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Protein

Proline-rich protein 3

Gene

PRR3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri155 – 183C3H1-typePROSITE-ProRule annotationAdd BLAST29

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • RNA binding Source: UniProtKB

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Proline-rich protein 3
Alternative name(s):
MHC class I region proline-rich protein CAT56
Gene namesi
Name:PRR3
Synonyms:CAT56
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000204576.11.
HGNCiHGNC:21149. PRR3.

Pathology & Biotechi

Organism-specific databases

DisGeNETi80742.
OpenTargetsiENSG00000204576.
PharmGKBiPA134950097.

Polymorphism and mutation databases

BioMutaiPRR3.
DMDMi59798092.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002138891 – 188Proline-rich protein 3Add BLAST188

Proteomic databases

EPDiP79522.
PaxDbiP79522.
PeptideAtlasiP79522.
PRIDEiP79522.

PTM databases

iPTMnetiP79522.
PhosphoSitePlusiP79522.

Expressioni

Gene expression databases

BgeeiENSG00000204576.
CleanExiHS_PRR3.
ExpressionAtlasiP79522. baseline and differential.
GenevisibleiP79522. HS.

Organism-specific databases

HPAiHPA064061.

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi123286. 30 interactors.
IntActiP79522. 26 interactors.
STRINGi9606.ENSP00000365744.

Structurei

3D structure databases

ProteinModelPortaliP79522.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi12 – 118Pro-richAdd BLAST107

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri155 – 183C3H1-typePROSITE-ProRule annotationAdd BLAST29

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiENOG410J4IA. Eukaryota.
ENOG4111CMK. LUCA.
GeneTreeiENSGT00530000063820.
HOVERGENiHBG053700.
InParanoidiP79522.
OMAiSAFHRGP.
OrthoDBiEOG091G07K1.
PhylomeDBiP79522.
TreeFamiTF337284.

Family and domain databases

Gene3Di4.10.1000.10. 1 hit.
InterProiView protein in InterPro
IPR000571. Znf_CCCH.
PfamiView protein in Pfam
PF00642. zf-CCCH. 1 hit.
SMARTiView protein in SMART
SM00356. ZnF_C3H1. 1 hit.
SUPFAMiSSF90229. SSF90229. 1 hit.
PROSITEiView protein in PROSITE
PS50103. ZF_C3H1. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P79522-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPKRKKQNHH QPPTQQQPPL PEREETGDEE DGSPIGPPSL LGPPPMANGK
60 70 80 90 100
PGDPKSALHR GPPGSRGPLI PPLLSLPPPP WGRGPIRRGL GPRSSPYGRG
110 120 130 140 150
WWGVNAEPPF PGPGHGGPTR GSFHKEQRNP RRLKSWSLIK NTCPPKDDPQ
160 170 180
VMEDKSDRPV CRHFAKKGHC RYEDLCAFYH PGVNGPPL
Length:188
Mass (Da):20,640
Last modified:February 15, 2005 - v2
Checksum:i1EFDAFB4FFBBE153
GO
Isoform 2 (identifier: P79522-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     36-56: Missing.

Note: No experimental confirmation available.
Show »
Length:167
Mass (Da):18,644
Checksum:i83E9572CC89E30D4
GO

Sequence cautioni

The sequence AAB40147 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05296361G → S1 PublicationCorresponds to variant dbSNP:rs3888778Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01281836 – 56Missing in isoform 2. CuratedAdd BLAST21

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U63336 mRNA. Translation: AAB40147.1. Different initiation.
AL662825 Genomic DNA. No translation available.
AL662800 Genomic DNA. No translation available.
BX000357 Genomic DNA. No translation available.
BX248518 Genomic DNA. No translation available.
BX927220 Genomic DNA. No translation available.
CR388372 Genomic DNA. No translation available.
CR847863 Genomic DNA. No translation available.
BC126457 mRNA. Translation: AAI26458.1.
CCDSiCCDS43440.1. [P79522-1]
CCDS43441.1. [P79522-2]
RefSeqiNP_079539.2. NM_025263.3. [P79522-1]
UniGeneiHs.118354.
Hs.651434.

Genome annotation databases

EnsembliENST00000376557; ENSP00000365740; ENSG00000204576. [P79522-2]
ENST00000376560; ENSP00000365744; ENSG00000204576. [P79522-1]
ENST00000383592; ENSP00000373086; ENSG00000206491. [P79522-1]
ENST00000418065; ENSP00000404669; ENSG00000206491. [P79522-2]
ENST00000422140; ENSP00000411802; ENSG00000228186. [P79522-2]
ENST00000422639; ENSP00000401499; ENSG00000229202. [P79522-2]
ENST00000427729; ENSP00000402596; ENSG00000223766. [P79522-1]
ENST00000432371; ENSP00000396416; ENSG00000228186. [P79522-1]
ENST00000436805; ENSP00000406321; ENSG00000233564. [P79522-2]
ENST00000442290; ENSP00000401612; ENSG00000223887. [P79522-2]
ENST00000444972; ENSP00000393410; ENSG00000223766. [P79522-2]
ENST00000449754; ENSP00000398352; ENSG00000233564. [P79522-1]
ENST00000453232; ENSP00000415432; ENSG00000229202. [P79522-1]
ENST00000454399; ENSP00000392826; ENSG00000223887. [P79522-1]
GeneIDi80742.
KEGGihsa:80742.
UCSCiuc003nqj.3. human. [P79522-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiPRR3_HUMAN
AccessioniPrimary (citable) accession number: P79522
Secondary accession number(s): A1A4H4, Q5RJB5, Q5STN6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: February 15, 2005
Last modified: September 27, 2017
This is version 132 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations