P79739 (CP26A_DANRE) Reviewed, UniProtKB/Swiss-Prot
Last modified
October 19, 2011.
Version 77.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Cytochrome P450 26A1 EC=1.14.-.- Alternative name(s): Cytochrome P450RAI Retinoic acid 4-hydroxylase Retinoic acid-metabolizing cytochrome | ||||
| Gene names |
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| Organism | Danio rerio (Zebrafish) (Brachydanio rerio) | ||||
| Taxonomic identifier | 7955 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Cyprinidae › Danio |
Protein attributes
| Sequence length | 492 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at transcript level |
General annotation (Comments)
| Function | Plays a key role in retinoic acid metabolism. Acts on retinoids, including all-trans-retinoic acid (RA) and its stereoisomer 9-cis-RA. Capable of 4-hydroxylation. Responsible for generation of several hydroxylated forms of RA, including 4-OH-RA and 4-oxo-RA. Ref.1 |
| Cofactor | Heme group By similarity. |
| Subcellular location | Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein. |
| Induction | By retinoic acid. Ref.1 |
| Sequence similarities | Belongs to the cytochrome P450 family. |
Ontologies
Sequence annotation (Features)
Sequences
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References
| [1] | "Identification of the retinoic acid-inducible all-trans-retinoic acid 4-hydroxylase." White J.A., Guo Y.-D., Baetz K., Beckett-Jones B., Bonasoro J., Hsu K.E., Dilworth F.J., Jones G., Petkovich M. J. Biol. Chem. 271:29922-29927(1996) [PubMed: 8939936] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INDUCTION. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | U68234 mRNA. Translation: AAC60045.1. |
| IPI | IPI00489219. |
| UniGene | Dr.75754. |
3D structure databases | |
| ProteinModelPortal | P79739. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | P79739. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Organism-specific databases | |
| ZFIN | ZDB-GENE-990415-44. cyp26a1. |
Phylogenomic databases | |
| eggNOG | fiNOG13911. |
| HOGENOM | HBG744016. |
| HOVERGEN | HBG051099. |
| InParanoid | P79739. |
| OrthoDB | EOG4BP1BM. |
| PhylomeDB | P79739. |
Gene expression databases | |
| ArrayExpress | P79739. |
| Bgee | P79739. |
Family and domain databases | |
| InterPro | IPR001128. Cyt_P450. IPR017972. Cyt_P450_CS. IPR002401. Cyt_P450_E_grp-I. [Graphical view] |
| Gene3D | G3DSA:1.10.630.10. Cyt_P450. 1 hit. |
| Pfam | PF00067. p450. 1 hit. [Graphical view] |
| PRINTS | PR00463. EP450I. PR00385. P450. |
| SUPFAM | SSF48264. Cytochrome_P450. 1 hit. |
| PROSITE | PS00086. CYTOCHROME_P450. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | CP26A_DANRE | ||||||||
| Accession | Primary (citable) accession number: P79739 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
Relevant documents
| SIMILARITY comments Index of protein domains and families |

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