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Protein

Proline-rich protein 3

Gene

PRR3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri155 – 18329C3H1-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • poly(A) RNA binding Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Proline-rich protein 3
Alternative name(s):
MHC class I region proline-rich protein CAT56
Gene namesi
Name:PRR3
Synonyms:CAT56
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:21149. PRR3.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134950097.

Polymorphism and mutation databases

BioMutaiPRR3.
DMDMi59798092.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 188188Proline-rich protein 3PRO_0000213889Add
BLAST

Proteomic databases

EPDiP79522.
MaxQBiP79522.
PaxDbiP79522.
PeptideAtlasiP79522.
PRIDEiP79522.

PTM databases

iPTMnetiP79522.
PhosphoSiteiP79522.

Expressioni

Gene expression databases

BgeeiP79522.
CleanExiHS_PRR3.
ExpressionAtlasiP79522. baseline and differential.
GenevisibleiP79522. HS.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
AESQ081173EBI-2803328,EBI-717810
ASF1AQ9Y2943EBI-2803328,EBI-749553
CCDC57Q2TAC23EBI-2803328,EBI-2808286
HNRNPKP619783EBI-2803328,EBI-304185
HNRPKQ6IBN13EBI-2803328,EBI-3440248
KHDRBS2Q5VWX13EBI-2803328,EBI-742808
PSMA3P257883EBI-2803328,EBI-348380
RBMXP381593EBI-2803328,EBI-743526
RBMY1A1P0DJD33EBI-2803328,EBI-8638511
RBMY1JQ154153EBI-2803328,EBI-8642021

Protein-protein interaction databases

BioGridi123286. 29 interactions.
IntActiP79522. 24 interactions.

Structurei

3D structure databases

ProteinModelPortaliP79522.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi12 – 118107Pro-richAdd
BLAST

Sequence similaritiesi

Contains 1 C3H1-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri155 – 18329C3H1-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiENOG410J4IA. Eukaryota.
ENOG4111CMK. LUCA.
GeneTreeiENSGT00530000063820.
HOVERGENiHBG053700.
InParanoidiP79522.
OMAiPKSAFHR.
OrthoDBiEOG7NSB23.
PhylomeDBiP79522.
TreeFamiTF337284.

Family and domain databases

InterProiIPR000571. Znf_CCCH.
[Graphical view]
PfamiPF00642. zf-CCCH. 1 hit.
[Graphical view]
SMARTiSM00356. ZnF_C3H1. 1 hit.
[Graphical view]
SUPFAMiSSF90229. SSF90229. 1 hit.
PROSITEiPS50103. ZF_C3H1. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P79522-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPKRKKQNHH QPPTQQQPPL PEREETGDEE DGSPIGPPSL LGPPPMANGK
60 70 80 90 100
PGDPKSALHR GPPGSRGPLI PPLLSLPPPP WGRGPIRRGL GPRSSPYGRG
110 120 130 140 150
WWGVNAEPPF PGPGHGGPTR GSFHKEQRNP RRLKSWSLIK NTCPPKDDPQ
160 170 180
VMEDKSDRPV CRHFAKKGHC RYEDLCAFYH PGVNGPPL
Length:188
Mass (Da):20,640
Last modified:February 15, 2005 - v2
Checksum:i1EFDAFB4FFBBE153
GO
Isoform 2 (identifier: P79522-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     36-56: Missing.

Note: No experimental confirmation available.
Show »
Length:167
Mass (Da):18,644
Checksum:i83E9572CC89E30D4
GO

Sequence cautioni

The sequence AAB40147.1 differs from that shown. Reason: Erroneous initiation. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti61 – 611G → S.1 Publication
Corresponds to variant rs3888778 [ dbSNP | Ensembl ].
VAR_052963

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei36 – 5621Missing in isoform 2. CuratedVSP_012818Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U63336 mRNA. Translation: AAB40147.1. Different initiation.
AL662825 Genomic DNA. Translation: CAI17833.2.
AL662800 Genomic DNA. Translation: CAI18153.2.
BX000357 Genomic DNA. Translation: CAI18560.1.
BX248518 Genomic DNA. Translation: CAM26014.1.
BX927220 Genomic DNA. Translation: CAQ09055.1.
CR388372 Genomic DNA. Translation: CAQ07870.1.
CR847863 Genomic DNA. Translation: CAQ10056.1.
BC126457 mRNA. Translation: AAI26458.1.
CCDSiCCDS43440.1. [P79522-1]
CCDS43441.1. [P79522-2]
RefSeqiNP_079539.2. NM_025263.3. [P79522-1]
UniGeneiHs.118354.
Hs.651434.

Genome annotation databases

EnsembliENST00000376557; ENSP00000365740; ENSG00000204576. [P79522-2]
ENST00000376560; ENSP00000365744; ENSG00000204576. [P79522-1]
ENST00000383592; ENSP00000373086; ENSG00000206491. [P79522-1]
ENST00000418065; ENSP00000404669; ENSG00000206491. [P79522-2]
ENST00000422140; ENSP00000411802; ENSG00000228186. [P79522-2]
ENST00000422639; ENSP00000401499; ENSG00000229202. [P79522-2]
ENST00000427729; ENSP00000402596; ENSG00000223766. [P79522-1]
ENST00000432371; ENSP00000396416; ENSG00000228186. [P79522-1]
ENST00000436805; ENSP00000406321; ENSG00000233564. [P79522-2]
ENST00000442290; ENSP00000401612; ENSG00000223887. [P79522-2]
ENST00000444972; ENSP00000393410; ENSG00000223766. [P79522-2]
ENST00000449754; ENSP00000398352; ENSG00000233564. [P79522-1]
ENST00000453232; ENSP00000415432; ENSG00000229202. [P79522-1]
ENST00000454399; ENSP00000392826; ENSG00000223887. [P79522-1]
GeneIDi80742.
KEGGihsa:80742.
UCSCiuc003nqj.3. human. [P79522-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U63336 mRNA. Translation: AAB40147.1. Different initiation.
AL662825 Genomic DNA. Translation: CAI17833.2.
AL662800 Genomic DNA. Translation: CAI18153.2.
BX000357 Genomic DNA. Translation: CAI18560.1.
BX248518 Genomic DNA. Translation: CAM26014.1.
BX927220 Genomic DNA. Translation: CAQ09055.1.
CR388372 Genomic DNA. Translation: CAQ07870.1.
CR847863 Genomic DNA. Translation: CAQ10056.1.
BC126457 mRNA. Translation: AAI26458.1.
CCDSiCCDS43440.1. [P79522-1]
CCDS43441.1. [P79522-2]
RefSeqiNP_079539.2. NM_025263.3. [P79522-1]
UniGeneiHs.118354.
Hs.651434.

3D structure databases

ProteinModelPortaliP79522.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123286. 29 interactions.
IntActiP79522. 24 interactions.

PTM databases

iPTMnetiP79522.
PhosphoSiteiP79522.

Polymorphism and mutation databases

BioMutaiPRR3.
DMDMi59798092.

Proteomic databases

EPDiP79522.
MaxQBiP79522.
PaxDbiP79522.
PeptideAtlasiP79522.
PRIDEiP79522.

Protocols and materials databases

DNASUi80742.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000376557; ENSP00000365740; ENSG00000204576. [P79522-2]
ENST00000376560; ENSP00000365744; ENSG00000204576. [P79522-1]
ENST00000383592; ENSP00000373086; ENSG00000206491. [P79522-1]
ENST00000418065; ENSP00000404669; ENSG00000206491. [P79522-2]
ENST00000422140; ENSP00000411802; ENSG00000228186. [P79522-2]
ENST00000422639; ENSP00000401499; ENSG00000229202. [P79522-2]
ENST00000427729; ENSP00000402596; ENSG00000223766. [P79522-1]
ENST00000432371; ENSP00000396416; ENSG00000228186. [P79522-1]
ENST00000436805; ENSP00000406321; ENSG00000233564. [P79522-2]
ENST00000442290; ENSP00000401612; ENSG00000223887. [P79522-2]
ENST00000444972; ENSP00000393410; ENSG00000223766. [P79522-2]
ENST00000449754; ENSP00000398352; ENSG00000233564. [P79522-1]
ENST00000453232; ENSP00000415432; ENSG00000229202. [P79522-1]
ENST00000454399; ENSP00000392826; ENSG00000223887. [P79522-1]
GeneIDi80742.
KEGGihsa:80742.
UCSCiuc003nqj.3. human. [P79522-1]

Organism-specific databases

CTDi80742.
GeneCardsiPRR3.
HGNCiHGNC:21149. PRR3.
neXtProtiNX_P79522.
PharmGKBiPA134950097.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J4IA. Eukaryota.
ENOG4111CMK. LUCA.
GeneTreeiENSGT00530000063820.
HOVERGENiHBG053700.
InParanoidiP79522.
OMAiPKSAFHR.
OrthoDBiEOG7NSB23.
PhylomeDBiP79522.
TreeFamiTF337284.

Miscellaneous databases

GenomeRNAii80742.
PROiP79522.

Gene expression databases

BgeeiP79522.
CleanExiHS_PRR3.
ExpressionAtlasiP79522. baseline and differential.
GenevisibleiP79522. HS.

Family and domain databases

InterProiIPR000571. Znf_CCCH.
[Graphical view]
PfamiPF00642. zf-CCCH. 1 hit.
[Graphical view]
SMARTiSM00356. ZnF_C3H1. 1 hit.
[Graphical view]
SUPFAMiSSF90229. SSF90229. 1 hit.
PROSITEiPS50103. ZF_C3H1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Human proline rich sequence (CAT 56) from the MHC class I region."
    Wei H., Weissman S.M.
    Submitted (JUL-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT SER-61.

Entry informationi

Entry nameiPRR3_HUMAN
AccessioniPrimary (citable) accession number: P79522
Secondary accession number(s): A1A4H4, Q5RJB5, Q5STN6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: February 15, 2005
Last modified: July 6, 2016
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.