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Protein

Neuropilin-1

Gene

NRP1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins (By similarity). Seems to have calcium-independent cell adhesion properties.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi193 – 1931CalciumBy similarity
Metal bindingi207 – 2071CalciumBy similarity
Metal bindingi248 – 2481CalciumBy similarity

GO - Molecular functioni

GO - Biological processi

  • angiogenesis Source: UniProtKB-KW
  • axon guidance Source: InterPro
  • cell adhesion Source: UniProtKB-KW
  • cell aggregation Source: AgBase
  • endothelial cell chemotaxis Source: InterPro
  • organ morphogenesis Source: InterPro
  • positive regulation of filopodium assembly Source: AgBase
  • rhombomere cell migration Source: AgBase
  • tissue morphogenesis Source: AgBase
  • vascular endothelial growth factor receptor signaling pathway Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Receptor

Keywords - Biological processi

Angiogenesis, Cell adhesion, Differentiation, Neurogenesis

Keywords - Ligandi

Calcium, Heparin-binding, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Neuropilin-1
Alternative name(s):
A5 protein
Gene namesi
Name:NRP1
Synonyms:NRP
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini20 – 847828ExtracellularSequence analysisAdd
BLAST
Transmembranei848 – 87023HelicalSequence analysisAdd
BLAST
Topological domaini871 – 91444CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • axon Source: AgBase
  • axonal growth cone Source: AgBase
  • axon terminus Source: AgBase
  • cell Source: AgBase
  • cell body fiber Source: AgBase
  • growth cone membrane Source: AgBase
  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: AgBase
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence analysisAdd
BLAST
Chaini19 – 914896Neuropilin-1PRO_0000021858Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi25 ↔ 52By similarity
Disulfide bondi80 ↔ 102By similarity
Disulfide bondi145 ↔ 171By similarity
Glycosylationi148 – 1481N-linked (GlcNAc...)Sequence analysis
Disulfide bondi204 ↔ 226By similarity
Glycosylationi259 – 2591N-linked (GlcNAc...)Sequence analysis
Disulfide bondi273 ↔ 422By similarity
Disulfide bondi429 ↔ 581By similarity
Glycosylationi520 – 5201N-linked (GlcNAc...)Sequence analysis
Glycosylationi610 – 6101O-linked (Xyl...) (chondroitin sulfate); alternateBy similarity
Glycosylationi610 – 6101O-linked (Xyl...) (heparan sulfate); alternateBy similarity
Glycosylationi817 – 8171N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein, Heparan sulfate, Proteoglycan

Proteomic databases

PaxDbiP79795.
PRIDEiP79795.

Expressioni

Tissue specificityi

Developing nervous system; optic tectum (layers D and E of SGFS), amacrine cells of retina, neurites of dorsal root ganglia. Also expressed in non-neuronal cells, e.g. blood vessels in the entire embryo.

Interactioni

Subunit structurei

Heterodimer with NRP2 (Probable). Binds PLXNB1 (By similarity).By similarityCurated

Protein-protein interaction databases

STRINGi9031.ENSGALP00000011550.

Structurei

3D structure databases

ProteinModelPortaliP79795.
SMRiP79795. Positions 143-584.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini25 – 139115CUB 1PROSITE-ProRule annotationAdd
BLAST
Domaini145 – 263119CUB 2PROSITE-ProRule annotationAdd
BLAST
Domaini273 – 422150F5/8 type C 1PROSITE-ProRule annotationAdd
BLAST
Domaini429 – 581153F5/8 type C 2PROSITE-ProRule annotationAdd
BLAST
Domaini636 – 801166MAMPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the neuropilin family.Curated
Contains 2 CUB domains.PROSITE-ProRule annotation
Contains 2 F5/8 type C domains.PROSITE-ProRule annotation
Contains 1 MAM domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IE8T. Eukaryota.
ENOG410YRBE. LUCA.
HOGENOMiHOG000039978.
HOVERGENiHBG000502.
InParanoidiP79795.
KOiK06724.
PhylomeDBiP79795.

Family and domain databases

Gene3Di2.60.120.260. 2 hits.
2.60.120.290. 2 hits.
InterProiIPR013320. ConA-like_dom.
IPR000859. CUB_dom.
IPR000421. FA58C.
IPR008979. Galactose-bd-like.
IPR000998. MAM_dom.
IPR014648. Neuropilin.
IPR022579. Neuropilin_C.
IPR027146. NRP1.
[Graphical view]
PANTHERiPTHR10127:SF654. PTHR10127:SF654. 1 hit.
PfamiPF00431. CUB. 2 hits.
PF11980. DUF3481. 1 hit.
PF00754. F5_F8_type_C. 2 hits.
PF00629. MAM. 1 hit.
[Graphical view]
PIRSFiPIRSF036960. Neuropilin. 1 hit.
PRINTSiPR00020. MAMDOMAIN.
SMARTiSM00042. CUB. 2 hits.
SM00231. FA58C. 2 hits.
SM00137. MAM. 1 hit.
[Graphical view]
SUPFAMiSSF49785. SSF49785. 2 hits.
SSF49854. SSF49854. 2 hits.
SSF49899. SSF49899. 1 hit.
PROSITEiPS01180. CUB. 2 hits.
PS01285. FA58C_1. 2 hits.
PS01286. FA58C_2. 2 hits.
PS50022. FA58C_3. 2 hits.
PS00740. MAM_1. 1 hit.
PS50060. MAM_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P79795-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDWGLFLHCA ALTFTLSRAL RSDKCGDTIK ILSPGYLTSP GYPQSYHPSQ
60 70 80 90 100
KCEWLIQAPE PYQRIMINFN PHFDLEDRDC KYDYVEVIDG DNAEGRLWGK
110 120 130 140 150
YCGKIAPPPL VSSGPYLFIK FVSDYETHGA GFSIRYEVFK RGPECSRNFT
160 170 180 190 200
SSSGMIKSPG FPEKYPNSLE CTYIIFAPKM SEIILEFESF ELEPDSNTPG
210 220 230 240 250
GAFCRYDRLE IWDGFPDVGP HIGRYCGQNN PGRVRSSTGI LSMVFYTDSA
260 270 280 290 300
IAKEGFSANY SVSQSSVSED FQCMEPLGME SGEIHSDQIT VSSQYSAIWS
310 320 330 340 350
SERSRLNYPE NGWTPGEDSV REWIQVDLGL LRFVSGIGTQ GAISKETKKE
360 370 380 390 400
YYLKTYRVDV SSNGEDWITL KEGNKPVVFQ GNSNPTDVVY RPFPKPVLTR
410 420 430 440 450
FVRIKPVSWE NGVSLRFEVY GCKITDYPCS GMLGMVSGLI PDSQITASTQ
460 470 480 490 500
VDRNWIPENA RLITSRSGWA LPPTTHPYTN EWLQIDLGEE KIVRGIIVQG
510 520 530 540 550
GKHRENKVFM KKFKIGYSNN GSDWKMIMDS SKKKIKTFEG NTNYDTPELR
560 570 580 590 600
TFEPVSTRII RVYPERATHA GLGLRMELLG CELEAPTAVP TVSEGKPVDE
610 620 630 640 650
CDDDQANCHS GTGGTTVLNT EKPTVIDNTV QPELPPYNLN CGFGWGSHKT
660 670 680 690 700
LCQWEHDNQV DLKWAILTSK TGPIQDHTGD GNFIYSQADE SQKGKVARLL
710 720 730 740 750
SPIIYSQNSA HCMTFWYHMS GPHVGTLKIK LRYQKPDEYD QVLLSLNGHQ
760 770 780 790 800
ANCWQEGRVL LHKSVKLYQV VIEGEIGKGN GGIAVDDINI DNHISQEDCQ
810 820 830 840 850
KSTDVESEIV EEDPESNQTG FTPSYRTDED YDDISRKPGN VLKTLDPILI
860 870 880 890 900
TIIAMSALGV LLGAICGVVL YCACWHNGMS ERNLSALENY NFELVDGVKL
910
KKDKLNTQNS YSEA
Length:914
Mass (Da):102,480
Last modified:May 1, 1997 - v1
Checksum:iDD2EE6D6F0CBB68C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D45416 mRNA. Translation: BAA08256.1.
RefSeqiNP_990113.1. NM_204782.1.
UniGeneiGga.4032.

Genome annotation databases

GeneIDi395560.
KEGGigga:395560.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D45416 mRNA. Translation: BAA08256.1.
RefSeqiNP_990113.1. NM_204782.1.
UniGeneiGga.4032.

3D structure databases

ProteinModelPortaliP79795.
SMRiP79795. Positions 143-584.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000011550.

Proteomic databases

PaxDbiP79795.
PRIDEiP79795.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi395560.
KEGGigga:395560.

Organism-specific databases

CTDi8829.

Phylogenomic databases

eggNOGiENOG410IE8T. Eukaryota.
ENOG410YRBE. LUCA.
HOGENOMiHOG000039978.
HOVERGENiHBG000502.
InParanoidiP79795.
KOiK06724.
PhylomeDBiP79795.

Miscellaneous databases

NextBioi20815635.
PROiP79795.

Family and domain databases

Gene3Di2.60.120.260. 2 hits.
2.60.120.290. 2 hits.
InterProiIPR013320. ConA-like_dom.
IPR000859. CUB_dom.
IPR000421. FA58C.
IPR008979. Galactose-bd-like.
IPR000998. MAM_dom.
IPR014648. Neuropilin.
IPR022579. Neuropilin_C.
IPR027146. NRP1.
[Graphical view]
PANTHERiPTHR10127:SF654. PTHR10127:SF654. 1 hit.
PfamiPF00431. CUB. 2 hits.
PF11980. DUF3481. 1 hit.
PF00754. F5_F8_type_C. 2 hits.
PF00629. MAM. 1 hit.
[Graphical view]
PIRSFiPIRSF036960. Neuropilin. 1 hit.
PRINTSiPR00020. MAMDOMAIN.
SMARTiSM00042. CUB. 2 hits.
SM00231. FA58C. 2 hits.
SM00137. MAM. 1 hit.
[Graphical view]
SUPFAMiSSF49785. SSF49785. 2 hits.
SSF49854. SSF49854. 2 hits.
SSF49899. SSF49899. 1 hit.
PROSITEiPS01180. CUB. 2 hits.
PS01285. FA58C_1. 2 hits.
PS01286. FA58C_2. 2 hits.
PS50022. FA58C_3. 2 hits.
PS00740. MAM_1. 1 hit.
PS50060. MAM_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Expression of a cell adhesion molecule, neuropilin, in the developing chick nervous system."
    Takagi S., Kasuya Y., Shimizu M., Matsuura T., Tsuboi M., Kawakami A., Fujisawa H.
    Dev. Biol. 170:207-222(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: White leghorn.
    Tissue: Embryonic brain.

Entry informationi

Entry nameiNRP1_CHICK
AccessioniPrimary (citable) accession number: P79795
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 1, 1997
Last modified: May 11, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.