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P79699

- CP19A_COTJA

UniProt

P79699 - CP19A_COTJA

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Protein
Aromatase
Gene
CYP19A1, CYP19
Organism
Coturnix coturnix japonica (Japanese quail) (Coturnix japonica)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalyzes the formation of aromatic C18 estrogens from C19 androgens.

Catalytic activityi

Testosterone + 3 O2 + 3 reduced flavoproteins = 17-beta-estradiol + formate + 4 H2O + 3 oxidized flavoproteins.
Androst-4-ene-3,17-dione + 3 O2 + 3 reduced flavoproteins = estrone + formate + 4 H2O + 3 oxidized flavoproteins.

Cofactori

Heme group By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi315 – 3151Iron (heme axial ligand) By similarity

GO - Molecular functioni

  1. heme binding Source: InterPro
  2. iron ion binding Source: InterPro
  3. monooxygenase activity Source: UniProtKB-KW
  4. oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen Source: InterPro
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Aromatase (EC:1.14.14.14)
    Alternative name(s):
    CYPXIX
    Cytochrome P-450AROM
    Cytochrome P450 19A1
    Estrogen synthase
    Gene namesi
    Name:CYP19A1
    Synonyms:CYP19
    OrganismiCoturnix coturnix japonica (Japanese quail) (Coturnix japonica)
    Taxonomic identifieri93934 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePerdicinaeCoturnix

    Subcellular locationi

    GO - Cellular componenti

    1. membrane Source: UniProtKB-SubCell
    Complete GO annotation...

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – ›327›327Aromatase
    PRO_0000051965Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP79699.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.

    Phylogenomic databases

    HOVERGENiHBG050750.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR002397. Cyt_P450_B.
    IPR017972. Cyt_P450_CS.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00359. BP450.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragments.

    P79699-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIPETLNPLN YYTSLVPDLI PAATVPIIIL ICVLFLIWNH EGTSSIPGPG    50
    YCMGIGPLIS HGRFLWMGVG NACNYYNKTY GEFVRVWFSG EETFIISYFD 100
    AWQALLLKPD IFFKISWLCK KYEEAAKDLK GAMEILIEQK RQKLSTVEKL 150
    DEHMDFASQL IFAQNRGDLT AENVNQCVLE MMIAAPDTLS VTLFIMLILI 200
    AEHPTVEEKM MREIETVMGD RDVQSDDMPN LKIVENFIYE SMRYQPVVDL 250
    IMRKALQDDV IDGYPVKKGT NIILNIGRMH KLEFFPKPNE FSLENFEKNV 300
    PSRYFQPFGF GPRGCVGKFI AMVMMKA 327
    Length:327
    Mass (Da):37,445
    Last modified:December 15, 1998 - v2
    Checksum:iCF568A94BA23127B
    GO

    Non-adjacent residues

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-adjacent residuesi97 – 982

    Non-terminal residue

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei327 – 3271

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D50336 Genomic DNA. Translation: BAA08872.1.
    S46949 mRNA. Translation: AAB23955.1.
    PIRiA48977.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D50336 Genomic DNA. Translation: BAA08872.1 .
    S46949 mRNA. Translation: AAB23955.1 .
    PIRi A48977.

    3D structure databases

    ProteinModelPortali P79699.
    ModBasei Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG050750.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR002397. Cyt_P450_B.
    IPR017972. Cyt_P450_CS.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00359. BP450.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Comparison of 5' upstream regions of chicken and quail aromatase genes."
      Kudo T., Yamamoto H., Sato S., Sutou S.
      J. Reprod. Dev. 42:101-107(1996)
      Cited for: NUCLEOTIDE SEQUENCE OF 1-97.
    2. "Regulation of aromatase cytochrome P-450 (estrogen synthetase) transcripts in the quail brain by testosterone."
      Harada N., Yamada K., Foidart A., Balthazart J.
      Brain Res. Mol. Brain Res. 15:19-26(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 98-327.
      Tissue: Brain.

    Entry informationi

    Entry nameiCP19A_COTJA
    AccessioniPrimary (citable) accession number: P79699
    Secondary accession number(s): Q92150
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: December 15, 1998
    Last modified: January 22, 2014
    This is version 84 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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