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Protein

HLA class II histocompatibility antigen, DR beta 3 chain

Gene

HLA-DRB3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and efficient peptide loading.

GO - Molecular functioni

  • MHC class II receptor activity Source: UniProtKB
  • peptide antigen binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Immunity

Enzyme and pathway databases

BioCyciZFISH:G66-32419-MONOMER.
ReactomeiR-HSA-202424. Downstream TCR signaling.
R-HSA-202427. Phosphorylation of CD3 and TCR zeta chains.
R-HSA-202430. Translocation of ZAP-70 to Immunological synapse.
R-HSA-202433. Generation of second messenger molecules.
R-HSA-2132295. MHC class II antigen presentation.
R-HSA-389948. PD-1 signaling.
R-HSA-877300. Interferon gamma signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
HLA class II histocompatibility antigen, DR beta 3 chain
Alternative name(s):
MHC class II antigen DRB3
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:4951. HLA-DRB3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini30 – 227ExtracellularSequence analysisAdd BLAST198
Transmembranei228 – 250HelicalSequence analysisAdd BLAST23
Topological domaini251 – 266CytoplasmicSequence analysisAdd BLAST16

GO - Cellular componenti

  • clathrin-coated endocytic vesicle membrane Source: Reactome
  • endocytic vesicle membrane Source: Reactome
  • ER to Golgi transport vesicle membrane Source: Reactome
  • Golgi membrane Source: Reactome
  • integral component of lumenal side of endoplasmic reticulum membrane Source: Reactome
  • integral component of plasma membrane Source: UniProtKB
  • late endosome membrane Source: UniProtKB
  • lysosomal membrane Source: UniProtKB
  • membrane Source: UniProtKB
  • MHC class II protein complex Source: UniProtKB
  • plasma membrane Source: Reactome
  • trans-Golgi network membrane Source: Reactome
  • transport vesicle membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Endosome, Golgi apparatus, Lysosome, Membrane, MHC II

Pathology & Biotechi

Organism-specific databases

DisGeNETi3125.
OpenTargetsiENSG00000231679.
PharmGKBiPA35074.

Chemistry databases

ChEMBLiCHEMBL3460.

Polymorphism and mutation databases

DMDMi34395491.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Add BLAST29
ChainiPRO_000001895630 – 266HLA class II histocompatibility antigen, DR beta 3 chainAdd BLAST237

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi44 ↔ 108
Glycosylationi48N-linked (GlcNAc...)1 Publication1
Disulfide bondi146 ↔ 202

Post-translational modificationi

Ubiquitinated by MARCH1 and MARCH8 at Lys-254 leading to sorting into the endosome system and down-regulation of MHC class II.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Ubl conjugation

Proteomic databases

MaxQBiP79483.
PeptideAtlasiP79483.
PRIDEiP79483.
TopDownProteomicsiP79483.

PTM databases

iPTMnetiP79483.
PhosphoSitePlusiP79483.

Expressioni

Gene expression databases

BgeeiENSG00000196101.

Organism-specific databases

HPAiHPA043151.

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit; also referred as MHC class II molecule. In the endoplasmic reticulum (ER) it forms a heterononamer; 3 MHC class II molecules bind to a CD74 homotrimer (also known as invariant chain or HLA class II histocompatibility antigen gamma chain). In the endosomal/lysosomal system; CD74 undergoes sequential degradation by various proteases; leaving a small fragment termed CLIP on each MHC class II molecule. MHC class II molecule interacts with HLA_DM, and HLA_DO in B-cells, in order to release CLIP and facilitate the binding of antigenic peptides.2 Publications

Protein-protein interaction databases

BioGridi109370. 14 interactors.
IntActiP79483. 3 interactors.

Chemistry databases

BindingDBiP79483.

Structurei

Secondary structure

1266
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi36 – 47Combined sources12
Turni48 – 51Combined sources4
Beta strandi52 – 61Combined sources10
Beta strandi64 – 70Combined sources7
Turni71 – 73Combined sources3
Beta strandi75 – 80Combined sources6
Helixi81 – 83Combined sources3
Helixi84 – 91Combined sources8
Turni94 – 96Combined sources3
Helixi100 – 102Combined sources3
Helixi103 – 106Combined sources4
Helixi108 – 115Combined sources8
Turni116 – 121Combined sources6
Beta strandi127 – 134Combined sources8
Beta strandi142 – 154Combined sources13
Beta strandi157 – 162Combined sources6
Beta strandi165 – 167Combined sources3
Beta strandi171 – 173Combined sources3
Beta strandi180 – 182Combined sources3
Beta strandi184 – 192Combined sources9
Beta strandi200 – 205Combined sources6
Beta strandi213 – 217Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2Q6WX-ray2.25B/E30-219[»]
3C5JX-ray1.80B30-219[»]
4H1LX-ray3.30B/E33-219[»]
ProteinModelPortaliP79483.
SMRiP79483.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP79483.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini126 – 214Ig-like C1-typeAdd BLAST89

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni30 – 124Beta-1Add BLAST95
Regioni125 – 227Beta-2Add BLAST103

Sequence similaritiesi

Belongs to the MHC class II family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG012730.
InParanoidiP79483.
KOiK06752.
OMAiNQKGHAG.
PhylomeDBiP79483.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.10.320.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011162. MHC_I/II-like_Ag-recog.
IPR014745. MHC_II_a/b_N.
IPR000353. MHC_II_b_N.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00969. MHC_II_beta. 1 hit.
[Graphical view]
ProDomiPD000328. MHC_II_b_N. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00407. IGc1. 1 hit.
SM00921. MHC_II_beta. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P79483-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVCLKLPGGS SLAALTVTLM VLSSRLAFAG DTRPRFLELR KSECHFFNGT
60 70 80 90 100
ERVRYLDRYF HNQEEFLRFD SDVGEYRAVT ELGRPVAESW NSQKDLLEQK
110 120 130 140 150
RGRVDNYCRH NYGVGESFTV QRRVHPQVTV YPAKTQPLQH HNLLVCSVSG
160 170 180 190 200
FYPGSIEVRW FRNGQEEKAG VVSTGLIQNG DWTFQTLVML ETVPRSGEVY
210 220 230 240 250
TCQVEHPSVT SALTVEWRAR SESAQSKMLS GVGGFVLGLL FLGAGLFIYF
260
RNQKGHSGLQ PTGFLS
Length:266
Mass (Da):29,962
Last modified:May 1, 1997 - v1
Checksum:i2FC3AE68D3B10EAD
GO

Polymorphismi

The following alleles of DRB3 are known: DRB3*01:01, DRB3*01:02, DRB3*01:03, DRB3*01:04, DRB3*01:05, DRB3*01:06, DRB3*01:07, DRB3*01:08, DRB3*01:09, DRB3*01:10, DRB3*01:11, DRB3*01:12, DRB3*01:13, DRB3*01:14, DRB3*02:01, DRB3*02:02, DRB3*02:03, DRB3*02:04, DRB3*02:05, DRB3*02:06, DRB3*02:07, DRB3*02:08, DRB3*02:09, DRB3*02:10, DRB3*02:11, DRB3*02:12, DRB3*02:13, DRB3*02:14, DRB3*02:15, DRB3*02:16, DRB3*02:17, DRB3*02:18, DRB3*02:19, DRB3*02:20, DRB3*02:21, DRB3*02:22, DRB3*02:23, DRB3*02:24, DRB3*02:25, DRB3*03:01, DRB3*03:02 and DRB3*03:03. The sequence shown is that of DRB3*01:01. Allele DRB3*01:01 belongs to an ancestral haplotype and is associated with autoimmune diseases that are linked to antigen presentation. It is found in more than 95% of the homozygous HPA-1B mothers that produce anti-HPA-1A antibodies, this leads to neonatal alloimmune thrombocytopenia (NAIT).

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06073937L → S in allele DRB3*01:04. 1
Natural variantiVAR_06074038E → Q in allele DRB3*02:12. Corresponds to variant rs1071747dbSNPEnsembl.1
Natural variantiVAR_06074139L → Y in allele DRB3*01:14; requires 2 nucleotide substitutions. 1
Natural variantiVAR_01668640R → C in allele DRB3*01:02. 1
Natural variantiVAR_06074240R → L in allele DRB3*02:01, allele DRB3*02:02, allele DRB3*02:03, allele DRB3*02:04, allele DRB3*02:05, allele DRB3*02:06, allele DRB3*02:07, allele DRB3*02:08, allele DRB3*02:09, allele DRB3*02:10, allele DRB3*02:11, allele DRB3*02:12, allele DRB3*02:13, allele DRB3*02:14, allele DRB3*02:15, allele DRB3*02:16, allele DRB3*02:17, allele DRB3*02:18, allele DRB3*02:19, allele DRB3*02:20, allele DRB3*02:21, allele DRB3*02:22, allele DRB3*02:23, allele DRB3*02:24, allele DRB3*02:25, allele DRB3*03:01, allele DRB3*03:02 and allele DRB3*03:03. Corresponds to variant rs1071748dbSNPEnsembl.1
Natural variantiVAR_06074340R → S in allele DRB3*01:14. Corresponds to variant rs1136752dbSNPEnsembl.1
Natural variantiVAR_06074441K → T in allele DRB3*01:14. Corresponds to variant rs200581589dbSNPEnsembl.1
Natural variantiVAR_06074655Y → F in allele DRB3*01:09, allele DRB3*02:01, allele DRB3*02:02, allele DRB3*02:03, allele DRB3*02:04, allele DRB3*02:05, allele DRB3*02:06, allele DRB3*02:07, allele DRB3*02:08, allele DRB3*02:09, allele DRB3*02:10, allele DRB3*02:11, allele DRB3*02:12, allele DRB3*02:14, allele DRB3*02:15, allele DRB3*02:16, allele DRB3*02:17, allele DRB3*02:18, allele DRB3*02:19, allele DRB3*02:20, allele DRB3*02:21, allele DRB3*02:22, allele DRB3*02:23, allele DRB3*02:24, allele DRB3*02:25, allele DRB3*03:01, allele DRB3*03:02 and allele DRB3*03:03. Corresponds to variant rs147440497dbSNPEnsembl.1
Natural variantiVAR_06074555Y → L in allele DRB3*02:13; requires 2 nucleotide substitutions. 1
Natural variantiVAR_06074757D → E in allele DRB3*01:03, allele DRB3*01:09, allele DRB3*02:01, allele DRB3*02:02, allele DRB3*02:03, allele DRB3*02:04, allele DRB3*02:05, allele DRB3*02:06, allele DRB3*02:07, allele DRB3*02:08, allele DRB3*02:09, allele DRB3*02:10, allele DRB3*02:11, allele DRB3*02:12, allele DRB3*02:13, allele DRB3*02:14, allele DRB3*02:15, allele DRB3*02:16, allele DRB3*02:17, allele DRB3*02:18, allele DRB3*02:19, allele DRB3*02:20, allele DRB3*02:21, allele DRB3*02:22, allele DRB3*02:23, allele DRB3*02:24, allele DRB3*02:25, allele DRB3*03:01, allele DRB3*03:02 and allele DRB3*03:03. Corresponds to variant rs202185589dbSNPEnsembl.1
Natural variantiVAR_06074857D → N in allele DRB3*01:05. Corresponds to variant rs142793258dbSNPEnsembl.1
Natural variantiVAR_06074958R → I in allele DRB3*01:11. 1
Natural variantiVAR_06075059Y → H in allele DRB3*01:09, allele DRB3*02:01, allele DRB3*02:02, allele DRB3*02:03, allele DRB3*02:04, allele DRB3*02:06, allele DRB3*02:07, allele DRB3*02:08, allele DRB3*02:09, allele DRB3*02:10, allele DRB3*02:11, allele DRB3*02:12, allele DRB3*02:13, allele DRB3*02:14, allele DRB3*02:15, allele DRB3*02:16, allele DRB3*02:17, allele DRB3*02:18, allele DRB3*02:19, allele DRB3*02:20, allele DRB3*02:21, allele DRB3*02:22, allele DRB3*02:23, allele DRB3*02:24, allele DRB3*02:25 and allele DRB3*03:02. Corresponds to variant rs138849995dbSNPEnsembl.1
Natural variantiVAR_06075266F → L in allele DRB3*01:13. Corresponds to variant rs707956dbSNPEnsembl.1
Natural variantiVAR_06075366F → N in allele DRB3*01:08, allele DRB3*02:06 and allele DRB3*02:20; requires 2 nucleotide substitutions. 1
Natural variantiVAR_06075166F → S in allele DRB3*02:03. Corresponds to variant rs200042906dbSNPEnsembl.1
Natural variantiVAR_06075466F → Y in allele DRB3*01:07, allele DRB3*01:09, allele DRB3*02:01, allele DRB3*02:02, allele DRB3*02:04, allele DRB3*02:05, allele DRB3*02:07, allele DRB3*02:08, allele DRB3*02:09, allele DRB3*02:10, allele DRB3*02:11, allele DRB3*02:12, allele DRB3*02:13, allele DRB3*02:14, allele DRB3*02:15, allele DRB3*02:16, allele DRB3*02:17, allele DRB3*02:18, allele DRB3*02:19, allele DRB3*02:21, allele DRB3*02:22, allele DRB3*02:23, allele DRB3*02:24 and allele DRB3*02:25. Corresponds to variant rs200042906dbSNPEnsembl.1
Natural variantiVAR_06075567L → A in allele DRB3*01:07, allele DRB3*01:09, allele DRB3*02:01, allele DRB3*02:02, allele DRB3*02:04, allele DRB3*02:05, allele DRB3*02:06, allele DRB3*02:07, allele DRB3*02:08, allele DRB3*02:09, allele DRB3*02:10, allele DRB3*02:11, allele DRB3*02:12, allele DRB3*02:13, allele DRB3*02:14, allele DRB3*02:15, allele DRB3*02:16, allele DRB3*02:17, allele DRB3*02:18, allele DRB3*02:19, allele DRB3*02:21, allele DRB3*02:22, allele DRB3*02:23, allele DRB3*02:24 and allele DRB3*02:25; requires 2 nucleotide substitutions. 1
Natural variantiVAR_06075667L → V in allele DRB3*01:06, allele DRB3*01:08, allele DRB3*02:03, allele DRB3*02:20, allele DRB3*03:01, allele DRB3*03:02 and allele DRB3*03:03. Corresponds to variant rs1059580dbSNPEnsembl.1
Natural variantiVAR_06075768R → S in allele DRB3*01:10. Corresponds to variant rs774894415dbSNPEnsembl.1
Natural variantiVAR_06075880T → R in allele DRB3*01:07, allele DRB3*02:01, allele DRB3*02:02, allele DRB3*02:03, allele DRB3*02:04, allele DRB3*02:05, allele DRB3*02:06, allele DRB3*02:07, allele DRB3*02:08, allele DRB3*02:11, allele DRB3*02:12, allele DRB3*02:13, allele DRB3*02:14, allele DRB3*02:15, allele DRB3*02:16, allele DRB3*02:17, allele DRB3*02:18, allele DRB3*02:19, allele DRB3*02:20, allele DRB3*02:21, allele DRB3*02:22, allele DRB3*02:23, allele DRB3*02:24 and allele DRB3*02:25. Corresponds to variant rs79606458dbSNPEnsembl.1
Natural variantiVAR_06075984R → L in allele DRB3*02:23. 1
Natural variantiVAR_06076086V → A in allele DRB3*02:16. Corresponds to variant rs144532965dbSNPEnsembl.1
Natural variantiVAR_06076286V → D in allele DRB3*01:07, allele DRB3*02:01, allele DRB3*02:02, allele DRB3*02:03, allele DRB3*02:04, allele DRB3*02:05, allele DRB3*02:06, allele DRB3*02:10, allele DRB3*02:11, allele DRB3*02:12, allele DRB3*02:13, allele DRB3*02:14, allele DRB3*02:15, allele DRB3*02:17, allele DRB3*02:18, allele DRB3*02:19, allele DRB3*02:20, allele DRB3*02:22, allele DRB3*02:23, allele DRB3*02:24 and allele DRB3*02:25. Corresponds to variant rs144532965dbSNPEnsembl.1
Natural variantiVAR_06076186V → S in allele DRB3*02:08; requires 2 nucleotide substitutions. 1
Natural variantiVAR_06076387A → E in allele DRB3*02:18. 1
Natural variantiVAR_06076489S → H in allele DRB3*02:16; requires 2 nucleotide substitutions. 1
Natural variantiVAR_06076589S → Y in allele DRB3*01:07, allele DRB3*02:01, allele DRB3*02:02, allele DRB3*02:03, allele DRB3*02:04, allele DRB3*02:05, allele DRB3*02:06, allele DRB3*02:07, allele DRB3*02:08, allele DRB3*02:10, allele DRB3*02:11, allele DRB3*02:12, allele DRB3*02:13, allele DRB3*02:14, allele DRB3*02:15, allele DRB3*02:17, allele DRB3*02:18, allele DRB3*02:20, allele DRB3*02:22, allele DRB3*02:23 and allele DRB3*02:24. Corresponds to variant rs41541218dbSNPEnsembl.1
Natural variantiVAR_06076696L → F in allele DRB3*02:17. Corresponds to variant rs41562819dbSNPEnsembl.1
Natural variantiVAR_06076796L → I in allele DRB3*02:11. Corresponds to variant rs41562819dbSNPEnsembl.1
Natural variantiVAR_033396102G → A.Corresponds to variant rs17878857dbSNPEnsembl.1
Natural variantiVAR_060768103R → Q in allele DRB3*01:07, allele DRB3*02:01, allele DRB3*02:02, allele DRB3*02:03, allele DRB3*02:05, allele DRB3*02:06, allele DRB3*02:07, allele DRB3*02:08, allele DRB3*02:09, allele DRB3*02:10, allele DRB3*02:11, allele DRB3*02:12, allele DRB3*02:13, allele DRB3*02:14, allele DRB3*02:15, allele DRB3*02:16, allele DRB3*02:17, allele DRB3*02:18, allele DRB3*02:20, allele DRB3*02:21, allele DRB3*02:23, allele DRB3*02:24, allele DRB3*02:25, allele DRB3*03:01 and allele DRB3*03:02. Corresponds to variant rs1059598dbSNPEnsembl.1
Natural variantiVAR_060769106N → T in allele DRB3*02:15. Corresponds to variant rs115817940dbSNPEnsembl.1
Natural variantiVAR_060770113G → R in allele DRB3*01:12. 1
Natural variantiVAR_033397114V → A.Corresponds to variant rs1136778dbSNPEnsembl.1
Natural variantiVAR_060771115G → A in allele DRB3*02:14. 1
Natural variantiVAR_060772115G → V in allele DRB3*02:01, allele DRB3*02:04, allele DRB3*02:24, allele DRB3*03:01 and allele DRB3*03:02. Corresponds to variant rs41556512dbSNPEnsembl.1
Natural variantiVAR_060773169A → T in allele DRB3*03:01. Corresponds to variant rs75709987dbSNPEnsembl.1
Natural variantiVAR_060774178Q → H in allele DRB3*03:01. Corresponds to variant rs139485758dbSNPEnsembl.1
Natural variantiVAR_060775193V → F in allele DRB3*02:01. 1
Natural variantiVAR_060776212A → P in allele DRB3*02:01, allele DRB3*02:02, allele DRB3*02:10, allele DRB3*02:11, allele DRB3*02:24 and allele DRB3*03:01. Corresponds to variant rs142204283dbSNPEnsembl.1
Natural variantiVAR_060777218R → S in allele DRB3*02:01, allele DRB3*02:02, allele DRB3*02:10 and allele DRB3*02:11. Corresponds to variant rs147669022dbSNPEnsembl.1
Natural variantiVAR_033398236V → M.Corresponds to variant rs2230816dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V00522 mRNA. Translation: CAA23781.1.
X04055 Genomic DNA. No translation available.
X04058 Genomic DNA. No translation available.
U66825 mRNA. Translation: AAD43828.1.
AF026467 Genomic DNA. Translation: AAC05599.1.
AF199236 mRNA. Translation: AAF13065.2.
U95819 mRNA. Translation: AAD00819.1.
AY138123 mRNA. Translation: AAN15205.1.
A06800 mRNA. Translation: CAA00596.1.
AL662842 Genomic DNA. Translation: CAI17549.1.
AL929581 Genomic DNA. Translation: CAI18691.1.
CR788283 Genomic DNA. Translation: CAQ11026.1.
Z84814 Genomic DNA. Translation: CAB06607.1.
BC008987 mRNA. Translation: AAH08987.1.
BC106057 mRNA. Translation: AAI06058.1.
M17380 mRNA. Translation: AAA59804.1.
AF192258 mRNA. Translation: AAF26358.1.
AF192259 mRNA. Translation: AAF26359.1.
FJ515276 Genomic DNA. Translation: ACL50609.1.
AY291205 Genomic DNA. Translation: AAP43643.1.
AF148518 Genomic DNA. Translation: AAF67837.1.
AF081677 Genomic DNA. Translation: AAC32202.1.
AY271986 Genomic DNA. Translation: AAP23230.1.
AM747470 Genomic DNA. Translation: CAO00528.1.
EU873151 Genomic DNA. Translation: ACF33221.1.
EU873152 Genomic DNA. Translation: ACF33222.1.
EU873153 Genomic DNA. Translation: ACF33223.1.
X91639 Genomic DNA. No translation available.
AF208484 Genomic DNA. Translation: AAF23165.1.
AF208485 Genomic DNA. Translation: AAF23166.1.
AJ290395 Genomic DNA. Translation: CAC27417.1.
AF427138 Genomic DNA. Translation: AAL26538.1.
AF455114 Genomic DNA. Translation: AAL57866.1.
AF461431 Genomic DNA. Translation: AAL66370.1.
AJ564210 Genomic DNA. Translation: CAD91915.2.
AY958608 Genomic DNA. Translation: AAY28717.1.
DQ311653 Genomic DNA. Translation: ABC33924.1.
AM413002 Genomic DNA. Translation: CAL85628.1.
FN424163 Genomic DNA. Translation: CAZ66795.1.
FN424162 Genomic DNA. Translation: CAZ66766.1.
AF177216 Genomic DNA. Translation: AAD53911.1.
AF361865 Genomic DNA. Translation: AAK38297.1.
AY042679 Genomic DNA. Translation: AAK94514.1.
U36826 Genomic DNA. Translation: AAB63531.1.
U94590 Genomic DNA. Translation: AAB53324.1.
X95760 Genomic DNA. Translation: CAA65066.1.
Y13715 Genomic DNA. Translation: CAA74043.1.
AJ001255 Genomic DNA. Translation: CAA04629.1.
AJ242860 Genomic DNA. Translation: CAB62390.1.
AJ242862 Genomic DNA. Translation: CAB62392.1.
AJ315477 Genomic DNA. Translation: CAC86562.1.
AF028012 Genomic DNA. Translation: AAB94614.1.
Y08063 Genomic DNA. Translation: CAA69301.1.
Y10180 Genomic DNA. Translation: CAA71253.1.
X86977 Genomic DNA. No translation available.
AF152845 Genomic DNA. Translation: AAD45286.1.
PIRiB60748.
E28043.
I37469. HLHU5D.
PT0164.
PT0165.
PT0166.
S03442.
RefSeqiNP_072049.2. NM_022555.3.
UniGeneiHs.696211.

Genome annotation databases

EnsembliENST00000307137; ENSP00000302517; ENSG00000196101.
ENST00000383126; ENSP00000372607; ENSG00000231679.
GeneIDi3125.
KEGGihsa:3125.
UCSCiuc011fni.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V00522 mRNA. Translation: CAA23781.1.
X04055 Genomic DNA. No translation available.
X04058 Genomic DNA. No translation available.
U66825 mRNA. Translation: AAD43828.1.
AF026467 Genomic DNA. Translation: AAC05599.1.
AF199236 mRNA. Translation: AAF13065.2.
U95819 mRNA. Translation: AAD00819.1.
AY138123 mRNA. Translation: AAN15205.1.
A06800 mRNA. Translation: CAA00596.1.
AL662842 Genomic DNA. Translation: CAI17549.1.
AL929581 Genomic DNA. Translation: CAI18691.1.
CR788283 Genomic DNA. Translation: CAQ11026.1.
Z84814 Genomic DNA. Translation: CAB06607.1.
BC008987 mRNA. Translation: AAH08987.1.
BC106057 mRNA. Translation: AAI06058.1.
M17380 mRNA. Translation: AAA59804.1.
AF192258 mRNA. Translation: AAF26358.1.
AF192259 mRNA. Translation: AAF26359.1.
FJ515276 Genomic DNA. Translation: ACL50609.1.
AY291205 Genomic DNA. Translation: AAP43643.1.
AF148518 Genomic DNA. Translation: AAF67837.1.
AF081677 Genomic DNA. Translation: AAC32202.1.
AY271986 Genomic DNA. Translation: AAP23230.1.
AM747470 Genomic DNA. Translation: CAO00528.1.
EU873151 Genomic DNA. Translation: ACF33221.1.
EU873152 Genomic DNA. Translation: ACF33222.1.
EU873153 Genomic DNA. Translation: ACF33223.1.
X91639 Genomic DNA. No translation available.
AF208484 Genomic DNA. Translation: AAF23165.1.
AF208485 Genomic DNA. Translation: AAF23166.1.
AJ290395 Genomic DNA. Translation: CAC27417.1.
AF427138 Genomic DNA. Translation: AAL26538.1.
AF455114 Genomic DNA. Translation: AAL57866.1.
AF461431 Genomic DNA. Translation: AAL66370.1.
AJ564210 Genomic DNA. Translation: CAD91915.2.
AY958608 Genomic DNA. Translation: AAY28717.1.
DQ311653 Genomic DNA. Translation: ABC33924.1.
AM413002 Genomic DNA. Translation: CAL85628.1.
FN424163 Genomic DNA. Translation: CAZ66795.1.
FN424162 Genomic DNA. Translation: CAZ66766.1.
AF177216 Genomic DNA. Translation: AAD53911.1.
AF361865 Genomic DNA. Translation: AAK38297.1.
AY042679 Genomic DNA. Translation: AAK94514.1.
U36826 Genomic DNA. Translation: AAB63531.1.
U94590 Genomic DNA. Translation: AAB53324.1.
X95760 Genomic DNA. Translation: CAA65066.1.
Y13715 Genomic DNA. Translation: CAA74043.1.
AJ001255 Genomic DNA. Translation: CAA04629.1.
AJ242860 Genomic DNA. Translation: CAB62390.1.
AJ242862 Genomic DNA. Translation: CAB62392.1.
AJ315477 Genomic DNA. Translation: CAC86562.1.
AF028012 Genomic DNA. Translation: AAB94614.1.
Y08063 Genomic DNA. Translation: CAA69301.1.
Y10180 Genomic DNA. Translation: CAA71253.1.
X86977 Genomic DNA. No translation available.
AF152845 Genomic DNA. Translation: AAD45286.1.
PIRiB60748.
E28043.
I37469. HLHU5D.
PT0164.
PT0165.
PT0166.
S03442.
RefSeqiNP_072049.2. NM_022555.3.
UniGeneiHs.696211.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2Q6WX-ray2.25B/E30-219[»]
3C5JX-ray1.80B30-219[»]
4H1LX-ray3.30B/E33-219[»]
ProteinModelPortaliP79483.
SMRiP79483.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109370. 14 interactors.
IntActiP79483. 3 interactors.

Chemistry databases

BindingDBiP79483.
ChEMBLiCHEMBL3460.

PTM databases

iPTMnetiP79483.
PhosphoSitePlusiP79483.

Polymorphism and mutation databases

DMDMi34395491.

Proteomic databases

MaxQBiP79483.
PeptideAtlasiP79483.
PRIDEiP79483.
TopDownProteomicsiP79483.

Protocols and materials databases

DNASUi3125.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000307137; ENSP00000302517; ENSG00000196101.
ENST00000383126; ENSP00000372607; ENSG00000231679.
GeneIDi3125.
KEGGihsa:3125.
UCSCiuc011fni.2. human.

Organism-specific databases

CTDi3125.
DisGeNETi3125.
GeneCardsiHLA-DRB3.
HGNCiHGNC:4951. HLA-DRB3.
HPAiHPA043151.
MIMi612735. gene.
neXtProtiNX_P79483.
OpenTargetsiENSG00000231679.
PharmGKBiPA35074.
GenAtlasiSearch...

Phylogenomic databases

HOVERGENiHBG012730.
InParanoidiP79483.
KOiK06752.
OMAiNQKGHAG.
PhylomeDBiP79483.

Enzyme and pathway databases

BioCyciZFISH:G66-32419-MONOMER.
ReactomeiR-HSA-202424. Downstream TCR signaling.
R-HSA-202427. Phosphorylation of CD3 and TCR zeta chains.
R-HSA-202430. Translocation of ZAP-70 to Immunological synapse.
R-HSA-202433. Generation of second messenger molecules.
R-HSA-2132295. MHC class II antigen presentation.
R-HSA-389948. PD-1 signaling.
R-HSA-877300. Interferon gamma signaling.

Miscellaneous databases

EvolutionaryTraceiP79483.
GeneWikiiHLA-DRB3_(gene).
GenomeRNAii3125.
PROiP79483.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000196101.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.10.320.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011162. MHC_I/II-like_Ag-recog.
IPR014745. MHC_II_a/b_N.
IPR000353. MHC_II_b_N.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00969. MHC_II_beta. 1 hit.
[Graphical view]
ProDomiPD000328. MHC_II_b_N. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00407. IGc1. 1 hit.
SM00921. MHC_II_beta. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDRB3_HUMAN
AccessioniPrimary (citable) accession number: P79483
Secondary accession number(s): A0ZXY9
, A7MA46, B5AU12, B5AU13, B5AU14, B8YAC6, C6H115, C6H116, O02875, O19590, O46701, O46794, O78049, O78162, P01913, P79663, Q29721, Q29809, Q2PPD0, Q30144, Q507L8, Q5SP44, Q5STE0, Q6YJU6, Q70M87, Q7YQ62, Q860I9, Q8SP69, Q8WLT7, Q8WLT8, Q95359, Q95HM8, Q95IE5, Q96H16, Q9BCP3, Q9BD18, Q9MYA4, Q9MYH3, Q9MYH4, Q9TP01, Q9TP02, Q9TPB5, Q9TQ21, Q9UIN3, Q9UIN5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 29, 2003
Last sequence update: May 1, 1997
Last modified: November 2, 2016
This is version 137 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

HLA-DRB3, HLA-DRB4 and HLA-DRB5 may represent a unique gene.Curated

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.