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Protein

Vascular endothelial growth factor receptor 3

Gene

FLT4

Organism
Coturnix coturnix (Common quail) (Tetrao coturnix)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFC and VEGFD, and plays an essential role in lymphangiogenesis and in the development of the vascular network and the cardiovascular system during embryonic development. Promotes proliferation, survival and migration of endothelial cells, and regulates angiogenic sprouting. Mediates activation of the MAPK1/ERK2, MAPK3/ERK1 signaling pathway, of MAPK8 and the JUN signaling pathway, and of the AKT1 signaling pathway (By similarity).By similarity

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

Enzyme regulationi

Present in an inactive conformation in the absence of bound ligand. Binding of VEGFC or VEGFD leads to dimerization and activation by autophosphorylation on tyrosine residues (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei892 – 8921ATPPROSITE-ProRule annotation
Active sitei1049 – 10491Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi864 – 8729ATPPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Receptor, Transferase, Tyrosine-protein kinase

Keywords - Biological processi

Angiogenesis, Differentiation

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Vascular endothelial growth factor receptor 3 (EC:2.7.10.1)
Short name:
VEGFR-3
Alternative name(s):
Endothelial kinase receptor EK2
Quek 2
Short name:
Quek2
Gene namesi
Name:FLT4
Synonyms:K2, VEGFR3
OrganismiCoturnix coturnix (Common quail) (Tetrao coturnix)
Taxonomic identifieri9091 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePerdicinaeCoturnix

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini20 – 788769ExtracellularSequence analysisAdd
BLAST
Transmembranei789 – 80921HelicalSequence analysisAdd
BLAST
Topological domaini810 – 1379570CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence analysisAdd
BLAST
Chaini20 – 13791360Vascular endothelial growth factor receptor 3PRO_0000249463Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi51 ↔ 120PROSITE-ProRule annotation
Glycosylationi113 – 1131N-linked (GlcNAc...)Sequence analysis
Disulfide bondi167 ↔ 215PROSITE-ProRule annotation
Glycosylationi175 – 1751N-linked (GlcNAc...)Sequence analysis
Glycosylationi260 – 2601N-linked (GlcNAc...)Sequence analysis
Disulfide bondi261 ↔ 319PROSITE-ProRule annotation
Glycosylationi308 – 3081N-linked (GlcNAc...)Sequence analysis
Disulfide bondi453 ↔ 548PROSITE-ProRule annotation
Glycosylationi529 – 5291N-linked (GlcNAc...)Sequence analysis
Glycosylationi541 – 5411N-linked (GlcNAc...)Sequence analysis
Disulfide bondi592 ↔ 666PROSITE-ProRule annotation
Glycosylationi596 – 5961N-linked (GlcNAc...)Sequence analysis
Glycosylationi608 – 6081N-linked (GlcNAc...)Sequence analysis
Glycosylationi655 – 6551N-linked (GlcNAc...)Sequence analysis
Glycosylationi696 – 6961N-linked (GlcNAc...)Sequence analysis
Glycosylationi703 – 7031N-linked (GlcNAc...)Sequence analysis
Disulfide bondi712 ↔ 761PROSITE-ProRule annotation
Glycosylationi771 – 7711N-linked (GlcNAc...)Sequence analysis
Modified residuei1075 – 10751Phosphotyrosine; by autocatalysisBy similarity
Modified residuei1080 – 10801Phosphotyrosine; by autocatalysisBy similarity
Modified residuei1239 – 12391Phosphotyrosine; by autocatalysisBy similarity
Modified residuei1240 – 12401Phosphotyrosine; by autocatalysisBy similarity
Modified residuei1274 – 12741Phosphotyrosine; by autocatalysisBy similarity
Modified residuei1342 – 13421Phosphotyrosine; by autocatalysisBy similarity
Modified residuei1346 – 13461Phosphotyrosine; by autocatalysisBy similarity

Post-translational modificationi

Autophosphorylated on tyrosine residues upon ligand binding. Autophosphorylation occurs in trans, i.e. one subunit of the dimeric receptor phosphorylates tyrosine residues on the other subunit (By similarity).By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PRIDEiP79701.

Interactioni

Subunit structurei

Interacts with VEGFC and VEGFD. Monomer in the absence of bound VEGFC or VEGFD. Homodimer in the presence of bound VEGFC or VEGFD (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliP79701.
SMRiP79701. Positions 840-1192.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini30 – 136107Ig-like C2-type 1Add
BLAST
Domaini160 – 22263Ig-like C2-type 2Add
BLAST
Domaini240 – 33596Ig-like C2-type 3Add
BLAST
Domaini340 – 42182Ig-like C2-type 4Add
BLAST
Domaini430 – 566137Ig-like C2-type 5Add
BLAST
Domaini569 – 684116Ig-like C2-type 6Add
BLAST
Domaini691 – 77787Ig-like C2-type 7Add
BLAST
Domaini858 – 1185328Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG053432.

Family and domain databases

Gene3Di2.60.40.10. 8 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR001824. Tyr_kinase_rcpt_3_CS.
IPR009137. VEGFR3_rcpt.
[Graphical view]
PANTHERiPTHR24416:SF49. PTHR24416:SF49. 3 hits.
PfamiPF07679. I-set. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PRINTSiPR01835. VEGFRECEPTR3.
SMARTiSM00409. IG. 6 hits.
SM00408. IGc2. 4 hits.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 8 hits.
SSF56112. SSF56112. 2 hits.
PROSITEiPS50835. IG_LIKE. 5 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS00240. RECEPTOR_TYR_KIN_III. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P79701-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKRVCTLPLW LWLGIVSEAD LVSSYSMTPP TLSITEEEHI INAKDTLTIT
60 70 80 90 100
CRGQHPLEWS WPGARWTPVE GRRRWNSQPQ QRPVGAGNPE EDCEGTGTKP
110 120 130 140 150
YCKVLVLTES QANDTGYYHC YYKYIDAKIE GTTAVSAYIF VRDFEQPFIN
160 170 180 190 200
KPETLLISKK ENTWVPCLVS IPDLNVTLIS QNSLIHPDRK TIFWDNKKGM
210 220 230 240 250
QVPTQLIRDS LFVQCETVID NKVFKSNFFI IHIAGIELYD IQLYPKKAME
260 270 280 290 300
LLVGEKLVLN CTVWAEFNSG VRFQWTYPGK QMQRAVIESE RRSLQTHTEL
310 320 330 340 350
SSILTLHNVS QQDLGRYTCT ATNGAQMLEE STDVIVHEKP FINVEWRKGP
360 370 380 390 400
VIEATAGDEA VKLPVKVVAY PQPDFQWYKA GKLIPKQSQS SMQIKDVAEH
410 420 430 440 450
HAGTYTLVLR NRLVGLEKRI SLQLIVNVPP RIHEKETSSP SIYSRRSPQA
460 470 480 490 500
LTCTVYGIPA PEVIQWQWRP WMPCRMFSRR SLNSRHRAAR RHQRDRMPEC
510 520 530 540 550
KDWKDVSRQD AVNPIESIDT WVEFVEGRNK TVSKLAIQEA NVSAMYKCIA
560 570 580 590 600
SNKVGRDERL IYFYVTTIPD GFEIESQPSE EPIEGQDLQL SCNADNYTYE
610 620 630 640 650
NLQWYRLNLS KLHDEEGNPL VLDCKNVHHY ATKMQGELRF QPDSNDATLL
660 670 680 690 700
LTIPNISLGE EGDYVCEVQN RKTREKHCHK KYISVQALEI PRLKQNLTDI
710 720 730 740 750
WVNVSDSIEM RCKVDGNHVP DISWYKDEKL VEEVSGIDLA DFNQRLSIQR
760 770 780 790 800
VREEDAGLYL CSVCNAKGCV NSSASVSVEG SDDKTNVEIV ILIGTGVIAV
810 820 830 840 850
FFWILLIIIF CNIKRPAHAD IKTGYLSIIM DPGEVPLEEQ CAYLPYDSSK
860 870 880 890 900
WEFPRDRLRL GKVLGHGAFG KVVEASAFGI NKSNSCETVA AKMLKEGATA
910 920 930 940 950
SEQKALMSEL KILIHIGNHL NVVNLLGACT KPNGPLMVIV EFCKYGNLSN
960 970 980 990 1000
YLRTKREGFS PYREKSPRLR IQVQSIVEAV RADRRSRSGT SDSAIFNRFL
1010 1020 1030 1040 1050
MHKSQTVQPI QEVDDLWQSP LTMEDLICYS FQVARGMEFL ASRKCIHRDL
1060 1070 1080 1090 1100
AARNILLSEN NVVKICDFGL ARDIYKDPDY VRKGSARLPL KWMAPESIFD
1110 1120 1130 1140 1150
KVYTTQSDVW SFGVLLWEIF SLGASPYPGV QINEEFCQRF KDGTRMRAPE
1160 1170 1180 1190 1200
YTTAEIYRIM LSCWHGDPKE RPTFSDLVEI LGNLLQENVQ QEGKDYIPLN
1210 1220 1230 1240 1250
DSHSSEDDGF SQVPSSAQQN SDEEDFDMRI RCHSLAARYY NCVSFPGCLT
1260 1270 1280 1290 1300
GGNQIRCSSR IKTFEEFPMT HTMYKAHPDN QTDSGMVLAS EEFERIENRH
1310 1320 1330 1340 1350
RKEGGFSSKG PNRTAELSAE QSDLRGRCRP SYGSQVGGQT FYNSEYGELS
1360 1370
EHSEDRSCTP PAEGASPPAL HASFFSEQY
Length:1,379
Mass (Da):156,963
Last modified:May 1, 1997 - v1
Checksum:i8411621AEF565520
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X83287 mRNA. Translation: CAA58267.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X83287 mRNA. Translation: CAA58267.1.

3D structure databases

ProteinModelPortaliP79701.
SMRiP79701. Positions 840-1192.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiP79701.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG053432.

Family and domain databases

Gene3Di2.60.40.10. 8 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR001824. Tyr_kinase_rcpt_3_CS.
IPR009137. VEGFR3_rcpt.
[Graphical view]
PANTHERiPTHR24416:SF49. PTHR24416:SF49. 3 hits.
PfamiPF07679. I-set. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PRINTSiPR01835. VEGFRECEPTR3.
SMARTiSM00409. IG. 6 hits.
SM00408. IGc2. 4 hits.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 8 hits.
SSF56112. SSF56112. 2 hits.
PROSITEiPS50835. IG_LIKE. 5 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS00240. RECEPTOR_TYR_KIN_III. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular cloning of Quek 1 and 2, two quail vascular endothelial growth factor (VEGF) receptor-like molecules."
    Eichmann A., Marcelle C., Breant C., Le Douarin N.M.
    Gene 174:3-8(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Embryo.

Entry informationi

Entry nameiVGFR3_COTCO
AccessioniPrimary (citable) accession number: P79701
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: May 1, 1997
Last modified: May 11, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.