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Protein

Brain aromatase

Gene

cyp19a1

Organism
Carassius auratus (Goldfish)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the formation of aromatic C18 estrogens from C19 androgens.

Catalytic activityi

Testosterone + 3 O2 + 3 reduced flavoproteins = 17-beta-estradiol + formate + 4 H2O + 3 oxidized flavoproteins.
Androst-4-ene-3,17-dione + 3 O2 + 3 reduced flavoproteins = estrone + formate + 4 H2O + 3 oxidized flavoproteins.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi435 – 4351Iron (heme axial ligand)By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Brain aromatase (EC:1.14.14.14)
Alternative name(s):
CYPXIXA1
Cytochrome P-450AROM
Cytochrome P450 19 type 1
Estrogen synthase
Gene namesi
Name:cyp19a1
Synonyms:cyp19
OrganismiCarassius auratus (Goldfish)
Taxonomic identifieri7957 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeCarassius

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 510510Brain aromatasePRO_0000051968Add
BLAST

Expressioni

Tissue specificityi

Brain specific.

Structurei

3D structure databases

ProteinModelPortaliP79690.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

HOVERGENiHBG050750.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P79690-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEVLKGTVN FAAAVQVTLM ALTGTLLLIL LHRIFTAKNW RNQSGVPGPG
60 70 80 90 100
WLLGLGPIMS YSRFLWMGIG SACNYYNEKY GSIARVWISG EETFILSKSS
110 120 130 140 150
AVYHVLKSNN YTGRFASKKG LQCIGMFEQG IIFNSNMALW KKVRTYFTKA
160 170 180 190 200
LTGPGLQKSV DVCVSATNKQ LNVLQEFTDH SGHVDVLNLL RCIVVDVSNR
210 220 230 240 250
LFLRIPLNEK DLLIKIHRYF STWQAVLIQP DVFFRLNFVY KKYHLAAKEL
260 270 280 290 300
QDEMGKLVEQ KRQAINNMEK LDETDFATEL IFAQNHDELS VDDVRQCVLE
310 320 330 340 350
MVIAAPDTLS ISLFFMLLLL KQNSVVEEQI VQEIQSQIGE RDVESADLQK
360 370 380 390 400
LNVLERFIKE SLRFHPVVDF IMRRALEDDE IDGYRVAKGT NLILNIGRMH
410 420 430 440 450
KSEFFQKPNE FNLENFENTV PSRYFQPFGC GPRACVGKHI AMVMTKAILV
460 470 480 490 500
TLLSRFTVCP RHGCTVSTIK QTNNLSMQPV EEDPDSLAMR FIPRAQNICG
510
DPHLGEKTEE
Length:510
Mass (Da):58,049
Last modified:May 1, 1997 - v1
Checksum:iFAAE56AACF3AC646
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti14 – 141A → T in BAA23757 (Ref. 2) Curated
Sequence conflicti495 – 4951A → S in BAA23757 (Ref. 2) Curated
Sequence conflicti509 – 5091E → Q in BAA23757 (Ref. 2) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18974 mRNA. Translation: AAB39408.1.
AB009335 mRNA. Translation: BAA23757.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18974 mRNA. Translation: AAB39408.1.
AB009335 mRNA. Translation: BAA23757.1.

3D structure databases

ProteinModelPortaliP79690.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG050750.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Isolation of a goldfish brain cytochrome P450 aromatase cDNA: mRNA expression during the seasonal cycle and after steroid treatment."
    Gelinas D.M., Pitoc G.A., Callard G.V.
    Mol. Cell. Endocrinol. 138:81-93(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. "Two differing cDNAs encoding cytochrome P450arom (aromatase) exist in goldfish."
    Sudrajat A., Yoshiura Y., Gen K., Suetake H., Aida K.
    Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiCP191_CARAU
AccessioniPrimary (citable) accession number: P79690
Secondary accession number(s): O57315
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: May 1, 1997
Last modified: January 7, 2015
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.