taxonomic identifieri8090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataOvalentariaAtherinomorphaeBeloniformesAdrianichthyidaeOryziinaeOryzias
Proteomesi

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001857211 – 352Cellular tumor antigen p53Add BLAST352

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei351PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Binds DNA as a homotetramer.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei105Interaction with DNABy similarity1

Protein-protein interaction databases

STRINGi8090.ENSORLP00000008029

Structurei

3D structure databases

ProteinModelPortaliP79820
SMRiP79820
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 48Transcription activation (acidic)Add BLAST48
Regioni254 – 261Interaction with DNABy similarity8
Regioni302 – 331OligomerizationAdd BLAST30
Regioni334 – 350Basic (repression of DNA-binding)Add BLAST17

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi276 – 291Bipartite nuclear localization signalBy similarityAdd BLAST16
Motifi316 – 327Nuclear export signalBy similarityAdd BLAST12

Sequence similaritiesi

Belongs to the p53 family.Curated

Phylogenomic databases

eggNOGiENOG410IITK Eukaryota
ENOG410ZSWV LUCA
HOGENOMiHOG000039957
HOVERGENiHBG005201
InParanoidiP79820
KOiK04451

Family and domain databases

CDDicd08367 P53, 1 hit
Gene3Di2.60.40.720, 1 hit
4.10.170.10, 1 hit
InterProiView protein in InterPro
IPR008967 p53-like_TF_DNA-bd
IPR012346 p53/RUNT-type_TF_DNA-bd_sf
IPR011615 p53_DNA-bd
IPR036674 p53_tetramer_sf
IPR010991 p53_tetrameristn
IPR002117 p53_tumour_suppressor
PANTHERiPTHR11447 PTHR11447, 1 hit
PfamiView protein in Pfam
PF00870 P53, 1 hit
PF07710 P53_tetramer, 1 hit
PRINTSiPR00386 P53SUPPRESSR
SUPFAMiSSF47719 SSF47719, 1 hit
SSF49417 SSF49417, 1 hit
PROSITEiView protein in PROSITE
PS00348 P53, 1 hit

Sequencei

Sequence statusi: Complete.

P79820-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPVPDLPES QGSFQELWET VSYPPLETLS LPTVNEPTGS WVATGDMFLL
60 70 80 90 100
DQDLSGTFDD KIFDIPIEPV PTNEVNPPPT TVPVTTDYPG SYELELRFQK
110 120 130 140 150
SGTAKSVTST YSETLNKLYC QLAKTSPIEV RVSKEPPKGA ILRATAVYKK
160 170 180 190 200
TEHVADVVRR CPHHQNEDSV EHRSHLIRVE GSQLAQYFED PYTKRQSVTV
210 220 230 240 250
PYEPPQPGSE MTTILLSYMC NSSCMGGMNR RPILTILTLE TEGLVLGRRC
260 270 280 290 300
FEVRICACPG RDRKTEEESR QKTQPKKRKV TPNTSSSKRK KSHSSGEEED
310 320 330 340 350
NREVFHFEVY GRERYEFLKK INDGLELLEK ESKSKNKDSG MVPSSGKKLK

SN
Length:352
Mass (Da):39,753
Last modified:May 27, 2002 - v2
Checksum:i196868A66351BFF5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti22Missing in AAC60146 (PubMed:9161419).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti91S → T1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U57306 mRNA Translation: AAC60146.1
AF003949 mRNA Translation: AAD01195.1
AF003950 mRNA Translation: AAD01196.1
RefSeqiNP_001098212.1, NM_001104742.1
XP_011485767.1, XM_011487465.1
UniGeneiOla.4812

Genome annotation databases

GeneIDi100049321
KEGGiola:100049321

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiP53_ORYLA
AccessioniPrimary (citable) accession number: P79820
Secondary accession number(s): Q9PSU7, Q9PSU8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 27, 2002
Last modified: May 23, 2018
This is version 121 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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