Reviewed, UniProtKB/Swiss-Prot P79699 (CP19A_COTJA)

Names and origin

Protein names

Recommended name:
    Cytochrome P450 19A1
    EC=1.14.14.1
Alternative name(s):
    CYPXIX
    Aromatase
    Estrogen synthetase
    P-450AROM

Gene names

Name:	CYP19A1
Synonyms:	CYP19

Organism

Coturnix coturnix japonica (Japanese quail)

Taxonomic identifier

93934 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Perdicinae › Coturnix

Protein attributes

Sequence length	327 AA.
Sequence status	Fragments.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Catalyzes the formation of aromatic C18 estrogens from C19 androgens.
Catalytic activity	RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.
Cofactor	Heme group By similarity.
Subcellular location	Membrane; Peripheral membrane protein.
Sequence similarities	Belongs to the cytochrome P450 family.

Ontologies

Keywords
Cellular component	Membrane
Ligand	Heme Iron Metal-binding
Molecular function	Monooxygenase Oxidoreductase
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	extrinsic to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	aromatase activity Inferred from electronic annotation. Source: EC electron carrier activity Inferred from electronic annotation. Source: InterPro heme binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – ›327	›327	Cytochrome P450 19A1		PRO_0000051965
Sites
	Metal binding	315	1	Iron (heme axial ligand) By similarity
Experimental info
	Non-adjacent residues	97 – 98	2
	Non-terminal residue	327	1

Sequences

	Sequence		Length	Mass (Da)
	P79699-1 [UniParc]. Last modified December 15, 1998. Version 2. Checksum: CF568A94BA23127B	FASTA	327	37,445
	10 20 30 40 50 60 MIPETLNPLN YYTSLVPDLI PAATVPIIIL ICVLFLIWNH EGTSSIPGPG YCMGIGPLIS 70 80 90 100 110 120 HGRFLWMGVG NACNYYNKTY GEFVRVWFSG EETFIISYFD AWQALLLKPD IFFKISWLCK 130 140 150 160 170 180 KYEEAAKDLK GAMEILIEQK RQKLSTVEKL DEHMDFASQL IFAQNRGDLT AENVNQCVLE 190 200 210 220 230 240 MMIAAPDTLS VTLFIMLILI AEHPTVEEKM MREIETVMGD RDVQSDDMPN LKIVENFIYE 250 260 270 280 290 300 SMRYQPVVDL IMRKALQDDV IDGYPVKKGT NIILNIGRMH KLEFFPKPNE FSLENFEKNV 310 320 PSRYFQPFGF GPRGCVGKFI AMVMMKA

References

[1]	"Comparison of 5' upstream regions of chicken and quail aromatase genes." Kudo T., Yamamoto H., Sato S., Sutou S. J. Reprod. Dev. 42:101-107(1996) Cited for: NUCLEOTIDE SEQUENCE OF 1-97.
[2]	"Regulation of aromatase cytochrome P-450 (estrogen synthetase) transcripts in the quail brain by testosterone." Harada N., Yamada K., Foidart A., Balthazart J. Brain Res. Mol. Brain Res. 15:19-26(1992) [PubMed: 1331667] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 98-327. Tissue: Brain.

Cross-references

Sequence databases
EMBLGenBankDDBJ	D50336 Genomic DNA. Translation: BAA08872.1. S46949 mRNA. Translation: AAB23955.1.
PIR	A48977.
3D structure databases
ModBase	Search...
Phylogenomic databases
HOVERGEN	P79699.
Enzyme and pathway databases
BRENDA	1.14.14.1. 142881.
Family and domain databases
InterPro	IPR001128. Cyt_P450. IPR002397. Cyt_P450_B. IPR017973. Cyt_P450_C. IPR017972. Cyt_P450_CS. [Graphical view]
Gene3D	G3DSA:1.10.630.10. Cyt_P450. 1 hit.
PANTHER	PTHR19383. Cyt_P450. 1 hit.
Pfam	PF00067. p450. 2 hits. [Graphical view]
PRINTS	PR00359. BP450. PR00385. P450.
PROSITE	PS00086. CYTOCHROME_P450. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CP19A_COTJA

Accession

Primary (citable) accession number: P79699
Secondary accession number(s): Q92150

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
Last sequence update:	December 15, 1998
Last modified:	October 13, 2009
This is version 63 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)