UniProtKB - P79745 (P3F3B_DANRE)
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Protein
POU domain, class 3, transcription factor 3-B
Gene
pou3f3b
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Functioni
Transcription factor that may play important roles in patterning the embryonic brain.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 330 – 389 | HomeoboxPROSITE-ProRule annotationAdd BLAST | 60 |
GO - Molecular functioni
- DNA binding transcription factor activity Source: InterPro
- sequence-specific DNA binding Source: InterPro
GO - Biological processi
- brain development Source: InterPro
- regulation of transcription by RNA polymerase II Source: InterPro
- transcription, DNA-templated Source: UniProtKB-KW
Keywordsi
Molecular function | Developmental protein, DNA-binding |
Biological process | Transcription, Transcription regulation |
Names & Taxonomyi
Protein namesi | Recommended name: POU domain, class 3, transcription factor 3-BAlternative name(s): Brain-specific homeobox/POU domain protein 1.0 Short name: Brain-1.0 Short name: zfBrn-1.0 POU domain protein 1 Short name: ZFPOU1 POU domain protein 23 Short name: ZP-23 |
Gene namesi | Name:pou3f3b Synonyms:brn-1.0, pou1, pou23, zp23, zp23pou |
Organismi | Danio rerio (Zebrafish) (Brachydanio rerio) |
Taxonomic identifieri | 7955 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Cyprinidae › Danio |
Proteomesi |
|
Organism-specific databases
ZFINi | ZDB-GENE-980526-140. pou3f3b. |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000100771 | 1 – 443 | POU domain, class 3, transcription factor 3-BAdd BLAST | 443 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 317 | Phosphoserine1 Publication | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
PaxDbi | P79745. |
PRIDEi | P79745. |
PTM databases
iPTMneti | P79745. |
Expressioni
Tissue specificityi
Predominantly expressed in the central nervous system.3 Publications
Developmental stagei
First expressed at early neurula stage (9-12 hours). Expression then increases greatly at the 16-somite stage, reached the maximum level at 36 hr of development, and thereafter decreased. Only expressed in adults in the brain.3 Publications
Gene expression databases
Bgeei | ENSDARG00000095896. |
Structurei
3D structure databases
ProteinModelPortali | P79745. |
SMRi | P79745. |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 238 – 312 | POU-specificPROSITE-ProRule annotationAdd BLAST | 75 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 84 – 98 | Ala-richAdd BLAST | 15 | |
Compositional biasi | 165 – 169 | Poly-Gln | 5 | |
Compositional biasi | 208 – 235 | His-richAdd BLAST | 28 |
Sequence similaritiesi
Keywords - Domaini
HomeoboxPhylogenomic databases
eggNOGi | KOG3802. Eukaryota. ENOG410XQ7X. LUCA. |
GeneTreei | ENSGT00760000118935. |
HOGENOMi | HOG000116303. |
HOVERGENi | HBG053120. |
InParanoidi | P79745. |
KOi | K09365. |
OMAi | PHQGHPG. |
OrthoDBi | EOG091G0U0S. |
PhylomeDBi | P79745. |
TreeFami | TF316413. |
Family and domain databases
CDDi | cd00086. homeodomain. 1 hit. |
InterProi | View protein in InterPro IPR009057. Homeobox-like_sf. IPR017970. Homeobox_CS. IPR001356. Homeobox_dom. IPR010982. Lambda_DNA-bd_dom_sf. IPR013847. POU. IPR000327. POU_dom. IPR016362. TF_POU_3. |
Pfami | View protein in Pfam PF00046. Homeobox. 1 hit. PF00157. Pou. 1 hit. |
PIRSFi | PIRSF002629. Transcription_factor_POU. 1 hit. |
PRINTSi | PR00028. POUDOMAIN. |
SMARTi | View protein in SMART SM00389. HOX. 1 hit. SM00352. POU. 1 hit. |
SUPFAMi | SSF46689. SSF46689. 1 hit. SSF47413. SSF47413. 1 hit. |
PROSITEi | View protein in PROSITE PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. PS00035. POU_1. 1 hit. PS00465. POU_2. 1 hit. PS51179. POU_3. 1 hit. |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basket
Isoform Long (identifier: P79745-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
10 20 30 40 50
MATAASNPYL ASSSILSSGS IVHSDSGGGM QQGSAAVTSV SGGYRGDPTV
60 70 80 90 100
KMVQSDFMQG AMAASNGGHM LSHAHQWVTS LPHAAAAAAA AAVAAAEAGS
110 120 130 140 150
PWSSSPVGMT GSPQQQDVKN NSGRDDLHSG TALHHRAPHL GPHQTHAGAW
160 170 180 190 200
GSTTAAHIPS LTGSQQQQQS LIYSQPGGFT VNGMLSPPGS QSLVHPGLVR
210 220 230 240 250
GDTPELDHSS HHHHHHHQHQ HHQQAHHGVN SHDPHSDEDT PTSDDLEHFA
260 270 280 290 300
KQFKQRRIKL GFTQADVGLA LGTLYGNVFS QTTICRFEAL QLSFKNMCKL
310 320 330 340 350
KPLLNKWLEE ADSSTGSPTS IDKIAAQGRK RKKRTSIEVS VKGALESHFL
360 370 380 390 400
KCPKPSAQEI TSLADNLQLE KEVVRVWFCN RRQKEKRMTP PGVPQTPEDV
410 420 430 440
YSQVGNGHFL VDYLKDASLT GPSEPGDQRV TTTSSFHQVI LAH
Isoform Short (identifier: P79745-2) [UniParc]FASTAAdd to basket
The sequence of this isoform differs from the canonical sequence as follows:
407-443: GHFLVDYLKDASLTGPSEPGDQRVTTTSSFHQVILAH → VSADTPPPSMDCKRMFSET
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 109 | M → I in BAA02377 (PubMed:1417821).Curated | 1 | |
Sequence conflicti | 116 | Q → QQ in AAH56549 (Ref. 3) Curated | 1 | |
Sequence conflicti | 116 | Q → QQ in AAI63489 (Ref. 3) Curated | 1 | |
Sequence conflicti | 135 | H → N in BAA02377 (PubMed:1417821).Curated | 1 | |
Sequence conflicti | 146 | H → Y in BAA02377 (PubMed:1417821).Curated | 1 | |
Sequence conflicti | 170 | S → F in BAA02377 (PubMed:1417821).Curated | 1 | |
Sequence conflicti | 174 – 175 | SQ → FA in BAA02377 (PubMed:1417821).Curated | 2 | |
Sequence conflicti | 185 | L → H in BAA02377 (PubMed:1417821).Curated | 1 | |
Sequence conflicti | 263 | T → K in BAA02377 (PubMed:1417821).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_002341 | 407 – 443 | GHFLV…VILAH → VSADTPPPSMDCKRMFSET in isoform Short. 4 PublicationsAdd BLAST | 37 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D13045 mRNA. Translation: BAA02377.1. Y07907 mRNA. Translation: CAA69215.1. Y07907 mRNA. Translation: CAA69214.1. BC056320 mRNA. Translation: AAH56320.1. BC056549 mRNA. Translation: AAH56549.1. BC163489 mRNA. Translation: AAI63489.1. |
PIRi | JH0710. |
RefSeqi | NP_571177.2. NM_131102.3. [P79745-2] NP_958855.2. NM_201447.2. [P79745-1] |
UniGenei | Dr.29717. |
Genome annotation databases
Ensembli | ENSDART00000149202; ENSDARP00000123893; ENSDARG00000095896. [P79745-2] ENSDART00000149949; ENSDARP00000124688; ENSDARG00000095896. [P79745-1] |
GeneIDi | 30321. |
KEGGi | dre:30321. |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Entry informationi
Entry namei | P3F3B_DANRE | |
Accessioni | P79745Primary (citable) accession number: P79745 Secondary accession number(s): B3DJH8 Q6PHH6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | May 1, 1997 | |
Last modified: | March 28, 2018 | |
This is version 143 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |