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P79756

- OPSD_GAMAF

UniProt

P79756 - OPSD_GAMAF

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Protein
Rhodopsin
Gene
rho
Organism
Gambusia affinis (Western mosquitofish) (Heterandria affinis)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Visual pigments such as rhodopsin and porphyropsin are light-absorbing molecules that mediate vision. Rhodopsin consists of an apoprotein, opsin, covalently linked to 11-cis-retinal. This receptor is coupled to the activation of phospholipase C. Porphyropsin consists of opsin covalently linked to 11-cis 3,4-didehydroretinal.

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. photoreceptor activity Source: UniProtKB-KW

GO - Biological processi

  1. phototransduction Source: UniProtKB-KW
  2. protein-chromophore linkage Source: UniProtKB-KW
  3. visual perception Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Photoreceptor protein, Receptor, Retinal protein, Transducer

Keywords - Biological processi

Sensory transduction, Vision

Keywords - Ligandi

Chromophore

Names & Taxonomyi

Protein namesi
Recommended name:
Rhodopsin
Gene namesi
Name:rho
OrganismiGambusia affinis (Western mosquitofish) (Heterandria affinis)
Taxonomic identifieri33528 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataOvalentariaAtherinomorphaeCyprinodontiformesPoeciliidaePoeciliinaeGambusia

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3636Extracellular Reviewed prediction
Add
BLAST
Transmembranei37 – 6125Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini62 – 7312Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei74 – 9825Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini99 – 11315Extracellular Reviewed prediction
Add
BLAST
Transmembranei114 – 13320Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini134 – 15219Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei153 – 17624Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini177 – 20226Extracellular Reviewed prediction
Add
BLAST
Transmembranei203 – 23028Helical; Name=5; Reviewed prediction
Add
BLAST
Topological domaini231 – 25222Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei253 – 27624Helical; Name=6; Reviewed prediction
Add
BLAST
Topological domaini277 – 2848Extracellular Reviewed prediction
Transmembranei285 – 30925Helical; Name=7; Reviewed prediction
Add
BLAST
Topological domaini310 – 35445Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 354354Rhodopsin
PRO_0000197674Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi2 – 21N-linked (GlcNAc...) By similarity
Glycosylationi15 – 151N-linked (GlcNAc...) By similarity
Disulfide bondi110 ↔ 187 By similarity
Modified residuei296 – 2961N6-(retinylidene)lysine By similarity
Lipidationi322 – 3221S-palmitoyl cysteine By similarity
Lipidationi323 – 3231S-palmitoyl cysteine By similarity

Post-translational modificationi

Phosphorylated on some or all of the serine and threonine residues present in the C-terminal region.

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Expressioni

Tissue specificityi

Rod shaped photoreceptor cells which mediates vision in dim light.

Structurei

3D structure databases

ProteinModelPortaliP79756.
SMRiP79756. Positions 1-349.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG107442.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
4.10.840.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001760. Opsin.
IPR027430. Retinal_BS.
IPR000732. Rhodopsin.
IPR019477. Rhodopsin_N.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
PF10413. Rhodopsin_N. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00238. OPSIN.
PR00579. RHODOPSIN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
PS00238. OPSIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P79756-1 [UniParc]FASTAAdd to Basket

« Hide

MNGTEGPYFY VPMVNTTGIV RSPYEYPQYY LVSPAAYACL GAYMFFLILV    50
GFPVNFLTLY VTIEHKKLRT PLNYILLNLA VADLFMVFGG FTTTIYTSMH 100
GYFVLGRLGC NLEGYFATLG GEIGLWSLVV LAVERWLVVC KPISNFRFTE 150
NHAIMGLVFT WIMANACAAP PLLGWSRYIP EGMQCSCGVD YYTRAEGFNN 200
ESFVIYMFIC HFCIPLVVVF FCYGRLLCAV KEAAAAQQES ETTQRAEREV 250
TRMVVILVIG FLVCWTPYAS VAWYIFSNQG SEFGPLFMTI PAFFAKSSSI 300
YNPMIYICMN KQFRHCMITT LCCGKNPFEE EEGASTTASK TEASSVSSSS 350
VSPA 354
Length:354
Mass (Da):39,644
Last modified:May 1, 1997 - v1
Checksum:i1CE46D74A03D406B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y11146 mRNA. Translation: CAA72033.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y11146 mRNA. Translation: CAA72033.1 .

3D structure databases

ProteinModelPortali P79756.
SMRi P79756. Positions 1-349.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

GPCRDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG107442.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
4.10.840.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001760. Opsin.
IPR027430. Retinal_BS.
IPR000732. Rhodopsin.
IPR019477. Rhodopsin_N.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
PF10413. Rhodopsin_N. 1 hit.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00238. OPSIN.
PR00579. RHODOPSIN.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
PS00238. OPSIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Opsin sequences of the rod visual pigments in two species of Poeciliid fish."
    Archer S.N., Hirano J.
    J. Fish Biol. 51:215-219(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Holbrooki.
    Tissue: Retina.

Entry informationi

Entry nameiOPSD_GAMAF
AccessioniPrimary (citable) accession number: P79756
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 1, 1997
Last modified: June 11, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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