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P79761

- CP1A5_CHICK

UniProt

P79761 - CP1A5_CHICK

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Protein

Cytochrome P450 1A5

Gene
CYP1A5
Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

Heme group By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi467 – 4671Iron (heme axial ligand) By similarity

GO - Molecular functioni

  1. aromatase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 1A5 (EC:1.14.14.1)
Alternative name(s):
CYPIA5
Cytochrome P450 TCDDAA
Gene namesi
Name:CYP1A5
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 528528Cytochrome P450 1A5PRO_0000051659Add
BLAST

Proteomic databases

PaxDbiP79761.

Expressioni

Inductioni

By 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000002010.

Structurei

3D structure databases

ProteinModelPortaliP79761.
SMRiP79761. Positions 43-523.

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.

Phylogenomic databases

eggNOGiCOG2124.
HOVERGENiHBG106944.
KOiK07408.
PhylomeDBiP79761.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008066. Cyt_P450_E_grp-I_CYP1.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR01683. EP450ICYP1A.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P79761-1 [UniParc]FASTAAdd to Basket

« Hide

MGPEEVMVQA SSPGLISATE VLVAAATFCL LLLLTQTRRQ HAPKGLRSPP    50
GPRGLPMLGS VLELRKDPHL VLTRLSRKYG DVMEVTIGSR PVVVLSGLET 100
IKQALVRQAE DFMGRPDLYS FRHITDGQSL TFSTDTGEMW KARRKLAQNA 150
LKNFSIAASP TASSSCLLEE HVSTEASYLV TKFLQLMEEK QSFDPYRYMV 200
VSVANVICAI CFGKRYDHDD QELLSVVNVV DEFVDVTAAG NPADFIPLLR 250
YLPSRNMDSF LDFNKRFMKL LQTAVEEHYQ TFDKNNIRDV TDSLIEQCVE 300
KKAEANGATQ IPNEKIINLV NDIFGAGFDT VTTALSWSLM YLVTYPHMQK 350
KIQAELDQTI GRERRPRLSD RGMLPYTEAF ILEMFRHSSF MPFTIPHSTT 400
RDTVLNGYYI PKDRCVFINQ WQVNHDEKLW KDPQAFNPER FLNAEGTEVN 450
KVDAEKVMTF GLGKRRCIGE NIGKWEVFLF LSTLLQQLEF SIQDGKKADM 500
TPIYGLSMKH KRCEHFQVKK RFSMKSSN 528
Length:528
Mass (Da):60,071
Last modified:May 1, 1997 - v1
Checksum:i5D73AAA637CEB957
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X99454 mRNA. Translation: CAA67816.1.
RefSeqiNP_990477.1. NM_205146.2.
UniGeneiGga.48615.

Genome annotation databases

GeneIDi396051.
KEGGigga:396051.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X99454 mRNA. Translation: CAA67816.1 .
RefSeqi NP_990477.1. NM_205146.2.
UniGenei Gga.48615.

3D structure databases

ProteinModelPortali P79761.
SMRi P79761. Positions 43-523.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9031.ENSGALP00000002010.

Proteomic databases

PaxDbi P79761.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 396051.
KEGGi gga:396051.

Organism-specific databases

CTDi 1543.

Phylogenomic databases

eggNOGi COG2124.
HOVERGENi HBG106944.
KOi K07408.
PhylomeDBi P79761.

Miscellaneous databases

NextBioi 20816111.
PROi P79761.

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008066. Cyt_P450_E_grp-I_CYP1.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00463. EP450I.
PR01683. EP450ICYP1A.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning and expression of two novel avian cytochrome P450 1A enzymes induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin."
    Gilday D.J., Gannon M., Yutzey K., Bader D., Rifkind A.B.
    J. Biol. Chem. 271:33054-33059(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.

Entry informationi

Entry nameiCP1A5_CHICK
AccessioniPrimary (citable) accession number: P79761
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: May 1, 1997
Last modified: April 16, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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