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P79690

- CP191_CARAU

UniProt

P79690 - CP191_CARAU

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Protein
Brain aromatase
Gene
cyp19a1, cyp19
Organism
Carassius auratus (Goldfish)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalyzes the formation of aromatic C18 estrogens from C19 androgens.

Catalytic activityi

Testosterone + 3 O2 + 3 reduced flavoproteins = 17-beta-estradiol + formate + 4 H2O + 3 oxidized flavoproteins.
Androst-4-ene-3,17-dione + 3 O2 + 3 reduced flavoproteins = estrone + formate + 4 H2O + 3 oxidized flavoproteins.

Cofactori

Heme group By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi435 – 4351Iron (heme axial ligand) By similarity

GO - Molecular functioni

  1. heme binding Source: InterPro
  2. iron ion binding Source: InterPro
  3. monooxygenase activity Source: UniProtKB-KW
  4. oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Brain aromatase (EC:1.14.14.14)
Alternative name(s):
CYPXIXA1
Cytochrome P-450AROM
Cytochrome P450 19 type 1
Estrogen synthase
Gene namesi
Name:cyp19a1
Synonyms:cyp19
OrganismiCarassius auratus (Goldfish)
Taxonomic identifieri7957 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeCarassius

Subcellular locationi

GO - Cellular componenti

  1. membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 510510Brain aromatase
PRO_0000051968Add
BLAST

Expressioni

Tissue specificityi

Brain specific.

Structurei

3D structure databases

ProteinModelPortaliP79690.

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.

Phylogenomic databases

HOVERGENiHBG050750.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P79690-1 [UniParc]FASTAAdd to Basket

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MEEVLKGTVN FAAAVQVTLM ALTGTLLLIL LHRIFTAKNW RNQSGVPGPG    50
WLLGLGPIMS YSRFLWMGIG SACNYYNEKY GSIARVWISG EETFILSKSS 100
AVYHVLKSNN YTGRFASKKG LQCIGMFEQG IIFNSNMALW KKVRTYFTKA 150
LTGPGLQKSV DVCVSATNKQ LNVLQEFTDH SGHVDVLNLL RCIVVDVSNR 200
LFLRIPLNEK DLLIKIHRYF STWQAVLIQP DVFFRLNFVY KKYHLAAKEL 250
QDEMGKLVEQ KRQAINNMEK LDETDFATEL IFAQNHDELS VDDVRQCVLE 300
MVIAAPDTLS ISLFFMLLLL KQNSVVEEQI VQEIQSQIGE RDVESADLQK 350
LNVLERFIKE SLRFHPVVDF IMRRALEDDE IDGYRVAKGT NLILNIGRMH 400
KSEFFQKPNE FNLENFENTV PSRYFQPFGC GPRACVGKHI AMVMTKAILV 450
TLLSRFTVCP RHGCTVSTIK QTNNLSMQPV EEDPDSLAMR FIPRAQNICG 500
DPHLGEKTEE 510
Length:510
Mass (Da):58,049
Last modified:May 1, 1997 - v1
Checksum:iFAAE56AACF3AC646
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti14 – 141A → T in BAA23757. 1 Publication
Sequence conflicti495 – 4951A → S in BAA23757. 1 Publication
Sequence conflicti509 – 5091E → Q in BAA23757. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U18974 mRNA. Translation: AAB39408.1.
AB009335 mRNA. Translation: BAA23757.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U18974 mRNA. Translation: AAB39408.1 .
AB009335 mRNA. Translation: BAA23757.1 .

3D structure databases

ProteinModelPortali P79690.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG050750.

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00463. EP450I.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Isolation of a goldfish brain cytochrome P450 aromatase cDNA: mRNA expression during the seasonal cycle and after steroid treatment."
    Gelinas D.M., Pitoc G.A., Callard G.V.
    Mol. Cell. Endocrinol. 138:81-93(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. "Two differing cDNAs encoding cytochrome P450arom (aromatase) exist in goldfish."
    Sudrajat A., Yoshiura Y., Gen K., Suetake H., Aida K.
    Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiCP191_CARAU
AccessioniPrimary (citable) accession number: P79690
Secondary accession number(s): O57315
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: May 1, 1997
Last modified: January 22, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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