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Protein

Ribonucleoside-diphosphate reductase subunit M2

Gene

rrm2

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

Catalytic activityi

2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.PROSITE-ProRule annotation

Cofactori

Fe cationBy similarityNote: Binds 2 iron ions per subunit.By similarity

Pathwayi: DNA replication

This protein is involved in the pathway DNA replication, which is part of Genetic information processing.
View all proteins of this organism that are known to be involved in the pathway DNA replication and in Genetic information processing.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi135Iron 1PROSITE-ProRule annotation1
Metal bindingi166Iron 1PROSITE-ProRule annotation1
Metal bindingi166Iron 2By similarity1
Metal bindingi169Iron 1PROSITE-ProRule annotation1
Active sitei173PROSITE-ProRule annotation1
Metal bindingi229Iron 2By similarity1
Metal bindingi263Iron 2By similarity1
Metal bindingi266Iron 2By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processDNA replication
LigandIron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00326

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonucleoside-diphosphate reductase subunit M2 (EC:1.17.4.1)
Alternative name(s):
Ribonucleotide reductase protein R2 class I
Ribonucleotide reductase small chain
Ribonucleotide reductase small subunit
Gene namesi
Name:rrm2
Synonyms:r2
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componentsi: Chromosome 19, Chromosome 20

Organism-specific databases

ZFINiZDB-GENE-990415-25 rrm2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001904521 – 386Ribonucleoside-diphosphate reductase subunit M2Add BLAST386

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei6Phosphoserine1 Publication1
Modified residuei31Phosphothreonine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP79733
PRIDEiP79733

PTM databases

iPTMnetiP79733

Expressioni

Gene expression databases

BgeeiENSDARG00000020711
ExpressionAtlasiP79733 baseline

Interactioni

Subunit structurei

Heterodimer of a large and a small subunit.

Protein-protein interaction databases

STRINGi7955.ENSDARP00000103553

Structurei

3D structure databases

ProteinModelPortaliP79733
SMRiP79733
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1567 Eukaryota
COG0208 LUCA
GeneTreeiENSGT00390000013305
HOGENOMiHOG000255975
HOVERGENiHBG001647
InParanoidiP79733
KOiK10808
OrthoDBiEOG09370HM1
PhylomeDBiP79733
TreeFamiTF300465

Family and domain databases

CDDicd01049 RNRR2, 1 hit
Gene3Di1.10.620.20, 1 hit
InterProiView protein in InterPro
IPR009078 Ferritin-like_SF
IPR012348 RNR-like
IPR033909 RNR_small
IPR030475 RNR_small_AS
IPR000358 RNR_small_fam
PANTHERiPTHR23409 PTHR23409, 1 hit
PfamiView protein in Pfam
PF00268 Ribonuc_red_sm, 1 hit
PIRSFiPIRSF000355 NrdB, 1 hit
SUPFAMiSSF47240 SSF47240, 1 hit
PROSITEiView protein in PROSITE
PS00368 RIBORED_SMALL, 1 hit

Sequencei

Sequence statusi: Complete.

P79733-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSTRSPLKT KNENTISTKM NNMSFVDKEN TPPSLSSTRI LASKTARKIF
60 70 80 90 100
DESEGQSKAK KGAVEEEPLL KENPHRFVIF PIQYHDIWQM YKKAEASFWT
110 120 130 140 150
AEEVDLSKDL QHWDSLKDEE RYFISHVLAF FAASDGIVNE NLVERFTQEV
160 170 180 190 200
QVTEARCFYG FQIAMENIHS EMYSLLIDTY IKDSKEREFL FNAIETMPCV
210 220 230 240 250
KKKADWALNW IGDKNARYGE RVVAFAAVEG IFFSGSFASI FWLKKRGLMP
260 270 280 290 300
GLTFSNELIS RDEGLHCDFA CLMFKHLINK PSEETVKKII MNAVEIEQEF
310 320 330 340 350
LTDALPVKLI GMNCDLMKQY IEFVADRLLL ELGFDKVYRV ENPFDFMENI
360 370 380
SLEGKTNFFE KRVGEYQRMG VMSGTTDNTF TLDADF
Length:386
Mass (Da):44,594
Last modified:May 1, 1997 - v1
Checksum:iC168846FB57F9F4E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti279N → S in AAH75746 (Ref. 3) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U57965 mRNA Translation: AAB37103.1
BX248136 Genomic DNA Translation: CAI21240.1
BC044355 mRNA Translation: AAH44355.1
BC075746 mRNA Translation: AAH75746.1
RefSeqiNP_571525.1, NM_131450.2
XP_002665783.1, XM_002665737.4
UniGeneiDr.75098

Genome annotation databases

EnsembliENSDART00000027851; ENSDARP00000008907; ENSDARG00000020711
ENSDART00000112155; ENSDARP00000103553; ENSDARG00000078069
ENSDART00000170972; ENSDARP00000133583; ENSDARG00000020711
GeneIDi30733
KEGGidre:30733

Similar proteinsi

Entry informationi

Entry nameiRIR2_DANRE
AccessioniPrimary (citable) accession number: P79733
Secondary accession number(s): Q6DI44
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: May 1, 1997
Last modified: March 28, 2018
This is version 145 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health