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P79760 (CP1A4_CHICK) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 94. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome P450 1A4

EC=1.14.14.1
Alternative name(s):
CYPIA4
Cytochrome P450 TCDDAHH
Gene names
Name:CYP1A4
OrganismGallus gallus (Chicken) [Reference proteome]
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus

Protein attributes

Sequence length530 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activity

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactor

Heme group By similarity.

Subcellular location

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Induction

By 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).

Sequence similarities

Belongs to the cytochrome P450 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 530530Cytochrome P450 1A4
PRO_0000051658

Sites

Metal binding4691Iron (heme axial ligand) By similarity

Sequences

Sequence LengthMass (Da)Tools
P79760 [UniParc].

Last modified May 1, 1997. Version 1.
Checksum: 40736B4CA5936F2E

FASTA53059,361
        10         20         30         40         50         60 
MAAGPQAAME QASSPGLISA TEVLVAAATF CLLLLLTQTR RQHAPKGLRS PPGPRGLPML 

        70         80         90        100        110        120 
GNVLELRKDP HLVLTRLSRK YGDVMEVTIG SRPVVVLSGL ETIKQALVRQ AEDFMGRPDL 

       130        140        150        160        170        180 
PSWQYVSNGH SLAFSYECGD AWKARRKLAQ NALKTFSIAA SPTASSSCLL EEHVSTEASY 

       190        200        210        220        230        240 
LVTKFLQLME EKQSFNPNSY LMVSVANVIC AICFGKRYDH DDQELLSVVN MNTEFGDVAA 

       250        260        270        280        290        300 
AGNPADFIPL LRYLPNRAMA AFKDVNARFS AFVQKIVQNH YSTFDKEHIR DVTDSLIGHC 

       310        320        330        340        350        360 
QEKRTGEDVR VQPSDESIIS IVNDLFGAGF DTVTTALSWC MMYAALYPHI QKKIQAELDQ 

       370        380        390        400        410        420 
TIGRERRPRL SDRGMLPYTE AFILEAFRHS SLLPFTIPHC TTKDTVLNGY YIPKDTCVFI 

       430        440        450        460        470        480 
NQWQANHDEK IWKDPPSFKP ERFLNAAGTE LSRTEADKVL IFGLGKRRCI GESIGRWEVF 

       490        500        510        520        530 
LFLTTILQQL EISLAPGQRV DITPQYGLTM KYKQCECFQM KKRFPSKGSA 

« Hide

References

[1]"Molecular cloning and expression of two novel avian cytochrome P450 1A enzymes induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin."
Gilday D.J., Gannon M., Yutzey K., Bader D., Rifkind A.B.
J. Biol. Chem. 271:33054-33059(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X99453 mRNA. Translation: CAA67815.1.
RefSeqNP_990478.1. NM_205147.1.
UniGeneGga.617.

3D structure databases

ProteinModelPortalP79760.
SMRP79760. Positions 44-523.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9031.ENSGALP00000039219.

Proteomic databases

PaxDbP79760.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID396052.
KEGGgga:396052.

Organism-specific databases

CTD396052.

Phylogenomic databases

eggNOGCOG2124.
HOGENOMHOG000036991.
HOVERGENHBG106944.
InParanoidP79760.
PhylomeDBP79760.

Family and domain databases

Gene3D1.10.630.10. 1 hit.
InterProIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008066. Cyt_P450_E_grp-I_CYP1.
[Graphical view]
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00463. EP450I.
PR01683. EP450ICYP1A.
PR00385. P450.
SUPFAMSSF48264. SSF48264. 1 hit.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20816112.

Entry information

Entry nameCP1A4_CHICK
AccessionPrimary (citable) accession number: P79760
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: May 1, 1997
Last modified: April 16, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families