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UniProtKB - P79745 (P3F3B_DANRE)

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Protein

POU domain, class 3, transcription factor 3-B

Gene

pou3f3b

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcription factor that may play important roles in patterning the embryonic brain.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi330 – 389HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

Complete GO annotation...

GO - Biological processi

Complete GO annotation...

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
POU domain, class 3, transcription factor 3-B
Alternative name(s):
Brain-specific homeobox/POU domain protein 1.0
Short name:
Brain-1.0
Short name:
zfBrn-1.0
POU domain protein 1
Short name:
ZFPOU1
POU domain protein 23
Short name:
ZP-23
Gene namesi
Name:pou3f3b
Synonyms:brn-1.0, pou1, pou23, zp23, zp23pou
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Cyprinidae › Danio
Proteomesi
  • UP000000437 Componenti: Chromosome 6

Organism-specific databases

ZFINiZDB-GENE-980526-140. pou3f3b.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001007711 – 443POU domain, class 3, transcription factor 3-BAdd BLAST443

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei317Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP79745.
PRIDEiP79745.

PTM databases

iPTMnetiP79745.

Expressioni

Tissue specificityi

Predominantly expressed in the central nervous system.3 Publications

Developmental stagei

First expressed at early neurula stage (9-12 hours). Expression then increases greatly at the 16-somite stage, reached the maximum level at 36 hr of development, and thereafter decreased. Only expressed in adults in the brain.3 Publications

Gene expression databases

BgeeiENSDARG00000095896.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000124688.

Structurei

3D structure databases

ProteinModelPortaliP79745.
SMRiP79745.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini238 – 312POU-specificPROSITE-ProRule annotationAdd BLAST75

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi84 – 98Ala-richAdd BLAST15
Compositional biasi165 – 169Poly-Gln5
Compositional biasi208 – 235His-richAdd BLAST28

Sequence similaritiesi

Belongs to the POU transcription factor family. Class-3 subfamily.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG3802. Eukaryota.
ENOG410XQ7X. LUCA.
GeneTreeiENSGT00760000118935.
HOGENOMiHOG000116303.
HOVERGENiHBG053120.
InParanoidiP79745.
KOiK09365.
OMAiGMTGSPQ.
OrthoDBiEOG091G0U0S.
PhylomeDBiP79745.
TreeFamiTF316413.

Family and domain databases

InterProiView protein in InterPro
IPR009057. Homeobox-like.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR010982. Lambda_DNA-bd_dom.
IPR013847. POU.
IPR000327. POU_dom.
IPR016362. TF_POU_3.
PfamiView protein in Pfam
PF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
PIRSFiPIRSF002629. Transcription_factor_POU. 1 hit.
PRINTSiPR00028. POUDOMAIN.
SMARTiView protein in SMART
SM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEiView protein in PROSITE
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00035. POU_1. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Long (identifier: P79745-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MATAASNPYL ASSSILSSGS IVHSDSGGGM QQGSAAVTSV SGGYRGDPTV 
        60         70         80         90        100
KMVQSDFMQG AMAASNGGHM LSHAHQWVTS LPHAAAAAAA AAVAAAEAGS 
       110        120        130        140        150
PWSSSPVGMT GSPQQQDVKN NSGRDDLHSG TALHHRAPHL GPHQTHAGAW 
       160        170        180        190        200
GSTTAAHIPS LTGSQQQQQS LIYSQPGGFT VNGMLSPPGS QSLVHPGLVR 
       210        220        230        240        250
GDTPELDHSS HHHHHHHQHQ HHQQAHHGVN SHDPHSDEDT PTSDDLEHFA 
       260        270        280        290        300
KQFKQRRIKL GFTQADVGLA LGTLYGNVFS QTTICRFEAL QLSFKNMCKL 
       310        320        330        340        350
KPLLNKWLEE ADSSTGSPTS IDKIAAQGRK RKKRTSIEVS VKGALESHFL 
       360        370        380        390        400
KCPKPSAQEI TSLADNLQLE KEVVRVWFCN RRQKEKRMTP PGVPQTPEDV 
       410        420        430        440 
YSQVGNGHFL VDYLKDASLT GPSEPGDQRV TTTSSFHQVI LAH
Length:443
Mass (Da):47,453
Last modified:May 1, 1997 - v1
Checksum:i5F2A6DC6BB333F5C
GO
Isoform Short (identifier: P79745-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     407-443: GHFLVDYLKDASLTGPSEPGDQRVTTTSSFHQVILAH → VSADTPPPSMDCKRMFSET

Show »
Length:425
Mass (Da):45,527
Checksum:iBAAC6D655310F131
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti109M → I in BAA02377 (PubMed:1417821).Curated1
Sequence conflicti116Q → QQ in AAH56549 (Ref. 3) Curated1
Sequence conflicti116Q → QQ in AAI63489 (Ref. 3) Curated1
Sequence conflicti135H → N in BAA02377 (PubMed:1417821).Curated1
Sequence conflicti146H → Y in BAA02377 (PubMed:1417821).Curated1
Sequence conflicti170S → F in BAA02377 (PubMed:1417821).Curated1
Sequence conflicti174 – 175SQ → FA in BAA02377 (PubMed:1417821).Curated2
Sequence conflicti185L → H in BAA02377 (PubMed:1417821).Curated1
Sequence conflicti263T → K in BAA02377 (PubMed:1417821).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_002341407 – 443GHFLV…VILAH → VSADTPPPSMDCKRMFSET in isoform Short. 4 PublicationsAdd BLAST37

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D13045 mRNA. Translation: BAA02377.1.
Y07907 mRNA. Translation: CAA69215.1.
Y07907 mRNA. Translation: CAA69214.1.
BC056320 mRNA. Translation: AAH56320.1.
BC056549 mRNA. Translation: AAH56549.1.
BC163489 mRNA. Translation: AAI63489.1.
PIRiJH0710.
RefSeqiNP_571177.2. NM_131102.3. [P79745-2]
NP_958855.2. NM_201447.2. [P79745-1]
UniGeneiDr.29717.

Genome annotation databases

EnsembliENSDART00000149202; ENSDARP00000123893; ENSDARG00000095896. [P79745-2]
ENSDART00000149949; ENSDARP00000124688; ENSDARG00000095896. [P79745-1]
GeneIDi30321.
KEGGidre:30321.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D13045 mRNA. Translation: BAA02377.1.
Y07907 mRNA. Translation: CAA69215.1.
Y07907 mRNA. Translation: CAA69214.1.
BC056320 mRNA. Translation: AAH56320.1.
BC056549 mRNA. Translation: AAH56549.1.
BC163489 mRNA. Translation: AAI63489.1.
PIRiJH0710.
RefSeqiNP_571177.2. NM_131102.3. [P79745-2]
NP_958855.2. NM_201447.2. [P79745-1]
UniGeneiDr.29717.

3D structure databases

ProteinModelPortaliP79745.
SMRiP79745.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000124688.

PTM databases

iPTMnetiP79745.

Proteomic databases

PaxDbiP79745.
PRIDEiP79745.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000149202; ENSDARP00000123893; ENSDARG00000095896. [P79745-2]
ENSDART00000149949; ENSDARP00000124688; ENSDARG00000095896. [P79745-1]
GeneIDi30321.
KEGGidre:30321.

Organism-specific databases

CTDi30321.
ZFINiZDB-GENE-980526-140. pou3f3b.

Phylogenomic databases

eggNOGiKOG3802. Eukaryota.
ENOG410XQ7X. LUCA.
GeneTreeiENSGT00760000118935.
HOGENOMiHOG000116303.
HOVERGENiHBG053120.
InParanoidiP79745.
KOiK09365.
OMAiGMTGSPQ.
OrthoDBiEOG091G0U0S.
PhylomeDBiP79745.
TreeFamiTF316413.

Miscellaneous databases

PROiPR:P79745.

Gene expression databases

BgeeiENSDARG00000095896.

Family and domain databases

InterProiView protein in InterPro
IPR009057. Homeobox-like.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR010982. Lambda_DNA-bd_dom.
IPR013847. POU.
IPR000327. POU_dom.
IPR016362. TF_POU_3.
PfamiView protein in Pfam
PF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
PIRSFiPIRSF002629. Transcription_factor_POU. 1 hit.
PRINTSiPR00028. POUDOMAIN.
SMARTiView protein in SMART
SM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEiView protein in PROSITE
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00035. POU_1. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiP3F3B_DANRE
AccessioniPrimary (citable) accession number: P79745
Secondary accession number(s): B3DJH8
, P31366, P79744, Q6PHH6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 1, 1997
Last modified: June 7, 2017
This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.