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P79690

- CP191_CARAU

UniProt

P79690 - CP191_CARAU

Protein

Brain aromatase

Gene

cyp19a1

Organism
Carassius auratus (Goldfish)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 80 (01 Oct 2014)
      Sequence version 1 (01 May 1997)
      Previous versions | rss
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    Functioni

    Catalyzes the formation of aromatic C18 estrogens from C19 androgens.

    Catalytic activityi

    Testosterone + 3 O2 + 3 reduced flavoproteins = 17-beta-estradiol + formate + 4 H2O + 3 oxidized flavoproteins.
    Androst-4-ene-3,17-dione + 3 O2 + 3 reduced flavoproteins = estrone + formate + 4 H2O + 3 oxidized flavoproteins.

    Cofactori

    Heme group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi435 – 4351Iron (heme axial ligand)By similarity

    GO - Molecular functioni

    1. heme binding Source: InterPro
    2. iron ion binding Source: InterPro
    3. monooxygenase activity Source: UniProtKB-KW
    4. oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen Source: InterPro

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Brain aromatase (EC:1.14.14.14)
    Alternative name(s):
    CYPXIXA1
    Cytochrome P-450AROM
    Cytochrome P450 19 type 1
    Estrogen synthase
    Gene namesi
    Name:cyp19a1
    Synonyms:cyp19
    OrganismiCarassius auratus (Goldfish)
    Taxonomic identifieri7957 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeCarassius

    Subcellular locationi

    GO - Cellular componenti

    1. membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 510510Brain aromatasePRO_0000051968Add
    BLAST

    Expressioni

    Tissue specificityi

    Brain specific.

    Structurei

    3D structure databases

    ProteinModelPortaliP79690.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Phylogenomic databases

    HOVERGENiHBG050750.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00463. EP450I.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P79690-1 [UniParc]FASTAAdd to Basket

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    MEEVLKGTVN FAAAVQVTLM ALTGTLLLIL LHRIFTAKNW RNQSGVPGPG    50
    WLLGLGPIMS YSRFLWMGIG SACNYYNEKY GSIARVWISG EETFILSKSS 100
    AVYHVLKSNN YTGRFASKKG LQCIGMFEQG IIFNSNMALW KKVRTYFTKA 150
    LTGPGLQKSV DVCVSATNKQ LNVLQEFTDH SGHVDVLNLL RCIVVDVSNR 200
    LFLRIPLNEK DLLIKIHRYF STWQAVLIQP DVFFRLNFVY KKYHLAAKEL 250
    QDEMGKLVEQ KRQAINNMEK LDETDFATEL IFAQNHDELS VDDVRQCVLE 300
    MVIAAPDTLS ISLFFMLLLL KQNSVVEEQI VQEIQSQIGE RDVESADLQK 350
    LNVLERFIKE SLRFHPVVDF IMRRALEDDE IDGYRVAKGT NLILNIGRMH 400
    KSEFFQKPNE FNLENFENTV PSRYFQPFGC GPRACVGKHI AMVMTKAILV 450
    TLLSRFTVCP RHGCTVSTIK QTNNLSMQPV EEDPDSLAMR FIPRAQNICG 500
    DPHLGEKTEE 510
    Length:510
    Mass (Da):58,049
    Last modified:May 1, 1997 - v1
    Checksum:iFAAE56AACF3AC646
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti14 – 141A → T in BAA23757. 1 PublicationCurated
    Sequence conflicti495 – 4951A → S in BAA23757. 1 PublicationCurated
    Sequence conflicti509 – 5091E → Q in BAA23757. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U18974 mRNA. Translation: AAB39408.1.
    AB009335 mRNA. Translation: BAA23757.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U18974 mRNA. Translation: AAB39408.1 .
    AB009335 mRNA. Translation: BAA23757.1 .

    3D structure databases

    ProteinModelPortali P79690.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG050750.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00463. EP450I.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation of a goldfish brain cytochrome P450 aromatase cDNA: mRNA expression during the seasonal cycle and after steroid treatment."
      Gelinas D.M., Pitoc G.A., Callard G.V.
      Mol. Cell. Endocrinol. 138:81-93(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain.
    2. "Two differing cDNAs encoding cytochrome P450arom (aromatase) exist in goldfish."
      Sudrajat A., Yoshiura Y., Gen K., Suetake H., Aida K.
      Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiCP191_CARAU
    AccessioniPrimary (citable) accession number: P79690
    Secondary accession number(s): O57315
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: May 1, 1997
    Last modified: October 1, 2014
    This is version 80 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3