Reviewed, UniProtKB/Swiss-Prot P79761 (CP1A5_CHICK)

Names and origin

Protein names

Recommended name:
    Cytochrome P450 1A5
    EC=1.14.14.1
Alternative name(s):
    CYPIA5
    Cytochrome P450 TCDDAA

Gene names

Name:

CYP1A5

Organism

Gallus gallus (Chicken)

Taxonomic identifier

9031 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Protein attributes

Sequence length	528 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Catalytic activity	RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.
Cofactor	Heme group By similarity.
Subcellular location	Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Induction	By 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).
Sequence similarities	Belongs to the cytochrome P450 family.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum Membrane Microsome
Ligand	Heme Iron Metal-binding
Molecular function	Monooxygenase Oxidoreductase
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	endoplasmic reticulum Inferred from electronic annotation. Source: UniProtKB-KW extrinsic to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell microsome Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	aromatase activity Inferred from electronic annotation. Source: EC electron carrier activity Inferred from electronic annotation. Source: InterPro heme binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 528	528	Cytochrome P450 1A5		PRO_0000051659
Sites
	Metal binding	467	1	Iron (heme axial ligand) By similarity

Sequences

	Sequence		Length	Mass (Da)
	P79761-1 [UniParc]. Last modified May 1, 1997. Version 1. Checksum: 5D73AAA637CEB957	FASTA	528	60,071
	10 20 30 40 50 60 MGPEEVMVQA SSPGLISATE VLVAAATFCL LLLLTQTRRQ HAPKGLRSPP GPRGLPMLGS 70 80 90 100 110 120 VLELRKDPHL VLTRLSRKYG DVMEVTIGSR PVVVLSGLET IKQALVRQAE DFMGRPDLYS 130 140 150 160 170 180 FRHITDGQSL TFSTDTGEMW KARRKLAQNA LKNFSIAASP TASSSCLLEE HVSTEASYLV 190 200 210 220 230 240 TKFLQLMEEK QSFDPYRYMV VSVANVICAI CFGKRYDHDD QELLSVVNVV DEFVDVTAAG 250 260 270 280 290 300 NPADFIPLLR YLPSRNMDSF LDFNKRFMKL LQTAVEEHYQ TFDKNNIRDV TDSLIEQCVE 310 320 330 340 350 360 KKAEANGATQ IPNEKIINLV NDIFGAGFDT VTTALSWSLM YLVTYPHMQK KIQAELDQTI 370 380 390 400 410 420 GRERRPRLSD RGMLPYTEAF ILEMFRHSSF MPFTIPHSTT RDTVLNGYYI PKDRCVFINQ 430 440 450 460 470 480 WQVNHDEKLW KDPQAFNPER FLNAEGTEVN KVDAEKVMTF GLGKRRCIGE NIGKWEVFLF 490 500 510 520 LSTLLQQLEF SIQDGKKADM TPIYGLSMKH KRCEHFQVKK RFSMKSSN

References

[1]

"Molecular cloning and expression of two novel avian cytochrome P450 1A enzymes induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin." Gilday D.J., Gannon M., Yutzey K., Bader D., Rifkind A.B. J. Biol. Chem. 271:33054-33059(1996) [PubMed: 8955152] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Liver.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X99454 mRNA. Translation: CAA67816.1.
IPI	IPI00577923.
RefSeq	NP_990477.1.
UniGene	Gga.617
3D structure databases
SMR	P79761. Positions 43-523.
ModBase	Search...
Protein-protein interaction databases
STRING	P79761.
Genome annotation databases
GeneID	396051.
KEGG	gga:396051.
Organism-specific databases
CTD	396051.
Phylogenomic databases
eggNOG	meNOG07338.
HOVERGEN	P79761.
Enzyme and pathway databases
BRENDA	1.14.14.1. 4.
Family and domain databases
InterPro	IPR001128. Cyt_P450. IPR017973. Cyt_P450_C. IPR017972. Cyt_P450_CS. IPR002401. Cyt_P450_E_grp-I. IPR008066. Cyt_P450_E_grp-I_CYP1. [Graphical view]
Gene3D	G3DSA:1.10.630.10. Cyt_P450. 1 hit.
PANTHER	PTHR19383. Cyt_P450. 1 hit. PTHR19383:SF63. Cyt_P450_E_grp-I_CYP1. 1 hit.
Pfam	PF00067. p450. 1 hit. [Graphical view]
PRINTS	PR00463. EP450I. PR01683. EP450ICYP1A. PR00385. P450.
PROSITE	PS00086. CYTOCHROME_P450. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CP1A5_CHICK

Accession

Primary (citable) accession number: P79761

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
Last sequence update:	May 1, 1997
Last modified:	January 19, 2010
This is version 68 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)