P79764 (GLRX1_CHICK) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glutaredoxin-1

Alternative name(s):
Thioltransferase-1
Short name=TTase-1

Gene names

Name:	GLRX
Synonyms:	GRX

Organism

Gallus gallus (Chicken)

Taxonomic identifier

9031 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Protein attributes

Sequence length	101 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins.
Subcellular location	Cytoplasm.
Sequence similarities	Belongs to the glutaredoxin family. Contains 1 glutaredoxin domain.

Ontologies

Keywords
Biological process	Electron transport Transport
Cellular component	Cytoplasm
Domain	Redox-active center
PTM	Disulfide bond
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	cell redox homeostasis Inferred from electronic annotation. Source: InterPro electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW transport Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	electron carrier activity Inferred from electronic annotation. Source: InterPro protein disulfide oxidoreductase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 101	101	Glutaredoxin-1		PRO_0000141605
Regions
	Domain	3 – 101	99	Glutaredoxin
Amino acid modifications
	Disulfide bond	23 ↔ 26		Redox-active By similarity

Sequences

	Sequence		Length	Mass (Da)
	P79764 [UniParc]. Last modified May 1, 1997. Version 1. Checksum: 50619DB1E54656F2	FASTA	101	11,397
	10 20 30 40 50 60 MVDSFVQSKL RDNKVTLFVK GSCPYCKNAI VLLKEFNFLP GCLEVVDITG MDDIQDYFQK 70 80 90 100 TTGQRTVPRV FIGTKCIGGF SDLQKMEQQL PMMLRQIGAL V

References

[1]	"Glutaredoxin is a direct target of oncogenic jun." Goller M.E., Iacovoni J.S., Vogt P.K., Kruse U. Oncogene 16:2945-2948(1998) [PubMed: 9671415] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Y09235 mRNA. Translation: CAA70437.1.
IPI	IPI00584182.
RefSeq	NP_990491.1. NM_205160.1.
UniGene	Gga.635.
3D structure databases
ProteinModelPortal	P79764.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	396069.
KEGG	gga:396069.
Organism-specific databases
CTD	2745.
Phylogenomic databases
eggNOG	veNOG21265.
GeneTree	ENSGT00390000003677.
HOVERGEN	HBG000283.
InParanoid	P79764.
OrthoDB	EOG4N8R6D.
PhylomeDB	P79764.
Family and domain databases
InterPro	IPR011767. GLR_AS. IPR002109. Glutaredoxin. IPR014025. Glutaredoxin_subgr. IPR012336. Thioredoxin-like_fold. [Graphical view]
Gene3D	G3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.
KO	K03676.
Pfam	PF00462. Glutaredoxin. 1 hit. [Graphical view]
PRINTS	PR00160. GLUTAREDOXIN.
SUPFAM	SSF52833. Thiordxn-like_fd. 1 hit.
PROSITE	PS00195. GLUTAREDOXIN_1. 1 hit. PS51354. GLUTAREDOXIN_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GLRX1_CHICK

Accession

Primary (citable) accession number: P79764

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	May 1, 1997
Last modified:	November 16, 2011
This is version 68 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program