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P79699 (CP19A_COTJA) Reviewed, UniProtKB/Swiss-Prot

Last modified January 22, 2014. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Aromatase

EC=1.14.14.14
Alternative name(s):
CYPXIX
Cytochrome P-450AROM
Cytochrome P450 19A1
Estrogen synthase
Gene names
Name:CYP19A1
Synonyms:CYP19
OrganismCoturnix coturnix japonica (Japanese quail) (Coturnix japonica)
Taxonomic identifier93934 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePerdicinaeCoturnix

Protein attributes

Sequence length327 AA.
Sequence statusFragments.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Catalyzes the formation of aromatic C18 estrogens from C19 androgens.

Catalytic activity

Testosterone + 3 O2 + 3 reduced flavoproteins = 17-beta-estradiol + formate + 4 H2O + 3 oxidized flavoproteins.

Androst-4-ene-3,17-dione + 3 O2 + 3 reduced flavoproteins = estrone + formate + 4 H2O + 3 oxidized flavoproteins.

Cofactor

Heme group By similarity.

Subcellular location

Membrane; Peripheral membrane protein.

Sequence similarities

Belongs to the cytochrome P450 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – ›327›327Aromatase
PRO_0000051965

Sites

Metal binding3151Iron (heme axial ligand) By similarity

Experimental info

Non-adjacent residues97 – 982
Non-terminal residue3271

Sequences

Sequence LengthMass (Da)Tools
P79699 [UniParc].

Last modified December 15, 1998. Version 2.
Checksum: CF568A94BA23127B

FASTA32737,445
        10         20         30         40         50         60 
MIPETLNPLN YYTSLVPDLI PAATVPIIIL ICVLFLIWNH EGTSSIPGPG YCMGIGPLIS 

        70         80         90        100        110        120 
HGRFLWMGVG NACNYYNKTY GEFVRVWFSG EETFIISYFD AWQALLLKPD IFFKISWLCK 

       130        140        150        160        170        180 
KYEEAAKDLK GAMEILIEQK RQKLSTVEKL DEHMDFASQL IFAQNRGDLT AENVNQCVLE 

       190        200        210        220        230        240 
MMIAAPDTLS VTLFIMLILI AEHPTVEEKM MREIETVMGD RDVQSDDMPN LKIVENFIYE 

       250        260        270        280        290        300 
SMRYQPVVDL IMRKALQDDV IDGYPVKKGT NIILNIGRMH KLEFFPKPNE FSLENFEKNV 

       310        320 
PSRYFQPFGF GPRGCVGKFI AMVMMKA 

« Hide

References

[1]"Comparison of 5' upstream regions of chicken and quail aromatase genes."
Kudo T., Yamamoto H., Sato S., Sutou S.
J. Reprod. Dev. 42:101-107(1996)
Cited for: NUCLEOTIDE SEQUENCE OF 1-97.
[2]"Regulation of aromatase cytochrome P-450 (estrogen synthetase) transcripts in the quail brain by testosterone."
Harada N., Yamada K., Foidart A., Balthazart J.
Brain Res. Mol. Brain Res. 15:19-26(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 98-327.
Tissue: Brain.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D50336 Genomic DNA. Translation: BAA08872.1.
S46949 mRNA. Translation: AAB23955.1.
PIRA48977.

3D structure databases

ProteinModelPortalP79699.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG050750.

Family and domain databases

Gene3D1.10.630.10. 1 hit.
InterProIPR001128. Cyt_P450.
IPR002397. Cyt_P450_B.
IPR017972. Cyt_P450_CS.
[Graphical view]
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00359. BP450.
PR00385. P450.
SUPFAMSSF48264. SSF48264. 1 hit.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCP19A_COTJA
AccessionPrimary (citable) accession number: P79699
Secondary accession number(s): Q92150
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: December 15, 1998
Last modified: January 22, 2014
This is version 84 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families