Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

POU domain, class 3, transcription factor 2

Gene

pou3f2

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcription factor that may play important roles in patterning the embryonic brain.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi292 – 351HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

  • brain development Source: InterPro
  • endothelial cell development Source: ZFIN
  • regulation of transcription by RNA polymerase II Source: InterPro
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
POU domain, class 3, transcription factor 2
Alternative name(s):
POU domain protein 47
Short name:
ZP-47
Gene namesi
Name:pou3f2
Synonyms:pou47, zp47, zp47pou
ORF Names:si:ch211-201n18.1
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi

Organism-specific databases

ZFINiZDB-GENE-980526-370 pou3f2b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001007721 – 378POU domain, class 3, transcription factor 2Add BLAST378

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei279Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP79746

PTM databases

iPTMnetiP79746

Expressioni

Tissue specificityi

Predominantly expressed in the central nervous system, with strong expression in the cerebellum.1 Publication

Developmental stagei

Detected after completion of the gastrula period. Maximal expression after 1 to 2 days of development.1 Publication

Gene expression databases

BgeeiENSDARG00000076262

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000087682

Structurei

3D structure databases

ProteinModelPortaliP79746
SMRiP79746
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini200 – 274POU-specificPROSITE-ProRule annotationAdd BLAST75

Sequence similaritiesi

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG3802 Eukaryota
ENOG410XQ7X LUCA
GeneTreeiENSGT00760000118935
HOGENOMiHOG000116303
HOVERGENiHBG053120
InParanoidiP79746
KOiK09365
OMAiSFTVNGM
OrthoDBiEOG091G0U0S
PhylomeDBiP79746
TreeFamiTF316413

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR010982 Lambda_DNA-bd_dom_sf
IPR013847 POU
IPR000327 POU_dom
IPR016362 TF_POU_3
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PF00157 Pou, 1 hit
PIRSFiPIRSF002629 Transcription_factor_POU, 1 hit
PRINTSiPR00028 POUDOMAIN
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SM00352 POU, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
SSF47413 SSF47413, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit
PS00035 POU_1, 1 hit
PS00465 POU_2, 1 hit
PS51179 POU_3, 1 hit

Sequencei

Sequence statusi: Complete.

P79746-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATTASNHYN ILTSSPSIVH SEPGSMQQAT AYRDAQTLLQ SDYSLQSNSH
60 70 80 90 100
PLSHAHQWIT ALSHGEGGPW SSSPLGEQDI KPAVQSPRDE MHNSSNLQHQ
110 120 130 140 150
SRPPHLVHQT HGNHHDSRAW RTTTAAHIPS MATSNGQSLI YSQPSFSVNG
160 170 180 190 200
LIPGSGQGIH HHSMRDAHED HHSPHLSDHG HPPSQHQHQS HQSHHDHSDE
210 220 230 240 250
DTPTSDDLEQ FAKQFKQRRI KLGFTQADVG LALGTLYGNV FSQTTICRFE
260 270 280 290 300
ALQLSFKNMC KLKPLLNKWL EEADSTSGSP TSLDKIAAQG RKRKKRTSIE
310 320 330 340 350
VSVKGALESH FLKCPKPAAS EITSLADSLQ LEKEVVRVWF CNRRQKEKRM
360 370
TPPGGPLPGT EDVYGDTPPH HGVQTPVQ
Length:378
Mass (Da):41,816
Last modified:May 1, 1997 - v1
Checksum:i1F35FE0831524246
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y07905 mRNA Translation: CAA69211.1
BX247875 Genomic DNA Translation: CAQ15526.1
BC067373 mRNA Translation: AAH67373.1
RefSeqiNP_571235.1, NM_131160.1
UniGeneiDr.221

Genome annotation databases

EnsembliENSDART00000093250; ENSDARP00000087682; ENSDARG00000076262
GeneIDi30397
KEGGidre:30397

Entry informationi

Entry nameiPO3F2_DANRE
AccessioniPrimary (citable) accession number: P79746
Secondary accession number(s): B0S5F1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 1, 1997
Last modified: May 23, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health