P79699 (CP19A_COTJA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cytochrome P450 19A1
EC=1.14.14.1

Alternative name(s):
Aromatase
CYPXIX
Cytochrome P-450AROM
Estrogen synthase

Gene names

Name:	CYP19A1
Synonyms:	CYP19

Organism

Coturnix coturnix japonica (Japanese quail) (Coturnix japonica)

Taxonomic identifier

93934 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Sauropsida › Sauria › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Perdicinae › Coturnix

Protein attributes

Sequence length	327 AA.
Sequence status	Fragments.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Catalyzes the formation of aromatic C18 estrogens from C19 androgens.
Catalytic activity	RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.
Cofactor	Heme group By similarity.
Subcellular location	Membrane; Peripheral membrane protein.
Sequence similarities	Belongs to the cytochrome P450 family.

Ontologies

Keywords
Cellular component	Membrane
Ligand	Heme Iron Metal-binding
Molecular function	Monooxygenase Oxidoreductase
Gene Ontology (GO)
Cellular_component	membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	aromatase activity Inferred from electronic annotation. Source: EC electron carrier activity Inferred from electronic annotation. Source: InterPro heme binding Inferred from electronic annotation. Source: InterPro iron ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – ›327	›327	Cytochrome P450 19A1		PRO_0000051965
Sites
	Metal binding	315	1	Iron (heme axial ligand) By similarity
Experimental info
	Non-adjacent residues	97 – 98	2
	Non-terminal residue	327	1

Sequences

	Sequence		Length	Mass (Da)
	P79699 [UniParc]. Last modified December 15, 1998. Version 2. Checksum: CF568A94BA23127B	FASTA	327	37,445
	10 20 30 40 50 60 MIPETLNPLN YYTSLVPDLI PAATVPIIIL ICVLFLIWNH EGTSSIPGPG YCMGIGPLIS 70 80 90 100 110 120 HGRFLWMGVG NACNYYNKTY GEFVRVWFSG EETFIISYFD AWQALLLKPD IFFKISWLCK 130 140 150 160 170 180 KYEEAAKDLK GAMEILIEQK RQKLSTVEKL DEHMDFASQL IFAQNRGDLT AENVNQCVLE 190 200 210 220 230 240 MMIAAPDTLS VTLFIMLILI AEHPTVEEKM MREIETVMGD RDVQSDDMPN LKIVENFIYE 250 260 270 280 290 300 SMRYQPVVDL IMRKALQDDV IDGYPVKKGT NIILNIGRMH KLEFFPKPNE FSLENFEKNV 310 320 PSRYFQPFGF GPRGCVGKFI AMVMMKA

References

[1]	"Comparison of 5' upstream regions of chicken and quail aromatase genes." Kudo T., Yamamoto H., Sato S., Sutou S. J. Reprod. Dev. 42:101-107(1996) Cited for: NUCLEOTIDE SEQUENCE OF 1-97.
[2]	"Regulation of aromatase cytochrome P-450 (estrogen synthetase) transcripts in the quail brain by testosterone." Harada N., Yamada K., Foidart A., Balthazart J. Brain Res. Mol. Brain Res. 15:19-26(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 98-327. Tissue: Brain.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D50336 Genomic DNA. Translation: BAA08872.1. S46949 mRNA. Translation: AAB23955.1.
PIR	A48977.
3D structure databases
ProteinModelPortal	P79699.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOVERGEN	HBG050750.
Family and domain databases
Gene3D	1.10.630.10. 1 hit.
InterPro	IPR001128. Cyt_P450. IPR002397. Cyt_P450_B. IPR017972. Cyt_P450_CS. [Graphical view]
Pfam	PF00067. p450. 1 hit. [Graphical view]
PRINTS	PR00359. BP450. PR00385. P450.
SUPFAM	SSF48264. Cytochrome_P450. 1 hit.
PROSITE	PS00086. CYTOCHROME_P450. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CP19A_COTJA

Accession

Primary (citable) accession number: P79699
Secondary accession number(s): Q92150

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
Last sequence update:	December 15, 1998
Last modified:	April 3, 2013
This is version 80 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program