Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P79728

- EFNA5_DANRE

UniProt

P79728 - EFNA5_DANRE

Protein

Ephrin-A5b

Gene

efna5b

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 1 (01 May 1997)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Induces compartmentalized signaling within a caveolae-like membrane microdomain when bound to the extracellular domain of its cognate receptor. This signaling event requires the activity of the Fyn tyrosine kinase. Activates the epha3 receptor to regulate cell-cell adhesion and cytoskeletal organization. With the receptor epha2 may regulate lens fiber cells shape and interactions and be important for lens transparency maintenance. May function actively to stimulate axon fasciculation By similarity. Controls axon growth and may be involved in the creation of the retino-tectal map.By similarity

    GO - Molecular functioni

    1. ephrin receptor binding Source: RefGenome

    GO - Biological processi

    1. axon guidance Source: RefGenome
    2. ephrin receptor signaling pathway Source: UniProtKB
    3. mesoderm migration involved in gastrulation Source: ZFIN
    4. positive regulation of peptidyl-tyrosine phosphorylation Source: UniProtKB
    5. regulation of actin cytoskeleton organization Source: UniProtKB
    6. regulation of cell-cell adhesion Source: UniProtKB
    7. regulation of focal adhesion assembly Source: UniProtKB
    8. regulation of microtubule cytoskeleton organization Source: UniProtKB
    9. regulation of Rac GTPase activity Source: UniProtKB
    10. regulation of Rho GTPase activity Source: UniProtKB
    11. somitogenesis Source: ZFIN

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Differentiation, Neurogenesis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ephrin-A5b
    Alternative name(s):
    AL-1
    EPH-related receptor tyrosine kinase ligand 7
    Short name:
    LERK-7
    ZfEPHL4
    Gene namesi
    Name:efna5b
    Synonyms:al1, efna5, eplg7, lerk7
    OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
    Taxonomic identifieri7955 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
    ProteomesiUP000000437: Unplaced

    Organism-specific databases

    ZFINiZDB-GENE-980526-186. efna5b.

    Subcellular locationi

    GO - Cellular componenti

    1. anchored component of external side of plasma membrane Source: UniProtKB
    2. anchored component of plasma membrane Source: RefGenome
    3. plasma membrane Source: UniProtKB

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020Sequence AnalysisAdd
    BLAST
    Chaini21 – 204184Ephrin-A5bPRO_0000008385Add
    BLAST
    Propeptidei205 – 22824Removed in mature formSequence AnalysisPRO_0000008386Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi37 – 371N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi62 ↔ 102PROSITE-ProRule annotation
    Disulfide bondi90 ↔ 151PROSITE-ProRule annotation
    Lipidationi204 – 2041GPI-anchor amidated serineSequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

    Expressioni

    Tissue specificityi

    Widespread expression in the embryo.

    Developmental stagei

    Expressed in the presumptive midbrain of developing embryos from the six-somite stage. By 24 hours, strongly expressed in the midbrain caudal to the presumptive tectum. At later stages, maintained at the posterior margin of the tectum.

    Gene expression databases

    BgeeiP79728.

    Structurei

    3D structure databases

    ProteinModelPortaliP79728.
    SMRiP79728. Positions 28-164.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini29 – 162134Ephrin RBDPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the ephrin family.PROSITE-ProRule annotation
    Contains 1 ephrin RBD (ephrin receptor-binding) domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    HOGENOMiHOG000234373.
    HOVERGENiHBG051447.
    KOiK05462.
    PhylomeDBiP79728.

    Family and domain databases

    Gene3Di2.60.40.420. 1 hit.
    InterProiIPR008972. Cupredoxin.
    IPR001799. Ephrin.
    IPR019765. Ephrin_CS.
    [Graphical view]
    PANTHERiPTHR11304. PTHR11304. 1 hit.
    PfamiPF00812. Ephrin. 1 hit.
    [Graphical view]
    PRINTSiPR01347. EPHRIN.
    ProDomiPD002533. Ephrin. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SUPFAMiSSF49503. SSF49503. 1 hit.
    PROSITEiPS01299. EPHRIN_RBD_1. 1 hit.
    PS51551. EPHRIN_RBD_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P79728-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLQAEMIVFV GVILWMCVFS QEPSSKVMAD RYAVFWNRTN PRFQRGDYHI    50
    DVCINDYLDV YCPHYEDSVP EERTERYVLY MVNYDGYSTC DHTAKGFKRW 100
    ECNRPHSPNG PLKFSEKFQL FTPFSLGFEF RPGREYYYIS SMITETGRRS 150
    CLKLKVFVRP PNGCEKTIGV HDRVFVDDKV DNALEPRDDT SHEAEPSRSD 200
    VSTSGLRHQT SRPLLALLLL CISLYLLL 228
    Length:228
    Mass (Da):26,595
    Last modified:May 1, 1997 - v1
    Checksum:i74B3406C05418E6E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y09669 mRNA. Translation: CAA70864.1.
    RefSeqiNP_571101.1. NM_131026.2.
    UniGeneiDr.19377.

    Genome annotation databases

    GeneIDi30223.
    KEGGidre:30223.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y09669 mRNA. Translation: CAA70864.1 .
    RefSeqi NP_571101.1. NM_131026.2.
    UniGenei Dr.19377.

    3D structure databases

    ProteinModelPortali P79728.
    SMRi P79728. Positions 28-164.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 30223.
    KEGGi dre:30223.

    Organism-specific databases

    CTDi 30223.
    ZFINi ZDB-GENE-980526-186. efna5b.

    Phylogenomic databases

    HOGENOMi HOG000234373.
    HOVERGENi HBG051447.
    KOi K05462.
    PhylomeDBi P79728.

    Miscellaneous databases

    NextBioi 20806682.
    PROi P79728.

    Gene expression databases

    Bgeei P79728.

    Family and domain databases

    Gene3Di 2.60.40.420. 1 hit.
    InterProi IPR008972. Cupredoxin.
    IPR001799. Ephrin.
    IPR019765. Ephrin_CS.
    [Graphical view ]
    PANTHERi PTHR11304. PTHR11304. 1 hit.
    Pfami PF00812. Ephrin. 1 hit.
    [Graphical view ]
    PRINTSi PR01347. EPHRIN.
    ProDomi PD002533. Ephrin. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SUPFAMi SSF49503. SSF49503. 1 hit.
    PROSITEi PS01299. EPHRIN_RBD_1. 1 hit.
    PS51551. EPHRIN_RBD_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Two Eph receptor tyrosine kinase ligands control axon growth and may be involved in the creation of the retinotectal map in the zebrafish."
      Brennan C., Monschau B., Lindberg R., Guthrie B., Drescher U., Bonhoeffer F., Holder N.
      Development 124:655-664(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Embryo.

    Entry informationi

    Entry nameiEFNA5_DANRE
    AccessioniPrimary (citable) accession number: P79728
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: May 1, 1997
    Last modified: October 1, 2014
    This is version 96 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3