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P79483

- DRB3_HUMAN

UniProt

P79483 - DRB3_HUMAN

Protein

HLA class II histocompatibility antigen, DR beta 3 chain

Gene

HLA-DRB3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 119 (01 Oct 2014)
      Sequence version 1 (01 May 1997)
      Previous versions | rss
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    Functioni

    Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and efficient peptide loading.

    GO - Molecular functioni

    1. MHC class II receptor activity Source: UniProtKB
    2. peptide antigen binding Source: UniProt

    GO - Biological processi

    1. antigen processing and presentation of exogenous peptide antigen via MHC class II Source: Reactome
    2. cytokine-mediated signaling pathway Source: Reactome
    3. interferon-gamma-mediated signaling pathway Source: Reactome
    4. signal transduction Source: ProtInc
    5. T cell costimulation Source: Reactome
    6. T cell receptor signaling pathway Source: Reactome

    Keywords - Biological processi

    Immunity

    Enzyme and pathway databases

    ReactomeiREACT_121399. MHC class II antigen presentation.
    REACT_12555. Downstream TCR signaling.
    REACT_12582. Phosphorylation of CD3 and TCR zeta chains.
    REACT_12596. Translocation of ZAP-70 to Immunological synapse.
    REACT_12623. Generation of second messenger molecules.
    REACT_19324. PD-1 signaling.
    REACT_25078. Interferon gamma signaling.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    HLA class II histocompatibility antigen, DR beta 3 chain
    Alternative name(s):
    MHC class II antigen DRB3
    Gene namesi
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Unplaced

    Organism-specific databases

    HGNCiHGNC:4951. HLA-DRB3.

    Subcellular locationi

    Cell membrane 1 Publication; Single-pass type I membrane protein 1 Publication. Endoplasmic reticulum membrane 1 Publication; Single-pass type I membrane protein 1 Publication. Golgi apparatustrans-Golgi network membrane 1 Publication; Single-pass type I membrane protein 1 Publication. Endosome membrane 1 Publication; Single-pass type I membrane protein 1 Publication. Lysosome membrane 1 Publication; Single-pass type I membrane protein 1 Publication. Late endosome membrane 1 Publication; Single-pass type I membrane protein 1 Publication
    Note: The MHC class II complex transits through a number of intracellular compartments in the endocytic pathway until it reaches the cell membrane for antigen presentation.

    GO - Cellular componenti

    1. clathrin-coated endocytic vesicle membrane Source: Reactome
    2. endocytic vesicle membrane Source: Reactome
    3. ER to Golgi transport vesicle membrane Source: Reactome
    4. Golgi membrane Source: Reactome
    5. integral component of lumenal side of endoplasmic reticulum membrane Source: Reactome
    6. integral component of plasma membrane Source: UniProtKB
    7. late endosome membrane Source: UniProtKB
    8. lysosomal membrane Source: UniProtKB
    9. membrane Source: UniProtKB
    10. MHC class II protein complex Source: UniProt
    11. plasma membrane Source: Reactome
    12. trans-Golgi network membrane Source: Reactome
    13. transport vesicle membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Endoplasmic reticulum, Endosome, Golgi apparatus, Lysosome, Membrane, MHC II

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA35074.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2929Add
    BLAST
    Chaini30 – 266237HLA class II histocompatibility antigen, DR beta 3 chainPRO_0000018956Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi44 ↔ 108
    Glycosylationi48 – 481N-linked (GlcNAc...)1 Publication
    Disulfide bondi146 ↔ 202
    Cross-linki254 – 254Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity

    Post-translational modificationi

    Ubiquitinated by MARCH1 and MARCH8 at Lys-254 leading to sorting into the endosome system and down-regulation of MHC class II.1 Publication

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Isopeptide bond, Ubl conjugation

    Proteomic databases

    MaxQBiP79483.
    PaxDbiP79483.
    PRIDEiP79483.

    Expressioni

    Gene expression databases

    GenevestigatoriP79483.

    Interactioni

    Subunit structurei

    Heterodimer of an alpha and a beta subunit; also referred as MHC class II molecule. In the endoplasmic reticulum (ER) it forms a heterononamer; 3 MHC class II molecules bind to a CD74 homotrimer (also known as invariant chain or HLA class II histocompatibility antigen gamma chain). In the endosomal/lysosomal system; CD74 undergoes sequential degradation by various proteases; leaving a small fragment termed CLIP on each MHC class II molecule. MHC class II molecule interacts with HLA_DM, and HLA_DO in B-cells, in order to release CLIP and facilitate the binding of antigenic peptides.2 Publications

    Protein-protein interaction databases

    BioGridi109370. 11 interactions.
    IntActiP79483. 3 interactions.

    Structurei

    Secondary structure

    1
    266
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi36 – 4712
    Turni48 – 514
    Beta strandi52 – 6110
    Beta strandi64 – 707
    Turni71 – 733
    Beta strandi74 – 807
    Helixi81 – 833
    Helixi84 – 918
    Helixi94 – 1007
    Helixi103 – 1064
    Helixi108 – 1158
    Helixi116 – 1183
    Turni119 – 1213
    Beta strandi127 – 1337
    Beta strandi143 – 15412
    Beta strandi157 – 1626
    Beta strandi165 – 1673
    Beta strandi168 – 1736
    Beta strandi180 – 1823
    Beta strandi184 – 1907
    Beta strandi199 – 2057
    Beta strandi213 – 2186

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2Q6WX-ray2.25B/E30-219[»]
    3C5JX-ray1.80B30-219[»]
    4H1LX-ray3.30B/E33-219[»]
    ProteinModelPortaliP79483.
    SMRiP79483. Positions 32-218.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP79483.

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini30 – 227198ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini251 – 26616CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei228 – 25023HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini126 – 21489Ig-like C1-typeAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni30 – 12495Beta-1Add
    BLAST
    Regioni125 – 227103Beta-2Add
    BLAST

    Sequence similaritiesi

    Belongs to the MHC class II family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG68200.
    HOVERGENiHBG012730.
    InParanoidiP01913.
    KOiK06752.
    OMAiNQKGHAG.
    OrthoDBiEOG7PS1GV.
    PhylomeDBiP79483.

    Family and domain databases

    Gene3Di2.60.40.10. 1 hit.
    3.10.320.10. 1 hit.
    InterProiIPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003006. Ig/MHC_CS.
    IPR003597. Ig_C1-set.
    IPR011162. MHC_I/II-like_Ag-recog.
    IPR014745. MHC_II_a/b_N.
    IPR000353. MHC_II_b_N.
    [Graphical view]
    PfamiPF07654. C1-set. 1 hit.
    PF00969. MHC_II_beta. 1 hit.
    [Graphical view]
    ProDomiPD000328. MHC_II_b_N. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SMARTiSM00407. IGc1. 1 hit.
    SM00921. MHC_II_beta. 1 hit.
    [Graphical view]
    SUPFAMiSSF54452. SSF54452. 1 hit.
    PROSITEiPS50835. IG_LIKE. 1 hit.
    PS00290. IG_MHC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P79483-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVCLKLPGGS SLAALTVTLM VLSSRLAFAG DTRPRFLELR KSECHFFNGT    50
    ERVRYLDRYF HNQEEFLRFD SDVGEYRAVT ELGRPVAESW NSQKDLLEQK 100
    RGRVDNYCRH NYGVGESFTV QRRVHPQVTV YPAKTQPLQH HNLLVCSVSG 150
    FYPGSIEVRW FRNGQEEKAG VVSTGLIQNG DWTFQTLVML ETVPRSGEVY 200
    TCQVEHPSVT SALTVEWRAR SESAQSKMLS GVGGFVLGLL FLGAGLFIYF 250
    RNQKGHSGLQ PTGFLS 266
    Length:266
    Mass (Da):29,962
    Last modified:May 1, 1997 - v1
    Checksum:i2FC3AE68D3B10EAD
    GO

    Polymorphismi

    The following alleles of DRB3 are known: DRB3*01:01, DRB3*01:02, DRB3*01:03, DRB3*01:04, DRB3*01:05, DRB3*01:06, DRB3*01:07, DRB3*01:08, DRB3*01:09, DRB3*01:10, DRB3*01:11, DRB3*01:12, DRB3*01:13, DRB3*01:14, DRB3*02:01, DRB3*02:02, DRB3*02:03, DRB3*02:04, DRB3*02:05, DRB3*02:06, DRB3*02:07, DRB3*02:08, DRB3*02:09, DRB3*02:10, DRB3*02:11, DRB3*02:12, DRB3*02:13, DRB3*02:14, DRB3*02:15, DRB3*02:16, DRB3*02:17, DRB3*02:18, DRB3*02:19, DRB3*02:20, DRB3*02:21, DRB3*02:22, DRB3*02:23, DRB3*02:24, DRB3*02:25, DRB3*03:01, DRB3*03:02 and DRB3*03:03. The sequence shown is that of DRB3*01:01. Allele DRB3*01:01 belongs to an ancestral haplotype and is associated with autoimmune diseases that are linked to antigen presentation. It is found in more than 95% of the homozygous HPA-1B mothers that produce anti-HPA-1A antibodies, this leads to neonatal alloimmune thrombocytopenia (NAIT).

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti37 – 371L → S in allele DRB3*01:04.
    VAR_060739
    Natural varianti38 – 381E → Q in allele DRB3*02:12.
    VAR_060740
    Natural varianti39 – 391L → Y in allele DRB3*01:14; requires 2 nucleotide substitutions.
    VAR_060741
    Natural varianti40 – 401R → C in allele DRB3*01:02.
    VAR_016686
    Natural varianti40 – 401R → L in allele DRB3*02:01, allele DRB3*02:02, allele DRB3*02:03, allele DRB3*02:04, allele DRB3*02:05, allele DRB3*02:06, allele DRB3*02:07, allele DRB3*02:08, allele DRB3*02:09, allele DRB3*02:10, allele DRB3*02:11, allele DRB3*02:12, allele DRB3*02:13, allele DRB3*02:14, allele DRB3*02:15, allele DRB3*02:16, allele DRB3*02:17, allele DRB3*02:18, allele DRB3*02:19, allele DRB3*02:20, allele DRB3*02:21, allele DRB3*02:22, allele DRB3*02:23, allele DRB3*02:24, allele DRB3*02:25, allele DRB3*03:01, allele DRB3*03:02 and allele DRB3*03:03.
    VAR_060742
    Natural varianti40 – 401R → S in allele DRB3*01:14.
    VAR_060743
    Natural varianti41 – 411K → T in allele DRB3*01:14.
    VAR_060744
    Natural varianti55 – 551Y → F in allele DRB3*01:09, allele DRB3*02:01, allele DRB3*02:02, allele DRB3*02:03, allele DRB3*02:04, allele DRB3*02:05, allele DRB3*02:06, allele DRB3*02:07, allele DRB3*02:08, allele DRB3*02:09, allele DRB3*02:10, allele DRB3*02:11, allele DRB3*02:12, allele DRB3*02:14, allele DRB3*02:15, allele DRB3*02:16, allele DRB3*02:17, allele DRB3*02:18, allele DRB3*02:19, allele DRB3*02:20, allele DRB3*02:21, allele DRB3*02:22, allele DRB3*02:23, allele DRB3*02:24, allele DRB3*02:25, allele DRB3*03:01, allele DRB3*03:02 and allele DRB3*03:03.
    VAR_060746
    Natural varianti55 – 551Y → L in allele DRB3*02:13; requires 2 nucleotide substitutions.
    VAR_060745
    Natural varianti57 – 571D → E in allele DRB3*01:03, allele DRB3*01:09, allele DRB3*02:01, allele DRB3*02:02, allele DRB3*02:03, allele DRB3*02:04, allele DRB3*02:05, allele DRB3*02:06, allele DRB3*02:07, allele DRB3*02:08, allele DRB3*02:09, allele DRB3*02:10, allele DRB3*02:11, allele DRB3*02:12, allele DRB3*02:13, allele DRB3*02:14, allele DRB3*02:15, allele DRB3*02:16, allele DRB3*02:17, allele DRB3*02:18, allele DRB3*02:19, allele DRB3*02:20, allele DRB3*02:21, allele DRB3*02:22, allele DRB3*02:23, allele DRB3*02:24, allele DRB3*02:25, allele DRB3*03:01, allele DRB3*03:02 and allele DRB3*03:03.
    VAR_060747
    Natural varianti57 – 571D → N in allele DRB3*01:05.
    VAR_060748
    Natural varianti58 – 581R → I in allele DRB3*01:11.
    VAR_060749
    Natural varianti59 – 591Y → H in allele DRB3*01:09, allele DRB3*02:01, allele DRB3*02:02, allele DRB3*02:03, allele DRB3*02:04, allele DRB3*02:06, allele DRB3*02:07, allele DRB3*02:08, allele DRB3*02:09, allele DRB3*02:10, allele DRB3*02:11, allele DRB3*02:12, allele DRB3*02:13, allele DRB3*02:14, allele DRB3*02:15, allele DRB3*02:16, allele DRB3*02:17, allele DRB3*02:18, allele DRB3*02:19, allele DRB3*02:20, allele DRB3*02:21, allele DRB3*02:22, allele DRB3*02:23, allele DRB3*02:24, allele DRB3*02:25 and allele DRB3*03:02.
    VAR_060750
    Natural varianti66 – 661F → L in allele DRB3*01:13.
    VAR_060752
    Natural varianti66 – 661F → N in allele DRB3*01:08, allele DRB3*02:06 and allele DRB3*02:20; requires 2 nucleotide substitutions.
    VAR_060753
    Natural varianti66 – 661F → S in allele DRB3*02:03.
    VAR_060751
    Natural varianti66 – 661F → Y in allele DRB3*01:07, allele DRB3*01:09, allele DRB3*02:01, allele DRB3*02:02, allele DRB3*02:04, allele DRB3*02:05, allele DRB3*02:07, allele DRB3*02:08, allele DRB3*02:09, allele DRB3*02:10, allele DRB3*02:11, allele DRB3*02:12, allele DRB3*02:13, allele DRB3*02:14, allele DRB3*02:15, allele DRB3*02:16, allele DRB3*02:17, allele DRB3*02:18, allele DRB3*02:19, allele DRB3*02:21, allele DRB3*02:22, allele DRB3*02:23, allele DRB3*02:24 and allele DRB3*02:25.
    VAR_060754
    Natural varianti67 – 671L → A in allele DRB3*01:07, allele DRB3*01:09, allele DRB3*02:01, allele DRB3*02:02, allele DRB3*02:04, allele DRB3*02:05, allele DRB3*02:06, allele DRB3*02:07, allele DRB3*02:08, allele DRB3*02:09, allele DRB3*02:10, allele DRB3*02:11, allele DRB3*02:12, allele DRB3*02:13, allele DRB3*02:14, allele DRB3*02:15, allele DRB3*02:16, allele DRB3*02:17, allele DRB3*02:18, allele DRB3*02:19, allele DRB3*02:21, allele DRB3*02:22, allele DRB3*02:23, allele DRB3*02:24 and allele DRB3*02:25; requires 2 nucleotide substitutions.
    VAR_060755
    Natural varianti67 – 671L → V in allele DRB3*01:06, allele DRB3*01:08, allele DRB3*02:03, allele DRB3*02:20, allele DRB3*03:01, allele DRB3*03:02 and allele DRB3*03:03.
    VAR_060756
    Natural varianti68 – 681R → S in allele DRB3*01:10.
    VAR_060757
    Natural varianti80 – 801T → R in allele DRB3*01:07, allele DRB3*02:01, allele DRB3*02:02, allele DRB3*02:03, allele DRB3*02:04, allele DRB3*02:05, allele DRB3*02:06, allele DRB3*02:07, allele DRB3*02:08, allele DRB3*02:11, allele DRB3*02:12, allele DRB3*02:13, allele DRB3*02:14, allele DRB3*02:15, allele DRB3*02:16, allele DRB3*02:17, allele DRB3*02:18, allele DRB3*02:19, allele DRB3*02:20, allele DRB3*02:21, allele DRB3*02:22, allele DRB3*02:23, allele DRB3*02:24 and allele DRB3*02:25.
    VAR_060758
    Natural varianti84 – 841R → L in allele DRB3*02:23.
    VAR_060759
    Natural varianti86 – 861V → A in allele DRB3*02:16.
    VAR_060760
    Natural varianti86 – 861V → D in allele DRB3*01:07, allele DRB3*02:01, allele DRB3*02:02, allele DRB3*02:03, allele DRB3*02:04, allele DRB3*02:05, allele DRB3*02:06, allele DRB3*02:10, allele DRB3*02:11, allele DRB3*02:12, allele DRB3*02:13, allele DRB3*02:14, allele DRB3*02:15, allele DRB3*02:17, allele DRB3*02:18, allele DRB3*02:19, allele DRB3*02:20, allele DRB3*02:22, allele DRB3*02:23, allele DRB3*02:24 and allele DRB3*02:25.
    VAR_060762
    Natural varianti86 – 861V → S in allele DRB3*02:08; requires 2 nucleotide substitutions.
    VAR_060761
    Natural varianti87 – 871A → E in allele DRB3*02:18.
    VAR_060763
    Natural varianti89 – 891S → H in allele DRB3*02:16; requires 2 nucleotide substitutions.
    VAR_060764
    Natural varianti89 – 891S → Y in allele DRB3*01:07, allele DRB3*02:01, allele DRB3*02:02, allele DRB3*02:03, allele DRB3*02:04, allele DRB3*02:05, allele DRB3*02:06, allele DRB3*02:07, allele DRB3*02:08, allele DRB3*02:10, allele DRB3*02:11, allele DRB3*02:12, allele DRB3*02:13, allele DRB3*02:14, allele DRB3*02:15, allele DRB3*02:17, allele DRB3*02:18, allele DRB3*02:20, allele DRB3*02:22, allele DRB3*02:23 and allele DRB3*02:24.
    VAR_060765
    Natural varianti96 – 961L → F in allele DRB3*02:17.
    VAR_060766
    Natural varianti96 – 961L → I in allele DRB3*02:11.
    VAR_060767
    Natural varianti102 – 1021G → A.
    Corresponds to variant rs17878857 [ dbSNP | Ensembl ].
    VAR_033396
    Natural varianti103 – 1031R → Q in allele DRB3*01:07, allele DRB3*02:01, allele DRB3*02:02, allele DRB3*02:03, allele DRB3*02:05, allele DRB3*02:06, allele DRB3*02:07, allele DRB3*02:08, allele DRB3*02:09, allele DRB3*02:10, allele DRB3*02:11, allele DRB3*02:12, allele DRB3*02:13, allele DRB3*02:14, allele DRB3*02:15, allele DRB3*02:16, allele DRB3*02:17, allele DRB3*02:18, allele DRB3*02:20, allele DRB3*02:21, allele DRB3*02:23, allele DRB3*02:24, allele DRB3*02:25, allele DRB3*03:01 and allele DRB3*03:02.
    VAR_060768
    Natural varianti106 – 1061N → T in allele DRB3*02:15.
    VAR_060769
    Natural varianti113 – 1131G → R in allele DRB3*01:12.
    VAR_060770
    Natural varianti114 – 1141V → A.
    Corresponds to variant rs17424145 [ dbSNP | Ensembl ].
    VAR_033397
    Natural varianti115 – 1151G → A in allele DRB3*02:14.
    VAR_060771
    Natural varianti115 – 1151G → V in allele DRB3*02:01, allele DRB3*02:04, allele DRB3*02:24, allele DRB3*03:01 and allele DRB3*03:02.
    VAR_060772
    Natural varianti169 – 1691A → T in allele DRB3*03:01.
    VAR_060773
    Natural varianti178 – 1781Q → H in allele DRB3*03:01.
    VAR_060774
    Natural varianti193 – 1931V → F in allele DRB3*02:01.
    VAR_060775
    Natural varianti212 – 2121A → P in allele DRB3*02:01, allele DRB3*02:02, allele DRB3*02:10, allele DRB3*02:11, allele DRB3*02:24 and allele DRB3*03:01.
    VAR_060776
    Natural varianti218 – 2181R → S in allele DRB3*02:01, allele DRB3*02:02, allele DRB3*02:10 and allele DRB3*02:11.
    VAR_060777
    Natural varianti236 – 2361V → M.
    Corresponds to variant rs2230816 [ dbSNP | Ensembl ].
    VAR_033398

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    V00522 mRNA. Translation: CAA23781.1.
    X04055 Genomic DNA. No translation available.
    X04058 Genomic DNA. No translation available.
    U66825 mRNA. Translation: AAD43828.1.
    AF026467 Genomic DNA. Translation: AAC05599.1.
    AF199236 mRNA. Translation: AAF13065.2.
    U95819 mRNA. Translation: AAD00819.1.
    AY138123 mRNA. Translation: AAN15205.1.
    A06800 mRNA. Translation: CAA00596.1.
    AL662842 Genomic DNA. Translation: CAI17549.1.
    AL929581 Genomic DNA. Translation: CAI18691.1.
    CR788283 Genomic DNA. Translation: CAQ11026.1.
    Z84814 Genomic DNA. Translation: CAB06607.1.
    BC008987 mRNA. Translation: AAH08987.1.
    BC106057 mRNA. Translation: AAI06058.1.
    M17380 mRNA. Translation: AAA59804.1.
    AF192258 mRNA. Translation: AAF26358.1.
    AF192259 mRNA. Translation: AAF26359.1.
    FJ515276 Genomic DNA. Translation: ACL50609.1.
    AY291205 Genomic DNA. Translation: AAP43643.1.
    AF148518 Genomic DNA. Translation: AAF67837.1.
    AF081677 Genomic DNA. Translation: AAC32202.1.
    AY271986 Genomic DNA. Translation: AAP23230.1.
    AM747470 Genomic DNA. Translation: CAO00528.1.
    EU873151 Genomic DNA. Translation: ACF33221.1.
    EU873152 Genomic DNA. Translation: ACF33222.1.
    EU873153 Genomic DNA. Translation: ACF33223.1.
    X91639 Genomic DNA. No translation available.
    AF208484 Genomic DNA. Translation: AAF23165.1.
    AF208485 Genomic DNA. Translation: AAF23166.1.
    AJ290395 Genomic DNA. Translation: CAC27417.1.
    AF427138 Genomic DNA. Translation: AAL26538.1.
    AF455114 Genomic DNA. Translation: AAL57866.1.
    AF461431 Genomic DNA. Translation: AAL66370.1.
    AJ564210 Genomic DNA. Translation: CAD91915.2.
    AY958608 Genomic DNA. Translation: AAY28717.1.
    DQ311653 Genomic DNA. Translation: ABC33924.1.
    AM413002 Genomic DNA. Translation: CAL85628.1.
    FN424163 Genomic DNA. Translation: CAZ66795.1.
    FN424162 Genomic DNA. Translation: CAZ66766.1.
    AF177216 Genomic DNA. Translation: AAD53911.1.
    AF361865 Genomic DNA. Translation: AAK38297.1.
    AY042679 Genomic DNA. Translation: AAK94514.1.
    U36826 Genomic DNA. Translation: AAB63531.1.
    U94590 Genomic DNA. Translation: AAB53324.1.
    X95760 Genomic DNA. Translation: CAA65066.1.
    Y13715 Genomic DNA. Translation: CAA74043.1.
    AJ001255 Genomic DNA. Translation: CAA04629.1.
    AJ242860 Genomic DNA. Translation: CAB62390.1.
    AJ242862 Genomic DNA. Translation: CAB62392.1.
    AJ315477 Genomic DNA. Translation: CAC86562.1.
    AF028012 Genomic DNA. Translation: AAB94614.1.
    Y08063 Genomic DNA. Translation: CAA69301.1.
    Y10180 Genomic DNA. Translation: CAA71253.1.
    X86977 Genomic DNA. No translation available.
    AF152845 Genomic DNA. Translation: AAD45286.1.
    PIRiB60748.
    E28043.
    I37469. HLHU5D.
    PT0164.
    PT0165.
    PT0166.
    S03442.
    RefSeqiNP_072049.2. NM_022555.3.
    UniGeneiHs.696211.

    Genome annotation databases

    EnsembliENST00000307137; ENSP00000302517; ENSG00000196101.
    GeneIDi3125.
    KEGGihsa:3125.
    UCSCiuc011fni.1. human.

    Polymorphism databases

    DMDMi34395491.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    V00522 mRNA. Translation: CAA23781.1 .
    X04055 Genomic DNA. No translation available.
    X04058 Genomic DNA. No translation available.
    U66825 mRNA. Translation: AAD43828.1 .
    AF026467 Genomic DNA. Translation: AAC05599.1 .
    AF199236 mRNA. Translation: AAF13065.2 .
    U95819 mRNA. Translation: AAD00819.1 .
    AY138123 mRNA. Translation: AAN15205.1 .
    A06800 mRNA. Translation: CAA00596.1 .
    AL662842 Genomic DNA. Translation: CAI17549.1 .
    AL929581 Genomic DNA. Translation: CAI18691.1 .
    CR788283 Genomic DNA. Translation: CAQ11026.1 .
    Z84814 Genomic DNA. Translation: CAB06607.1 .
    BC008987 mRNA. Translation: AAH08987.1 .
    BC106057 mRNA. Translation: AAI06058.1 .
    M17380 mRNA. Translation: AAA59804.1 .
    AF192258 mRNA. Translation: AAF26358.1 .
    AF192259 mRNA. Translation: AAF26359.1 .
    FJ515276 Genomic DNA. Translation: ACL50609.1 .
    AY291205 Genomic DNA. Translation: AAP43643.1 .
    AF148518 Genomic DNA. Translation: AAF67837.1 .
    AF081677 Genomic DNA. Translation: AAC32202.1 .
    AY271986 Genomic DNA. Translation: AAP23230.1 .
    AM747470 Genomic DNA. Translation: CAO00528.1 .
    EU873151 Genomic DNA. Translation: ACF33221.1 .
    EU873152 Genomic DNA. Translation: ACF33222.1 .
    EU873153 Genomic DNA. Translation: ACF33223.1 .
    X91639 Genomic DNA. No translation available.
    AF208484 Genomic DNA. Translation: AAF23165.1 .
    AF208485 Genomic DNA. Translation: AAF23166.1 .
    AJ290395 Genomic DNA. Translation: CAC27417.1 .
    AF427138 Genomic DNA. Translation: AAL26538.1 .
    AF455114 Genomic DNA. Translation: AAL57866.1 .
    AF461431 Genomic DNA. Translation: AAL66370.1 .
    AJ564210 Genomic DNA. Translation: CAD91915.2 .
    AY958608 Genomic DNA. Translation: AAY28717.1 .
    DQ311653 Genomic DNA. Translation: ABC33924.1 .
    AM413002 Genomic DNA. Translation: CAL85628.1 .
    FN424163 Genomic DNA. Translation: CAZ66795.1 .
    FN424162 Genomic DNA. Translation: CAZ66766.1 .
    AF177216 Genomic DNA. Translation: AAD53911.1 .
    AF361865 Genomic DNA. Translation: AAK38297.1 .
    AY042679 Genomic DNA. Translation: AAK94514.1 .
    U36826 Genomic DNA. Translation: AAB63531.1 .
    U94590 Genomic DNA. Translation: AAB53324.1 .
    X95760 Genomic DNA. Translation: CAA65066.1 .
    Y13715 Genomic DNA. Translation: CAA74043.1 .
    AJ001255 Genomic DNA. Translation: CAA04629.1 .
    AJ242860 Genomic DNA. Translation: CAB62390.1 .
    AJ242862 Genomic DNA. Translation: CAB62392.1 .
    AJ315477 Genomic DNA. Translation: CAC86562.1 .
    AF028012 Genomic DNA. Translation: AAB94614.1 .
    Y08063 Genomic DNA. Translation: CAA69301.1 .
    Y10180 Genomic DNA. Translation: CAA71253.1 .
    X86977 Genomic DNA. No translation available.
    AF152845 Genomic DNA. Translation: AAD45286.1 .
    PIRi B60748.
    E28043.
    I37469. HLHU5D.
    PT0164.
    PT0165.
    PT0166.
    S03442.
    RefSeqi NP_072049.2. NM_022555.3.
    UniGenei Hs.696211.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2Q6W X-ray 2.25 B/E 30-219 [» ]
    3C5J X-ray 1.80 B 30-219 [» ]
    4H1L X-ray 3.30 B/E 33-219 [» ]
    ProteinModelPortali P79483.
    SMRi P79483. Positions 32-218.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109370. 11 interactions.
    IntActi P79483. 3 interactions.

    Chemistry

    BindingDBi P79483.
    ChEMBLi CHEMBL3460.

    Polymorphism databases

    DMDMi 34395491.

    Proteomic databases

    MaxQBi P79483.
    PaxDbi P79483.
    PRIDEi P79483.

    Protocols and materials databases

    DNASUi 3125.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000307137 ; ENSP00000302517 ; ENSG00000196101 .
    GeneIDi 3125.
    KEGGi hsa:3125.
    UCSCi uc011fni.1. human.

    Organism-specific databases

    CTDi 3125.
    GeneCardsi GC06M8T3720.
    GC06Mi32470.
    GC06Mj32412.
    HGNCi HGNC:4951. HLA-DRB3.
    MIMi 612735. gene.
    neXtProti NX_P79483.
    PharmGKBi PA35074.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG68200.
    HOVERGENi HBG012730.
    InParanoidi P01913.
    KOi K06752.
    OMAi NQKGHAG.
    OrthoDBi EOG7PS1GV.
    PhylomeDBi P79483.

    Enzyme and pathway databases

    Reactomei REACT_121399. MHC class II antigen presentation.
    REACT_12555. Downstream TCR signaling.
    REACT_12582. Phosphorylation of CD3 and TCR zeta chains.
    REACT_12596. Translocation of ZAP-70 to Immunological synapse.
    REACT_12623. Generation of second messenger molecules.
    REACT_19324. PD-1 signaling.
    REACT_25078. Interferon gamma signaling.

    Miscellaneous databases

    EvolutionaryTracei P79483.
    GeneWikii HLA-DRB3_(gene).
    GenomeRNAii 3125.
    NextBioi 12400.
    PROi P79483.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori P79483.

    Family and domain databases

    Gene3Di 2.60.40.10. 1 hit.
    3.10.320.10. 1 hit.
    InterProi IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003006. Ig/MHC_CS.
    IPR003597. Ig_C1-set.
    IPR011162. MHC_I/II-like_Ag-recog.
    IPR014745. MHC_II_a/b_N.
    IPR000353. MHC_II_b_N.
    [Graphical view ]
    Pfami PF07654. C1-set. 1 hit.
    PF00969. MHC_II_beta. 1 hit.
    [Graphical view ]
    ProDomi PD000328. MHC_II_b_N. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SMARTi SM00407. IGc1. 1 hit.
    SM00921. MHC_II_beta. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54452. SSF54452. 1 hit.
    PROSITEi PS50835. IG_LIKE. 1 hit.
    PS00290. IG_MHC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of an HLA-DR beta chain deduced from a cDNA clone and identification of multiple non-allelic DR beta chain genes."
      Long E.O., Wake C.T., Gorski J., Mach B.
      EMBO J. 2:389-394(1983) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE DRB3*02:01).
    2. "Polymorphism of human Ia antigens: gene conversion between two DR beta loci results in a new HLA-D/DR specificity."
      Gorski J., Mach B.
      Nature 322:67-70(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE DRB3*01:01).
    3. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE DRB3*01:01).
      Tissue: Blood.
    4. "DRB3 alleles with variations in the annealing sites of commonly used amplification primers."
      Coquillard G.J., Tang T.F., Steiner N., Perlee L., Ng J., Hartzman R.J., Hurley C.K.
      Tissue Antigens 55:558-563(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE DRB3*01:01), NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-119 (ALLELE DRB3*01:04).
      Tissue: Blood.
    5. "Cloning and nucleotide sequence analysis of HLA-DRB3*01012 from EBV-transformed Korean B-cell line by sequence based typing."
      Kim K.H., Kang J.H., Maeng C.Y., Han H., Park J.H., Hahm K.S., Kim K.L.
      Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE DRB3*01:01).
    6. "HLA-DRB3*03011 sequence complete mRNA."
      Spierings E., Zegveld S.T., Goulmy E.
      Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE DRB3*03:01).
    7. "DNA sequences coding for the DR beta-chain locus of the human lymphocyte antigen complex and polypeptides, diagnostic typing processes and products related thereto."
      Mach B.F., Long E.O., Wake C.T.
      Patent number EP0103960, 28-MAR-1984
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE DRB3*02:01).
    8. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ALLELES DRB3*01:01 AND DRB3*02:02).
    9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ALLELES DRB3*01:01 AND DRB3*02:02).
      Tissue: Brain.
    10. "Molecular analysis of the genes for human class II antigens of the major histocompatibility complex."
      Long E.O., Gorski J., Rollini P., Wake C.T., Strubin M., Rabourdin-Combe C., Mach B.
      Hum. Immunol. 8:113-121(1983) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 30-266 (ALLELE DRB3*02:01).
    11. "Allelic variation in the DR subregion of the human major histocompatibility complex."
      Bell J.I., Denney D. Jr., Foster L., Belt T.K., Todd J.A., McDevitt H.O.
      Proc. Natl. Acad. Sci. U.S.A. 84:6234-6238(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 30-266 (ALLELE DRB3*02:01).
    12. "Identification by sequencing based typing and complete coding region analysis of three new HLA class II alleles: DRB3*0210, DRB3*0211 and DQB1*0310."
      Balas A., Santos S., Aviles M.J., Garcia-Sanchez F., Lillo R., Vicario J.L.
      Tissue Antigens 56:380-384(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 30-266 (ALLELES DRB3*02:10 AND DRB3*02:11).
    13. "A new HLA-DRB3*02 allele identified by sequencing based typing."
      Westerink N., Bacelar M., Arts-Hilkes Y., Mulder W., Rozemuller E.H.
      Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-217 (ALLELE DRB3*02:24).
    14. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-124 (ALLELE DRB3*02:18).
    15. "Identification of a new DRB3*02 allelic variant (DRB3*0209) by high-resolution sequence-based typing."
      Morabito A., Pera C., Longo A., Delfino L., Ferrara G.B.
      Tissue Antigens 56:90-94(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB3*02:09).
    16. "Description of fourteen new DRB alleles found in a stem cell donor registry."
      Tang T.F., Lin Y.-S., Robbins F.M., Li L., Sintasath D., Coquillard G., Huang A., Heine U., Ng J., Hartzman R.J., Hurley C.K.
      Tissue Antigens 59:63-65(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB3*01:05).
    17. "Three new DRB alleles routinely identified by sequence-based typing: DRB1*010103, DRB1*0326 and DRB3*0219."
      Dubois V., Favre-Victoire I., Gebuhrer L.
      Tissue Antigens 64:621-623(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB3*02:19).
    18. "Characterisation of two novel HLA alleles, HLA-Cw*0429 and HLA-DRB3*0223."
      Danzer M., Polin H., Hofer K., Proll J., Gabriel C.
      Tissue Antigens 72:498-499(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB3*02:23).
      Tissue: Peripheral blood.
    19. "Description of three novel HLA-DRB3 alleles: DRB3*010105, DRB3*0112 and DRB3*0113."
      Lee K.W., Jung Y.A.
      Tissue Antigens 73:83-84(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELES DRB3*01:01; DRB3*01:12 AND DRB3*01:13).
    20. "New DRB3*02 variant."
      Keller E.
      Submitted (APR-1996) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB3*02:04).
    21. "An HLA-DRB3 allele detected by SBT."
      Greville W.D., Ng G., Kennedy A., Dunckley H.
      Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELES DRB3*02:12 AND DRB3*02:13).
    22. "A new HLA DRB3* allele very similar to DRB3*02021 and DRB3*0212 alleles."
      Moine A.
      Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB3*02:14).
    23. "A novel DRB3 allele."
      Varney M.
      Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB3*02:15).
    24. "Identification of a novel DRB3*0216 allele."
      Avergas C.U., Iglehart B.A., Leffell M.S.
      Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB3*02:16).
    25. "Novel HLA-DRB3 allele revealed by sequencing based typing."
      Hogbin J.-P., Chapman G., Greville W.D.
      Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB3*02:17).
    26. "Description of a new DRB3* allele."
      Perasaari J., Egle Jansson I., Partanen J., Bengtsson M.
      Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB3*01:11).
    27. "New HLA-DRB3*02 allele."
      Colombini I., Malagoli A., Carella G.
      Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB3*02:20).
    28. "New HLA-DRB3*02 allelic variant identified by high resolution sequence-based typing."
      Garino E., Berrino M., Bertinetto F., Brancatello F., Caropreso P., Chidichimo R., Frisaldi E., Mazzola G., Panniello M., Tondat F., Locatelli F., Amoroso A.
      Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB3*02:21).
    29. "The DRB3 new allele is identical to the current HLA-DRB3*020201 allele except a point substitution at codon 74 where a G is found in place of A."
      Dormoy A., Froelich N.
      Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELES DRB3*02:22).
    30. "The new DRB3 allele is identical to the DRB3*020201 allele except a mutation at position 266 leading to the change of the amino acid 65 (Tyr (TAC) -> Ser(TCC)."
      Dormoy A., Derin R., Jollet I., Weschler B., Leisenbach R.
      Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB3*02:25).
      Tissue: Peripheral blood.
    31. "Identification of a novel HLA-DRB3*01 allele containing a DRB1 sequence motive by micro-TGGE and confirmed by cloning and direct sequencing."
      Garritsen H.S.P., Fae I., Legath N., Hannig H., Fischer G.F.
      Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB3*01:14).
    32. "New HLA class II (DRB3) allele detected by sequencing-based typing."
      Greville W.D., Ng G., Kennedy A., Dunckley H.
      Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-122 (ALLELE DRB3*02:02).
    33. "Description of a new HLA-DRB3 allele in a Spanish bone marrow donor."
      Loeliger C.
      Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-122 (ALLELE DRB3*01:08).
      Tissue: Bone marrow.
    34. "Novel HLA*DRB3 allele."
      Li L., Hurley C.K.
      Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-122 (ALLELE DRB3*01:09).
    35. "Diversity associated with the second expressed HLA-DRB locus in the human population."
      Robbins F., Hurley C.K., Tang T., Yao H., Lin Y.S., Wade J., Goeken N., Hartzman R.J.
      Immunogenetics 46:104-110(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-121 (ALLELE DRB3*02:05).
    36. Olerup O.
      Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-117 (ALLELE DRB3*01:03).
    37. "Identification of new DRB1*01 (DRB1*01022), DRB1*14 (DRB1*1428) and DRB3* (DRB3*0206) alleles."
      Hashemi-Tavoularis S., Couture C., Buyse I.M.
      Tissue Antigens 50:89-93(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-115 (ALLELE DRB3*02:06).
    38. "A novel DRB3 allele (DRB3*0208), a new allelic variant of DRB1*1502 (DRB1*15023) and two new DQB1 (DQB1*03012 and DQB1*0614) alleles."
      Hashemi-tavoularis S., Ouellet S., Sengar D.P.S., Buyse I.M.
      Tissue Antigens 52:294-299(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-115 (ALLELES DRB3*02:08 AND DRB3*03:02).
      Tissue: Blood.
    39. "Identification of three new DRB3* (DRB3*0106, DRB3*0107 and DRB3*02022) alleles."
      Tavoularis S., Ouellet S., Stephens S.
      Tissue Antigens 57:390-393(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-115 (ALLELES DRB3*01:06 AND DRB3*01:07).
      Tissue: Peripheral blood.
    40. "Identification of three novel alleles: DRB3*0110, DRB1*1140, and DRB1*140102."
      Tavoularis S., Couture C., Ribeiro-Barros E.
      Tissue Antigens 63:496-500(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-115 (ALLELE DRB3*01:10).
      Tissue: Peripheral blood.
    41. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 36-119 (ALLELE DRB3*03:03).
    42. "Identification and nucleotide sequence of two novel DRB3 alleles, DRB3*0102 and DRB3*010133."
      Guttridge M.G., Hudson L., Williams H., Dunn P., Duy S., Darke C.
      Tissue Antigens 49:665-667(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 36-117 (ALLELE DRB3*01:02).
    43. "Identification of a new DRB3*02 allele (DRB3*0207) by sequence-based typing."
      Voorter C.E., Hentges F., van den Berg-Loonen E.M.
      Tissue Antigens 50:552-554(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 37-116 (ALLELE DRB3*02:07).
    44. "Five new DRB1 alleles found during routine DRB oligotyping."
      Anholts J.D.H., Verduijn W., Schreuder G.M.T.
      Submitted (MAY-1995) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 37-116 (ALLELE DRB3*02:03).
    45. "Identification of a putative DR8 founder haplotype containing a novel DRB1*0801 allele."
      Eberle M., Asu U., Taylor M., Hunter J.B., Fuller T.C., Maurer D.
      Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 43-120 (ALLELE DRB3*02:02).
    46. "HLA-DR beta-chain polymorphism. Second domain polymorphism reflects evolutionary relatedness of alleles and may explain public serologic epitopes."
      Gorski J.
      J. Immunol. 143:329-333(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 124-217 (ALLELE DRB3*01:01/DRB3*01:02).
    47. "Naturally processed peptides spanning the HPA-1a polymorphism are efficiently generated and displayed from platelet glycoprotein by HLA-DRB3*0101-positive antigen-presenting cells."
      Anani Sarab G., Moss M., Barker R.N., Urbaniak S.J.
      Blood 114:1954-1957(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION OF THE ALLOANTIGEN HPA-1A BY MASS SPECTROMETRY, ASSOCIATION TO ALLELE HLA-DRB3*01:01.
    48. "Invariant chain structure and MHC class II function."
      Cresswell P.
      Cell 84:505-507(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.
    49. "Presentation of antigens by MHC class II molecules: getting the most out of them."
      Villadangos J.A.
      Mol. Immunol. 38:329-346(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.
    50. "Autophagy in MHC class II presentation: sampling from within."
      Menendez-Benito V., Neefjes J.
      Immunity 26:1-3(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.
    51. "MHC class II molecules on the move for successful antigen presentation."
      Rocha N., Neefjes J.
      EMBO J. 27:1-5(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.
    52. "MHC class II stabilization at the surface of human dendritic cells is the result of maturation-dependent MARCH I down-regulation."
      De Gassart A., Camosseto V., Thibodeau J., Ceppi M., Catalan N., Pierre P., Gatti E.
      Proc. Natl. Acad. Sci. U.S.A. 105:3491-3496(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: UBIQUITINATION BY MARCH1, SUBCELLULAR LOCATION.
    53. "MHC class II transport at a glance."
      Berger A.C., Roche P.A.
      J. Cell Sci. 122:1-4(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.
    54. "CD74 in antigen presentation, inflammation, and cancers of the gastrointestinal tract."
      Beswick E.J., Reyes V.E.
      World J. Gastroenterol. 15:2855-2861(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.
    55. "Crystallographic structure of the human leukocyte antigen DRA, DRB3*0101: models of a directional alloimmune response and autoimmunity."
      Parry C.S., Gorski J., Stern L.J.
      J. Mol. Biol. 371:435-446(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.25 ANGSTROMS) OF 30-219 OF HLA-DRA/HLA-DRB3 HETERODIMER IN COMPLEX WITH ITGB3 PEPTIDE (ALLOANTIGEN HPA-1A), SUBUNIT, DISULFIDE BOND.
    56. "The structure of HLA-DR52c: comparison to other HLA-DRB3 alleles."
      Dai S., Crawford F., Marrack P., Kappler J.W.
      Proc. Natl. Acad. Sci. U.S.A. 105:11893-11897(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 30-219 OF HLA-DRA/HLA-DRB3 HETERODIMER IN COMPLEX WITH EEF1A2 PEPTIDE, GLYCOSYLATION AT ASN-48, DISULFIDE BOND.

    Entry informationi

    Entry nameiDRB3_HUMAN
    AccessioniPrimary (citable) accession number: P79483
    Secondary accession number(s): A0ZXY9
    , A7MA46, B5AU12, B5AU13, B5AU14, B8YAC6, C6H115, C6H116, O02875, O19590, O46701, O46794, O78049, O78162, P01913, P79663, Q29721, Q29809, Q2PPD0, Q30144, Q507L8, Q5SP44, Q5STE0, Q6YJU6, Q70M87, Q7YQ62, Q860I9, Q8SP69, Q8WLT7, Q8WLT8, Q95359, Q95HM8, Q95IE5, Q96H16, Q9BCP3, Q9BD18, Q9MYA4, Q9MYH3, Q9MYH4, Q9TP01, Q9TP02, Q9TPB5, Q9TQ21, Q9UIN3, Q9UIN5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 29, 2003
    Last sequence update: May 1, 1997
    Last modified: October 1, 2014
    This is version 119 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    HLA-DRB3, HLA-DRB4 and HLA-DRB5 may represent a unique gene.Curated

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3