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Protein
Submitted name:

Cathepsin L

Gene

ctslb

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol proteaseSAAS annotation

Protein family/group databases

MEROPSiC01.A65.

Names & Taxonomyi

Protein namesi
Submitted name:
Cathepsin LImported
Gene namesi
Name:ctslbImported
Synonyms:ctsl1bImported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Organism-specific databases

ZFINiZDB-GENE-980526-285. ctslb.

Subcellular locationi

GO - Cellular componenti

  • extracellular region Source: ZFIN
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1616UniRule annotationAdd
BLAST
Chaini17 – 336320UniRule annotationPRO_5005399933Add
BLAST

Proteomic databases

PaxDbiP79722.
PRIDEiP79722.

Expressioni

Gene expression databases

BgeeiP79722.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000119564.

Structurei

3D structure databases

ProteinModelPortaliP79722.
SMRiP79722. Positions 21-336.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini28 – 8760Inhibitor_I29InterPro annotationAdd
BLAST
Domaini115 – 335221Pept_C1InterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase C1 family.UniRule annotationSAAS annotation

Keywords - Domaini

SignalUniRule annotation

Phylogenomic databases

eggNOGiKOG1543. Eukaryota.
COG4870. LUCA.
HOGENOMiHOG000230774.
HOVERGENiHBG011513.
KOiK01365.

Family and domain databases

InterProiIPR025661. Pept_asp_AS.
IPR000169. Pept_cys_AS.
IPR025660. Pept_his_AS.
IPR013128. Peptidase_C1A.
IPR000668. Peptidase_C1A_C.
IPR013201. Prot_inhib_I29.
[Graphical view]
PANTHERiPTHR12411. PTHR12411. 1 hit.
PfamiPF08246. Inhibitor_I29. 1 hit.
PF00112. Peptidase_C1. 1 hit.
[Graphical view]
PRINTSiPR00705. PAPAIN.
SMARTiSM00848. Inhibitor_I29. 1 hit.
SM00645. Pept_C1. 1 hit.
[Graphical view]
PROSITEiPS00640. THIOL_PROTEASE_ASN. 1 hit.
PS00139. THIOL_PROTEASE_CYS. 1 hit.
PS00639. THIOL_PROTEASE_HIS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P79722-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMFALLVTLY ISAVFAAPSI DIQLDDHWNS WKSQHGKSYH EDVEVGRRMI
60 70 80 90 100
WEENLRKIEQ HNFEYSYGNH TFKMGMNQFG DMTNEEFRQA MNGYTHDPNQ
110 120 130 140 150
TSQGPLFMEP SFFAAPQQVD WRQRGYVTPV KDQKQCGSCW SFSSTGALEG
160 170 180 190 200
QLFRKTGKLI SMSEQNLVDC SRPQGNQGCN GGLMDQAFQY VKENKGLDSE
210 220 230 240 250
QSYPYLARDD LPCRYDPRFN VAKITGFVDI PSGNELALMN AVAAVGPVSV
260 270 280 290 300
AIDASHQSLQ FYQSGIYYER ACSSSRLDHA VLVVGYGYQG ADVAGNRYWI
310 320 330
VKNSWSDKWG DKGYIYMAKD KNNHCGVATK ASYPLM
Length:336
Mass (Da):38,030
Last modified:May 1, 1997 - v1
Checksum:i5E795879F85F6FC2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y08321 mRNA. Translation: CAA69623.1.
RefSeqiNP_571273.1. NM_131198.1.
UniGeneiDr.25683.

Genome annotation databases

GeneIDi30443.
KEGGidre:30443.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y08321 mRNA. Translation: CAA69623.1.
RefSeqiNP_571273.1. NM_131198.1.
UniGeneiDr.25683.

3D structure databases

ProteinModelPortaliP79722.
SMRiP79722. Positions 21-336.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000119564.

Protein family/group databases

MEROPSiC01.A65.

Proteomic databases

PaxDbiP79722.
PRIDEiP79722.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi30443.
KEGGidre:30443.

Organism-specific databases

CTDi30443.
ZFINiZDB-GENE-980526-285. ctslb.

Phylogenomic databases

eggNOGiKOG1543. Eukaryota.
COG4870. LUCA.
HOGENOMiHOG000230774.
HOVERGENiHBG011513.
KOiK01365.

Gene expression databases

BgeeiP79722.

Family and domain databases

InterProiIPR025661. Pept_asp_AS.
IPR000169. Pept_cys_AS.
IPR025660. Pept_his_AS.
IPR013128. Peptidase_C1A.
IPR000668. Peptidase_C1A_C.
IPR013201. Prot_inhib_I29.
[Graphical view]
PANTHERiPTHR12411. PTHR12411. 1 hit.
PfamiPF08246. Inhibitor_I29. 1 hit.
PF00112. Peptidase_C1. 1 hit.
[Graphical view]
PRINTSiPR00705. PAPAIN.
SMARTiSM00848. Inhibitor_I29. 1 hit.
SM00645. Pept_C1. 1 hit.
[Graphical view]
PROSITEiPS00640. THIOL_PROTEASE_ASN. 1 hit.
PS00139. THIOL_PROTEASE_CYS. 1 hit.
PS00639. THIOL_PROTEASE_HIS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Gerster T.P.
    Submitted (SEP-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "Expression of a zebrafish cathepsin L gene in anterior mesendoderm and hatching gland."
    Vogel A., Gerster T.
    Dev. Genes Evol. 206:477-479(1997)
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiP79722_DANRE
AccessioniPrimary (citable) accession number: P79722
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 1997
Last sequence update: May 1, 1997
Last modified: June 8, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.