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P79761 (CP1A5_CHICK) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 90. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome P450 1A5

EC=1.14.14.1
Alternative name(s):
CYPIA5
Cytochrome P450 TCDDAA
Gene names
Name:CYP1A5
OrganismGallus gallus (Chicken) [Reference proteome]
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus

Protein attributes

Sequence length528 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activity

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactor

Heme group By similarity.

Subcellular location

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Induction

By 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).

Sequence similarities

Belongs to the cytochrome P450 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 528528Cytochrome P450 1A5
PRO_0000051659

Sites

Metal binding4671Iron (heme axial ligand) By similarity

Sequences

Sequence LengthMass (Da)Tools
P79761 [UniParc].

Last modified May 1, 1997. Version 1.
Checksum: 5D73AAA637CEB957

FASTA52860,071
        10         20         30         40         50         60 
MGPEEVMVQA SSPGLISATE VLVAAATFCL LLLLTQTRRQ HAPKGLRSPP GPRGLPMLGS 

        70         80         90        100        110        120 
VLELRKDPHL VLTRLSRKYG DVMEVTIGSR PVVVLSGLET IKQALVRQAE DFMGRPDLYS 

       130        140        150        160        170        180 
FRHITDGQSL TFSTDTGEMW KARRKLAQNA LKNFSIAASP TASSSCLLEE HVSTEASYLV 

       190        200        210        220        230        240 
TKFLQLMEEK QSFDPYRYMV VSVANVICAI CFGKRYDHDD QELLSVVNVV DEFVDVTAAG 

       250        260        270        280        290        300 
NPADFIPLLR YLPSRNMDSF LDFNKRFMKL LQTAVEEHYQ TFDKNNIRDV TDSLIEQCVE 

       310        320        330        340        350        360 
KKAEANGATQ IPNEKIINLV NDIFGAGFDT VTTALSWSLM YLVTYPHMQK KIQAELDQTI 

       370        380        390        400        410        420 
GRERRPRLSD RGMLPYTEAF ILEMFRHSSF MPFTIPHSTT RDTVLNGYYI PKDRCVFINQ 

       430        440        450        460        470        480 
WQVNHDEKLW KDPQAFNPER FLNAEGTEVN KVDAEKVMTF GLGKRRCIGE NIGKWEVFLF 

       490        500        510        520 
LSTLLQQLEF SIQDGKKADM TPIYGLSMKH KRCEHFQVKK RFSMKSSN 

« Hide

References

[1]"Molecular cloning and expression of two novel avian cytochrome P450 1A enzymes induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin."
Gilday D.J., Gannon M., Yutzey K., Bader D., Rifkind A.B.
J. Biol. Chem. 271:33054-33059(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Liver.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X99454 mRNA. Translation: CAA67816.1.
RefSeqNP_990477.1. NM_205146.2.
UniGeneGga.48615.

3D structure databases

ProteinModelPortalP79761.
SMRP79761. Positions 43-523.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9031.ENSGALP00000002010.

Proteomic databases

PaxDbP79761.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID396051.
KEGGgga:396051.

Organism-specific databases

CTD1543.

Phylogenomic databases

eggNOGCOG2124.
HOVERGENHBG106944.
KOK07408.
PhylomeDBP79761.

Family and domain databases

Gene3D1.10.630.10. 1 hit.
InterProIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008066. Cyt_P450_E_grp-I_CYP1.
[Graphical view]
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00463. EP450I.
PR01683. EP450ICYP1A.
PR00385. P450.
SUPFAMSSF48264. SSF48264. 1 hit.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20816111.
PROP79761.

Entry information

Entry nameCP1A5_CHICK
AccessionPrimary (citable) accession number: P79761
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: May 1, 1997
Last modified: April 16, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families