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Protein

Cytochrome P450 1A4

Gene

CYP1A4

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi469 – 4691Iron (heme axial ligand)By similarity

GO - Molecular functioni

  1. aromatase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 1A4 (EC:1.14.14.1)
Alternative name(s):
CYPIA4
Cytochrome P450 TCDDAHH
Gene namesi
Name:CYP1A4
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 530530Cytochrome P450 1A4PRO_0000051658Add
BLAST

Proteomic databases

PaxDbiP79760.

Expressioni

Inductioni

By 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000039219.

Structurei

3D structure databases

ProteinModelPortaliP79760.
SMRiP79760. Positions 44-523.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiCOG2124.
HOGENOMiHOG000036991.
HOVERGENiHBG106944.
InParanoidiP79760.
PhylomeDBiP79760.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008066. Cyt_P450_E_grp-I_CYP1.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR01683. EP450ICYP1A.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P79760-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAGPQAAME QASSPGLISA TEVLVAAATF CLLLLLTQTR RQHAPKGLRS
60 70 80 90 100
PPGPRGLPML GNVLELRKDP HLVLTRLSRK YGDVMEVTIG SRPVVVLSGL
110 120 130 140 150
ETIKQALVRQ AEDFMGRPDL PSWQYVSNGH SLAFSYECGD AWKARRKLAQ
160 170 180 190 200
NALKTFSIAA SPTASSSCLL EEHVSTEASY LVTKFLQLME EKQSFNPNSY
210 220 230 240 250
LMVSVANVIC AICFGKRYDH DDQELLSVVN MNTEFGDVAA AGNPADFIPL
260 270 280 290 300
LRYLPNRAMA AFKDVNARFS AFVQKIVQNH YSTFDKEHIR DVTDSLIGHC
310 320 330 340 350
QEKRTGEDVR VQPSDESIIS IVNDLFGAGF DTVTTALSWC MMYAALYPHI
360 370 380 390 400
QKKIQAELDQ TIGRERRPRL SDRGMLPYTE AFILEAFRHS SLLPFTIPHC
410 420 430 440 450
TTKDTVLNGY YIPKDTCVFI NQWQANHDEK IWKDPPSFKP ERFLNAAGTE
460 470 480 490 500
LSRTEADKVL IFGLGKRRCI GESIGRWEVF LFLTTILQQL EISLAPGQRV
510 520 530
DITPQYGLTM KYKQCECFQM KKRFPSKGSA
Length:530
Mass (Da):59,361
Last modified:April 30, 1997 - v1
Checksum:i40736B4CA5936F2E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X99453 mRNA. Translation: CAA67815.1.
RefSeqiNP_990478.1. NM_205147.1.
UniGeneiGga.617.

Genome annotation databases

GeneIDi396052.
KEGGigga:396052.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X99453 mRNA. Translation: CAA67815.1.
RefSeqiNP_990478.1. NM_205147.1.
UniGeneiGga.617.

3D structure databases

ProteinModelPortaliP79760.
SMRiP79760. Positions 44-523.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000039219.

Proteomic databases

PaxDbiP79760.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi396052.
KEGGigga:396052.

Organism-specific databases

CTDi396052.

Phylogenomic databases

eggNOGiCOG2124.
HOGENOMiHOG000036991.
HOVERGENiHBG106944.
InParanoidiP79760.
PhylomeDBiP79760.

Miscellaneous databases

NextBioi20816112.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008066. Cyt_P450_E_grp-I_CYP1.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR01683. EP450ICYP1A.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular cloning and expression of two novel avian cytochrome P450 1A enzymes induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin."
    Gilday D.J., Gannon M., Yutzey K., Bader D., Rifkind A.B.
    J. Biol. Chem. 271:33054-33059(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiCP1A4_CHICK
AccessioniPrimary (citable) accession number: P79760
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 14, 1998
Last sequence update: April 30, 1997
Last modified: February 3, 2015
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.