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Protein

HLA class II histocompatibility antigen, DR beta 3 chain

Gene

HLA-DRB3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and efficient peptide loading.

GO - Molecular functioni

  • MHC class II receptor activity Source: UniProtKB
  • peptide antigen binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Immunity

Enzyme and pathway databases

ReactomeiR-HSA-202424. Downstream TCR signaling.
R-HSA-202427. Phosphorylation of CD3 and TCR zeta chains.
R-HSA-202430. Translocation of ZAP-70 to Immunological synapse.
R-HSA-202433. Generation of second messenger molecules.
R-HSA-2132295. MHC class II antigen presentation.
R-HSA-389948. PD-1 signaling.
R-HSA-877300. Interferon gamma signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
HLA class II histocompatibility antigen, DR beta 3 chain
Alternative name(s):
MHC class II antigen DRB3
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:4951. HLA-DRB3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini30 – 227198ExtracellularSequence analysisAdd
BLAST
Transmembranei228 – 25023HelicalSequence analysisAdd
BLAST
Topological domaini251 – 26616CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • clathrin-coated endocytic vesicle membrane Source: Reactome
  • endocytic vesicle membrane Source: Reactome
  • ER to Golgi transport vesicle membrane Source: Reactome
  • Golgi membrane Source: Reactome
  • integral component of lumenal side of endoplasmic reticulum membrane Source: Reactome
  • integral component of plasma membrane Source: UniProtKB
  • late endosome membrane Source: UniProtKB
  • lysosomal membrane Source: UniProtKB
  • membrane Source: UniProtKB
  • MHC class II protein complex Source: UniProtKB
  • plasma membrane Source: Reactome
  • trans-Golgi network membrane Source: Reactome
  • transport vesicle membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Endosome, Golgi apparatus, Lysosome, Membrane, MHC II

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35074.

Chemistry

ChEMBLiCHEMBL3460.

Polymorphism and mutation databases

DMDMi34395491.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2929Add
BLAST
Chaini30 – 266237HLA class II histocompatibility antigen, DR beta 3 chainPRO_0000018956Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi44 ↔ 108
Glycosylationi48 – 481N-linked (GlcNAc...)1 Publication
Disulfide bondi146 ↔ 202

Post-translational modificationi

Ubiquitinated by MARCH1 and MARCH8 at Lys-254 leading to sorting into the endosome system and down-regulation of MHC class II.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Ubl conjugation

Proteomic databases

MaxQBiP79483.
PeptideAtlasiP79483.
PRIDEiP79483.
TopDownProteomicsiP79483.

PTM databases

iPTMnetiP79483.
PhosphoSiteiP79483.

Expressioni

Gene expression databases

BgeeiENSG00000196101.

Organism-specific databases

HPAiHPA043151.

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit; also referred as MHC class II molecule. In the endoplasmic reticulum (ER) it forms a heterononamer; 3 MHC class II molecules bind to a CD74 homotrimer (also known as invariant chain or HLA class II histocompatibility antigen gamma chain). In the endosomal/lysosomal system; CD74 undergoes sequential degradation by various proteases; leaving a small fragment termed CLIP on each MHC class II molecule. MHC class II molecule interacts with HLA_DM, and HLA_DO in B-cells, in order to release CLIP and facilitate the binding of antigenic peptides.2 Publications

Protein-protein interaction databases

BioGridi109370. 14 interactions.
IntActiP79483. 3 interactions.

Chemistry

BindingDBiP79483.

Structurei

Secondary structure

1
266
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi36 – 4712Combined sources
Turni48 – 514Combined sources
Beta strandi52 – 6110Combined sources
Beta strandi64 – 707Combined sources
Turni71 – 733Combined sources
Beta strandi75 – 806Combined sources
Helixi81 – 833Combined sources
Helixi84 – 918Combined sources
Turni94 – 963Combined sources
Helixi100 – 1023Combined sources
Helixi103 – 1064Combined sources
Helixi108 – 1158Combined sources
Turni116 – 1216Combined sources
Beta strandi127 – 1348Combined sources
Beta strandi142 – 15413Combined sources
Beta strandi157 – 1626Combined sources
Beta strandi165 – 1673Combined sources
Beta strandi171 – 1733Combined sources
Beta strandi180 – 1823Combined sources
Beta strandi184 – 1929Combined sources
Beta strandi200 – 2056Combined sources
Beta strandi213 – 2175Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2Q6WX-ray2.25B/E30-219[»]
3C5JX-ray1.80B30-219[»]
4H1LX-ray3.30B/E33-219[»]
ProteinModelPortaliP79483.
SMRiP79483. Positions 32-218.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP79483.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini126 – 21489Ig-like C1-typeAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni30 – 12495Beta-1Add
BLAST
Regioni125 – 227103Beta-2Add
BLAST

Sequence similaritiesi

Belongs to the MHC class II family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG012730.
InParanoidiP79483.
KOiK06752.
OMAiNQKGHAG.
PhylomeDBiP79483.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.10.320.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011162. MHC_I/II-like_Ag-recog.
IPR014745. MHC_II_a/b_N.
IPR000353. MHC_II_b_N.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00969. MHC_II_beta. 1 hit.
[Graphical view]
ProDomiPD000328. MHC_II_b_N. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00407. IGc1. 1 hit.
SM00921. MHC_II_beta. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P79483-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVCLKLPGGS SLAALTVTLM VLSSRLAFAG DTRPRFLELR KSECHFFNGT
60 70 80 90 100
ERVRYLDRYF HNQEEFLRFD SDVGEYRAVT ELGRPVAESW NSQKDLLEQK
110 120 130 140 150
RGRVDNYCRH NYGVGESFTV QRRVHPQVTV YPAKTQPLQH HNLLVCSVSG
160 170 180 190 200
FYPGSIEVRW FRNGQEEKAG VVSTGLIQNG DWTFQTLVML ETVPRSGEVY
210 220 230 240 250
TCQVEHPSVT SALTVEWRAR SESAQSKMLS GVGGFVLGLL FLGAGLFIYF
260
RNQKGHSGLQ PTGFLS
Length:266
Mass (Da):29,962
Last modified:May 1, 1997 - v1
Checksum:i2FC3AE68D3B10EAD
GO

Polymorphismi

The following alleles of DRB3 are known: DRB3*01:01, DRB3*01:02, DRB3*01:03, DRB3*01:04, DRB3*01:05, DRB3*01:06, DRB3*01:07, DRB3*01:08, DRB3*01:09, DRB3*01:10, DRB3*01:11, DRB3*01:12, DRB3*01:13, DRB3*01:14, DRB3*02:01, DRB3*02:02, DRB3*02:03, DRB3*02:04, DRB3*02:05, DRB3*02:06, DRB3*02:07, DRB3*02:08, DRB3*02:09, DRB3*02:10, DRB3*02:11, DRB3*02:12, DRB3*02:13, DRB3*02:14, DRB3*02:15, DRB3*02:16, DRB3*02:17, DRB3*02:18, DRB3*02:19, DRB3*02:20, DRB3*02:21, DRB3*02:22, DRB3*02:23, DRB3*02:24, DRB3*02:25, DRB3*03:01, DRB3*03:02 and DRB3*03:03. The sequence shown is that of DRB3*01:01. Allele DRB3*01:01 belongs to an ancestral haplotype and is associated with autoimmune diseases that are linked to antigen presentation. It is found in more than 95% of the homozygous HPA-1B mothers that produce anti-HPA-1A antibodies, this leads to neonatal alloimmune thrombocytopenia (NAIT).

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti37 – 371L → S in allele DRB3*01:04.
VAR_060739
Natural varianti38 – 381E → Q in allele DRB3*02:12.
Corresponds to variant rs1071747 [ dbSNP | Ensembl ].
VAR_060740
Natural varianti39 – 391L → Y in allele DRB3*01:14; requires 2 nucleotide substitutions.
VAR_060741
Natural varianti40 – 401R → C in allele DRB3*01:02.
VAR_016686
Natural varianti40 – 401R → L in allele DRB3*02:01, allele DRB3*02:02, allele DRB3*02:03, allele DRB3*02:04, allele DRB3*02:05, allele DRB3*02:06, allele DRB3*02:07, allele DRB3*02:08, allele DRB3*02:09, allele DRB3*02:10, allele DRB3*02:11, allele DRB3*02:12, allele DRB3*02:13, allele DRB3*02:14, allele DRB3*02:15, allele DRB3*02:16, allele DRB3*02:17, allele DRB3*02:18, allele DRB3*02:19, allele DRB3*02:20, allele DRB3*02:21, allele DRB3*02:22, allele DRB3*02:23, allele DRB3*02:24, allele DRB3*02:25, allele DRB3*03:01, allele DRB3*03:02 and allele DRB3*03:03.
Corresponds to variant rs1071748 [ dbSNP | Ensembl ].
VAR_060742
Natural varianti40 – 401R → S in allele DRB3*01:14.
VAR_060743
Natural varianti41 – 411K → T in allele DRB3*01:14.
Corresponds to variant rs200581589 [ dbSNP | Ensembl ].
VAR_060744
Natural varianti55 – 551Y → F in allele DRB3*01:09, allele DRB3*02:01, allele DRB3*02:02, allele DRB3*02:03, allele DRB3*02:04, allele DRB3*02:05, allele DRB3*02:06, allele DRB3*02:07, allele DRB3*02:08, allele DRB3*02:09, allele DRB3*02:10, allele DRB3*02:11, allele DRB3*02:12, allele DRB3*02:14, allele DRB3*02:15, allele DRB3*02:16, allele DRB3*02:17, allele DRB3*02:18, allele DRB3*02:19, allele DRB3*02:20, allele DRB3*02:21, allele DRB3*02:22, allele DRB3*02:23, allele DRB3*02:24, allele DRB3*02:25, allele DRB3*03:01, allele DRB3*03:02 and allele DRB3*03:03.
Corresponds to variant rs147440497 [ dbSNP | Ensembl ].
VAR_060746
Natural varianti55 – 551Y → L in allele DRB3*02:13; requires 2 nucleotide substitutions.
VAR_060745
Natural varianti57 – 571D → E in allele DRB3*01:03, allele DRB3*01:09, allele DRB3*02:01, allele DRB3*02:02, allele DRB3*02:03, allele DRB3*02:04, allele DRB3*02:05, allele DRB3*02:06, allele DRB3*02:07, allele DRB3*02:08, allele DRB3*02:09, allele DRB3*02:10, allele DRB3*02:11, allele DRB3*02:12, allele DRB3*02:13, allele DRB3*02:14, allele DRB3*02:15, allele DRB3*02:16, allele DRB3*02:17, allele DRB3*02:18, allele DRB3*02:19, allele DRB3*02:20, allele DRB3*02:21, allele DRB3*02:22, allele DRB3*02:23, allele DRB3*02:24, allele DRB3*02:25, allele DRB3*03:01, allele DRB3*03:02 and allele DRB3*03:03.
Corresponds to variant rs202185589 [ dbSNP | Ensembl ].
VAR_060747
Natural varianti57 – 571D → N in allele DRB3*01:05.
Corresponds to variant rs142793258 [ dbSNP | Ensembl ].
VAR_060748
Natural varianti58 – 581R → I in allele DRB3*01:11.
VAR_060749
Natural varianti59 – 591Y → H in allele DRB3*01:09, allele DRB3*02:01, allele DRB3*02:02, allele DRB3*02:03, allele DRB3*02:04, allele DRB3*02:06, allele DRB3*02:07, allele DRB3*02:08, allele DRB3*02:09, allele DRB3*02:10, allele DRB3*02:11, allele DRB3*02:12, allele DRB3*02:13, allele DRB3*02:14, allele DRB3*02:15, allele DRB3*02:16, allele DRB3*02:17, allele DRB3*02:18, allele DRB3*02:19, allele DRB3*02:20, allele DRB3*02:21, allele DRB3*02:22, allele DRB3*02:23, allele DRB3*02:24, allele DRB3*02:25 and allele DRB3*03:02.
Corresponds to variant rs138849995 [ dbSNP | Ensembl ].
VAR_060750
Natural varianti66 – 661F → L in allele DRB3*01:13.
Corresponds to variant rs707956 [ dbSNP | Ensembl ].
VAR_060752
Natural varianti66 – 661F → N in allele DRB3*01:08, allele DRB3*02:06 and allele DRB3*02:20; requires 2 nucleotide substitutions.
VAR_060753
Natural varianti66 – 661F → S in allele DRB3*02:03.
Corresponds to variant rs200042906 [ dbSNP | Ensembl ].
VAR_060751
Natural varianti66 – 661F → Y in allele DRB3*01:07, allele DRB3*01:09, allele DRB3*02:01, allele DRB3*02:02, allele DRB3*02:04, allele DRB3*02:05, allele DRB3*02:07, allele DRB3*02:08, allele DRB3*02:09, allele DRB3*02:10, allele DRB3*02:11, allele DRB3*02:12, allele DRB3*02:13, allele DRB3*02:14, allele DRB3*02:15, allele DRB3*02:16, allele DRB3*02:17, allele DRB3*02:18, allele DRB3*02:19, allele DRB3*02:21, allele DRB3*02:22, allele DRB3*02:23, allele DRB3*02:24 and allele DRB3*02:25.
Corresponds to variant rs200042906 [ dbSNP | Ensembl ].
VAR_060754
Natural varianti67 – 671L → A in allele DRB3*01:07, allele DRB3*01:09, allele DRB3*02:01, allele DRB3*02:02, allele DRB3*02:04, allele DRB3*02:05, allele DRB3*02:06, allele DRB3*02:07, allele DRB3*02:08, allele DRB3*02:09, allele DRB3*02:10, allele DRB3*02:11, allele DRB3*02:12, allele DRB3*02:13, allele DRB3*02:14, allele DRB3*02:15, allele DRB3*02:16, allele DRB3*02:17, allele DRB3*02:18, allele DRB3*02:19, allele DRB3*02:21, allele DRB3*02:22, allele DRB3*02:23, allele DRB3*02:24 and allele DRB3*02:25; requires 2 nucleotide substitutions.
VAR_060755
Natural varianti67 – 671L → V in allele DRB3*01:06, allele DRB3*01:08, allele DRB3*02:03, allele DRB3*02:20, allele DRB3*03:01, allele DRB3*03:02 and allele DRB3*03:03.
Corresponds to variant rs1059580 [ dbSNP | Ensembl ].
VAR_060756
Natural varianti68 – 681R → S in allele DRB3*01:10.
Corresponds to variant rs774894415 [ dbSNP | Ensembl ].
VAR_060757
Natural varianti80 – 801T → R in allele DRB3*01:07, allele DRB3*02:01, allele DRB3*02:02, allele DRB3*02:03, allele DRB3*02:04, allele DRB3*02:05, allele DRB3*02:06, allele DRB3*02:07, allele DRB3*02:08, allele DRB3*02:11, allele DRB3*02:12, allele DRB3*02:13, allele DRB3*02:14, allele DRB3*02:15, allele DRB3*02:16, allele DRB3*02:17, allele DRB3*02:18, allele DRB3*02:19, allele DRB3*02:20, allele DRB3*02:21, allele DRB3*02:22, allele DRB3*02:23, allele DRB3*02:24 and allele DRB3*02:25.
Corresponds to variant rs79606458 [ dbSNP | Ensembl ].
VAR_060758
Natural varianti84 – 841R → L in allele DRB3*02:23.
VAR_060759
Natural varianti86 – 861V → A in allele DRB3*02:16.
Corresponds to variant rs144532965 [ dbSNP | Ensembl ].
VAR_060760
Natural varianti86 – 861V → D in allele DRB3*01:07, allele DRB3*02:01, allele DRB3*02:02, allele DRB3*02:03, allele DRB3*02:04, allele DRB3*02:05, allele DRB3*02:06, allele DRB3*02:10, allele DRB3*02:11, allele DRB3*02:12, allele DRB3*02:13, allele DRB3*02:14, allele DRB3*02:15, allele DRB3*02:17, allele DRB3*02:18, allele DRB3*02:19, allele DRB3*02:20, allele DRB3*02:22, allele DRB3*02:23, allele DRB3*02:24 and allele DRB3*02:25.
Corresponds to variant rs144532965 [ dbSNP | Ensembl ].
VAR_060762
Natural varianti86 – 861V → S in allele DRB3*02:08; requires 2 nucleotide substitutions.
VAR_060761
Natural varianti87 – 871A → E in allele DRB3*02:18.
VAR_060763
Natural varianti89 – 891S → H in allele DRB3*02:16; requires 2 nucleotide substitutions.
VAR_060764
Natural varianti89 – 891S → Y in allele DRB3*01:07, allele DRB3*02:01, allele DRB3*02:02, allele DRB3*02:03, allele DRB3*02:04, allele DRB3*02:05, allele DRB3*02:06, allele DRB3*02:07, allele DRB3*02:08, allele DRB3*02:10, allele DRB3*02:11, allele DRB3*02:12, allele DRB3*02:13, allele DRB3*02:14, allele DRB3*02:15, allele DRB3*02:17, allele DRB3*02:18, allele DRB3*02:20, allele DRB3*02:22, allele DRB3*02:23 and allele DRB3*02:24.
Corresponds to variant rs41541218 [ dbSNP | Ensembl ].
VAR_060765
Natural varianti96 – 961L → F in allele DRB3*02:17.
Corresponds to variant rs41562819 [ dbSNP | Ensembl ].
VAR_060766
Natural varianti96 – 961L → I in allele DRB3*02:11.
Corresponds to variant rs41562819 [ dbSNP | Ensembl ].
VAR_060767
Natural varianti102 – 1021G → A.
Corresponds to variant rs17878857 [ dbSNP | Ensembl ].
VAR_033396
Natural varianti103 – 1031R → Q in allele DRB3*01:07, allele DRB3*02:01, allele DRB3*02:02, allele DRB3*02:03, allele DRB3*02:05, allele DRB3*02:06, allele DRB3*02:07, allele DRB3*02:08, allele DRB3*02:09, allele DRB3*02:10, allele DRB3*02:11, allele DRB3*02:12, allele DRB3*02:13, allele DRB3*02:14, allele DRB3*02:15, allele DRB3*02:16, allele DRB3*02:17, allele DRB3*02:18, allele DRB3*02:20, allele DRB3*02:21, allele DRB3*02:23, allele DRB3*02:24, allele DRB3*02:25, allele DRB3*03:01 and allele DRB3*03:02.
Corresponds to variant rs1059598 [ dbSNP | Ensembl ].
VAR_060768
Natural varianti106 – 1061N → T in allele DRB3*02:15.
Corresponds to variant rs115817940 [ dbSNP | Ensembl ].
VAR_060769
Natural varianti113 – 1131G → R in allele DRB3*01:12.
VAR_060770
Natural varianti114 – 1141V → A.
Corresponds to variant rs1136778 [ dbSNP | Ensembl ].
VAR_033397
Natural varianti115 – 1151G → A in allele DRB3*02:14.
VAR_060771
Natural varianti115 – 1151G → V in allele DRB3*02:01, allele DRB3*02:04, allele DRB3*02:24, allele DRB3*03:01 and allele DRB3*03:02.
Corresponds to variant rs41556512 [ dbSNP | Ensembl ].
VAR_060772
Natural varianti169 – 1691A → T in allele DRB3*03:01.
Corresponds to variant rs75709987 [ dbSNP | Ensembl ].
VAR_060773
Natural varianti178 – 1781Q → H in allele DRB3*03:01.
Corresponds to variant rs139485758 [ dbSNP | Ensembl ].
VAR_060774
Natural varianti193 – 1931V → F in allele DRB3*02:01.
VAR_060775
Natural varianti212 – 2121A → P in allele DRB3*02:01, allele DRB3*02:02, allele DRB3*02:10, allele DRB3*02:11, allele DRB3*02:24 and allele DRB3*03:01.
Corresponds to variant rs142204283 [ dbSNP | Ensembl ].
VAR_060776
Natural varianti218 – 2181R → S in allele DRB3*02:01, allele DRB3*02:02, allele DRB3*02:10 and allele DRB3*02:11.
Corresponds to variant rs147669022 [ dbSNP | Ensembl ].
VAR_060777
Natural varianti236 – 2361V → M.
Corresponds to variant rs2230816 [ dbSNP | Ensembl ].
VAR_033398

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V00522 mRNA. Translation: CAA23781.1.
X04055 Genomic DNA. No translation available.
X04058 Genomic DNA. No translation available.
U66825 mRNA. Translation: AAD43828.1.
AF026467 Genomic DNA. Translation: AAC05599.1.
AF199236 mRNA. Translation: AAF13065.2.
U95819 mRNA. Translation: AAD00819.1.
AY138123 mRNA. Translation: AAN15205.1.
A06800 mRNA. Translation: CAA00596.1.
AL662842 Genomic DNA. Translation: CAI17549.1.
AL929581 Genomic DNA. Translation: CAI18691.1.
CR788283 Genomic DNA. Translation: CAQ11026.1.
Z84814 Genomic DNA. Translation: CAB06607.1.
BC008987 mRNA. Translation: AAH08987.1.
BC106057 mRNA. Translation: AAI06058.1.
M17380 mRNA. Translation: AAA59804.1.
AF192258 mRNA. Translation: AAF26358.1.
AF192259 mRNA. Translation: AAF26359.1.
FJ515276 Genomic DNA. Translation: ACL50609.1.
AY291205 Genomic DNA. Translation: AAP43643.1.
AF148518 Genomic DNA. Translation: AAF67837.1.
AF081677 Genomic DNA. Translation: AAC32202.1.
AY271986 Genomic DNA. Translation: AAP23230.1.
AM747470 Genomic DNA. Translation: CAO00528.1.
EU873151 Genomic DNA. Translation: ACF33221.1.
EU873152 Genomic DNA. Translation: ACF33222.1.
EU873153 Genomic DNA. Translation: ACF33223.1.
X91639 Genomic DNA. No translation available.
AF208484 Genomic DNA. Translation: AAF23165.1.
AF208485 Genomic DNA. Translation: AAF23166.1.
AJ290395 Genomic DNA. Translation: CAC27417.1.
AF427138 Genomic DNA. Translation: AAL26538.1.
AF455114 Genomic DNA. Translation: AAL57866.1.
AF461431 Genomic DNA. Translation: AAL66370.1.
AJ564210 Genomic DNA. Translation: CAD91915.2.
AY958608 Genomic DNA. Translation: AAY28717.1.
DQ311653 Genomic DNA. Translation: ABC33924.1.
AM413002 Genomic DNA. Translation: CAL85628.1.
FN424163 Genomic DNA. Translation: CAZ66795.1.
FN424162 Genomic DNA. Translation: CAZ66766.1.
AF177216 Genomic DNA. Translation: AAD53911.1.
AF361865 Genomic DNA. Translation: AAK38297.1.
AY042679 Genomic DNA. Translation: AAK94514.1.
U36826 Genomic DNA. Translation: AAB63531.1.
U94590 Genomic DNA. Translation: AAB53324.1.
X95760 Genomic DNA. Translation: CAA65066.1.
Y13715 Genomic DNA. Translation: CAA74043.1.
AJ001255 Genomic DNA. Translation: CAA04629.1.
AJ242860 Genomic DNA. Translation: CAB62390.1.
AJ242862 Genomic DNA. Translation: CAB62392.1.
AJ315477 Genomic DNA. Translation: CAC86562.1.
AF028012 Genomic DNA. Translation: AAB94614.1.
Y08063 Genomic DNA. Translation: CAA69301.1.
Y10180 Genomic DNA. Translation: CAA71253.1.
X86977 Genomic DNA. No translation available.
AF152845 Genomic DNA. Translation: AAD45286.1.
PIRiB60748.
E28043.
I37469. HLHU5D.
PT0164.
PT0165.
PT0166.
S03442.
RefSeqiNP_072049.2. NM_022555.3.
UniGeneiHs.696211.

Genome annotation databases

EnsembliENST00000307137; ENSP00000302517; ENSG00000196101.
ENST00000383126; ENSP00000372607; ENSG00000231679.
GeneIDi3125.
KEGGihsa:3125.
UCSCiuc011fni.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V00522 mRNA. Translation: CAA23781.1.
X04055 Genomic DNA. No translation available.
X04058 Genomic DNA. No translation available.
U66825 mRNA. Translation: AAD43828.1.
AF026467 Genomic DNA. Translation: AAC05599.1.
AF199236 mRNA. Translation: AAF13065.2.
U95819 mRNA. Translation: AAD00819.1.
AY138123 mRNA. Translation: AAN15205.1.
A06800 mRNA. Translation: CAA00596.1.
AL662842 Genomic DNA. Translation: CAI17549.1.
AL929581 Genomic DNA. Translation: CAI18691.1.
CR788283 Genomic DNA. Translation: CAQ11026.1.
Z84814 Genomic DNA. Translation: CAB06607.1.
BC008987 mRNA. Translation: AAH08987.1.
BC106057 mRNA. Translation: AAI06058.1.
M17380 mRNA. Translation: AAA59804.1.
AF192258 mRNA. Translation: AAF26358.1.
AF192259 mRNA. Translation: AAF26359.1.
FJ515276 Genomic DNA. Translation: ACL50609.1.
AY291205 Genomic DNA. Translation: AAP43643.1.
AF148518 Genomic DNA. Translation: AAF67837.1.
AF081677 Genomic DNA. Translation: AAC32202.1.
AY271986 Genomic DNA. Translation: AAP23230.1.
AM747470 Genomic DNA. Translation: CAO00528.1.
EU873151 Genomic DNA. Translation: ACF33221.1.
EU873152 Genomic DNA. Translation: ACF33222.1.
EU873153 Genomic DNA. Translation: ACF33223.1.
X91639 Genomic DNA. No translation available.
AF208484 Genomic DNA. Translation: AAF23165.1.
AF208485 Genomic DNA. Translation: AAF23166.1.
AJ290395 Genomic DNA. Translation: CAC27417.1.
AF427138 Genomic DNA. Translation: AAL26538.1.
AF455114 Genomic DNA. Translation: AAL57866.1.
AF461431 Genomic DNA. Translation: AAL66370.1.
AJ564210 Genomic DNA. Translation: CAD91915.2.
AY958608 Genomic DNA. Translation: AAY28717.1.
DQ311653 Genomic DNA. Translation: ABC33924.1.
AM413002 Genomic DNA. Translation: CAL85628.1.
FN424163 Genomic DNA. Translation: CAZ66795.1.
FN424162 Genomic DNA. Translation: CAZ66766.1.
AF177216 Genomic DNA. Translation: AAD53911.1.
AF361865 Genomic DNA. Translation: AAK38297.1.
AY042679 Genomic DNA. Translation: AAK94514.1.
U36826 Genomic DNA. Translation: AAB63531.1.
U94590 Genomic DNA. Translation: AAB53324.1.
X95760 Genomic DNA. Translation: CAA65066.1.
Y13715 Genomic DNA. Translation: CAA74043.1.
AJ001255 Genomic DNA. Translation: CAA04629.1.
AJ242860 Genomic DNA. Translation: CAB62390.1.
AJ242862 Genomic DNA. Translation: CAB62392.1.
AJ315477 Genomic DNA. Translation: CAC86562.1.
AF028012 Genomic DNA. Translation: AAB94614.1.
Y08063 Genomic DNA. Translation: CAA69301.1.
Y10180 Genomic DNA. Translation: CAA71253.1.
X86977 Genomic DNA. No translation available.
AF152845 Genomic DNA. Translation: AAD45286.1.
PIRiB60748.
E28043.
I37469. HLHU5D.
PT0164.
PT0165.
PT0166.
S03442.
RefSeqiNP_072049.2. NM_022555.3.
UniGeneiHs.696211.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2Q6WX-ray2.25B/E30-219[»]
3C5JX-ray1.80B30-219[»]
4H1LX-ray3.30B/E33-219[»]
ProteinModelPortaliP79483.
SMRiP79483. Positions 32-218.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109370. 14 interactions.
IntActiP79483. 3 interactions.

Chemistry

BindingDBiP79483.
ChEMBLiCHEMBL3460.

PTM databases

iPTMnetiP79483.
PhosphoSiteiP79483.

Polymorphism and mutation databases

DMDMi34395491.

Proteomic databases

MaxQBiP79483.
PeptideAtlasiP79483.
PRIDEiP79483.
TopDownProteomicsiP79483.

Protocols and materials databases

DNASUi3125.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000307137; ENSP00000302517; ENSG00000196101.
ENST00000383126; ENSP00000372607; ENSG00000231679.
GeneIDi3125.
KEGGihsa:3125.
UCSCiuc011fni.2. human.

Organism-specific databases

CTDi3125.
GeneCardsiHLA-DRB3.
HGNCiHGNC:4951. HLA-DRB3.
HPAiHPA043151.
MIMi612735. gene.
neXtProtiNX_P79483.
PharmGKBiPA35074.
GenAtlasiSearch...

Phylogenomic databases

HOVERGENiHBG012730.
InParanoidiP79483.
KOiK06752.
OMAiNQKGHAG.
PhylomeDBiP79483.

Enzyme and pathway databases

ReactomeiR-HSA-202424. Downstream TCR signaling.
R-HSA-202427. Phosphorylation of CD3 and TCR zeta chains.
R-HSA-202430. Translocation of ZAP-70 to Immunological synapse.
R-HSA-202433. Generation of second messenger molecules.
R-HSA-2132295. MHC class II antigen presentation.
R-HSA-389948. PD-1 signaling.
R-HSA-877300. Interferon gamma signaling.

Miscellaneous databases

EvolutionaryTraceiP79483.
GeneWikiiHLA-DRB3_(gene).
GenomeRNAii3125.
PROiP79483.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000196101.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.10.320.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011162. MHC_I/II-like_Ag-recog.
IPR014745. MHC_II_a/b_N.
IPR000353. MHC_II_b_N.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00969. MHC_II_beta. 1 hit.
[Graphical view]
ProDomiPD000328. MHC_II_b_N. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00407. IGc1. 1 hit.
SM00921. MHC_II_beta. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDRB3_HUMAN
AccessioniPrimary (citable) accession number: P79483
Secondary accession number(s): A0ZXY9
, A7MA46, B5AU12, B5AU13, B5AU14, B8YAC6, C6H115, C6H116, O02875, O19590, O46701, O46794, O78049, O78162, P01913, P79663, Q29721, Q29809, Q2PPD0, Q30144, Q507L8, Q5SP44, Q5STE0, Q6YJU6, Q70M87, Q7YQ62, Q860I9, Q8SP69, Q8WLT7, Q8WLT8, Q95359, Q95HM8, Q95IE5, Q96H16, Q9BCP3, Q9BD18, Q9MYA4, Q9MYH3, Q9MYH4, Q9TP01, Q9TP02, Q9TPB5, Q9TQ21, Q9UIN3, Q9UIN5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 29, 2003
Last sequence update: May 1, 1997
Last modified: September 7, 2016
This is version 135 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

HLA-DRB3, HLA-DRB4 and HLA-DRB5 may represent a unique gene.Curated

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.