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Reviewed, UniProtKB/Swiss-Prot P79739 (CP26A_DANRE)

Last modified October 13, 2009. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Cytochrome P450 26A1
    EC=1.14.-.-
Alternative name(s):
    Retinoic acid-metabolizing cytochrome
    P450RAI
    Retinoic acid 4-hydroxylase
Gene names
Name: cyp26a1
Synonyms: cyp26
OrganismDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifier7955 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Protein attributes

Sequence length492 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

General annotation (Comments)

Function

Plays a key role in retinoic acid metabolism. Acts on retinoids, including all-trans-retinoic acid (RA) and its stereoisomer 9-cis-RA. Capable of 4-hydroxylation. Responsible for generation of several hydroxylated forms of RA, including 4-OH-RA and 4-oxo-RA. Ref.1

Cofactor

Heme group By similarity.

Subcellular location

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Induction

By retinoic acid. Ref.1

Sequence similarities

Belongs to the cytochrome P450 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 492492Cytochrome P450 26A1
PRO_0000051983

Sites

Metal binding4381Iron (heme axial ligand) By similarity

Sequences

Sequence LengthMass (Da)Tools
P79739-1 [UniParc].

Last modified May 1, 1997. Version 1.
Checksum: FD471435B2F30509

FASTA49256,281
        10         20         30         40         50         60 
MGLYTLMVTF LCTIVLPVLL FLAAVKLWEM LMIRRVDPNC RSPLPPGTMG LPFIGETLQL 

        70         80         90        100        110        120 
ILQRRKFLRM KRQKYGCIYK THLFGNPTVR VMGADNVRQI LLGEHKLVSV QWPASVRTIL 

       130        140        150        160        170        180 
GSDTLSNVHG VQHKNKKKAI MRAFSRDALE HYIPVIQQEV KSAIQEWLQK DSCVLVYPEM 

       190        200        210        220        230        240 
KKLMFRIAMR ILLGFEPEQI KTDEQELVEA FEEMIKNLFS LPIDVPFSGL YRGLRARNFI 

       250        260        270        280        290        300 
HSKIEENIRK KIQDDDNENE QKYKDALQLL IENSRRSDEP FSLQAMKEAA TELLFGGHET 

       310        320        330        340        350        360 
TASTATSLVM FLGLNTEVVQ KVREEVQEKV EMGMYTPGKG LSMELLDQLK YTGCVIKETL 

       370        380        390        400        410        420 
RINPPVPGGF RVALKTFELN GYQIPKGWNV IYSICDTHDV ADVFPNKEEF QPERFMSKGL 

       430        440        450        460        470        480 
EDGSRFNYIP FGGGSRMCVG KEFAKVLLKI FLVELTQHCN WILSNGPPTM KTGPTIYPVD 

       490 
NLPTKFTSYV RN 

« Hide

References

[1]"Identification of the retinoic acid-inducible all-trans-retinoic acid 4-hydroxylase."
White J.A., Guo Y.-D., Baetz K., Beckett-Jones B., Bonasoro J., Hsu K.E., Dilworth F.J., Jones G., Petkovich M.
J. Biol. Chem. 271:29922-29927(1996) [PubMed: 8939936] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INDUCTION.
+Additional computationally mapped references.

Cross-references

Sequence databases

U68234 mRNA. Translation: AAC60045.1.
IPIIPI00489219.
UniGeneDr.75754

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGP79739.

Genome annotation databases

EnsemblENSDART00000041728; ENSDARP00000041727; ENSDARG00000033999; Danio rerio. [Genome view]

Organism-specific databases

ZFINZDB-GENE-990415-44. cyp26a1.

Phylogenomic databases

HOGENOMP79739.
HOVERGENP79739.

Gene expression databases

ArrayExpressP79739.
BgeeP79739.

Family and domain databases

InterProIPR001128. Cyt_P450.
IPR017973. Cyt_P450_C.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
Gene3DG3DSA:1.10.630.10. Cyt_P450. 1 hit.
PANTHERPTHR19383. Cyt_P450. 1 hit.
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00463. EP450I.
PR00385. P450.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCP26A_DANRE
AccessionPrimary (citable) accession number: P79739
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: May 1, 1997
Last modified: October 13, 2009
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectZebrafish annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents