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P79761

- CP1A5_CHICK

UniProt

P79761 - CP1A5_CHICK

Protein

Cytochrome P450 1A5

Gene

CYP1A5

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 91 (01 Oct 2014)
      Sequence version 1 (01 May 1997)
      Previous versions | rss
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    Functioni

    Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

    Catalytic activityi

    RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

    Cofactori

    Heme group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi467 – 4671Iron (heme axial ligand)By similarity

    GO - Molecular functioni

    1. aromatase activity Source: UniProtKB-EC
    2. heme binding Source: InterPro
    3. iron ion binding Source: InterPro

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome P450 1A5 (EC:1.14.14.1)
    Alternative name(s):
    CYPIA5
    Cytochrome P450 TCDDAA
    Gene namesi
    Name:CYP1A5
    OrganismiGallus gallus (Chicken)
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 528528Cytochrome P450 1A5PRO_0000051659Add
    BLAST

    Proteomic databases

    PaxDbiP79761.

    Expressioni

    Inductioni

    By 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).

    Interactioni

    Protein-protein interaction databases

    STRINGi9031.ENSGALP00000002010.

    Structurei

    3D structure databases

    ProteinModelPortaliP79761.
    SMRiP79761. Positions 43-523.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Phylogenomic databases

    eggNOGiCOG2124.
    HOVERGENiHBG106944.
    KOiK07408.
    PhylomeDBiP79761.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    IPR008066. Cyt_P450_E_grp-I_CYP1.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00463. EP450I.
    PR01683. EP450ICYP1A.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P79761-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGPEEVMVQA SSPGLISATE VLVAAATFCL LLLLTQTRRQ HAPKGLRSPP    50
    GPRGLPMLGS VLELRKDPHL VLTRLSRKYG DVMEVTIGSR PVVVLSGLET 100
    IKQALVRQAE DFMGRPDLYS FRHITDGQSL TFSTDTGEMW KARRKLAQNA 150
    LKNFSIAASP TASSSCLLEE HVSTEASYLV TKFLQLMEEK QSFDPYRYMV 200
    VSVANVICAI CFGKRYDHDD QELLSVVNVV DEFVDVTAAG NPADFIPLLR 250
    YLPSRNMDSF LDFNKRFMKL LQTAVEEHYQ TFDKNNIRDV TDSLIEQCVE 300
    KKAEANGATQ IPNEKIINLV NDIFGAGFDT VTTALSWSLM YLVTYPHMQK 350
    KIQAELDQTI GRERRPRLSD RGMLPYTEAF ILEMFRHSSF MPFTIPHSTT 400
    RDTVLNGYYI PKDRCVFINQ WQVNHDEKLW KDPQAFNPER FLNAEGTEVN 450
    KVDAEKVMTF GLGKRRCIGE NIGKWEVFLF LSTLLQQLEF SIQDGKKADM 500
    TPIYGLSMKH KRCEHFQVKK RFSMKSSN 528
    Length:528
    Mass (Da):60,071
    Last modified:May 1, 1997 - v1
    Checksum:i5D73AAA637CEB957
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X99454 mRNA. Translation: CAA67816.1.
    RefSeqiNP_990477.1. NM_205146.2.
    UniGeneiGga.48615.

    Genome annotation databases

    GeneIDi396051.
    KEGGigga:396051.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X99454 mRNA. Translation: CAA67816.1 .
    RefSeqi NP_990477.1. NM_205146.2.
    UniGenei Gga.48615.

    3D structure databases

    ProteinModelPortali P79761.
    SMRi P79761. Positions 43-523.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9031.ENSGALP00000002010.

    Proteomic databases

    PaxDbi P79761.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 396051.
    KEGGi gga:396051.

    Organism-specific databases

    CTDi 1543.

    Phylogenomic databases

    eggNOGi COG2124.
    HOVERGENi HBG106944.
    KOi K07408.
    PhylomeDBi P79761.

    Miscellaneous databases

    NextBioi 20816111.
    PROi P79761.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    IPR008066. Cyt_P450_E_grp-I_CYP1.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00463. EP450I.
    PR01683. EP450ICYP1A.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and expression of two novel avian cytochrome P450 1A enzymes induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin."
      Gilday D.J., Gannon M., Yutzey K., Bader D., Rifkind A.B.
      J. Biol. Chem. 271:33054-33059(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Liver.

    Entry informationi

    Entry nameiCP1A5_CHICK
    AccessioniPrimary (citable) accession number: P79761
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: May 1, 1997
    Last modified: October 1, 2014
    This is version 91 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3