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P79760

- CP1A4_CHICK

UniProt

P79760 - CP1A4_CHICK

Protein

Cytochrome P450 1A4

Gene

CYP1A4

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 1 (01 May 1997)
      Previous versions | rss
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    Functioni

    Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

    Catalytic activityi

    RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

    Cofactori

    Heme group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi469 – 4691Iron (heme axial ligand)By similarity

    GO - Molecular functioni

    1. aromatase activity Source: UniProtKB-EC
    2. heme binding Source: InterPro
    3. iron ion binding Source: InterPro

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome P450 1A4 (EC:1.14.14.1)
    Alternative name(s):
    CYPIA4
    Cytochrome P450 TCDDAHH
    Gene namesi
    Name:CYP1A4
    OrganismiGallus gallus (Chicken)
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 530530Cytochrome P450 1A4PRO_0000051658Add
    BLAST

    Proteomic databases

    PaxDbiP79760.

    Expressioni

    Inductioni

    By 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).

    Interactioni

    Protein-protein interaction databases

    STRINGi9031.ENSGALP00000039219.

    Structurei

    3D structure databases

    ProteinModelPortaliP79760.
    SMRiP79760. Positions 44-523.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Phylogenomic databases

    eggNOGiCOG2124.
    HOGENOMiHOG000036991.
    HOVERGENiHBG106944.
    InParanoidiP79760.
    PhylomeDBiP79760.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    IPR008066. Cyt_P450_E_grp-I_CYP1.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00463. EP450I.
    PR01683. EP450ICYP1A.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P79760-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAAGPQAAME QASSPGLISA TEVLVAAATF CLLLLLTQTR RQHAPKGLRS    50
    PPGPRGLPML GNVLELRKDP HLVLTRLSRK YGDVMEVTIG SRPVVVLSGL 100
    ETIKQALVRQ AEDFMGRPDL PSWQYVSNGH SLAFSYECGD AWKARRKLAQ 150
    NALKTFSIAA SPTASSSCLL EEHVSTEASY LVTKFLQLME EKQSFNPNSY 200
    LMVSVANVIC AICFGKRYDH DDQELLSVVN MNTEFGDVAA AGNPADFIPL 250
    LRYLPNRAMA AFKDVNARFS AFVQKIVQNH YSTFDKEHIR DVTDSLIGHC 300
    QEKRTGEDVR VQPSDESIIS IVNDLFGAGF DTVTTALSWC MMYAALYPHI 350
    QKKIQAELDQ TIGRERRPRL SDRGMLPYTE AFILEAFRHS SLLPFTIPHC 400
    TTKDTVLNGY YIPKDTCVFI NQWQANHDEK IWKDPPSFKP ERFLNAAGTE 450
    LSRTEADKVL IFGLGKRRCI GESIGRWEVF LFLTTILQQL EISLAPGQRV 500
    DITPQYGLTM KYKQCECFQM KKRFPSKGSA 530
    Length:530
    Mass (Da):59,361
    Last modified:May 1, 1997 - v1
    Checksum:i40736B4CA5936F2E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X99453 mRNA. Translation: CAA67815.1.
    RefSeqiNP_990478.1. NM_205147.1.
    UniGeneiGga.617.

    Genome annotation databases

    GeneIDi396052.
    KEGGigga:396052.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X99453 mRNA. Translation: CAA67815.1 .
    RefSeqi NP_990478.1. NM_205147.1.
    UniGenei Gga.617.

    3D structure databases

    ProteinModelPortali P79760.
    SMRi P79760. Positions 44-523.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9031.ENSGALP00000039219.

    Proteomic databases

    PaxDbi P79760.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 396052.
    KEGGi gga:396052.

    Organism-specific databases

    CTDi 396052.

    Phylogenomic databases

    eggNOGi COG2124.
    HOGENOMi HOG000036991.
    HOVERGENi HBG106944.
    InParanoidi P79760.
    PhylomeDBi P79760.

    Miscellaneous databases

    NextBioi 20816112.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    IPR008066. Cyt_P450_E_grp-I_CYP1.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00463. EP450I.
    PR01683. EP450ICYP1A.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and expression of two novel avian cytochrome P450 1A enzymes induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin."
      Gilday D.J., Gannon M., Yutzey K., Bader D., Rifkind A.B.
      J. Biol. Chem. 271:33054-33059(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiCP1A4_CHICK
    AccessioniPrimary (citable) accession number: P79760
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: May 1, 1997
    Last modified: October 1, 2014
    This is version 95 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3