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Protein

Type II iodothyronine deiodinase

Gene

dio2

Organism
Fundulus heteroclitus (Killifish) (Mummichog)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into T3 (3,5,3'-triiodothyronine). Essential for providing the brain with appropriate levels of T3 during the critical period of development.By similarity

Catalytic activityi

3,5,3'-triiodo-L-thyronine + iodide + A + H+ = L-thyroxine + AH2.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei1341

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processThyroid hormones biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Type II iodothyronine deiodinase (EC:1.21.99.4)
Alternative name(s):
5DII
DIOII
Type 2 DI
Type-II 5'-deiodinase
Gene namesi
Name:dio2
OrganismiFundulus heteroclitus (Killifish) (Mummichog)
Taxonomic identifieri8078 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataOvalentariaAtherinomorphaeCyprinodontiformesFundulidaeFundulus

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei14 – 34HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001543211 – 266Type II iodothyronine deiodinaseAdd BLAST266

Proteomic databases

PRIDEiP79747

Family & Domainsi

Sequence similaritiesi

Belongs to the iodothyronine deiodinase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG000099
OrthoDBiEOG091G0V5C

Family and domain databases

InterProiView protein in InterPro
IPR000643 Iodothyronine_deiodinase
IPR008261 Iodothyronine_deiodinase_AS
IPR036249 Thioredoxin-like_sf
PANTHERiPTHR11781 PTHR11781, 1 hit
PfamiView protein in Pfam
PF00837 T4_deiodinase, 1 hit
PIRSFiPIRSF001330 IOD, 1 hit
SUPFAMiSSF52833 SSF52833, 1 hit
PROSITEiView protein in PROSITE
PS01205 T4_DEIODINASE, 1 hit

Sequencei

Sequence statusi: Complete.

P79747-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSASEDLLV TLQILPGFFS NCLFLALYDS VVLVKRVVAL LSRSRSAGCG
60 70 80 90 100
EWRRMLTSEG LRSIWNSFLL DAHKQVKLGC EAPNSKVVKV PDGPRWSSTV
110 120 130 140 150
VPCGSRIQTG GECRLLDFES SDRPLVVNFG SATUPPFISH LPAFRQLVED
160 170 180 190 200
FSDVADFLLV YIDEAHPSDG WVAPQMGACS FSFRKHQNLE ERIGAARKLI
210 220 230 240 250
EHFSLPPQCQ LVADCMDNNA NVAYGVANER VCIVHQRKIA YLGGKGPFFY
260
SLKDVRQWLE LSYGRR
Length:266
Mass (Da):29,678
Last modified:February 26, 2008 - v4
Checksum:i99E44E44888B3A6F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti109T → A in AAB39651 (PubMed:9002998).Curated1

Non-standard residue

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-standard residuei134Selenocysteine1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U70869 mRNA Translation: AAB39651.2
AY065833 mRNA Translation: AAC79662.2
AY065834 Genomic DNA Translation: AAL62449.1
RefSeqiNP_001296885.1, NM_001309956.1
UniGeneiFhe.427

Genome annotation databases

GeneIDi105917782

Keywords - Coding sequence diversityi

Selenocysteine

Similar proteinsi

Entry informationi

Entry nameiIOD2_FUNHE
AccessioniPrimary (citable) accession number: P79747
Secondary accession number(s): Q8QFX5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: February 26, 2008
Last modified: May 23, 2018
This is version 92 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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