pou3f3b

Functionⁱ

Transcription factor that may play important roles in patterning the embryonic brain.

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
DNA bindingⁱ	330 – 389	HomeoboxPROSITE-ProRule annotationAdd BLAST		60

GO - Molecular functionⁱ

DNA binding transcription factor activity Source: InterPro
sequence-specific DNA binding Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

brain development Source: InterPro
regulation of transcription by RNA polymerase II Source: InterPro
transcription, DNA-templated Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Developmental protein, DNA-binding
Biological process	Transcription, Transcription regulation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: POU domain, class 3, transcription factor 3-B Alternative name(s): Brain-specific homeobox/POU domain protein 1.0 Short name: Brain-1.0 Short name: zfBrn-1.0 POU domain protein 1 Short name: ZFPOU1 POU domain protein 23 Short name: ZP-23
Gene namesⁱ	Name:pou3f3b Synonyms:brn-1.0, pou1, pou23, zp23, zp23pou
Organismⁱ	Danio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifierⁱ	7955 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Actinopterygii › Actinopteri › Neopterygii › Teleostei › Osteoglossocephalai › Clupeocephala › Otomorpha › Ostariophysi › Otophysi › Cypriniphysae › Cypriniformes › Cyprinoidea › Cyprinidae › Danio
Proteomesⁱ	UP000000437 Componentⁱ: Chromosome 6

Organism-specific databases

ZFINⁱ	ZDB-GENE-980526-140 pou3f3b

ZFINⁱ

ZDB-GENE-980526-140 pou3f3b

Keywords - Cellular componentⁱ

Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000100771	1 – 443	POU domain, class 3, transcription factor 3-BAdd BLAST		443

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	317	Phosphoserine1 Publication		1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

PaxDbⁱ	P79745

PaxDbⁱ

P79745

PTM databases

iPTMnetⁱ	P79745

iPTMnetⁱ

P79745

Expressionⁱ

Tissue specificityⁱ

Predominantly expressed in the central nervous system.3 Publications

Developmental stageⁱ

First expressed at early neurula stage (9-12 hours). Expression then increases greatly at the 16-somite stage, reached the maximum level at 36 hr of development, and thereafter decreased. Only expressed in adults in the brain.3 Publications

Gene expression databases

Bgeeⁱ	ENSDARG00000095896

Bgeeⁱ

ENSDARG00000095896

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	7955.ENSDARP00000124688

STRINGⁱ

7955.ENSDARP00000124688

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P79745
SMRⁱ	P79745
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	238 – 312	POU-specificPROSITE-ProRule annotationAdd BLAST		75

Compositional bias

Feature key	Position(s)	DescriptionActions	Length
Compositional biasⁱ	84 – 98	Ala-richAdd BLAST	15
Compositional biasⁱ	165 – 169	Poly-Gln	5
Compositional biasⁱ	208 – 235	His-richAdd BLAST	28

Sequence similaritiesⁱ

Belongs to the POU transcription factor family. Class-3 subfamily.Curated

Keywords - Domainⁱ

Homeobox

Phylogenomic databases

eggNOGⁱ	KOG3802 Eukaryota ENOG410XQ7X LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118935
HOGENOMⁱ	HOG000116303
HOVERGENⁱ	HBG053120
InParanoidⁱ	P79745
KEGG Orthology (KO) More...KOⁱ	K09365
OMAⁱ	PHQGHPG
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0U0S
PhylomeDBⁱ	P79745
TreeFamⁱ	TF316413

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00086 homeodomain, 1 hit
InterProⁱ	View protein in InterPro IPR009057 Homeobox-like_sf IPR017970 Homeobox_CS IPR001356 Homeobox_dom IPR010982 Lambda_DNA-bd_dom_sf IPR013847 POU IPR000327 POU_dom IPR016362 TF_POU_3
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00046 Homeobox, 1 hit PF00157 Pou, 1 hit
PIRSFⁱ	PIRSF002629 Transcription_factor_POU, 1 hit
PRINTSⁱ	PR00028 POUDOMAIN
SMARTⁱ	View protein in SMART SM00389 HOX, 1 hit SM00352 POU, 1 hit
SUPFAMⁱ	SSF46689 SSF46689, 1 hit SSF47413 SSF47413, 1 hit
PROSITEⁱ	View protein in PROSITE PS00027 HOMEOBOX_1, 1 hit PS50071 HOMEOBOX_2, 1 hit PS00035 POU_1, 1 hit PS00465 POU_2, 1 hit PS51179 POU_3, 1 hit

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket Added to basket

Isoform Long (identifier: P79745-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MATAASNPYL ASSSILSSGS IVHSDSGGGM QQGSAAVTSV SGGYRGDPTV 
        60         70         80         90        100
KMVQSDFMQG AMAASNGGHM LSHAHQWVTS LPHAAAAAAA AAVAAAEAGS 
       110        120        130        140        150
PWSSSPVGMT GSPQQQDVKN NSGRDDLHSG TALHHRAPHL GPHQTHAGAW 
       160        170        180        190        200
GSTTAAHIPS LTGSQQQQQS LIYSQPGGFT VNGMLSPPGS QSLVHPGLVR 
       210        220        230        240        250
GDTPELDHSS HHHHHHHQHQ HHQQAHHGVN SHDPHSDEDT PTSDDLEHFA 
       260        270        280        290        300
KQFKQRRIKL GFTQADVGLA LGTLYGNVFS QTTICRFEAL QLSFKNMCKL 
       310        320        330        340        350
KPLLNKWLEE ADSSTGSPTS IDKIAAQGRK RKKRTSIEVS VKGALESHFL 
       360        370        380        390        400
KCPKPSAQEI TSLADNLQLE KEVVRVWFCN RRQKEKRMTP PGVPQTPEDV 
       410        420        430        440 
YSQVGNGHFL VDYLKDASLT GPSEPGDQRV TTTSSFHQVI LAH

Length:443

Mass (Da):47,453

Last modified:May 1, 1997 - v1

Checksum:ⁱ5F2A6DC6BB333F5C

GO

Isoform Short (identifier: P79745-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
407-443: GHFLVDYLKDASLTGPSEPGDQRVTTTSSFHQVILAH → VSADTPPPSMDCKRMFSET

« Hide

        10         20         30         40         50
MATAASNPYL ASSSILSSGS IVHSDSGGGM QQGSAAVTSV SGGYRGDPTV 
        60         70         80         90        100
KMVQSDFMQG AMAASNGGHM LSHAHQWVTS LPHAAAAAAA AAVAAAEAGS 
       110        120        130        140        150
PWSSSPVGMT GSPQQQDVKN NSGRDDLHSG TALHHRAPHL GPHQTHAGAW 
       160        170        180        190        200
GSTTAAHIPS LTGSQQQQQS LIYSQPGGFT VNGMLSPPGS QSLVHPGLVR 
       210        220        230        240        250
GDTPELDHSS HHHHHHHQHQ HHQQAHHGVN SHDPHSDEDT PTSDDLEHFA 
       260        270        280        290        300
KQFKQRRIKL GFTQADVGLA LGTLYGNVFS QTTICRFEAL QLSFKNMCKL 
       310        320        330        340        350
KPLLNKWLEE ADSSTGSPTS IDKIAAQGRK RKKRTSIEVS VKGALESHFL 
       360        370        380        390        400
KCPKPSAQEI TSLADNLQLE KEVVRVWFCN RRQKEKRMTP PGVPQTPEDV 
       410        420 
YSQVGNVSAD TPPPSMDCKR MFSET

Show »

Length:425

Mass (Da):45,527

Checksum:ⁱBAAC6D655310F131

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	109	M → I in BAA02377 (PubMed:1417821).Curated	1
Sequence conflictⁱ	116	Q → QQ in AAH56549 (Ref. 3) Curated	1
Sequence conflictⁱ	116	Q → QQ in AAI63489 (Ref. 3) Curated	1
Sequence conflictⁱ	135	H → N in BAA02377 (PubMed:1417821).Curated	1
Sequence conflictⁱ	146	H → Y in BAA02377 (PubMed:1417821).Curated	1
Sequence conflictⁱ	170	S → F in BAA02377 (PubMed:1417821).Curated	1
Sequence conflictⁱ	174 – 175	SQ → FA in BAA02377 (PubMed:1417821).Curated	2
Sequence conflictⁱ	185	L → H in BAA02377 (PubMed:1417821).Curated	1
Sequence conflictⁱ	263	T → K in BAA02377 (PubMed:1417821).Curated	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_002341	407 – 443	GHFLV…VILAH → VSADTPPPSMDCKRMFSET in isoform Short. 4 PublicationsAdd BLAST		37

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	D13045 mRNA Translation: BAA02377.1 Y07907 mRNA Translation: CAA69215.1 Y07907 mRNA Translation: CAA69214.1 BC056320 mRNA Translation: AAH56320.1 BC056549 mRNA Translation: AAH56549.1 BC163489 mRNA Translation: AAI63489.1
PIRⁱ	JH0710
NCBI Reference Sequences More...RefSeqⁱ	NP_571177.2, NM_131102.3 [P79745-2] NP_958855.2, NM_201447.2 [P79745-1]
UniGeneⁱ	Dr.29717

Genome annotation databases

Ensemblⁱ	ENSDART00000149202; ENSDARP00000123893; ENSDARG00000095896 [P79745-2] ENSDART00000149949; ENSDARP00000124688; ENSDARG00000095896 [P79745-1]
GeneIDⁱ	30321
KEGGⁱ	dre:30321

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length
P79745	POU domain protein		FUNHE		485
UPI00097338DB		ESOLU		445
UPI000D098BE7		ONCTS		444
UPI0009A02506		ONCKI		444
UPI000CEB041E		SALAL		444
+48

Protein	Similar proteins		Species	Score	Length
P79745	POU domain protein		FUNHE		485
UPI00097338DB		ESOLU		445
UPI000CEB041E		SALAL		444
UPI000D098BE7		ONCTS		444
UPI000B4EF354		ONCMY		444
+258
P79745-2	POU domain, class 3, transcription factor 3		MOUSE		497
UPI000BB6DFD6		DELLE		505
UPI000B4E8C22		MERUN		503
UPI000C2FAF2D		FELCA		502
UPI000A2B5EAF		PIG		501
+61

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	D13045 mRNA Translation: BAA02377.1 Y07907 mRNA Translation: CAA69215.1 Y07907 mRNA Translation: CAA69214.1 BC056320 mRNA Translation: AAH56320.1 BC056549 mRNA Translation: AAH56549.1 BC163489 mRNA Translation: AAI63489.1
PIRⁱ	JH0710
NCBI Reference Sequences More...RefSeqⁱ	NP_571177.2, NM_131102.3 [P79745-2] NP_958855.2, NM_201447.2 [P79745-1]
UniGeneⁱ	Dr.29717

3D structure databases

ProteinModelPortalⁱ	P79745
SMRⁱ	P79745
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	7955.ENSDARP00000124688

STRINGⁱ

7955.ENSDARP00000124688

PTM databases

iPTMnetⁱ	P79745

iPTMnetⁱ

P79745

Proteomic databases

PaxDbⁱ	P79745

PaxDbⁱ

P79745

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSDART00000149202; ENSDARP00000123893; ENSDARG00000095896 [P79745-2] ENSDART00000149949; ENSDARP00000124688; ENSDARG00000095896 [P79745-1]
GeneIDⁱ	30321
KEGGⁱ	dre:30321

Organism-specific databases

CTDⁱ	30321
ZFINⁱ	ZDB-GENE-980526-140 pou3f3b

Phylogenomic databases

eggNOGⁱ	KOG3802 Eukaryota ENOG410XQ7X LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118935
HOGENOMⁱ	HOG000116303
HOVERGENⁱ	HBG053120
InParanoidⁱ	P79745
KEGG Orthology (KO) More...KOⁱ	K09365
OMAⁱ	PHQGHPG
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0U0S
PhylomeDBⁱ	P79745
TreeFamⁱ	TF316413

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:P79745

PROⁱ

PR:P79745

Gene expression databases

Bgeeⁱ	ENSDARG00000095896

Bgeeⁱ

ENSDARG00000095896

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00086 homeodomain, 1 hit
InterProⁱ	View protein in InterPro IPR009057 Homeobox-like_sf IPR017970 Homeobox_CS IPR001356 Homeobox_dom IPR010982 Lambda_DNA-bd_dom_sf IPR013847 POU IPR000327 POU_dom IPR016362 TF_POU_3
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00046 Homeobox, 1 hit PF00157 Pou, 1 hit
PIRSFⁱ	PIRSF002629 Transcription_factor_POU, 1 hit
PRINTSⁱ	PR00028 POUDOMAIN
SMARTⁱ	View protein in SMART SM00389 HOX, 1 hit SM00352 POU, 1 hit
SUPFAMⁱ	SSF46689 SSF46689, 1 hit SSF47413 SSF47413, 1 hit
PROSITEⁱ	View protein in PROSITE PS00027 HOMEOBOX_1, 1 hit PS50071 HOMEOBOX_2, 1 hit PS00035 POU_1, 1 hit PS00465 POU_2, 1 hit PS51179 POU_3, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	P3F3B_DANRE
Accessionⁱ	P79745Primary (citable) accession number: P79745 Secondary accession number(s): B3DJH8 , P31366, P79744, Q6PHH6
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
	Last sequence update:	May 1, 1997
	Last modified:	May 23, 2018
	This is version 144 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P79745 (P3F3B_DANRE)

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POU domain, class 3, transcription factor 3-B

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ