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P79760

- CP1A4_CHICK

UniProt

P79760 - CP1A4_CHICK

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Protein
Cytochrome P450 1A4
Gene
CYP1A4
Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

Heme group By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi469 – 4691Iron (heme axial ligand) By similarity

GO - Molecular functioni

  1. aromatase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 1A4 (EC:1.14.14.1)
Alternative name(s):
CYPIA4
Cytochrome P450 TCDDAHH
Gene namesi
Name:CYP1A4
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 530530Cytochrome P450 1A4
PRO_0000051658Add
BLAST

Proteomic databases

PaxDbiP79760.

Expressioni

Inductioni

By 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000039219.

Structurei

3D structure databases

ProteinModelPortaliP79760.
SMRiP79760. Positions 44-523.

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.

Phylogenomic databases

eggNOGiCOG2124.
HOGENOMiHOG000036991.
HOVERGENiHBG106944.
InParanoidiP79760.
PhylomeDBiP79760.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008066. Cyt_P450_E_grp-I_CYP1.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR01683. EP450ICYP1A.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P79760-1 [UniParc]FASTAAdd to Basket

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MAAGPQAAME QASSPGLISA TEVLVAAATF CLLLLLTQTR RQHAPKGLRS    50
PPGPRGLPML GNVLELRKDP HLVLTRLSRK YGDVMEVTIG SRPVVVLSGL 100
ETIKQALVRQ AEDFMGRPDL PSWQYVSNGH SLAFSYECGD AWKARRKLAQ 150
NALKTFSIAA SPTASSSCLL EEHVSTEASY LVTKFLQLME EKQSFNPNSY 200
LMVSVANVIC AICFGKRYDH DDQELLSVVN MNTEFGDVAA AGNPADFIPL 250
LRYLPNRAMA AFKDVNARFS AFVQKIVQNH YSTFDKEHIR DVTDSLIGHC 300
QEKRTGEDVR VQPSDESIIS IVNDLFGAGF DTVTTALSWC MMYAALYPHI 350
QKKIQAELDQ TIGRERRPRL SDRGMLPYTE AFILEAFRHS SLLPFTIPHC 400
TTKDTVLNGY YIPKDTCVFI NQWQANHDEK IWKDPPSFKP ERFLNAAGTE 450
LSRTEADKVL IFGLGKRRCI GESIGRWEVF LFLTTILQQL EISLAPGQRV 500
DITPQYGLTM KYKQCECFQM KKRFPSKGSA 530
Length:530
Mass (Da):59,361
Last modified:May 1, 1997 - v1
Checksum:i40736B4CA5936F2E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X99453 mRNA. Translation: CAA67815.1.
RefSeqiNP_990478.1. NM_205147.1.
UniGeneiGga.617.

Genome annotation databases

GeneIDi396052.
KEGGigga:396052.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X99453 mRNA. Translation: CAA67815.1 .
RefSeqi NP_990478.1. NM_205147.1.
UniGenei Gga.617.

3D structure databases

ProteinModelPortali P79760.
SMRi P79760. Positions 44-523.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9031.ENSGALP00000039219.

Proteomic databases

PaxDbi P79760.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 396052.
KEGGi gga:396052.

Organism-specific databases

CTDi 396052.

Phylogenomic databases

eggNOGi COG2124.
HOGENOMi HOG000036991.
HOVERGENi HBG106944.
InParanoidi P79760.
PhylomeDBi P79760.

Miscellaneous databases

NextBioi 20816112.

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008066. Cyt_P450_E_grp-I_CYP1.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00463. EP450I.
PR01683. EP450ICYP1A.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning and expression of two novel avian cytochrome P450 1A enzymes induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin."
    Gilday D.J., Gannon M., Yutzey K., Bader D., Rifkind A.B.
    J. Biol. Chem. 271:33054-33059(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiCP1A4_CHICK
AccessioniPrimary (citable) accession number: P79760
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: May 1, 1997
Last modified: April 16, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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