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P79690 (CP191_CARAU) Reviewed, UniProtKB/Swiss-Prot

Last modified January 22, 2014. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Brain aromatase

EC=1.14.14.14
Alternative name(s):
CYPXIXA1
Cytochrome P-450AROM
Cytochrome P450 19 type 1
Estrogen synthase
Gene names
Name:cyp19a1
Synonyms:cyp19
OrganismCarassius auratus (Goldfish)
Taxonomic identifier7957 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeCarassius

Protein attributes

Sequence length510 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Catalyzes the formation of aromatic C18 estrogens from C19 androgens.

Catalytic activity

Testosterone + 3 O2 + 3 reduced flavoproteins = 17-beta-estradiol + formate + 4 H2O + 3 oxidized flavoproteins.

Androst-4-ene-3,17-dione + 3 O2 + 3 reduced flavoproteins = estrone + formate + 4 H2O + 3 oxidized flavoproteins.

Cofactor

Heme group By similarity.

Subcellular location

Membrane; Peripheral membrane protein.

Tissue specificity

Brain specific.

Sequence similarities

Belongs to the cytochrome P450 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 510510Brain aromatase
PRO_0000051968

Sites

Metal binding4351Iron (heme axial ligand) By similarity

Experimental info

Sequence conflict141A → T in BAA23757. Ref.2
Sequence conflict4951A → S in BAA23757. Ref.2
Sequence conflict5091E → Q in BAA23757. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P79690 [UniParc].

Last modified May 1, 1997. Version 1.
Checksum: FAAE56AACF3AC646

FASTA51058,049
        10         20         30         40         50         60 
MEEVLKGTVN FAAAVQVTLM ALTGTLLLIL LHRIFTAKNW RNQSGVPGPG WLLGLGPIMS 

        70         80         90        100        110        120 
YSRFLWMGIG SACNYYNEKY GSIARVWISG EETFILSKSS AVYHVLKSNN YTGRFASKKG 

       130        140        150        160        170        180 
LQCIGMFEQG IIFNSNMALW KKVRTYFTKA LTGPGLQKSV DVCVSATNKQ LNVLQEFTDH 

       190        200        210        220        230        240 
SGHVDVLNLL RCIVVDVSNR LFLRIPLNEK DLLIKIHRYF STWQAVLIQP DVFFRLNFVY 

       250        260        270        280        290        300 
KKYHLAAKEL QDEMGKLVEQ KRQAINNMEK LDETDFATEL IFAQNHDELS VDDVRQCVLE 

       310        320        330        340        350        360 
MVIAAPDTLS ISLFFMLLLL KQNSVVEEQI VQEIQSQIGE RDVESADLQK LNVLERFIKE 

       370        380        390        400        410        420 
SLRFHPVVDF IMRRALEDDE IDGYRVAKGT NLILNIGRMH KSEFFQKPNE FNLENFENTV 

       430        440        450        460        470        480 
PSRYFQPFGC GPRACVGKHI AMVMTKAILV TLLSRFTVCP RHGCTVSTIK QTNNLSMQPV 

       490        500        510 
EEDPDSLAMR FIPRAQNICG DPHLGEKTEE 

« Hide

References

[1]"Isolation of a goldfish brain cytochrome P450 aromatase cDNA: mRNA expression during the seasonal cycle and after steroid treatment."
Gelinas D.M., Pitoc G.A., Callard G.V.
Mol. Cell. Endocrinol. 138:81-93(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brain.
[2]"Two differing cDNAs encoding cytochrome P450arom (aromatase) exist in goldfish."
Sudrajat A., Yoshiura Y., Gen K., Suetake H., Aida K.
Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brain.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U18974 mRNA. Translation: AAB39408.1.
AB009335 mRNA. Translation: BAA23757.1.

3D structure databases

ProteinModelPortalP79690.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG050750.

Family and domain databases

Gene3D1.10.630.10. 1 hit.
InterProIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00463. EP450I.
PR00385. P450.
SUPFAMSSF48264. SSF48264. 1 hit.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCP191_CARAU
AccessionPrimary (citable) accession number: P79690
Secondary accession number(s): O57315
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: May 1, 1997
Last modified: January 22, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families