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P79747 (IOD2_FUNHE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Type II iodothyronine deiodinase
EC=1.97.1.10
Alternative name(s):
5DII
DIOII
Type 2 DI
Type-II 5'-deiodinase
Gene names
Name:dio2
OrganismFundulus heteroclitus (Killifish) (Mummichog)
Taxonomic identifier8078 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Euteleostei › Neoteleostei › Acanthomorpha › Acanthopterygii › Percomorpha › Atherinomorpha › Cyprinodontiformes › Fundulidae › Fundulus

Protein attributes

Sequence length266 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into T3 (3,5,3'-triiodothyronine). Essential for providing the brain with appropriate levels of T3 during the critical period of development By similarity.

Catalytic activity

3,5,3'-triiodo-L-thyronine + iodide + A + H+ = L-thyroxine + AH2.

Subcellular location

Membrane; Single-pass membrane protein Potential.

Sequence similarities

Belongs to the iodothyronine deiodinase family.

Ontologies

Keywords
   Biological processThyroid hormones biosynthesis
   Cellular componentMembrane
   Coding sequence diversitySelenocysteine
   DomainTransmembrane
Transmembrane helix
   Molecular functionOxidoreductase
Gene Ontology (GO)
   Biological_processhormone biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

thyroid hormone metabolic process

Inferred from sequence or structural similarity. Source: UniProtKB

   Cellular_componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionthyroxine 5'-deiodinase activity

Inferred from sequence or structural similarity. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 266266Type II iodothyronine deiodinase
PRO_0000154321

Regions

Transmembrane14 – 3421Helical; Potential

Sites

Active site1341

Amino acid modifications

Non-standard residue1341Selenocysteine

Experimental info

Sequence conflict1091T → A in AAB39651. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P79747 [UniParc].

Last modified February 26, 2008. Version 4.
Checksum: 99E44E44888B3A6F

FASTA26629,678
        10         20         30         40         50         60 
MGSASEDLLV TLQILPGFFS NCLFLALYDS VVLVKRVVAL LSRSRSAGCG EWRRMLTSEG 

        70         80         90        100        110        120 
LRSIWNSFLL DAHKQVKLGC EAPNSKVVKV PDGPRWSSTV VPCGSRIQTG GECRLLDFES 

       130        140        150        160        170        180 
SDRPLVVNFG SATUPPFISH LPAFRQLVED FSDVADFLLV YIDEAHPSDG WVAPQMGACS 

       190        200        210        220        230        240 
FSFRKHQNLE ERIGAARKLI EHFSLPPQCQ LVADCMDNNA NVAYGVANER VCIVHQRKIA 

       250        260 
YLGGKGPFFY SLKDVRQWLE LSYGRR

« Hide

References

[1]"Cloning and expression of a 5'-iodothyronine deiodinase from the liver of Fundulus heteroclitus."
Valverde C., Croteau W., Lafleur G.J. Jr., Orozco A., St Germain D.L.
Endocrinology 138:642-648(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Liver.
[2]"Cloning of the gene and complete cDNA encoding a type 2 deiodinase from Fundulus heteroclitus."
Orozco A., Jeziorski M.C., Linser P.J., Greenberg R.M., Valverde-R C.
Gen. Comp. Endocrinol. 128:162-167(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], SEQUENCE REVISION TO 109.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		U70869 mRNA. Translation: AAB39651.2.
AY065833 mRNA. Translation: AAC79662.2.
AY065834 Genomic DNA. Translation: AAL62449.1.

3D structure databases

ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG000099.

Family and domain databases

Gene3D3.40.30.10. 1 hit.
InterProIPR000643. Iodothyronine_deiodinase.
IPR008261. Iodothyronine_deiodinase_AS.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PANTHERPTHR11781. PTHR11781. 1 hit.
PfamPF00837. T4_deiodinase. 1 hit.
[Graphical view]
PIRSFPIRSF001330. IOD. 1 hit.
PROSITEPS01205. T4_DEIODINASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameIOD2_FUNHE
AccessionPrimary (citable) accession number: P79747
Secondary accession number(s): Q8QFX5
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: February 26, 2008
Last modified: April 3, 2013
This is version 78 of the entry and version 4 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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