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P79728

- EFNA5_DANRE

UniProt

P79728 - EFNA5_DANRE

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Protein

Ephrin-A5b

Gene

efna5b

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Induces compartmentalized signaling within a caveolae-like membrane microdomain when bound to the extracellular domain of its cognate receptor. This signaling event requires the activity of the Fyn tyrosine kinase. Activates the epha3 receptor to regulate cell-cell adhesion and cytoskeletal organization. With the receptor epha2 may regulate lens fiber cells shape and interactions and be important for lens transparency maintenance. May function actively to stimulate axon fasciculation (By similarity). Controls axon growth and may be involved in the creation of the retino-tectal map.By similarity

GO - Molecular functioni

  1. ephrin receptor binding Source: RefGenome

GO - Biological processi

  1. axon guidance Source: RefGenome
  2. ephrin receptor signaling pathway Source: UniProtKB
  3. mesoderm migration involved in gastrulation Source: ZFIN
  4. positive regulation of peptidyl-tyrosine phosphorylation Source: UniProtKB
  5. regulation of actin cytoskeleton organization Source: UniProtKB
  6. regulation of cell-cell adhesion Source: UniProtKB
  7. regulation of focal adhesion assembly Source: UniProtKB
  8. regulation of microtubule cytoskeleton organization Source: UniProtKB
  9. regulation of Rac GTPase activity Source: UniProtKB
  10. regulation of Rho GTPase activity Source: UniProtKB
  11. somitogenesis Source: ZFIN
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Neurogenesis

Enzyme and pathway databases

ReactomeiREACT_237315. EPH-Ephrin signaling.
REACT_250881. EPH-ephrin mediated repulsion of cells.
REACT_258838. EPHA-mediated growth cone collapse.

Names & Taxonomyi

Protein namesi
Recommended name:
Ephrin-A5b
Alternative name(s):
AL-1
EPH-related receptor tyrosine kinase ligand 7
Short name:
LERK-7
ZfEPHL4
Gene namesi
Name:efna5b
Synonyms:al1, efna5, eplg7, lerk7
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
ProteomesiUP000000437: Unplaced

Organism-specific databases

ZFINiZDB-GENE-980526-186. efna5b.

Subcellular locationi

GO - Cellular componenti

  1. anchored component of external side of plasma membrane Source: UniProtKB
  2. anchored component of plasma membrane Source: RefGenome
  3. plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence AnalysisAdd
BLAST
Chaini21 – 204184Ephrin-A5bPRO_0000008385Add
BLAST
Propeptidei205 – 22824Removed in mature formSequence AnalysisPRO_0000008386Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi37 – 371N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi62 ↔ 102PROSITE-ProRule annotation
Disulfide bondi90 ↔ 151PROSITE-ProRule annotation
Lipidationi204 – 2041GPI-anchor amidated serineSequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Expressioni

Tissue specificityi

Widespread expression in the embryo.

Developmental stagei

Expressed in the presumptive midbrain of developing embryos from the six-somite stage. By 24 hours, strongly expressed in the midbrain caudal to the presumptive tectum. At later stages, maintained at the posterior margin of the tectum.

Gene expression databases

BgeeiP79728.

Structurei

3D structure databases

ProteinModelPortaliP79728.
SMRiP79728. Positions 28-164.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini29 – 162134Ephrin RBDPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the ephrin family.PROSITE-ProRule annotation
Contains 1 ephrin RBD (ephrin receptor-binding) domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000234373.
HOVERGENiHBG051447.
InParanoidiP79728.
KOiK05462.
PhylomeDBiP79728.

Family and domain databases

Gene3Di2.60.40.420. 1 hit.
InterProiIPR008972. Cupredoxin.
IPR001799. Ephrin.
IPR019765. Ephrin_CS.
[Graphical view]
PANTHERiPTHR11304. PTHR11304. 1 hit.
PfamiPF00812. Ephrin. 1 hit.
[Graphical view]
PRINTSiPR01347. EPHRIN.
ProDomiPD002533. Ephrin. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF49503. SSF49503. 1 hit.
PROSITEiPS01299. EPHRIN_RBD_1. 1 hit.
PS51551. EPHRIN_RBD_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P79728-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLQAEMIVFV GVILWMCVFS QEPSSKVMAD RYAVFWNRTN PRFQRGDYHI
60 70 80 90 100
DVCINDYLDV YCPHYEDSVP EERTERYVLY MVNYDGYSTC DHTAKGFKRW
110 120 130 140 150
ECNRPHSPNG PLKFSEKFQL FTPFSLGFEF RPGREYYYIS SMITETGRRS
160 170 180 190 200
CLKLKVFVRP PNGCEKTIGV HDRVFVDDKV DNALEPRDDT SHEAEPSRSD
210 220
VSTSGLRHQT SRPLLALLLL CISLYLLL
Length:228
Mass (Da):26,595
Last modified:May 1, 1997 - v1
Checksum:i74B3406C05418E6E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y09669 mRNA. Translation: CAA70864.1.
RefSeqiNP_571101.1. NM_131026.2.
UniGeneiDr.19377.

Genome annotation databases

GeneIDi30223.
KEGGidre:30223.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y09669 mRNA. Translation: CAA70864.1 .
RefSeqi NP_571101.1. NM_131026.2.
UniGenei Dr.19377.

3D structure databases

ProteinModelPortali P79728.
SMRi P79728. Positions 28-164.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 30223.
KEGGi dre:30223.

Organism-specific databases

CTDi 30223.
ZFINi ZDB-GENE-980526-186. efna5b.

Phylogenomic databases

HOGENOMi HOG000234373.
HOVERGENi HBG051447.
InParanoidi P79728.
KOi K05462.
PhylomeDBi P79728.

Enzyme and pathway databases

Reactomei REACT_237315. EPH-Ephrin signaling.
REACT_250881. EPH-ephrin mediated repulsion of cells.
REACT_258838. EPHA-mediated growth cone collapse.

Miscellaneous databases

NextBioi 20806682.
PROi P79728.

Gene expression databases

Bgeei P79728.

Family and domain databases

Gene3Di 2.60.40.420. 1 hit.
InterProi IPR008972. Cupredoxin.
IPR001799. Ephrin.
IPR019765. Ephrin_CS.
[Graphical view ]
PANTHERi PTHR11304. PTHR11304. 1 hit.
Pfami PF00812. Ephrin. 1 hit.
[Graphical view ]
PRINTSi PR01347. EPHRIN.
ProDomi PD002533. Ephrin. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SUPFAMi SSF49503. SSF49503. 1 hit.
PROSITEi PS01299. EPHRIN_RBD_1. 1 hit.
PS51551. EPHRIN_RBD_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Two Eph receptor tyrosine kinase ligands control axon growth and may be involved in the creation of the retinotectal map in the zebrafish."
    Brennan C., Monschau B., Lindberg R., Guthrie B., Drescher U., Bonhoeffer F., Holder N.
    Development 124:655-664(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Embryo.

Entry informationi

Entry nameiEFNA5_DANRE
AccessioniPrimary (citable) accession number: P79728
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 1, 1997
Last modified: November 26, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3