Reviewed,
UniProtKB/Swiss-Prot P79699 (CP19A_COTJA)
Last modified
October 13, 2009.
Version 63.
History...
Clusters with 100%,
90%,
50% identity |
Documents (1) |
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Cytochrome P450 19A1 EC=1.14.14.1 Alternative name(s): CYPXIX Aromatase Estrogen synthetase P-450AROM | ||||
| Gene names |
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| Organism | Coturnix coturnix japonica (Japanese quail) | ||||
| Taxonomic identifier | 93934 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Perdicinae › Coturnix |
Protein attributes
| Sequence length | 327 AA. |
| Sequence status | Fragments. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Catalyzes the formation of aromatic C18 estrogens from C19 androgens. |
| Catalytic activity | RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O. |
| Cofactor | Heme group By similarity. |
| Subcellular location | |
| Sequence similarities | Belongs to the cytochrome P450 family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Membrane |
| Ligand | Heme Iron Metal-binding |
| Molecular function | Monooxygenase Oxidoreductase |
| Gene Ontology (GO) | |
| Biological process | oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | extrinsic to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | aromatase activity Inferred from electronic annotation. Source: EC electron carrier activityInferred from electronic annotation. Source: InterPro heme bindingInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
Sequences
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References
| [1] | "Comparison of 5' upstream regions of chicken and quail aromatase genes." Kudo T., Yamamoto H., Sato S., Sutou S. J. Reprod. Dev. 42:101-107(1996) Cited for: NUCLEOTIDE SEQUENCE OF 1-97. |
| [2] | "Regulation of aromatase cytochrome P-450 (estrogen synthetase) transcripts in the quail brain by testosterone." Harada N., Yamada K., Foidart A., Balthazart J. Brain Res. Mol. Brain Res. 15:19-26(1992) [PubMed: 1331667] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 98-327. Tissue: Brain. |
Cross-references
Sequence databases | |
|---|---|
| D50336 Genomic DNA. Translation: BAA08872.1. S46949 mRNA. Translation: AAB23955.1. | |
| PIR | A48977. |
3D structure databases | |
| ModBase | Search... |
Phylogenomic databases | |
| HOVERGEN | P79699. |
Enzyme and pathway databases | |
| BRENDA | 1.14.14.1. 142881. |
Family and domain databases | |
| InterPro | IPR001128. Cyt_P450. IPR002397. Cyt_P450_B. IPR017973. Cyt_P450_C. IPR017972. Cyt_P450_CS. [Graphical view] |
| Gene3D | G3DSA:1.10.630.10. Cyt_P450. 1 hit. |
| PANTHER | PTHR19383. Cyt_P450. 1 hit. |
| Pfam | PF00067. p450. 2 hits. [Graphical view] |
| PRINTS | PR00359. BP450. PR00385. P450. |
| PROSITE | PS00086. CYTOCHROME_P450. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | CP19A_COTJA | ||||||||
| Accession | Primary (citable) accession number: P79699 Secondary accession number(s): Q92150 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||

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