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P79756

- OPSD_GAMAF

UniProt

P79756 - OPSD_GAMAF

Protein

Rhodopsin

Gene

rho

Organism
Gambusia affinis (Western mosquitofish) (Heterandria affinis)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 71 (01 Oct 2014)
      Sequence version 1 (01 May 1997)
      Previous versions | rss
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    Functioni

    Visual pigments such as rhodopsin and porphyropsin are light-absorbing molecules that mediate vision. Rhodopsin consists of an apoprotein, opsin, covalently linked to 11-cis-retinal. This receptor is coupled to the activation of phospholipase C. Porphyropsin consists of opsin covalently linked to 11-cis 3,4-didehydroretinal.

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW
    2. photoreceptor activity Source: UniProtKB-KW

    GO - Biological processi

    1. phototransduction Source: UniProtKB-KW
    2. protein-chromophore linkage Source: UniProtKB-KW
    3. visual perception Source: UniProtKB-KW

    Keywords - Molecular functioni

    G-protein coupled receptor, Photoreceptor protein, Receptor, Retinal protein, Transducer

    Keywords - Biological processi

    Sensory transduction, Vision

    Keywords - Ligandi

    Chromophore

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Rhodopsin
    Gene namesi
    Name:rho
    OrganismiGambusia affinis (Western mosquitofish) (Heterandria affinis)
    Taxonomic identifieri33528 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataOvalentariaAtherinomorphaeCyprinodontiformesPoeciliidaePoeciliinaeGambusia

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 354354RhodopsinPRO_0000197674Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi2 – 21N-linked (GlcNAc...)By similarity
    Glycosylationi15 – 151N-linked (GlcNAc...)By similarity
    Disulfide bondi110 ↔ 187PROSITE-ProRule annotation
    Modified residuei296 – 2961N6-(retinylidene)lysineBy similarity
    Lipidationi322 – 3221S-palmitoyl cysteineBy similarity
    Lipidationi323 – 3231S-palmitoyl cysteineBy similarity

    Post-translational modificationi

    Phosphorylated on some or all of the serine and threonine residues present in the C-terminal region.

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

    Expressioni

    Tissue specificityi

    Rod shaped photoreceptor cells which mediates vision in dim light.

    Structurei

    3D structure databases

    ProteinModelPortaliP79756.
    SMRiP79756. Positions 1-349.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3636ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini62 – 7312CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini99 – 11315ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini134 – 15219CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini177 – 20226ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini231 – 25222CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini277 – 2848ExtracellularSequence Analysis
    Topological domaini310 – 35445CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei37 – 6125Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei74 – 9825Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei114 – 13320Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei153 – 17624Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei203 – 23028Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei253 – 27624Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei285 – 30925Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    HOVERGENiHBG107442.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    4.10.840.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR001760. Opsin.
    IPR027430. Retinal_BS.
    IPR000732. Rhodopsin.
    IPR019477. Rhodopsin_N.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    PF10413. Rhodopsin_N. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00238. OPSIN.
    PR00579. RHODOPSIN.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    PS00238. OPSIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P79756-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNGTEGPYFY VPMVNTTGIV RSPYEYPQYY LVSPAAYACL GAYMFFLILV    50
    GFPVNFLTLY VTIEHKKLRT PLNYILLNLA VADLFMVFGG FTTTIYTSMH 100
    GYFVLGRLGC NLEGYFATLG GEIGLWSLVV LAVERWLVVC KPISNFRFTE 150
    NHAIMGLVFT WIMANACAAP PLLGWSRYIP EGMQCSCGVD YYTRAEGFNN 200
    ESFVIYMFIC HFCIPLVVVF FCYGRLLCAV KEAAAAQQES ETTQRAEREV 250
    TRMVVILVIG FLVCWTPYAS VAWYIFSNQG SEFGPLFMTI PAFFAKSSSI 300
    YNPMIYICMN KQFRHCMITT LCCGKNPFEE EEGASTTASK TEASSVSSSS 350
    VSPA 354
    Length:354
    Mass (Da):39,644
    Last modified:May 1, 1997 - v1
    Checksum:i1CE46D74A03D406B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y11146 mRNA. Translation: CAA72033.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y11146 mRNA. Translation: CAA72033.1 .

    3D structure databases

    ProteinModelPortali P79756.
    SMRi P79756. Positions 1-349.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    GPCRDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG107442.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    4.10.840.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR001760. Opsin.
    IPR027430. Retinal_BS.
    IPR000732. Rhodopsin.
    IPR019477. Rhodopsin_N.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    PF10413. Rhodopsin_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00238. OPSIN.
    PR00579. RHODOPSIN.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    PS00238. OPSIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Opsin sequences of the rod visual pigments in two species of Poeciliid fish."
      Archer S.N., Hirano J.
      J. Fish Biol. 51:215-219(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Holbrooki.
      Tissue: Retina.

    Entry informationi

    Entry nameiOPSD_GAMAF
    AccessioniPrimary (citable) accession number: P79756
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: May 1, 1997
    Last modified: October 1, 2014
    This is version 71 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3