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P79699

- CP19A_COTJA

UniProt

P79699 - CP19A_COTJA

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Protein

Aromatase

Gene

CYP19A1

Organism
Coturnix coturnix japonica (Japanese quail) (Coturnix japonica)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Catalyzes the formation of aromatic C18 estrogens from C19 androgens.

Catalytic activityi

Testosterone + 3 O2 + 3 reduced flavoproteins = 17-beta-estradiol + formate + 4 H2O + 3 oxidized flavoproteins.
Androst-4-ene-3,17-dione + 3 O2 + 3 reduced flavoproteins = estrone + formate + 4 H2O + 3 oxidized flavoproteins.

Cofactori

Heme group.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi315 – 3151Iron (heme axial ligand)By similarity

GO - Molecular functioni

  1. heme binding Source: InterPro
  2. iron ion binding Source: InterPro
  3. monooxygenase activity Source: UniProtKB-KW
  4. oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Aromatase (EC:1.14.14.14)
Alternative name(s):
CYPXIX
Cytochrome P-450AROM
Cytochrome P450 19A1
Estrogen synthase
Gene namesi
Name:CYP19A1
Synonyms:CYP19
OrganismiCoturnix coturnix japonica (Japanese quail) (Coturnix japonica)
Taxonomic identifieri93934 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePerdicinaeCoturnix

Subcellular locationi

GO - Cellular componenti

  1. membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – ›327›327AromatasePRO_0000051965Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP79699.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

HOVERGENiHBG050750.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR002397. Cyt_P450_B.
IPR017972. Cyt_P450_CS.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00359. BP450.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragments.

P79699-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIPETLNPLN YYTSLVPDLI PAATVPIIIL ICVLFLIWNH EGTSSIPGPG
60 70 80 90 100
YCMGIGPLIS HGRFLWMGVG NACNYYNKTY GEFVRVWFSG EETFIISYFD
110 120 130 140 150
AWQALLLKPD IFFKISWLCK KYEEAAKDLK GAMEILIEQK RQKLSTVEKL
160 170 180 190 200
DEHMDFASQL IFAQNRGDLT AENVNQCVLE MMIAAPDTLS VTLFIMLILI
210 220 230 240 250
AEHPTVEEKM MREIETVMGD RDVQSDDMPN LKIVENFIYE SMRYQPVVDL
260 270 280 290 300
IMRKALQDDV IDGYPVKKGT NIILNIGRMH KLEFFPKPNE FSLENFEKNV
310 320
PSRYFQPFGF GPRGCVGKFI AMVMMKA
Length:327
Mass (Da):37,445
Last modified:December 15, 1998 - v2
Checksum:iCF568A94BA23127B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-adjacent residuesi97 – 982Curated
Non-terminal residuei327 – 3271

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D50336 Genomic DNA. Translation: BAA08872.1.
S46949 mRNA. Translation: AAB23955.1.
PIRiA48977.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D50336 Genomic DNA. Translation: BAA08872.1 .
S46949 mRNA. Translation: AAB23955.1 .
PIRi A48977.

3D structure databases

ProteinModelPortali P79699.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG050750.

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR002397. Cyt_P450_B.
IPR017972. Cyt_P450_CS.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00359. BP450.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Comparison of 5' upstream regions of chicken and quail aromatase genes."
    Kudo T., Yamamoto H., Sato S., Sutou S.
    J. Reprod. Dev. 42:101-107(1996)
    Cited for: NUCLEOTIDE SEQUENCE OF 1-97.
  2. "Regulation of aromatase cytochrome P-450 (estrogen synthetase) transcripts in the quail brain by testosterone."
    Harada N., Yamada K., Foidart A., Balthazart J.
    Brain Res. Mol. Brain Res. 15:19-26(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 98-327.
    Tissue: Brain.

Entry informationi

Entry nameiCP19A_COTJA
AccessioniPrimary (citable) accession number: P79699
Secondary accession number(s): Q92150
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: December 15, 1998
Last modified: October 29, 2014
This is version 86 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3