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P79746

- PO3F2_DANRE

UniProt

P79746 - PO3F2_DANRE

Protein

POU domain, class 3, transcription factor 2

Gene

pou3f2

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 110 (01 Oct 2014)
      Sequence version 1 (01 May 1997)
      Previous versions | rss
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    Functioni

    Transcription factor that may play important roles in patterning the embryonic brain.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi292 – 35160HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: InterPro
    2. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. multicellular organismal development Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    POU domain, class 3, transcription factor 2
    Alternative name(s):
    POU domain protein 47
    Short name:
    ZP-47
    Gene namesi
    Name:pou3f2
    Synonyms:pou47, zp47, zp47pou
    ORF Names:si:ch211-201n18.1
    OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
    Taxonomic identifieri7955 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
    ProteomesiUP000000437: Chromosome 16

    Organism-specific databases

    ZFINiZDB-GENE-980526-370. pou3f2b.

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 378378POU domain, class 3, transcription factor 2PRO_0000100772Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei279 – 2791Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiP79746.

    Expressioni

    Tissue specificityi

    Predominantly expressed in the central nervous system, with strong expression in the cerebellum.1 Publication

    Developmental stagei

    Detected after completion of the gastrula period. Maximal expression after 1 to 2 days of development.1 Publication

    Gene expression databases

    BgeeiP79746.

    Structurei

    3D structure databases

    ProteinModelPortaliP79746.
    SMRiP79746. Positions 206-352.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini200 – 27475POU-specificPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation
    Contains 1 POU-specific domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG261729.
    GeneTreeiENSGT00730000110809.
    HOGENOMiHOG000116303.
    HOVERGENiHBG053120.
    InParanoidiP79746.
    KOiK09365.
    OMAiNLQHQSR.
    OrthoDBiEOG7DJSMG.
    PhylomeDBiP79746.
    TreeFamiTF316413.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    1.10.260.40. 1 hit.
    InterProiIPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR010982. Lambda_DNA-bd_dom.
    IPR013847. POU.
    IPR000327. POU_specific.
    IPR016362. Transcription_factor_POU.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    PF00157. Pou. 1 hit.
    [Graphical view]
    PIRSFiPIRSF002629. Transcription_factor_POU. 1 hit.
    PRINTSiPR00028. POUDOMAIN.
    SMARTiSM00389. HOX. 1 hit.
    SM00352. POU. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    SSF47413. SSF47413. 1 hit.
    PROSITEiPS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    PS00035. POU_1. 1 hit.
    PS00465. POU_2. 1 hit.
    PS51179. POU_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P79746-1 [UniParc]FASTAAdd to Basket

    « Hide

    MATTASNHYN ILTSSPSIVH SEPGSMQQAT AYRDAQTLLQ SDYSLQSNSH    50
    PLSHAHQWIT ALSHGEGGPW SSSPLGEQDI KPAVQSPRDE MHNSSNLQHQ 100
    SRPPHLVHQT HGNHHDSRAW RTTTAAHIPS MATSNGQSLI YSQPSFSVNG 150
    LIPGSGQGIH HHSMRDAHED HHSPHLSDHG HPPSQHQHQS HQSHHDHSDE 200
    DTPTSDDLEQ FAKQFKQRRI KLGFTQADVG LALGTLYGNV FSQTTICRFE 250
    ALQLSFKNMC KLKPLLNKWL EEADSTSGSP TSLDKIAAQG RKRKKRTSIE 300
    VSVKGALESH FLKCPKPAAS EITSLADSLQ LEKEVVRVWF CNRRQKEKRM 350
    TPPGGPLPGT EDVYGDTPPH HGVQTPVQ 378
    Length:378
    Mass (Da):41,816
    Last modified:May 1, 1997 - v1
    Checksum:i1F35FE0831524246
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y07905 mRNA. Translation: CAA69211.1.
    BX247875 Genomic DNA. Translation: CAQ15526.1.
    BC067373 mRNA. Translation: AAH67373.1.
    RefSeqiNP_571235.1. NM_131160.1.
    UniGeneiDr.221.

    Genome annotation databases

    EnsembliENSDART00000093250; ENSDARP00000087682; ENSDARG00000076262.
    GeneIDi30397.
    KEGGidre:30397.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y07905 mRNA. Translation: CAA69211.1 .
    BX247875 Genomic DNA. Translation: CAQ15526.1 .
    BC067373 mRNA. Translation: AAH67373.1 .
    RefSeqi NP_571235.1. NM_131160.1.
    UniGenei Dr.221.

    3D structure databases

    ProteinModelPortali P79746.
    SMRi P79746. Positions 206-352.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi P79746.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSDART00000093250 ; ENSDARP00000087682 ; ENSDARG00000076262 .
    GeneIDi 30397.
    KEGGi dre:30397.

    Organism-specific databases

    CTDi 30397.
    ZFINi ZDB-GENE-980526-370. pou3f2b.

    Phylogenomic databases

    eggNOGi NOG261729.
    GeneTreei ENSGT00730000110809.
    HOGENOMi HOG000116303.
    HOVERGENi HBG053120.
    InParanoidi P79746.
    KOi K09365.
    OMAi NLQHQSR.
    OrthoDBi EOG7DJSMG.
    PhylomeDBi P79746.
    TreeFami TF316413.

    Miscellaneous databases

    NextBioi 20806808.

    Gene expression databases

    Bgeei P79746.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    1.10.260.40. 1 hit.
    InterProi IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR010982. Lambda_DNA-bd_dom.
    IPR013847. POU.
    IPR000327. POU_specific.
    IPR016362. Transcription_factor_POU.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    PF00157. Pou. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF002629. Transcription_factor_POU. 1 hit.
    PRINTSi PR00028. POUDOMAIN.
    SMARTi SM00389. HOX. 1 hit.
    SM00352. POU. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    SSF47413. SSF47413. 1 hit.
    PROSITEi PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    PS00035. POU_1. 1 hit.
    PS00465. POU_2. 1 hit.
    PS51179. POU_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Class III POU genes of zebrafish are predominantly expressed in the central nervous system."
      Spaniol P., Bornmann C., Hauptmann G., Gerster T.
      Nucleic Acids Res. 24:4874-4881(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
      Tissue: Embryo.
    2. "The zebrafish reference genome sequence and its relationship to the human genome."
      Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.
      , White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., Clee C., Oliver K., Clark R., Riddle C., Eliott D., Threadgold G., Harden G., Ware D., Mortimer B., Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.
      Nature 496:498-503(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Tuebingen.
    3. NIH - Zebrafish Gene Collection (ZGC) project
      Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Embryo.
    4. "Online automated in vivo zebrafish phosphoproteomics: from large-scale analysis down to a single embryo."
      Lemeer S., Pinkse M.W.H., Mohammed S., van Breukelen B., den Hertog J., Slijper M., Heck A.J.R.
      J. Proteome Res. 7:1555-1564(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-279, IDENTIFICATION BY MASS SPECTROMETRY.
      Tissue: Embryo.

    Entry informationi

    Entry nameiPO3F2_DANRE
    AccessioniPrimary (citable) accession number: P79746
    Secondary accession number(s): B0S5F1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: May 1, 1997
    Last modified: October 1, 2014
    This is version 110 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3