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P79761

- CP1A5_CHICK

UniProt

P79761 - CP1A5_CHICK

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Protein

Cytochrome P450 1A5

Gene

CYP1A5

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

Heme group.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi467 – 4671Iron (heme axial ligand)By similarity

GO - Molecular functioni

  1. aromatase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 1A5 (EC:1.14.14.1)
Alternative name(s):
CYPIA5
Cytochrome P450 TCDDAA
Gene namesi
Name:CYP1A5
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 528528Cytochrome P450 1A5PRO_0000051659Add
BLAST

Proteomic databases

PaxDbiP79761.

Expressioni

Inductioni

By 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000002010.

Structurei

3D structure databases

ProteinModelPortaliP79761.
SMRiP79761. Positions 43-523.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiCOG2124.
HOVERGENiHBG106944.
InParanoidiP79761.
KOiK07408.
PhylomeDBiP79761.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008066. Cyt_P450_E_grp-I_CYP1.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR01683. EP450ICYP1A.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P79761-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGPEEVMVQA SSPGLISATE VLVAAATFCL LLLLTQTRRQ HAPKGLRSPP
60 70 80 90 100
GPRGLPMLGS VLELRKDPHL VLTRLSRKYG DVMEVTIGSR PVVVLSGLET
110 120 130 140 150
IKQALVRQAE DFMGRPDLYS FRHITDGQSL TFSTDTGEMW KARRKLAQNA
160 170 180 190 200
LKNFSIAASP TASSSCLLEE HVSTEASYLV TKFLQLMEEK QSFDPYRYMV
210 220 230 240 250
VSVANVICAI CFGKRYDHDD QELLSVVNVV DEFVDVTAAG NPADFIPLLR
260 270 280 290 300
YLPSRNMDSF LDFNKRFMKL LQTAVEEHYQ TFDKNNIRDV TDSLIEQCVE
310 320 330 340 350
KKAEANGATQ IPNEKIINLV NDIFGAGFDT VTTALSWSLM YLVTYPHMQK
360 370 380 390 400
KIQAELDQTI GRERRPRLSD RGMLPYTEAF ILEMFRHSSF MPFTIPHSTT
410 420 430 440 450
RDTVLNGYYI PKDRCVFINQ WQVNHDEKLW KDPQAFNPER FLNAEGTEVN
460 470 480 490 500
KVDAEKVMTF GLGKRRCIGE NIGKWEVFLF LSTLLQQLEF SIQDGKKADM
510 520
TPIYGLSMKH KRCEHFQVKK RFSMKSSN
Length:528
Mass (Da):60,071
Last modified:May 1, 1997 - v1
Checksum:i5D73AAA637CEB957
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X99454 mRNA. Translation: CAA67816.1.
RefSeqiNP_990477.1. NM_205146.2.
UniGeneiGga.48615.

Genome annotation databases

GeneIDi396051.
KEGGigga:396051.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X99454 mRNA. Translation: CAA67816.1 .
RefSeqi NP_990477.1. NM_205146.2.
UniGenei Gga.48615.

3D structure databases

ProteinModelPortali P79761.
SMRi P79761. Positions 43-523.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9031.ENSGALP00000002010.

Proteomic databases

PaxDbi P79761.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 396051.
KEGGi gga:396051.

Organism-specific databases

CTDi 1543.

Phylogenomic databases

eggNOGi COG2124.
HOVERGENi HBG106944.
InParanoidi P79761.
KOi K07408.
PhylomeDBi P79761.

Miscellaneous databases

NextBioi 20816111.
PROi P79761.

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008066. Cyt_P450_E_grp-I_CYP1.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00463. EP450I.
PR01683. EP450ICYP1A.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning and expression of two novel avian cytochrome P450 1A enzymes induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin."
    Gilday D.J., Gannon M., Yutzey K., Bader D., Rifkind A.B.
    J. Biol. Chem. 271:33054-33059(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.

Entry informationi

Entry nameiCP1A5_CHICK
AccessioniPrimary (citable) accession number: P79761
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: May 1, 1997
Last modified: October 29, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3