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Protein

Type-1 angiotensin II receptor

Gene

AGTR1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-GGA-375276. Peptide ligand-binding receptors.
R-GGA-416476. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Type-1 angiotensin II receptor
Alternative name(s):
Angiotensin II type-1 receptor
Short name:
AT1
Gene namesi
Name:AGTR1
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 9

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 27ExtracellularSequence analysisAdd BLAST27
Transmembranei28 – 52Helical; Name=1Sequence analysisAdd BLAST25
Topological domaini53 – 64CytoplasmicSequence analysisAdd BLAST12
Transmembranei65 – 87Helical; Name=2Sequence analysisAdd BLAST23
Topological domaini88 – 102ExtracellularSequence analysisAdd BLAST15
Transmembranei103 – 124Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini125 – 142CytoplasmicSequence analysisAdd BLAST18
Transmembranei143 – 162Helical; Name=4Sequence analysisAdd BLAST20
Topological domaini163 – 192ExtracellularSequence analysisAdd BLAST30
Transmembranei193 – 214Helical; Name=5Sequence analysisAdd BLAST22
Topological domaini215 – 240CytoplasmicSequence analysisAdd BLAST26
Transmembranei241 – 262Helical; Name=6Sequence analysisAdd BLAST22
Topological domaini263 – 275ExtracellularSequence analysisAdd BLAST13
Transmembranei276 – 296Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini297 – 359CytoplasmicSequence analysisAdd BLAST63

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000691631 – 359Type-1 angiotensin II receptorAdd BLAST359

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi4N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi101 ↔ 180PROSITE-ProRule annotation
Glycosylationi176N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi187N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi188N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

C-terminal Ser or Thr residues may be phosphorylated.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP79785.

Expressioni

Gene expression databases

BgeeiENSGALG00000024000.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000039674.

Structurei

3D structure databases

ProteinModelPortaliP79785.
SMRiP79785.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000119055.
HOGENOMiHOG000234122.
HOVERGENiHBG104998.
InParanoidiP79785.
KOiK04166.
OMAiYTLIWKT.
OrthoDBiEOG091G0C1Y.
PhylomeDBiP79785.
TreeFamiTF330024.

Family and domain databases

CDDicd15192. 7tmA_AT1R. 1 hit.
InterProiView protein in InterPro
IPR000190. ATII_AT1_rcpt.
IPR000248. ATII_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
PfamiView protein in Pfam
PF00001. 7tm_1. 1 hit.
PRINTSiPR00241. ANGIOTENSINR.
PR00635. ANGIOTENSN1R.
PR00237. GPCRRHODOPSN.
SMARTiView protein in SMART
SM01381. 7TM_GPCR_Srsx. 1 hit.
PROSITEiView protein in PROSITE
PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P79785-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVPNYSTEET VKRIHVDCPV SGRHSYIYIM VPTVYSIIFI IGIFGNSLVV
60 70 80 90 100
IVIYCYMKLK TVASIFLLNL ALADLCFLIT LPLWAAYTAM EYQWPFGNCL
110 120 130 140 150
CKLASAGISF NLYASVFLLT CLSIDRYLAI VHPVKSRIRR TMFVARVTCI
160 170 180 190 200
VIWLLAGVAS LPVIIHRNIF FAENLNMTVC GFRYDNNNTT LRVGLGLSKN
210 220 230 240 250
LLGFLIPFLI ILTSYTLIWK TLKKAYQIQR NKTRNDDIFK MIVAIVFFFF
260 270 280 290 300
FSWIPHQVFT FLDVLIQLHV ITDCKITDIV DTAMPFTICI AYFNNCLNPF
310 320 330 340 350
FYVFFGKNFK KYFLQLIKYI PPNVSTHPSL TTKMSSLSYR PPENIRLPTK

KTAGSFDAE
Length:359
Mass (Da):41,220
Last modified:May 1, 1997 - v1
Checksum:i94FEC1AF9CE4CB4F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U76704 mRNA. Translation: AAB41201.1.
RefSeqiNP_990488.1. NM_205157.3.
XP_015146861.1. XM_015291375.1.
XP_015146862.1. XM_015291376.1.
XP_015146863.1. XM_015291377.1.
XP_015146864.1. XM_015291378.1.
XP_015146865.1. XM_015291379.1.
XP_015146866.1. XM_015291380.1.
XP_015146867.1. XM_015291381.1.
UniGeneiGga.632.

Genome annotation databases

EnsembliENSGALT00000048034; ENSGALP00000057556; ENSGALG00000038512.
GeneIDi396065.
KEGGigga:396065.

Similar proteinsi

Entry informationi

Entry nameiAGTR1_CHICK
AccessioniPrimary (citable) accession number: P79785
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 1, 1997
Last modified: August 30, 2017
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families