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Protein

GTP-binding nuclear protein Ran

Gene

ran

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle. In concert with nemp1a/b, required for proper eye development (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi16 – 238GTPBy similarity
Nucleotide bindingi64 – 685GTPBy similarity
Nucleotide bindingi121 – 1244GTPBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-DRE-1655829. Regulation of cholesterol biosynthesis by SREBP (SREBF).
R-DRE-203927. MicroRNA (miRNA) biogenesis.
R-DRE-5578749. Transcriptional regulation by small RNAs.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP-binding nuclear protein Ran
Alternative name(s):
GTPase Ran
Ras-related nuclear protein
Gene namesi
Name:ran
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 14

Organism-specific databases

ZFINiZDB-GENE-990415-88. ran.

Subcellular locationi

  • Nucleus By similarity
  • Nucleus envelope By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 215215GTP-binding nuclear protein RanPRO_0000208704Add
BLAST

Proteomic databases

PaxDbiP79735.
PRIDEiP79735.

Expressioni

Gene expression databases

BgeeiENSDARG00000057026.

Interactioni

Subunit structurei

Interacts with nemp1a and nemp1b.By similarity

Protein-protein interaction databases

STRINGi7955.ENSDARP00000108629.

Structurei

3D structure databases

ProteinModelPortaliP79735.
SMRiP79735. Positions 2-215.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the small GTPase superfamily. Ran family.Curated

Phylogenomic databases

eggNOGiKOG0096. Eukaryota.
ENOG410XNRS. LUCA.
GeneTreeiENSGT00840000129836.
HOGENOMiHOG000216664.
HOVERGENiHBG107376.
InParanoidiP79735.
KOiK07936.
OMAiVEMPALK.
OrthoDBiEOG091G0L3X.
PhylomeDBiP79735.
TreeFamiTF106302.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR002041. Ran_GTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
PRINTSiPR00627. GTPRANTC4.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51418. RAN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P79735-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAENEPQVQF KLVLVGDGGT GKTTFVKRHL TGEFEKKYVA TLGVEVHPLV
60 70 80 90 100
FHTNRGAIKY NVWDTAGQEK FGGLRDGYYI QAQCAIIMFD VTSRVTYKNV
110 120 130 140 150
PNWHRDLVRV CENIPIVLCG NKVDIKDRKV KAKSIVFHRK KNLQYYDISA
160 170 180 190 200
KSNYNFEKPF LWLARKLIGD PNLEFVEMPA LAPPEIAMDP TLAAQYEHDL
210
KVASETALPD EDDDL
Length:215
Mass (Da):24,460
Last modified:May 1, 1997 - v1
Checksum:i26A49A42440133A0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U61395 mRNA. Translation: AAB97093.1.
BC050517 mRNA. Translation: AAH50517.2.
RefSeqiNP_571384.1. NM_131309.3.
XP_005173151.1. XM_005173094.2.
UniGeneiDr.32354.

Genome annotation databases

EnsembliENSDART00000034438; ENSDARP00000032532; ENSDARG00000057026.
ENSDART00000128717; ENSDARP00000108629; ENSDARG00000057026.
ENSDART00000144503; ENSDARP00000121831; ENSDARG00000057026.
GeneIDi30572.
KEGGidre:30572.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U61395 mRNA. Translation: AAB97093.1.
BC050517 mRNA. Translation: AAH50517.2.
RefSeqiNP_571384.1. NM_131309.3.
XP_005173151.1. XM_005173094.2.
UniGeneiDr.32354.

3D structure databases

ProteinModelPortaliP79735.
SMRiP79735. Positions 2-215.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000108629.

Proteomic databases

PaxDbiP79735.
PRIDEiP79735.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000034438; ENSDARP00000032532; ENSDARG00000057026.
ENSDART00000128717; ENSDARP00000108629; ENSDARG00000057026.
ENSDART00000144503; ENSDARP00000121831; ENSDARG00000057026.
GeneIDi30572.
KEGGidre:30572.

Organism-specific databases

CTDi5901.
ZFINiZDB-GENE-990415-88. ran.

Phylogenomic databases

eggNOGiKOG0096. Eukaryota.
ENOG410XNRS. LUCA.
GeneTreeiENSGT00840000129836.
HOGENOMiHOG000216664.
HOVERGENiHBG107376.
InParanoidiP79735.
KOiK07936.
OMAiVEMPALK.
OrthoDBiEOG091G0L3X.
PhylomeDBiP79735.
TreeFamiTF106302.

Enzyme and pathway databases

ReactomeiR-DRE-1655829. Regulation of cholesterol biosynthesis by SREBP (SREBF).
R-DRE-203927. MicroRNA (miRNA) biogenesis.
R-DRE-5578749. Transcriptional regulation by small RNAs.

Miscellaneous databases

PROiP79735.

Gene expression databases

BgeeiENSDARG00000057026.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR002041. Ran_GTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
PRINTSiPR00627. GTPRANTC4.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51418. RAN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRAN_DANRE
AccessioniPrimary (citable) accession number: P79735
Secondary accession number(s): Q7ZU75
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 1, 1997
Last modified: September 7, 2016
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.