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P79747

- IOD2_FUNHE

UniProt

P79747 - IOD2_FUNHE

Protein

Type II iodothyronine deiodinase

Gene

dio2

Organism
Fundulus heteroclitus (Killifish) (Mummichog)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 82 (01 Oct 2014)
      Sequence version 4 (26 Feb 2008)
      Previous versions | rss
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    Functioni

    Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into T3 (3,5,3'-triiodothyronine). Essential for providing the brain with appropriate levels of T3 during the critical period of development By similarity.By similarity

    Catalytic activityi

    3,5,3'-triiodo-L-thyronine + iodide + A + H+ = L-thyroxine + AH2.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei134 – 1341

    GO - Molecular functioni

    1. thyroxine 5'-deiodinase activity Source: UniProtKB

    GO - Biological processi

    1. hormone biosynthetic process Source: UniProtKB-KW
    2. thyroid hormone metabolic process Source: UniProtKB

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Thyroid hormones biosynthesis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Type II iodothyronine deiodinase (EC:1.97.1.10)
    Alternative name(s):
    5DII
    DIOII
    Type 2 DI
    Type-II 5'-deiodinase
    Gene namesi
    Name:dio2
    OrganismiFundulus heteroclitus (Killifish) (Mummichog)
    Taxonomic identifieri8078 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataOvalentariaAtherinomorphaeCyprinodontiformesFundulidaeFundulus

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 266266Type II iodothyronine deiodinasePRO_0000154321Add
    BLAST

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei14 – 3421HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the iodothyronine deiodinase family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    HOVERGENiHBG000099.

    Family and domain databases

    Gene3Di3.40.30.10. 1 hit.
    InterProiIPR000643. Iodothyronine_deiodinase.
    IPR008261. Iodothyronine_deiodinase_AS.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view]
    PANTHERiPTHR11781. PTHR11781. 1 hit.
    PfamiPF00837. T4_deiodinase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001330. IOD. 1 hit.
    SUPFAMiSSF52833. SSF52833. 1 hit.
    PROSITEiPS01205. T4_DEIODINASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P79747-1 [UniParc]FASTAAdd to Basket

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    MGSASEDLLV TLQILPGFFS NCLFLALYDS VVLVKRVVAL LSRSRSAGCG    50
    EWRRMLTSEG LRSIWNSFLL DAHKQVKLGC EAPNSKVVKV PDGPRWSSTV 100
    VPCGSRIQTG GECRLLDFES SDRPLVVNFG SATUPPFISH LPAFRQLVED 150
    FSDVADFLLV YIDEAHPSDG WVAPQMGACS FSFRKHQNLE ERIGAARKLI 200
    EHFSLPPQCQ LVADCMDNNA NVAYGVANER VCIVHQRKIA YLGGKGPFFY 250
    SLKDVRQWLE LSYGRR 266
    Length:266
    Mass (Da):29,678
    Last modified:February 26, 2008 - v4
    Checksum:i99E44E44888B3A6F
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti109 – 1091T → A in AAB39651. (PubMed:9002998)Curated

    Non-standard residue

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-standard residuei134 – 1341Selenocysteine

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U70869 mRNA. Translation: AAB39651.2.
    AY065833 mRNA. Translation: AAC79662.2.
    AY065834 Genomic DNA. Translation: AAL62449.1.

    Keywords - Coding sequence diversityi

    Selenocysteine

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U70869 mRNA. Translation: AAB39651.2 .
    AY065833 mRNA. Translation: AAC79662.2 .
    AY065834 Genomic DNA. Translation: AAL62449.1 .

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG000099.

    Family and domain databases

    Gene3Di 3.40.30.10. 1 hit.
    InterProi IPR000643. Iodothyronine_deiodinase.
    IPR008261. Iodothyronine_deiodinase_AS.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view ]
    PANTHERi PTHR11781. PTHR11781. 1 hit.
    Pfami PF00837. T4_deiodinase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001330. IOD. 1 hit.
    SUPFAMi SSF52833. SSF52833. 1 hit.
    PROSITEi PS01205. T4_DEIODINASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and expression of a 5'-iodothyronine deiodinase from the liver of Fundulus heteroclitus."
      Valverde C., Croteau W., Lafleur G.J. Jr., Orozco A., St Germain D.L.
      Endocrinology 138:642-648(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Liver.
    2. "Cloning of the gene and complete cDNA encoding a type 2 deiodinase from Fundulus heteroclitus."
      Orozco A., Jeziorski M.C., Linser P.J., Greenberg R.M., Valverde-R C.
      Gen. Comp. Endocrinol. 128:162-167(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], SEQUENCE REVISION TO 109.

    Entry informationi

    Entry nameiIOD2_FUNHE
    AccessioniPrimary (citable) accession number: P79747
    Secondary accession number(s): Q8QFX5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: February 26, 2008
    Last modified: October 1, 2014
    This is version 82 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3