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P79756 (OPSD_GAMAF) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 70. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Protein attributes

Sequence length354 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Visual pigments such as rhodopsin and porphyropsin are light-absorbing molecules that mediate vision. Rhodopsin consists of an apoprotein, opsin, covalently linked to 11-cis-retinal. This receptor is coupled to the activation of phospholipase C. Porphyropsin consists of opsin covalently linked to 11-cis 3,4-didehydroretinal.

Subcellular location

Membrane; Multi-pass membrane protein.

Tissue specificity

Rod shaped photoreceptor cells which mediates vision in dim light.

Post-translational modification

Phosphorylated on some or all of the serine and threonine residues present in the C-terminal region.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 354354Rhodopsin
PRO_0000197674

Regions

Topological domain1 – 3636Extracellular Potential
Transmembrane37 – 6125Helical; Name=1; Potential
Topological domain62 – 7312Cytoplasmic Potential
Transmembrane74 – 9825Helical; Name=2; Potential
Topological domain99 – 11315Extracellular Potential
Transmembrane114 – 13320Helical; Name=3; Potential
Topological domain134 – 15219Cytoplasmic Potential
Transmembrane153 – 17624Helical; Name=4; Potential
Topological domain177 – 20226Extracellular Potential
Transmembrane203 – 23028Helical; Name=5; Potential
Topological domain231 – 25222Cytoplasmic Potential
Transmembrane253 – 27624Helical; Name=6; Potential
Topological domain277 – 2848Extracellular Potential
Transmembrane285 – 30925Helical; Name=7; Potential
Topological domain310 – 35445Cytoplasmic Potential

Amino acid modifications

Modified residue2961N6-(retinylidene)lysine By similarity
Lipidation3221S-palmitoyl cysteine By similarity
Lipidation3231S-palmitoyl cysteine By similarity
Glycosylation21N-linked (GlcNAc...) By similarity
Glycosylation151N-linked (GlcNAc...) By similarity
Disulfide bond110 ↔ 187 By similarity

Sequences

Sequence LengthMass (Da)Tools
P79756 [UniParc].

Last modified May 1, 1997. Version 1.
Checksum: 1CE46D74A03D406B

FASTA35439,644
        10         20         30         40         50         60 
MNGTEGPYFY VPMVNTTGIV RSPYEYPQYY LVSPAAYACL GAYMFFLILV GFPVNFLTLY 

        70         80         90        100        110        120 
VTIEHKKLRT PLNYILLNLA VADLFMVFGG FTTTIYTSMH GYFVLGRLGC NLEGYFATLG 

       130        140        150        160        170        180 
GEIGLWSLVV LAVERWLVVC KPISNFRFTE NHAIMGLVFT WIMANACAAP PLLGWSRYIP 

       190        200        210        220        230        240 
EGMQCSCGVD YYTRAEGFNN ESFVIYMFIC HFCIPLVVVF FCYGRLLCAV KEAAAAQQES 

       250        260        270        280        290        300 
ETTQRAEREV TRMVVILVIG FLVCWTPYAS VAWYIFSNQG SEFGPLFMTI PAFFAKSSSI 

       310        320        330        340        350 
YNPMIYICMN KQFRHCMITT LCCGKNPFEE EEGASTTASK TEASSVSSSS VSPA 

« Hide

References

[1]"Opsin sequences of the rod visual pigments in two species of Poeciliid fish."
Archer S.N., Hirano J.
J. Fish Biol. 51:215-219(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Holbrooki.
Tissue: Retina.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Y11146 mRNA. Translation: CAA72033.1.

3D structure databases

ProteinModelPortalP79756.
SMRP79756. Positions 1-349.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

GPCRDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG107442.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
4.10.840.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001760. Opsin.
IPR027430. Retinal_BS.
IPR000732. Rhodopsin.
IPR019477. Rhodopsin_N.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
PF10413. Rhodopsin_N. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00238. OPSIN.
PR00579. RHODOPSIN.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
PS00238. OPSIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameOPSD_GAMAF
AccessionPrimary (citable) accession number: P79756
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 1, 1997
Last modified: June 11, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries