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P79737 (RASN_DANRE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 99. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
GTPase NRas
Alternative name(s):
Transforming protein N-Ras
ZRas-B1
Gene names
Name:nras
OrganismDanio rerio (Zebrafish) (Brachydanio rerio) [Reference proteome]
Taxonomic identifier7955 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Protein attributes

Sequence length188 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Ras proteins bind GDP/GTP and possess intrinsic GTPase activity.

Enzyme regulation

Alternates between an inactive form bound to GDP and an active form bound to GTP. Activated by a guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase-activating protein (GAP).

Subcellular location

Cell membrane; Lipid-anchor; Cytoplasmic side By similarity. Golgi apparatus membrane; Lipid-anchor By similarity. Note: Shuttles between the plasma membrane and the Golgi apparatus By similarity.

Post-translational modification

Palmitoylated by the ZDHHC9-GOLGA7 complex. A continuous cycle of de- and re-palmitoylation regulates rapid exchange between plasma membrane and Golgi By similarity.

Sequence similarities

Belongs to the small GTPase superfamily. Ras family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 185185GTPase NRas
PRO_0000043018
Propeptide186 – 1883Removed in mature form By similarity
PRO_0000043019

Regions

Nucleotide binding10 – 178GTP By similarity
Nucleotide binding57 – 615GTP By similarity
Nucleotide binding116 – 1194GTP By similarity
Region165 – 18420Hypervariable region By similarity
Motif32 – 409Effector region

Amino acid modifications

Modified residue1851Cysteine methyl ester By similarity
Lipidation1801S-palmitoyl cysteine By similarity
Lipidation1851S-farnesyl cysteine By similarity

Sequences

Sequence LengthMass (Da)Tools
P79737 [UniParc].

Last modified May 1, 1997. Version 1.
Checksum: E9FDD913CF5BCFDE

FASTA18821,339
        10         20         30         40         50         60 
MTEYKLVVVG AGGVGKSALT IQLIQNHFVD EYDPTIEDSY RKQVVIDGET CLLDILDTAG 

        70         80         90        100        110        120 
QEEYSAMRDQ YMRTGEGFLC VFAINNSKSF ADVHLYREQI KRVKDSDDVP MVLVGNICDL 

       130        140        150        160        170        180 
ARTVDTKQAQ ELARSYGIEF VETSAKTRQG VEDAFYTLVR EIRHYRMKKL NSREDRKQGC 


LGVSCEVM 

« Hide

References

[1]"Cloning, sequencing, and embryonic expression of an N-ras proto-oncogene isolated from an enriched zebrafish (Danio rerio) cDNA library."
Cheng R., Bradford S., Barnes D., Williams D., Hendricks J., Bailey G.
Mol. Mar. Biol. Biotechnol. 6:40-47(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U62619 mRNA. Translation: AAB40625.1.
RefSeqNP_571220.1. NM_131145.1.
UniGeneDr.233.

3D structure databases

ProteinModelPortalP79737.
SMRP79737. Positions 1-165.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING7955.ENSDARP00000055741.

Proteomic databases

PRIDEP79737.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID30380.
KEGGdre:30380.

Organism-specific databases

CTD4893.
ZFINZDB-GENE-990415-166. nras.

Phylogenomic databases

eggNOGCOG1100.
HOVERGENHBG009351.
InParanoidP79737.
KOK07828.

Family and domain databases

Gene3D3.40.50.300. 1 hit.
InterProIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
[Graphical view]
PANTHERPTHR24070. PTHR24070. 1 hit.
PfamPF00071. Ras. 1 hit.
[Graphical view]
PRINTSPR00449. RASTRNSFRMNG.
SMARTSM00173. RAS. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR00231. small_GTP. 1 hit.
PROSITEPS51421. RAS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20806795.

Entry information

Entry nameRASN_DANRE
AccessionPrimary (citable) accession number: P79737
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 1, 1997
Last modified: April 16, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families