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P79716

- CP1A1_DICLA

UniProt

P79716 - CP1A1_DICLA

Protein

Cytochrome P450 1A1

Gene

cyp1a1

Organism
Dicentrarchus labrax (European seabass) (Morone labrax)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 79 (01 Oct 2014)
      Sequence version 1 (01 May 1997)
      Previous versions | rss
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    Functioni

    Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

    Catalytic activityi

    RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

    Cofactori

    Heme group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei230 – 2301SubstrateBy similarity
    Metal bindingi464 – 4641Iron (heme axial ligand)By similarity

    GO - Molecular functioni

    1. aromatase activity Source: UniProtKB-EC
    2. heme binding Source: InterPro
    3. iron ion binding Source: InterPro

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome P450 1A1 (EC:1.14.14.1)
    Alternative name(s):
    CYPIA1
    Gene namesi
    Name:cyp1a1
    OrganismiDicentrarchus labrax (European seabass) (Morone labrax)
    Taxonomic identifieri13489 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataPercomorphariaMoronidaeDicentrarchus

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 520520Cytochrome P450 1A1PRO_0000051635Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP79716.
    SMRiP79716. Positions 38-519.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Phylogenomic databases

    HOVERGENiHBG106944.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    IPR008066. Cyt_P450_E_grp-I_CYP1.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00463. EP450I.
    PR01683. EP450ICYP1A.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P79716-1 [UniParc]FASTAAdd to Basket

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    MVLMILPFIG SVSVSESLVA LTTVCLVYLI LKFFRTEIPE GLHRLPGPKP    50
    LPLIGNVLEV GNKPYLSLTA MSKRYGDVFR FRLGMRPSGC LSGSETVRKA 100
    LIKQGDEFAG RPDLYSFRFI NDGKSLAFST DKAGVWRALR KLAYSALRSF 150
    SSLEESTPRD SCVLEEHSAK EGEYLYSNML NAVMKVTGSF DPFRHIVVSV 200
    ANVICGMCFG RRYGHNDQEL LSLVNLSDPF GQVVGSGNPA DFIPVLQFLP 250
    STTMKNFMDI NARFNKFVQK IVSEHYTTYD KDNIRDITDS LIDHCEDRKL 300
    DENANVQMSD EKIVGIVNDL FGAGFDTIST ALSWSVMYLV AYPEIEERLY 350
    QELKENVGLD RTPLLCDRPN LPFLEAFILE IFRHSSFLPF TIPHCTSKDT 400
    SLNGYFIPKD TCVFINQWQI NHDPELWKDP SSFNPDRFLS ADGTELNKLE 450
    GEKVMVFGLG KRRCIGEVIA RNGVFLFLAI IVQKLHFKTL PGEPLDMTPE 500
    YGLTMKHKRC HLRATMRASE 520
    Length:520
    Mass (Da):58,744
    Last modified:May 1, 1997 - v1
    Checksum:i86761584B28E57FB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U78316 mRNA. Translation: AAB36951.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U78316 mRNA. Translation: AAB36951.1 .

    3D structure databases

    ProteinModelPortali P79716.
    SMRi P79716. Positions 38-519.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG106944.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    IPR008066. Cyt_P450_E_grp-I_CYP1.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00463. EP450I.
    PR01683. EP450ICYP1A.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of a CYP1A cDNA from the teleost fish Dicentrarchus labrax."
      Stien X., Amichot M., Berge J.-B., Lafaurie M.
      Comp. Biochem. Physiol. 121C:241-248(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Liver.

    Entry informationi

    Entry nameiCP1A1_DICLA
    AccessioniPrimary (citable) accession number: P79716
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1999
    Last sequence update: May 1, 1997
    Last modified: October 1, 2014
    This is version 79 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3