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Protein

Serotransferrin

Gene

tf

Organism
Oryzias latipes (Japanese rice fish) (Japanese killifish)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Transferrins are iron binding transport proteins which can bind two Fe3+ ions in association with the binding of an anion, usually bicarbonate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi73 – 731Iron 1PROSITE-ProRule annotation
Metal bindingi103 – 1031Iron 1PROSITE-ProRule annotation
Binding sitei128 – 1281Carbonate 1PROSITE-ProRule annotation
Binding sitei132 – 1321Carbonate 1PROSITE-ProRule annotation
Binding sitei134 – 1341Carbonate 1; via amide nitrogenPROSITE-ProRule annotation
Binding sitei135 – 1351Carbonate 1; via amide nitrogenPROSITE-ProRule annotation
Metal bindingi200 – 2001Iron 1PROSITE-ProRule annotation
Metal bindingi256 – 2561Iron 1PROSITE-ProRule annotation
Metal bindingi394 – 3941Iron 2PROSITE-ProRule annotation
Metal bindingi429 – 4291Iron 2PROSITE-ProRule annotation
Binding sitei454 – 4541Carbonate 2PROSITE-ProRule annotation
Binding sitei458 – 4581Carbonate 2PROSITE-ProRule annotation
Binding sitei460 – 4601Carbonate 2; via amide nitrogenPROSITE-ProRule annotation
Binding sitei461 – 4611Carbonate 2; via amide nitrogenPROSITE-ProRule annotation
Metal bindingi524 – 5241Iron 2PROSITE-ProRule annotation
Metal bindingi592 – 5921Iron 2PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ion transport, Iron transport, Transport

Keywords - Ligandi

Iron, Metal-binding

Protein family/group databases

MEROPSiS60.970.

Names & Taxonomyi

Protein namesi
Recommended name:
Serotransferrin
Gene namesi
Name:tf
OrganismiOryzias latipes (Japanese rice fish) (Japanese killifish)
Taxonomic identifieri8090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataOvalentariaAtherinomorphaeBeloniformesAdrianichthyidaeOryziinaeOryzias
Proteomesi
  • UP000001038 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717By similarityAdd
BLAST
Chaini18 – 690673SerotransferrinPRO_0000035722Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi27 ↔ 49PROSITE-ProRule annotation
Disulfide bondi126 ↔ 206PROSITE-ProRule annotation
Disulfide bondi171 ↔ 185PROSITE-ProRule annotation
Disulfide bondi234 ↔ 248PROSITE-ProRule annotation
Disulfide bondi343 ↔ 379PROSITE-ProRule annotation
Disulfide bondi353 ↔ 370PROSITE-ProRule annotation
Disulfide bondi404 ↔ 682PROSITE-ProRule annotation
Disulfide bondi419 ↔ 643PROSITE-ProRule annotation
Disulfide bondi452 ↔ 530PROSITE-ProRule annotation
Disulfide bondi476 ↔ 671PROSITE-ProRule annotation
Disulfide bondi486 ↔ 499PROSITE-ProRule annotation
Disulfide bondi496 ↔ 513PROSITE-ProRule annotation
Disulfide bondi570 ↔ 584PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiP79819.

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi8090.ENSORLP00000020672.

Structurei

3D structure databases

ProteinModelPortaliP79819.
SMRiP79819. Positions 103-255.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini24 – 329306Transferrin-like 1PROSITE-ProRule annotationAdd
BLAST
Domaini340 – 670331Transferrin-like 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the transferrin family.PROSITE-ProRule annotation
Contains 2 transferrin-like domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IEAI. Eukaryota.
ENOG410XQ36. LUCA.
HOGENOMiHOG000043759.
HOVERGENiHBG000055.
InParanoidiP79819.

Family and domain databases

InterProiIPR016357. Transferrin.
IPR001156. Transferrin-like_dom.
IPR018195. Transferrin_Fe_BS.
[Graphical view]
PfamiPF00405. Transferrin. 2 hits.
[Graphical view]
PIRSFiPIRSF002549. Transferrin. 1 hit.
PRINTSiPR00422. TRANSFERRIN.
SMARTiSM00094. TR_FER. 2 hits.
[Graphical view]
PROSITEiPS00205. TRANSFERRIN_LIKE_1. 2 hits.
PS00206. TRANSFERRIN_LIKE_2. 2 hits.
PS00207. TRANSFERRIN_LIKE_3. 1 hit.
PS51408. TRANSFERRIN_LIKE_4. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P79819-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKPLLLLTLL GCLAAALAVP AQKVKWCVKS DQEFRKCSDL AAASPAFSCV
60 70 80 90 100
KKESTLDCII AIKAGEADAI TVDGGDVYTA GLNNYDLHPI IAEDYGTSSE
110 120 130 140 150
TCYYAVAVAK KGTTFGIRDL RGKKSCHTGL GKSAGWNIPI GTLVSMDIIQ
160 170 180 190 200
WAGVEDKPVE EEVSTFFQAS CVPGATRGSK LCELCKGDCS RSQKEPYYDY
210 220 230 240 250
NGAFNCLAEG AGDVAFVKHL TVPDQEKSKY ELLCRDNTRA PIDDYKKCNL
260 270 280 290 300
ARVPAHAIVT HKDPQLAELI WTSLNSVQNF NLFSSEAYAP SKNLMFKDST
310 320 330 340 350
QRLVKLPQNT DSFLYLGAQY MSIVRSLKKE QSVGTNSNAI KWCAVGHAET
360 370 380 390 400
AKCDTWSINS VTDDTAAIEC QNAPSVEECL KKIMRKEADA MAVDGGEVYT
410 420 430 440 450
AGKCGLVPAM VEQYDAELCS SSGGQASSYY AVAVVKKDSG VTWENLKGKK
460 470 480 490 500
SCHTGIGRTA GWNIPMGRIY DQTKDCDFTK FFPSGCAPEP KPALHCALCV
510 520 530 540 550
KAAAKLSGDE AKCKARPEEQ YYGYAGAFRC LAEGAGDVAF IKHTIVGENT
560 570 580 590 600
DGNGPDWARS LKSDDYQLIC PGKGPVPISE YASCNLAVVP AHAVVTRPES
610 620 630 640 650
RSDVVRVLQV QQTFFGASGS DPSFKLFQSQ NGNNLLFKDS TKCLQEVPAG
660 670 680 690
TSYDQFLGSG YMEAMTSLRK CSDTASDLEK SCTFHSCQQT
Length:690
Mass (Da):74,601
Last modified:May 1, 1997 - v1
Checksum:i2F996CA1AEE79570
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D64033 Genomic DNA. Translation: BAA10901.1.
UniGeneiOla.129.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D64033 Genomic DNA. Translation: BAA10901.1.
UniGeneiOla.129.

3D structure databases

ProteinModelPortaliP79819.
SMRiP79819. Positions 103-255.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi8090.ENSORLP00000020672.

Protein family/group databases

MEROPSiS60.970.

Proteomic databases

PRIDEiP79819.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG410IEAI. Eukaryota.
ENOG410XQ36. LUCA.
HOGENOMiHOG000043759.
HOVERGENiHBG000055.
InParanoidiP79819.

Family and domain databases

InterProiIPR016357. Transferrin.
IPR001156. Transferrin-like_dom.
IPR018195. Transferrin_Fe_BS.
[Graphical view]
PfamiPF00405. Transferrin. 2 hits.
[Graphical view]
PIRSFiPIRSF002549. Transferrin. 1 hit.
PRINTSiPR00422. TRANSFERRIN.
SMARTiSM00094. TR_FER. 2 hits.
[Graphical view]
PROSITEiPS00205. TRANSFERRIN_LIKE_1. 2 hits.
PS00206. TRANSFERRIN_LIKE_2. 2 hits.
PS00207. TRANSFERRIN_LIKE_3. 1 hit.
PS51408. TRANSFERRIN_LIKE_4. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Structure of medaka transferrin gene and its 5'-flanking region."
    Mikawa N., Hirono I., Aoki T.
    Mol. Mar. Biol. Biotechnol. 5:225-229(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiTRFE_ORYLA
AccessioniPrimary (citable) accession number: P79819
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: May 1, 1997
Last modified: November 11, 2015
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.