P79483 (DRB3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
HLA class II histocompatibility antigen, DR beta 3 chain

Alternative name(s):
MHC class II antigen DRB3

Gene names

Name:

HLA-DRB3

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	266 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal miroenvironment has been implicated in the regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and efficient peptide loading.
Subunit structure	Heterodimer of an alpha and a beta subunit; also referred as MHC class II molecule. In the endoplasmic reticulum (ER) it forms a heterononamer; 3 MHC class II molecules bind to a CD74 homotrimer (also known as invariant chain or HLA class II histocompatibility antigen gamma chain). In the endosomal/lysosomal system; CD74 undergoes sequential degradation by various proteases; leaving a small fragment termed CLIP on each MHC class II molecule. MHC class II molecule interacts with HLA_DM, and HLA_DO in B-cells, in order to release CLIP and facilitate the binding of antigenic peptides. Ref.55
Subcellular location	Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus › trans-Golgi network membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Late endosome membrane; Single-pass type I membrane protein. Note: The MHC class II complex transits through a number of intracellular compartments in the endocytic pathway until it reaches the cell membrane for antigen presentation. Ref.52
Post-translational modification	Ubiquitinated by MARCH1 and MARCH8 at Lys-254 leading to sorting into the endosome system and down-regulation of MHC class II Probable. Ref.52
Polymorphism	The following alleles of DRB3 are known: DRB3*01:01, DRB3*01:02, DRB3*01:03, DRB3*01:04, DRB3*01:05, DRB3*01:06, DRB3*01:07, DRB3*01:08, DRB3*01:09, DRB3*01:10, DRB3*01:11, DRB3*01:12, DRB3*01:13, DRB3*01:14, DRB3*02:01, DRB3*02:02, DRB3*02:03, DRB3*02:04, DRB3*02:05, DRB3*02:06, DRB3*02:07, DRB3*02:08, DRB3*02:09, DRB3*02:10, DRB3*02:11, DRB3*02:12, DRB3*02:13, DRB3*02:14, DRB3*02:15, DRB3*02:16, DRB3*02:17, DRB3*02:18, DRB3*02:19, DRB3*02:20, DRB3*02:21, DRB3*02:22, DRB3*02:23, DRB3*02:24, DRB3*02:25, DRB3*03:01, DRB3*03:02 and DRB3*03:03. The sequence shown is that of DRB3*01:01. Allele DRB3*01:01 belongs to an ancestral haplotype and is associated with autoimmune diseases that are linked to antigen presentation. It is found in more than 95% of the homozygous HPA-1B mothers that produce anti-HPA-1A antibodies, this leads to neonatal alloimune thrombocytopenia (NAIT).
Sequence similarities	Belongs to the MHC class II family. Contains 1 Ig-like C1-type (immunoglobulin-like) domain.
Caution	HLA-DRB3, HLA-DRB4 and HLA-DRB5 may represent a unique gene.

Ontologies

Keywords
Biological process	Immunity
Cellular component	Cell membrane Endoplasmic reticulum Endosome Golgi apparatus Lysosome MHC II Membrane
Coding sequence diversity	Polymorphism
Domain	Signal Transmembrane Transmembrane helix
PTM	Disulfide bond Glycoprotein Isopeptide bond Ubl conjugation
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	T cell costimulation Traceable author statement. Source: Reactome T cell receptor signaling pathway Traceable author statement. Source: Reactome antigen processing and presentation of exogenous peptide antigen via MHC class II Traceable author statement. Source: Reactome interferon-gamma-mediated signaling pathway Traceable author statement. Source: Reactome
Cellular_component	ER to Golgi transport vesicle membrane Traceable author statement. Source: Reactome Golgi membrane Traceable author statement. Source: Reactome MHC class II protein complex Inferred from electronic annotation. Source: UniProtKB-KW clathrin-coated endocytic vesicle membrane Traceable author statement. Source: Reactome integral to lumenal side of endoplasmic reticulum membrane Traceable author statement. Source: Reactome integral to plasma membrane Non-traceable author statement Ref.10. Source: UniProtKB late endosome membrane Inferred from direct assay Ref.52. Source: UniProtKB lysosomal membrane Inferred from direct assay Ref.52. Source: UniProtKB trans-Golgi network membrane Traceable author statement. Source: Reactome
Molecular_function	MHC class II receptor activity Non-traceable author statement Ref.10. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 29

29

Chain

30 – 266

237

HLA class II histocompatibility antigen, DR beta 3 chain

PRO_0000018956

Regions

Topological domain

30 – 227

198

Extracellular Potential

Transmembrane

228 – 250

23

Helical; Potential

Topological domain

251 – 266

16

Cytoplasmic Potential

Domain

126 – 214

89

Ig-like C1-type

Region

30 – 124

95

Beta-1

Region

125 – 227

103

Beta-2

Amino acid modifications

Glycosylation

48

1

N-linked (GlcNAc...) Ref.56

Disulfide bond

44 ↔ 108

Ref.55 Ref.56

Disulfide bond

146 ↔ 202

Ref.55 Ref.56

Cross-link

254

Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) By similarity

Natural variations

Natural variant

37

1

L → S in allele DRB3*01:04.

VAR_060739

Natural variant

38

1

E → Q in allele DRB3*02:12.

VAR_060740

Natural variant

39

1

L → Y in allele DRB3*01:14; requires 2 nucleotide substitutions.

VAR_060741

Natural variant

40

1

R → C in allele DRB3*01:02.

VAR_016686

Natural variant

40

1

R → L in allele DRB3*02:01, allele DRB3*02:02, allele DRB3*02:03, allele DRB3*02:04, allele DRB3*02:05, allele DRB3*02:06, allele DRB3*02:07, allele DRB3*02:08, allele DRB3*02:09, allele DRB3*02:10, allele DRB3*02:11, allele DRB3*02:12, allele DRB3*02:13, allele DRB3*02:14, allele DRB3*02:15, allele DRB3*02:16, allele DRB3*02:17, allele DRB3*02:18, allele DRB3*02:19, allele DRB3*02:20, allele DRB3*02:21, allele DRB3*02:22, allele DRB3*02:23, allele DRB3*02:24, allele DRB3*02:25, allele DRB3*03:01, allele DRB3*03:02 and allele DRB3*03:03.

VAR_060742

Natural variant

40

1

R → S in allele DRB3*01:14.

VAR_060743

Natural variant

41

1

K → T in allele DRB3*01:14.

VAR_060744

Natural variant

55

1

Y → F in allele DRB3*01:09, allele DRB3*02:01, allele DRB3*02:02, allele DRB3*02:03, allele DRB3*02:04, allele DRB3*02:05, allele DRB3*02:06, allele DRB3*02:07, allele DRB3*02:08, allele DRB3*02:09, allele DRB3*02:10, allele DRB3*02:11, allele DRB3*02:12, allele DRB3*02:14, allele DRB3*02:15, allele DRB3*02:16, allele DRB3*02:17, allele DRB3*02:18, allele DRB3*02:19, allele DRB3*02:20, allele DRB3*02:21, allele DRB3*02:22, allele DRB3*02:23, allele DRB3*02:24, allele DRB3*02:25, allele DRB3*03:01, allele DRB3*03:02 and allele DRB3*03:03.

VAR_060746

Natural variant

55

1

Y → L in allele DRB3*02:13; requires 2 nucleotide substitutions.

VAR_060745

Natural variant

57

1

D → E in allele DRB3*01:03, allele DRB3*01:09, allele DRB3*02:01, allele DRB3*02:02, allele DRB3*02:03, allele DRB3*02:04, allele DRB3*02:05, allele DRB3*02:06, allele DRB3*02:07, allele DRB3*02:08, allele DRB3*02:09, allele DRB3*02:10, allele DRB3*02:11, allele DRB3*02:12, allele DRB3*02:13, allele DRB3*02:14, allele DRB3*02:15, allele DRB3*02:16, allele DRB3*02:17, allele DRB3*02:18, allele DRB3*02:19, allele DRB3*02:20, allele DRB3*02:21, allele DRB3*02:22, allele DRB3*02:23, allele DRB3*02:24, allele DRB3*02:25, allele DRB3*03:01, allele DRB3*03:02 and allele DRB3*03:03.

VAR_060747

Natural variant

57

1

D → N in allele DRB3*01:05.

VAR_060748

Natural variant

58

1

R → I in allele DRB3*01:11.

VAR_060749

Natural variant

59

1

Y → H in allele DRB3*01:09, allele DRB3*02:01, allele DRB3*02:02, allele DRB3*02:03, allele DRB3*02:04, allele DRB3*02:06, allele DRB3*02:07, allele DRB3*02:08, allele DRB3*02:09, allele DRB3*02:10, allele DRB3*02:11, allele DRB3*02:12, allele DRB3*02:13, allele DRB3*02:14, allele DRB3*02:15, allele DRB3*02:16, allele DRB3*02:17, allele DRB3*02:18, allele DRB3*02:19, allele DRB3*02:20, allele DRB3*02:21, allele DRB3*02:22, allele DRB3*02:23, allele DRB3*02:24, allele DRB3*02:25 and allele DRB3*03:02.

VAR_060750

Natural variant

66

1

F → L in allele DRB3*01:13.

VAR_060752

Natural variant

66

1

F → N in allele DRB3*01:08, allele DRB3*02:06 and allele DRB3*02:20; requires 2 nucleotide substitutions.

VAR_060753

Natural variant

66

1

F → S in allele DRB3*02:03.

VAR_060751

Natural variant

66

1

F → Y in allele DRB3*01:07, allele DRB3*01:09, allele DRB3*02:01, allele DRB3*02:02, allele DRB3*02:04, allele DRB3*02:05, allele DRB3*02:07, allele DRB3*02:08, allele DRB3*02:09, allele DRB3*02:10, allele DRB3*02:11, allele DRB3*02:12, allele DRB3*02:13, allele DRB3*02:14, allele DRB3*02:15, allele DRB3*02:16, allele DRB3*02:17, allele DRB3*02:18, allele DRB3*02:19, allele DRB3*02:21, allele DRB3*02:22, allele DRB3*02:23, allele DRB3*02:24 and allele DRB3*02:25.

VAR_060754

Natural variant

67

1

L → A in allele DRB3*01:07, allele DRB3*01:09, allele DRB3*02:01, allele DRB3*02:02, allele DRB3*02:04, allele DRB3*02:05, allele DRB3*02:06, allele DRB3*02:07, allele DRB3*02:08, allele DRB3*02:09, allele DRB3*02:10, allele DRB3*02:11, allele DRB3*02:12, allele DRB3*02:13, allele DRB3*02:14, allele DRB3*02:15, allele DRB3*02:16, allele DRB3*02:17, allele DRB3*02:18, allele DRB3*02:19, allele DRB3*02:21, allele DRB3*02:22, allele DRB3*02:23, allele DRB3*02:24 and allele DRB3*02:25; requires 2 nucleotide substitutions.

VAR_060755

Natural variant

67

1

L → V in allele DRB3*01:06, allele DRB3*01:08, allele DRB3*02:03, allele DRB3*02:20, allele DRB3*03:01, allele DRB3*03:02 and allele DRB3*03:03.

VAR_060756

Natural variant

68

1

R → S in allele DRB3*01:10.

VAR_060757

Natural variant

80

1

T → R in allele DRB3*01:07, allele DRB3*02:01, allele DRB3*02:02, allele DRB3*02:03, allele DRB3*02:04, allele DRB3*02:05, allele DRB3*02:06, allele DRB3*02:07, allele DRB3*02:08, allele DRB3*02:11, allele DRB3*02:12, allele DRB3*02:13, allele DRB3*02:14, allele DRB3*02:15, allele DRB3*02:16, allele DRB3*02:17, allele DRB3*02:18, allele DRB3*02:19, allele DRB3*02:20, allele DRB3*02:21, allele DRB3*02:22, allele DRB3*02:23, allele DRB3*02:24 and allele DRB3*02:25.

VAR_060758

Natural variant

84

1

R → L in allele DRB3*02:23.

VAR_060759

Natural variant

86

1

V → A in allele DRB3*02:16.

VAR_060760

Natural variant

86

1

V → D in allele DRB3*01:07, allele DRB3*02:01, allele DRB3*02:02, allele DRB3*02:03, allele DRB3*02:04, allele DRB3*02:05, allele DRB3*02:06, allele DRB3*02:10, allele DRB3*02:11, allele DRB3*02:12, allele DRB3*02:13, allele DRB3*02:14, allele DRB3*02:15, allele DRB3*02:17, allele DRB3*02:18, allele DRB3*02:19, allele DRB3*02:20, allele DRB3*02:22, allele DRB3*02:23, allele DRB3*02:24 and allele DRB3*02:25.

VAR_060762

Natural variant

86

1

V → S in allele DRB3*02:08; requires 2 nucleotide substitutions.

VAR_060761

Natural variant

87

1

A → E in allele DRB3*02:18.

VAR_060763

Natural variant

89

1

S → H in allele DRB3*02:16; requires 2 nucleotide substitutions.

VAR_060764

Natural variant

89

1

S → Y in allele DRB3*01:07, allele DRB3*02:01, allele DRB3*02:02, allele DRB3*02:03, allele DRB3*02:04, allele DRB3*02:05, allele DRB3*02:06, allele DRB3*02:07, allele DRB3*02:08, allele DRB3*02:10, allele DRB3*02:11, allele DRB3*02:12, allele DRB3*02:13, allele DRB3*02:14, allele DRB3*02:15, allele DRB3*02:17, allele DRB3*02:18, allele DRB3*02:20, allele DRB3*02:22, allele DRB3*02:23 and allele DRB3*02:24.

VAR_060765

Natural variant

96

1

L → F in allele DRB3*02:17.

VAR_060766

Natural variant

96

1

L → I in allele DRB3*02:11.

VAR_060767

Natural variant

102

1

G → A.
Corresponds to variant rs17878857 [ dbSNP | Ensembl ].

VAR_033396

Natural variant

103

1

R → Q in allele DRB3*01:07, allele DRB3*02:01, allele DRB3*02:02, allele DRB3*02:03, allele DRB3*02:05, allele DRB3*02:06, allele DRB3*02:07, allele DRB3*02:08, allele DRB3*02:09, allele DRB3*02:10, allele DRB3*02:11, allele DRB3*02:12, allele DRB3*02:13, allele DRB3*02:14, allele DRB3*02:15, allele DRB3*02:16, allele DRB3*02:17, allele DRB3*02:18, allele DRB3*02:20, allele DRB3*02:21, allele DRB3*02:23, allele DRB3*02:24, allele DRB3*02:25, allele DRB3*03:01 and allele DRB3*03:02.

VAR_060768

Natural variant

106

1

N → T in allele DRB3*02:15.

VAR_060769

Natural variant

113

1

G → R in allele DRB3*01:12.

VAR_060770

Natural variant

114

1

V → A.
Corresponds to variant rs17424145 [ dbSNP | Ensembl ].

VAR_033397

Natural variant

115

1

G → A in allele DRB3*02:14.

VAR_060771

Natural variant

115

1

G → V in allele DRB3*02:01, allele DRB3*02:04, allele DRB3*02:24, allele DRB3*03:01 and allele DRB3*03:02.

VAR_060772

Natural variant

169

1

A → T in allele DRB3*03:01.

VAR_060773

Natural variant

178

1

Q → H in allele DRB3*03:01.

VAR_060774

Natural variant

193

1

V → F in allele DRB3*02:01.

VAR_060775

Natural variant

212

1

A → P in allele DRB3*02:01, allele DRB3*02:02, allele DRB3*02:10, allele DRB3*02:11, allele DRB3*02:24 and allele DRB3*03:01.

VAR_060776

Natural variant

218

1

R → S in allele DRB3*02:01, allele DRB3*02:02, allele DRB3*02:10 and allele DRB3*02:11.

VAR_060777

Natural variant

236

1

V → M.
Corresponds to variant rs2230816 [ dbSNP | Ensembl ].

VAR_033398

Secondary structure

1

.

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266

Helix Strand Turn

Details...

Beta strand

36 – 47

12

Turn

48 – 51

4

Beta strand

52 – 61

10

Beta strand

64 – 70

7

Turn

71 – 73

3

Beta strand

74 – 80

7

Helix

81 – 83

3

Helix

84 – 91

8

Helix

94 – 100

7

Helix

103 – 106

4

Helix

108 – 115

8

Helix

116 – 118

3

Turn

119 – 121

3

Beta strand

127 – 133

7

Beta strand

143 – 154

12

Beta strand

157 – 162

6

Beta strand

165 – 167

3

Beta strand

168 – 173

6

Beta strand

180 – 182

3

Beta strand

184 – 190

7

Beta strand

199 – 205

7

Beta strand

213 – 218

6

Sequences

	Sequence		Length	Mass (Da)
	P79483 [UniParc]. Last modified May 1, 1997. Version 1. Checksum: 2FC3AE68D3B10EAD	FASTA	266	29,962
	10 20 30 40 50 60 MVCLKLPGGS SLAALTVTLM VLSSRLAFAG DTRPRFLELR KSECHFFNGT ERVRYLDRYF 70 80 90 100 110 120 HNQEEFLRFD SDVGEYRAVT ELGRPVAESW NSQKDLLEQK RGRVDNYCRH NYGVGESFTV 130 140 150 160 170 180 QRRVHPQVTV YPAKTQPLQH HNLLVCSVSG FYPGSIEVRW FRNGQEEKAG VVSTGLIQNG 190 200 210 220 230 240 DWTFQTLVML ETVPRSGEVY TCQVEHPSVT SALTVEWRAR SESAQSKMLS GVGGFVLGLL 250 260 FLGAGLFIYF RNQKGHSGLQ PTGFLS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete sequence of an HLA-DR beta chain deduced from a cDNA clone and identification of multiple non-allelic DR beta chain genes." Long E.O., Wake C.T., Gorski J., Mach B. EMBO J. 2:389-394(1983) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE DRB3*02:01).
[2]	"Polymorphism of human Ia antigens: gene conversion between two DR beta loci results in a new HLA-D/DR specificity." Gorski J., Mach B. Nature 322:67-70(1986) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE DRB3*01:01).
[3]	"Description of two new HLA-DRB alleles (DRB1*0310 and DRB3*01012) found in a Spanish infant." Martinez-Quiles N., Martin-Villa J.M., Martinez-Laso J., Perez-Blas M., Ferre-Lopez S., Moreno-Pelayo M.A., Alvarez-Tejado M., Arnaiz-Villena A. Tissue Antigens 49:658-661(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE DRB3*01:01). Tissue: Blood.
[4]	"DRB3 alleles with variations in the annealing sites of commonly used amplification primers." Coquillard G.J., Tang T.F., Steiner N., Perlee L., Ng J., Hartzman R.J., Hurley C.K. Tissue Antigens 55:558-563(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE DRB3*01:01), NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-119 (ALLELE DRB3*01:04). Tissue: Blood.
[5]	"Cloning and nucleotide sequence analysis of HLA-DRB3*01012 from EBV-transformed Korean B-cell line by sequence based typing." Kim K.H., Kang J.H., Maeng C.Y., Han H., Park J.H., Hahm K.S., Kim K.L. Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE DRB3*01:01).
[6]	"HLA-DRB3*03011 sequence complete mRNA." Spierings E., Zegveld S.T., Goulmy E. Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE DRB3*03:01).
[7]	"DNA sequences coding for the DR beta-chain locus of the human lymphocyte antigen complex and polypeptides, diagnostic typing processes and products related thereto." Mach B.F., Long E.O., Wake C.T. Patent number EP0103960, 28-MAR-1984 Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE DRB3*02:01).
[8]	"The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S. Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ALLELES DRB3*01:01 AND DRB3*02:02).
[9]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ALLELES DRB3*01:01 AND DRB3*02:02). Tissue: Brain.
[10]	"Molecular analysis of the genes for human class II antigens of the major histocompatibility complex." Long E.O., Gorski J., Rollini P., Wake C.T., Strubin M., Rabourdin-Combe C., Mach B. Hum. Immunol. 8:113-121(1983) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 30-266 (ALLELE DRB3*02:01).
[11]	"Allelic variation in the DR subregion of the human major histocompatibility complex." Bell J.I., Denney D. Jr., Foster L., Belt T.K., Todd J.A., McDevitt H.O. Proc. Natl. Acad. Sci. U.S.A. 84:6234-6238(1987) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 30-266 (ALLELE DRB3*02:01).
[12]	"Identification by sequencing based typing and complete coding region analysis of three new HLA class II alleles: DRB3*0210, DRB3*0211 and DQB1*0310." Balas A., Santos S., Aviles M.J., Garcia-Sanchez F., Lillo R., Vicario J.L. Tissue Antigens 56:380-384(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 30-266 (ALLELES DRB3*02:10 AND DRB3*02:11).
[13]	"A new HLA-DRB3*02 allele identified by sequencing based typing." Westerink N., Bacelar M., Arts-Hilkes Y., Mulder W., Rozemuller E.H. Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-217 (ALLELE DRB3*02:24).
[14]	"Sequencing of two new HLA class II alleles: DRB3*0218 and DQB1*030202." Balas A., Aviles M.J., Lillo R., Alonso-Nieto M., Zarapuz L., Garcia-Villaescusa R., Garcia-Sanchez F., Vicario J.L. Tissue Antigens 63:614-616(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-124 (ALLELE DRB3*02:18).
[15]	"Identification of a new DRB3*02 allelic variant (DRB3*0209) by high-resolution sequence-based typing." Morabito A., Pera C., Longo A., Delfino L., Ferrara G.B. Tissue Antigens 56:90-94(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB3*02:09).
[16]	"Description of fourteen new DRB alleles found in a stem cell donor registry." Tang T.F., Lin Y.-S., Robbins F.M., Li L., Sintasath D., Coquillard G., Huang A., Heine U., Ng J., Hartzman R.J., Hurley C.K. Tissue Antigens 59:63-65(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB3*01:05).
[17]	"Three new DRB alleles routinely identified by sequence-based typing: DRB1*010103, DRB1*0326 and DRB3*0219." Dubois V., Favre-Victoire I., Gebuhrer L. Tissue Antigens 64:621-623(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB3*02:19).
[18]	"Characterisation of two novel HLA alleles, HLA-Cw*0429 and HLA-DRB3*0223." Danzer M., Polin H., Hofer K., Proll J., Gabriel C. Tissue Antigens 72:498-499(2008) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB3*02:23). Tissue: Peripheral blood.
[19]	"Description of three novel HLA-DRB3 alleles: DRB3*010105, DRB3*0112 and DRB3*0113." Lee K.W., Jung Y.A. Tissue Antigens 73:83-84(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELES DRB3*01:01; DRB3*01:12 AND DRB3*01:13).
[20]	"New DRB3*02 variant." Keller E. Submitted (APR-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB3*02:04).
[21]	"An HLA-DRB3 allele detected by SBT." Greville W.D., Ng G., Kennedy A., Dunckley H. Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELES DRB3*02:12 AND DRB3*02:13).
[22]	"A new HLA DRB3* allele very similar to DRB3*02021 and DRB3*0212 alleles." Moine A. Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB3*02:14).
[23]	"A novel DRB3 allele." Varney M. Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB3*02:15).
[24]	"Identification of a novel DRB3*0216 allele." Avergas C.U., Iglehart B.A., Leffell M.S. Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB3*02:16).
[25]	"Novel HLA-DRB3 allele revealed by sequencing based typing." Hogbin J.-P., Chapman G., Greville W.D. Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB3*02:17).
[26]	"Description of a new DRB3* allele." Perasaari J., Egle Jansson I., Partanen J., Bengtsson M. Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB3*01:11).
[27]	"New HLA-DRB3*02 allele." Colombini I., Malagoli A., Carella G. Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB3*02:20).
[28]	"New HLA-DRB3*02 allelic variant identified by high resolution sequence-based typing." Garino E., Berrino M., Bertinetto F., Brancatello F., Caropreso P., Chidichimo R., Frisaldi E., Mazzola G., Panniello M., Tondat F., Locatelli F., Amoroso A. Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB3*02:21).
[29]	"The DRB3 new allele is identical to the current HLA-DRB3*020201 allele except a point substitution at codon 74 where a G is found in place of A." Dormoy A., Froelich N. Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELES DRB3*02:22).
[30]	"The new DRB3 allele is identical to the DRB3*020201 allele except a mutation at position 266 leading to the change of the amino acid 65 (Tyr (TAC) -> Ser(TCC)." Dormoy A., Derin R., Jollet I., Weschler B., Leisenbach R. Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB3*02:25). Tissue: Peripheral blood.
[31]	"Identification of a novel HLA-DRB3*01 allele containing a DRB1 sequence motive by micro-TGGE and confirmed by cloning and direct sequencing." Garritsen H.S.P., Fae I., Legath N., Hannig H., Fischer G.F. Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB3*01:14).
[32]	"New HLA class II (DRB3) allele detected by sequencing-based typing." Greville W.D., Ng G., Kennedy A., Dunckley H. Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-122 (ALLELE DRB3*02:02).
[33]	"Description of a new HLA-DRB3 allele in a Spanish bone marrow donor." Loeliger C. Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-122 (ALLELE DRB3*01:08). Tissue: Bone marrow.
[34]	"Novel HLA*DRB3 allele." Li L., Hurley C.K. Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-122 (ALLELE DRB3*01:09).
[35]	"Diversity associated with the second expressed HLA-DRB locus in the human population." Robbins F., Hurley C.K., Tang T., Yao H., Lin Y.S., Wade J., Goeken N., Hartzman R.J. Immunogenetics 46:104-110(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-121 (ALLELE DRB3*02:05).
[36]	Olerup O. Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-117 (ALLELE DRB3*01:03).
[37]	"Identification of new DRB1*01 (DRB1*01022), DRB1*14 (DRB1*1428) and DRB3* (DRB3*0206) alleles." Hashemi-Tavoularis S., Couture C., Buyse I.M. Tissue Antigens 50:89-93(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-115 (ALLELE DRB3*02:06).
[38]	"A novel DRB3 allele (DRB3*0208), a new allelic variant of DRB1*1502 (DRB1*15023) and two new DQB1 (DQB1*03012 and DQB1*0614) alleles." Hashemi-tavoularis S., Ouellet S., Sengar D.P.S., Buyse I.M. Tissue Antigens 52:294-299(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-115 (ALLELES DRB3*02:08 AND DRB3*03:02). Tissue: Blood.
[39]	"Identification of three new DRB3* (DRB3*0106, DRB3*0107 and DRB3*02022) alleles." Tavoularis S., Ouellet S., Stephens S. Tissue Antigens 57:390-393(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-115 (ALLELES DRB3*01:06 AND DRB3*01:07). Tissue: Peripheral blood.
[40]	"Identification of three novel alleles: DRB3*0110, DRB1*1140, and DRB1*140102." Tavoularis S., Couture C., Ribeiro-Barros E. Tissue Antigens 63:496-500(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-115 (ALLELE DRB3*01:10). Tissue: Peripheral blood.
[41]	"New HLA class II alleles in the Indonesian population." Panigoro R., Greville W.D., Kennedy A., Trejaut J., Dunckley H. Tissue Antigens 54:521-523(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 36-119 (ALLELE DRB3*03:03).
[42]	"Identification and nucleotide sequence of two novel DRB3 alleles, DRB3*0102 and DRB3*010133." Guttridge M.G., Hudson L., Williams H., Dunn P., Duy S., Darke C. Tissue Antigens 49:665-667(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 36-117 (ALLELE DRB3*01:02).
[43]	"Identification of a new DRB3*02 allele (DRB3*0207) by sequence-based typing." Voorter C.E., Hentges F., van den Berg-Loonen E.M. Tissue Antigens 50:552-554(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 37-116 (ALLELE DRB3*02:07).
[44]	"Five new DRB1 alleles found during routine DRB oligotyping." Anholts J.D.H., Verduijn W., Schreuder G.M.T. Submitted (MAY-1995) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 37-116 (ALLELE DRB3*02:03).
[45]	"Identification of a putative DR8 founder haplotype containing a novel DRB1*0801 allele." Eberle M., Asu U., Taylor M., Hunter J.B., Fuller T.C., Maurer D. Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 43-120 (ALLELE DRB3*02:02).
[46]	"HLA-DR beta-chain polymorphism. Second domain polymorphism reflects evolutionary relatedness of alleles and may explain public serologic epitopes." Gorski J. J. Immunol. 143:329-333(1989) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 124-217 (ALLELE DRB3*01:01/DRB3*01:02).
[47]	"Naturally processed peptides spanning the HPA-1a polymorphism are efficiently generated and displayed from platelet glycoprotein by HLA-DRB3*0101-positive antigen-presenting cells." Anani Sarab G., Moss M., Barker R.N., Urbaniak S.J. Blood 114:1954-1957(2009) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION OF THE ALLOANTIGEN HPA-1A BY MASS SPECTROMETRY, ASSOCIATION TO ALLELE HLA-DRB3*01:01.
[48]	"Invariant chain structure and MHC class II function." Cresswell P. Cell 84:505-507(1996) [PubMed] [Europe PMC] [Abstract] Cited for: REVIEW.
[49]	"Presentation of antigens by MHC class II molecules: getting the most out of them." Villadangos J.A. Mol. Immunol. 38:329-346(2001) [PubMed] [Europe PMC] [Abstract] Cited for: REVIEW.
[50]	"Autophagy in MHC class II presentation: sampling from within." Menendez-Benito V., Neefjes J. Immunity 26:1-3(2007) [PubMed] [Europe PMC] [Abstract] Cited for: REVIEW.
[51]	"MHC class II molecules on the move for successful antigen presentation." Rocha N., Neefjes J. EMBO J. 27:1-5(2008) [PubMed] [Europe PMC] [Abstract] Cited for: REVIEW.
[52]	"MHC class II stabilization at the surface of human dendritic cells is the result of maturation-dependent MARCH I down-regulation." De Gassart A., Camosseto V., Thibodeau J., Ceppi M., Catalan N., Pierre P., Gatti E. Proc. Natl. Acad. Sci. U.S.A. 105:3491-3496(2008) [PubMed] [Europe PMC] [Abstract] Cited for: UBIQUITINATION BY MARCH1, SUBCELLULAR LOCATION.
[53]	"MHC class II transport at a glance." Berger A.C., Roche P.A. J. Cell Sci. 122:1-4(2009) [PubMed] [Europe PMC] [Abstract] Cited for: REVIEW.
[54]	"CD74 in antigen presentation, inflammation, and cancers of the gastrointestinal tract." Beswick E.J., Reyes V.E. World J. Gastroenterol. 15:2855-2861(2009) [PubMed] [Europe PMC] [Abstract] Cited for: REVIEW.
[55]	"Crystallographic structure of the human leukocyte antigen DRA, DRB3*0101: models of a directional alloimmune response and autoimmunity." Parry C.S., Gorski J., Stern L.J. J. Mol. Biol. 371:435-446(2007) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.25 ANGSTROMS) OF 30-219 OF HLA-DRA/HLA-DRB3 HETERODIMER IN COMPLEX WITH ITGB3 PEPTIDE (ALLOANTIGEN HPA-1A), SUBUNIT, DISULFIDE BOND.
[56]	"The structure of HLA-DR52c: comparison to other HLA-DRB3 alleles." Dai S., Crawford F., Marrack P., Kappler J.W. Proc. Natl. Acad. Sci. U.S.A. 105:11893-11897(2008) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 30-219 OF HLA-DRA/HLA-DRB3 HETERODIMER IN COMPLEX WITH EEF1A2 PEPTIDE, GLYCOSYLATION AT ASN-48, DISULFIDE BOND.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

V00522 mRNA. Translation: CAA23781.1.
X04055 Genomic DNA. No translation available.
X04058 Genomic DNA. No translation available.
U66825 mRNA. Translation: AAD43828.1.
AF026467 Genomic DNA. Translation: AAC05599.1.
AF199236 mRNA. Translation: AAF13065.2.
U95819 mRNA. Translation: AAD00819.1.
AY138123 mRNA. Translation: AAN15205.1.
A06800 mRNA. Translation: CAA00596.1.
AL662842 Genomic DNA. Translation: CAI17549.1.
AL929581 Genomic DNA. Translation: CAI18691.1.
CR788283 Genomic DNA. Translation: CAQ11026.1.
Z84814 Genomic DNA. Translation: CAB06607.1.
BC008987 mRNA. Translation: AAH08987.1.
BC106057 mRNA. Translation: AAI06058.1.
M17380 mRNA. Translation: AAA59804.1.
AF192258 mRNA. Translation: AAF26358.1.
AF192259 mRNA. Translation: AAF26359.1.
FJ515276 Genomic DNA. Translation: ACL50609.1.
AY291205 Genomic DNA. Translation: AAP43643.1.
AF148518 Genomic DNA. Translation: AAF67837.1.
AF081677 Genomic DNA. Translation: AAC32202.1.
AY271986 Genomic DNA. Translation: AAP23230.1.
AM747470 Genomic DNA. Translation: CAO00528.1.
EU873151 Genomic DNA. Translation: ACF33221.1.
EU873152 Genomic DNA. Translation: ACF33222.1.
EU873153 Genomic DNA. Translation: ACF33223.1.
X91639 Genomic DNA. No translation available.
AF208484 Genomic DNA. Translation: AAF23165.1.
AF208485 Genomic DNA. Translation: AAF23166.1.
AJ290395 Genomic DNA. Translation: CAC27417.1.
AF427138 Genomic DNA. Translation: AAL26538.1.
AF455114 Genomic DNA. Translation: AAL57866.1.
AF461431 Genomic DNA. Translation: AAL66370.1.
AJ564210 Genomic DNA. Translation: CAD91915.2.
AY958608 Genomic DNA. Translation: AAY28717.1.
DQ311653 Genomic DNA. Translation: ABC33924.1.
AM413002 Genomic DNA. Translation: CAL85628.1.
FN424163 Genomic DNA. Translation: CAZ66795.1.
FN424162 Genomic DNA. Translation: CAZ66766.1.
AF177216 Genomic DNA. Translation: AAD53911.1.
AF361865 Genomic DNA. Translation: AAK38297.1.
AY042679 Genomic DNA. Translation: AAK94514.1.
U36826 Genomic DNA. Translation: AAB63531.1.
U94590 Genomic DNA. Translation: AAB53324.1.
X95760 Genomic DNA. Translation: CAA65066.1.
Y13715 Genomic DNA. Translation: CAA74043.1.
AJ001255 Genomic DNA. Translation: CAA04629.1.
AJ242860 Genomic DNA. Translation: CAB62390.1.
AJ242862 Genomic DNA. Translation: CAB62392.1.
AJ315477 Genomic DNA. Translation: CAC86562.1.
AF028012 Genomic DNA. Translation: AAB94614.1.
Y08063 Genomic DNA. Translation: CAA69301.1.
Y10180 Genomic DNA. Translation: CAA71253.1.
X86977 Genomic DNA. No translation available.
AF152845 Genomic DNA. Translation: AAD45286.1.

IPI

IPI00553012.

PIR

B60748.
E28043.
HLHU5D. I37469.
PT0164.
PT0165.
PT0166.
S03442.

RefSeq

NP_072049.2. NM_022555.3.
XP_003846510.1. XM_003846462.1.
XP_003846511.1. XM_003846463.1.
XP_003846512.1. XM_003846464.1.

UniGene

Hs.696211.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2Q6W	X-ray	2.25	B/E	30-219	[»]
3C5J	X-ray	1.80	B	30-219	[»]
4H1L	X-ray	3.30	B/E	33-219	[»]

ProteinModelPortal

P79483.

ModBase

Search...

Protein-protein interaction databases

IntAct

P79483. 2 interactions.

Polymorphism databases

DMDM

34395491.

Proteomic databases

PaxDb

P79483.

PRIDE

P79483.

Protocols and materials databases

DNASU

3125.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000307137; ENSP00000302517; ENSG00000196101.
ENST00000383126; ENSP00000372607; ENSG00000231679.
ENST00000426847; ENSP00000416022; ENSG00000230463.

GeneID

3125.

KEGG

hsa:3125.

UCSC

uc011fni.1. human.

Organism-specific databases

CTD

3125.

GeneCards

GC06Mi32479.

HGNC

HGNC:4951. HLA-DRB3.

MIM

612735. gene.

neXtProt

NX_P79483.

PharmGKB

PA35074.

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG68200.

HOVERGEN

HBG012730.

InParanoid

P01913.

KO

K06752.

OrthoDB

EOG461454.

PhylomeDB

P79483.

Enzyme and pathway databases

Reactome

REACT_6900. Immune System.

Gene expression databases

ArrayExpress

P79483.

Genevestigator

P79483.

Family and domain databases

Gene3D

2.60.40.10. 1 hit.
3.10.320.10. 1 hit.

InterPro

IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011162. MHC_I/II-like_Ag-recog.
IPR014745. MHC_II_a/b_N.
IPR000353. MHC_II_b_N.
[Graphical view]

Pfam

PF07654. C1-set. 1 hit.
PF00969. MHC_II_beta. 1 hit.
[Graphical view]

ProDom

PD000328. MHC_II_b_N. 1 hit.
[Graphical view] [Entries sharing at least one domain]

SMART

SM00407. IGc1. 1 hit.
SM00921. MHC_II_beta. 1 hit.
[Graphical view]

SUPFAM

SSF54452. MHC_I/II-like_Ag-recog. 1 hit.

PROSITE

PS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

BindingDB

P79483.

ChEMBL

CHEMBL3460.

EvolutionaryTrace

P79483.

GenomeRNAi

3125.

NextBio

12400.

SOURCE

Search...

Entry information

Entry name

DRB3_HUMAN

Accession

Primary (citable) accession number: P79483
Secondary accession number(s): A0ZXY9 , A7MA46, B5AU12, B5AU13, B5AU14, B8YAC6, C6H115, C6H116, O02875, O19590, O46701, O46794, O78049, O78162, P01913, P79663, Q29721, Q29809, Q2PPD0, Q30144, Q507L8, Q5SP44, Q5STE0, Q6YJU6, Q70M87, Q7YQ62, Q860I9, Q8SP69, Q8WLT7, Q8WLT8, Q95359, Q95HM8, Q95IE5, Q96H16, Q9BCP3, Q9BD18, Q9MYA4, Q9MYH3, Q9MYH4, Q9TP01, Q9TP02, Q9TPB5, Q9TQ21, Q9UIN3, Q9UIN5

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 29, 2003
Last sequence update:	May 1, 1997
Last modified:	May 1, 2013
This is version 107 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.