P79739 (CP26A_DANRE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cytochrome P450 26A1
EC=1.14.-.-

Alternative name(s):
Cytochrome P450RAI
Retinoic acid 4-hydroxylase
Retinoic acid-metabolizing cytochrome

Gene names

Name:	cyp26a1
Synonyms:	cyp26

Organism

Danio rerio (Zebrafish) (Brachydanio rerio)

Taxonomic identifier

7955 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Cyprinidae › Danio

Protein attributes

Sequence length	492 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Plays a key role in retinoic acid metabolism. Acts on retinoids, including all-trans-retinoic acid (RA) and its stereoisomer 9-cis-RA. Capable of 4-hydroxylation. Responsible for generation of several hydroxylated forms of RA, including 4-OH-RA and 4-oxo-RA. Ref.1
Cofactor	Heme group By similarity.
Subcellular location	Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Induction	By retinoic acid. Ref.1
Sequence similarities	Belongs to the cytochrome P450 family.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum Membrane Microsome
Ligand	Heme Iron Metal-binding
Molecular function	Monooxygenase Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	blood vessel development Inferred from mutant phenotype. Source: ZFIN brain morphogenesis Inferred from mutant phenotype. Source: ZFIN mesodermal-endodermal cell signaling Inferred from mutant phenotype. Source: ZFIN pancreas development Inferred from mutant phenotype. Source: ZFIN response to chemical stimulus Inferred from direct assay. Source: ZFIN retinal metabolic process Inferred from mutant phenotype. Source: ZFIN retinoic acid catabolic process Inferred from mutant phenotype. Source: ZFIN rhombomere 4 morphogenesis Inferred from mutant phenotype. Source: ZFIN somitogenesis Inferred from mutant phenotype. Source: ZFIN
Cellular component	endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell microsome Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	electron carrier activity Inferred from electronic annotation. Source: InterPro heme binding Inferred from electronic annotation. Source: InterPro retinoic acid 4-hydroxylase activity Inferred from direct assay. Source: ZFIN
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 492	492	Cytochrome P450 26A1		PRO_0000051983
Sites
	Metal binding	438	1	Iron (heme axial ligand) By similarity

Sequences

	Sequence		Length	Mass (Da)
	P79739 [UniParc]. Last modified May 1, 1997. Version 1. Checksum: FD471435B2F30509	FASTA	492	56,281
	10 20 30 40 50 60 MGLYTLMVTF LCTIVLPVLL FLAAVKLWEM LMIRRVDPNC RSPLPPGTMG LPFIGETLQL 70 80 90 100 110 120 ILQRRKFLRM KRQKYGCIYK THLFGNPTVR VMGADNVRQI LLGEHKLVSV QWPASVRTIL 130 140 150 160 170 180 GSDTLSNVHG VQHKNKKKAI MRAFSRDALE HYIPVIQQEV KSAIQEWLQK DSCVLVYPEM 190 200 210 220 230 240 KKLMFRIAMR ILLGFEPEQI KTDEQELVEA FEEMIKNLFS LPIDVPFSGL YRGLRARNFI 250 260 270 280 290 300 HSKIEENIRK KIQDDDNENE QKYKDALQLL IENSRRSDEP FSLQAMKEAA TELLFGGHET 310 320 330 340 350 360 TASTATSLVM FLGLNTEVVQ KVREEVQEKV EMGMYTPGKG LSMELLDQLK YTGCVIKETL 370 380 390 400 410 420 RINPPVPGGF RVALKTFELN GYQIPKGWNV IYSICDTHDV ADVFPNKEEF QPERFMSKGL 430 440 450 460 470 480 EDGSRFNYIP FGGGSRMCVG KEFAKVLLKI FLVELTQHCN WILSNGPPTM KTGPTIYPVD 490 NLPTKFTSYV RN

References

[1]	"Identification of the retinoic acid-inducible all-trans-retinoic acid 4-hydroxylase." White J.A., Guo Y.-D., Baetz K., Beckett-Jones B., Bonasoro J., Hsu K.E., Dilworth F.J., Jones G., Petkovich M. J. Biol. Chem. 271:29922-29927(1996) [PubMed: 8939936] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INDUCTION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U68234 mRNA. Translation: AAC60045.1.
IPI	IPI00489219.
UniGene	Dr.75754.
3D structure databases
ProteinModelPortal	P79739.
ModBase	Search...
Protein-protein interaction databases
STRING	P79739.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
ZFIN	ZDB-GENE-990415-44. cyp26a1.
Phylogenomic databases
eggNOG	fiNOG13911.
HOGENOM	HBG744016.
HOVERGEN	HBG051099.
InParanoid	P79739.
OrthoDB	EOG4BP1BM.
PhylomeDB	P79739.
Gene expression databases
ArrayExpress	P79739.
Bgee	P79739.
Family and domain databases
InterPro	IPR001128. Cyt_P450. IPR017972. Cyt_P450_CS. IPR002401. Cyt_P450_E_grp-I. [Graphical view]
Gene3D	G3DSA:1.10.630.10. Cyt_P450. 1 hit.
Pfam	PF00067. p450. 1 hit. [Graphical view]
PRINTS	PR00463. EP450I. PR00385. P450.
SUPFAM	SSF48264. Cytochrome_P450. 1 hit.
PROSITE	PS00086. CYTOCHROME_P450. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CP26A_DANRE

Accession

Primary (citable) accession number: P79739

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
Last sequence update:	May 1, 1997
Last modified:	October 19, 2011
This is version 77 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program