P79748 (5HT1D_TAKRU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
5-hydroxytryptamine receptor 1D
Short name=5-HT-1D
Short name=5-HT1D
Short name=5HT1D

Alternative name(s):
F1D
Serotonin receptor 1D

Gene names

Name:

htr1d

Organism

Takifugu rubripes (Japanese pufferfish) (Fugu rubripes) [Reference proteome]

Taxonomic identifier

31033 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Actinopterygii › Actinopteri › Neopterygii › Teleostei › Elopocephala › Clupeocephala › Euteleostei › Neognathi › Neoteleostei › Eurypterygii › Ctenosquamata › Acanthomorpha › Euacanthomorpha › Holacanthopterygii › Acanthopterygii › Euacanthopterygii › Percomorpha › Tetraodontiformes › Tetraodontoidei › Tetradontoidea › Tetraodontidae › Takifugu

Protein attributes

Sequence length	379 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity By similarity.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	serotonin receptor signaling pathway Inferred from electronic annotation. Source: GOC
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	serotonin receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 379	379	5-hydroxytryptamine receptor 1D		PRO_0000068932
Regions
	Topological domain	1 – 36	36	Extracellular By similarity
	Transmembrane	37 – 60	24	Helical; Name=1; By similarity
	Topological domain	61 – 73	13	Cytoplasmic By similarity
	Transmembrane	74 – 96	23	Helical; Name=2; By similarity
	Topological domain	97 – 106	10	Extracellular By similarity
	Transmembrane	107 – 132	26	Helical; Name=3; By similarity
	Topological domain	133 – 152	20	Cytoplasmic By similarity
	Transmembrane	153 – 174	22	Helical; Name=4; By similarity
	Topological domain	175 – 192	18	Extracellular By similarity
	Transmembrane	193 – 216	24	Helical; Name=5; By similarity
	Topological domain	217 – 307	91	Cytoplasmic By similarity
	Transmembrane	308 – 331	24	Helical; Name=6; By similarity
	Topological domain	332 – 339	8	Extracellular By similarity
	Transmembrane	340 – 364	25	Helical; Name=7; By similarity
	Topological domain	365 – 379	15	Cytoplasmic By similarity
Amino acid modifications
	Glycosylation	5	1	N-linked (GlcNAc...) Potential
	Glycosylation	14	1	N-linked (GlcNAc...) Potential
	Glycosylation	21	1	N-linked (GlcNAc...) Potential
	Disulfide bond	109 ↔ 186		By similarity

Sequences

	Sequence		Length	Mass (Da)
	P79748 [UniParc]. Last modified May 1, 1997. Version 1. Checksum: 99B6E2C0379EBC78	FASTA	379	42,302
	10 20 30 40 50 60 MELDNNSLDY FSSNFTDIPS NTTVAHWTEA TLLGLQISVS VVLAIVTLAT MLSNAFVIAT 70 80 90 100 110 120 IFLTRKLHTP ANFLIGSLAV TDMLVSILVM PISIVYTVSK TWSLGQIVCD IWLSSDITFC 130 140 150 160 170 180 TASILHLCVI ALDRYWAITD ALEYSKRRTM RRAAVMVAVV WVISISISMP PLFWRQAKAH 190 200 210 220 230 240 EELKECMVNT DQISYTLYST FGAFYVPTVL LIILYGRIYV AARSRIFKTP SYSGKRFTTA 250 260 270 280 290 300 QLIQTSAGSS LCSLNSASNQ EAHLHSGAGG EGGGSPLFVN SVKVKLADNV LERKRLCAAR 310 320 330 340 350 360 ERKATKTLGI ILGAFIICWL PFFVVTLVWA ICKECSFDPL LFDVFTWLGY LNSLINPVIY 370 TVFNDEFKQA FQKLIKFRR

References

[1]	"Molecular cloning of 5-hydroxytryptamine (5-HT) type 1 receptor genes from the Japanese puffer fish, Fugu rubripes." Yamaguchi F., Brenner S. Gene 191:219-223(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Tissue: Testis.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X83865 Genomic DNA. Translation: CAA58745.1.
RefSeq	XP_003962547.1. XM_003962498.1.
3D structure databases
ProteinModelPortal	P79748.
SMR	P79748. Positions 121-152.
ModBase	Search...
Protein-protein interaction databases
STRING	31033.ENSTRUP00000021542.
Protein family/group databases
GPCRDB	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	101076478.
KEGG	tru:101076478.
Phylogenomic databases
eggNOG	NOG249628.
InParanoid	P79748.
KO	K04153.
Family and domain databases
InterPro	IPR000505. 5HT1D_rcpt. IPR002231. 5HT_rcpt. IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. [Graphical view]
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00514. 5HT1DRECEPTR. PR01101. 5HTRECEPTOR. PR00237. GPCRRHODOPSN.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

5HT1D_TAKRU

Accession

Primary (citable) accession number: P79748

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	May 1, 1997
Last modified:	May 1, 2013
This is version 83 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program