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P79483 (DRB3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 115. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
HLA class II histocompatibility antigen, DR beta 3 chain
Alternative name(s):
MHC class II antigen DRB3
Gene names
Name:HLA-DRB3
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length266 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and efficient peptide loading.

Subunit structure

Heterodimer of an alpha and a beta subunit; also referred as MHC class II molecule. In the endoplasmic reticulum (ER) it forms a heterononamer; 3 MHC class II molecules bind to a CD74 homotrimer (also known as invariant chain or HLA class II histocompatibility antigen gamma chain). In the endosomal/lysosomal system; CD74 undergoes sequential degradation by various proteases; leaving a small fragment termed CLIP on each MHC class II molecule. MHC class II molecule interacts with HLA_DM, and HLA_DO in B-cells, in order to release CLIP and facilitate the binding of antigenic peptides. Ref.55

Subcellular location

Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatustrans-Golgi network membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Late endosome membrane; Single-pass type I membrane protein. Note: The MHC class II complex transits through a number of intracellular compartments in the endocytic pathway until it reaches the cell membrane for antigen presentation. Ref.52

Post-translational modification

Ubiquitinated by MARCH1 and MARCH8 at Lys-254 leading to sorting into the endosome system and down-regulation of MHC class II Probable. Ref.52

Polymorphism

The following alleles of DRB3 are known: DRB3*01:01, DRB3*01:02, DRB3*01:03, DRB3*01:04, DRB3*01:05, DRB3*01:06, DRB3*01:07, DRB3*01:08, DRB3*01:09, DRB3*01:10, DRB3*01:11, DRB3*01:12, DRB3*01:13, DRB3*01:14, DRB3*02:01, DRB3*02:02, DRB3*02:03, DRB3*02:04, DRB3*02:05, DRB3*02:06, DRB3*02:07, DRB3*02:08, DRB3*02:09, DRB3*02:10, DRB3*02:11, DRB3*02:12, DRB3*02:13, DRB3*02:14, DRB3*02:15, DRB3*02:16, DRB3*02:17, DRB3*02:18, DRB3*02:19, DRB3*02:20, DRB3*02:21, DRB3*02:22, DRB3*02:23, DRB3*02:24, DRB3*02:25, DRB3*03:01, DRB3*03:02 and DRB3*03:03. The sequence shown is that of DRB3*01:01. Allele DRB3*01:01 belongs to an ancestral haplotype and is associated with autoimmune diseases that are linked to antigen presentation. It is found in more than 95% of the homozygous HPA-1B mothers that produce anti-HPA-1A antibodies, this leads to neonatal alloimmune thrombocytopenia (NAIT).

Sequence similarities

Belongs to the MHC class II family.

Contains 1 Ig-like C1-type (immunoglobulin-like) domain.

Caution

HLA-DRB3, HLA-DRB4 and HLA-DRB5 may represent a unique gene.

Ontologies

Keywords
   Biological processImmunity
   Cellular componentCell membrane
Endoplasmic reticulum
Endosome
Golgi apparatus
Lysosome
Membrane
MHC II
   Coding sequence diversityPolymorphism
   DomainSignal
Transmembrane
Transmembrane helix
   PTMDisulfide bond
Glycoprotein
Isopeptide bond
Ubl conjugation
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processT cell costimulation

Traceable author statement. Source: Reactome

T cell receptor signaling pathway

Traceable author statement. Source: Reactome

antigen processing and presentation of exogenous peptide antigen via MHC class II

Traceable author statement. Source: Reactome

cytokine-mediated signaling pathway

Traceable author statement. Source: Reactome

interferon-gamma-mediated signaling pathway

Traceable author statement. Source: Reactome

signal transduction

Non-traceable author statement PubMed 8775462. Source: ProtInc

   Cellular_componentER to Golgi transport vesicle membrane

Traceable author statement. Source: Reactome

Golgi membrane

Traceable author statement. Source: Reactome

MHC class II protein complex

Inferred from electronic annotation. Source: UniProtKB-KW

clathrin-coated endocytic vesicle membrane

Traceable author statement. Source: Reactome

endocytic vesicle membrane

Traceable author statement. Source: Reactome

integral component of lumenal side of endoplasmic reticulum membrane

Traceable author statement. Source: Reactome

integral component of plasma membrane

Non-traceable author statement Ref.10. Source: UniProtKB

late endosome membrane

Inferred from direct assay Ref.52. Source: UniProtKB

lysosomal membrane

Inferred from direct assay Ref.52. Source: UniProtKB

plasma membrane

Traceable author statement. Source: Reactome

trans-Golgi network membrane

Traceable author statement. Source: Reactome

transport vesicle membrane

Traceable author statement. Source: Reactome

   Molecular_functionMHC class II receptor activity

Non-traceable author statement Ref.10. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2929
Chain30 – 266237HLA class II histocompatibility antigen, DR beta 3 chain
PRO_0000018956

Regions

Topological domain30 – 227198Extracellular Potential
Transmembrane228 – 25023Helical; Potential
Topological domain251 – 26616Cytoplasmic Potential
Domain126 – 21489Ig-like C1-type
Region30 – 12495Beta-1
Region125 – 227103Beta-2

Amino acid modifications

Glycosylation481N-linked (GlcNAc...) Ref.56
Disulfide bond44 ↔ 108 Ref.55 Ref.56
Disulfide bond146 ↔ 202 Ref.55 Ref.56
Cross-link254Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) By similarity

Natural variations

Natural variant371L → S in allele DRB3*01:04.
VAR_060739
Natural variant381E → Q in allele DRB3*02:12.
VAR_060740
Natural variant391L → Y in allele DRB3*01:14; requires 2 nucleotide substitutions.
VAR_060741
Natural variant401R → C in allele DRB3*01:02.
VAR_016686
Natural variant401R → L in allele DRB3*02:01, allele DRB3*02:02, allele DRB3*02:03, allele DRB3*02:04, allele DRB3*02:05, allele DRB3*02:06, allele DRB3*02:07, allele DRB3*02:08, allele DRB3*02:09, allele DRB3*02:10, allele DRB3*02:11, allele DRB3*02:12, allele DRB3*02:13, allele DRB3*02:14, allele DRB3*02:15, allele DRB3*02:16, allele DRB3*02:17, allele DRB3*02:18, allele DRB3*02:19, allele DRB3*02:20, allele DRB3*02:21, allele DRB3*02:22, allele DRB3*02:23, allele DRB3*02:24, allele DRB3*02:25, allele DRB3*03:01, allele DRB3*03:02 and allele DRB3*03:03.
VAR_060742
Natural variant401R → S in allele DRB3*01:14.
VAR_060743
Natural variant411K → T in allele DRB3*01:14.
VAR_060744
Natural variant551Y → F in allele DRB3*01:09, allele DRB3*02:01, allele DRB3*02:02, allele DRB3*02:03, allele DRB3*02:04, allele DRB3*02:05, allele DRB3*02:06, allele DRB3*02:07, allele DRB3*02:08, allele DRB3*02:09, allele DRB3*02:10, allele DRB3*02:11, allele DRB3*02:12, allele DRB3*02:14, allele DRB3*02:15, allele DRB3*02:16, allele DRB3*02:17, allele DRB3*02:18, allele DRB3*02:19, allele DRB3*02:20, allele DRB3*02:21, allele DRB3*02:22, allele DRB3*02:23, allele DRB3*02:24, allele DRB3*02:25, allele DRB3*03:01, allele DRB3*03:02 and allele DRB3*03:03.
VAR_060746
Natural variant551Y → L in allele DRB3*02:13; requires 2 nucleotide substitutions.
VAR_060745
Natural variant571D → E in allele DRB3*01:03, allele DRB3*01:09, allele DRB3*02:01, allele DRB3*02:02, allele DRB3*02:03, allele DRB3*02:04, allele DRB3*02:05, allele DRB3*02:06, allele DRB3*02:07, allele DRB3*02:08, allele DRB3*02:09, allele DRB3*02:10, allele DRB3*02:11, allele DRB3*02:12, allele DRB3*02:13, allele DRB3*02:14, allele DRB3*02:15, allele DRB3*02:16, allele DRB3*02:17, allele DRB3*02:18, allele DRB3*02:19, allele DRB3*02:20, allele DRB3*02:21, allele DRB3*02:22, allele DRB3*02:23, allele DRB3*02:24, allele DRB3*02:25, allele DRB3*03:01, allele DRB3*03:02 and allele DRB3*03:03.
VAR_060747
Natural variant571D → N in allele DRB3*01:05.
VAR_060748
Natural variant581R → I in allele DRB3*01:11.
VAR_060749
Natural variant591Y → H in allele DRB3*01:09, allele DRB3*02:01, allele DRB3*02:02, allele DRB3*02:03, allele DRB3*02:04, allele DRB3*02:06, allele DRB3*02:07, allele DRB3*02:08, allele DRB3*02:09, allele DRB3*02:10, allele DRB3*02:11, allele DRB3*02:12, allele DRB3*02:13, allele DRB3*02:14, allele DRB3*02:15, allele DRB3*02:16, allele DRB3*02:17, allele DRB3*02:18, allele DRB3*02:19, allele DRB3*02:20, allele DRB3*02:21, allele DRB3*02:22, allele DRB3*02:23, allele DRB3*02:24, allele DRB3*02:25 and allele DRB3*03:02.
VAR_060750
Natural variant661F → L in allele DRB3*01:13.
VAR_060752
Natural variant661F → N in allele DRB3*01:08, allele DRB3*02:06 and allele DRB3*02:20; requires 2 nucleotide substitutions.
VAR_060753
Natural variant661F → S in allele DRB3*02:03.
VAR_060751
Natural variant661F → Y in allele DRB3*01:07, allele DRB3*01:09, allele DRB3*02:01, allele DRB3*02:02, allele DRB3*02:04, allele DRB3*02:05, allele DRB3*02:07, allele DRB3*02:08, allele DRB3*02:09, allele DRB3*02:10, allele DRB3*02:11, allele DRB3*02:12, allele DRB3*02:13, allele DRB3*02:14, allele DRB3*02:15, allele DRB3*02:16, allele DRB3*02:17, allele DRB3*02:18, allele DRB3*02:19, allele DRB3*02:21, allele DRB3*02:22, allele DRB3*02:23, allele DRB3*02:24 and allele DRB3*02:25.
VAR_060754
Natural variant671L → A in allele DRB3*01:07, allele DRB3*01:09, allele DRB3*02:01, allele DRB3*02:02, allele DRB3*02:04, allele DRB3*02:05, allele DRB3*02:06, allele DRB3*02:07, allele DRB3*02:08, allele DRB3*02:09, allele DRB3*02:10, allele DRB3*02:11, allele DRB3*02:12, allele DRB3*02:13, allele DRB3*02:14, allele DRB3*02:15, allele DRB3*02:16, allele DRB3*02:17, allele DRB3*02:18, allele DRB3*02:19, allele DRB3*02:21, allele DRB3*02:22, allele DRB3*02:23, allele DRB3*02:24 and allele DRB3*02:25; requires 2 nucleotide substitutions.
VAR_060755
Natural variant671L → V in allele DRB3*01:06, allele DRB3*01:08, allele DRB3*02:03, allele DRB3*02:20, allele DRB3*03:01, allele DRB3*03:02 and allele DRB3*03:03.
VAR_060756
Natural variant681R → S in allele DRB3*01:10.
VAR_060757
Natural variant801T → R in allele DRB3*01:07, allele DRB3*02:01, allele DRB3*02:02, allele DRB3*02:03, allele DRB3*02:04, allele DRB3*02:05, allele DRB3*02:06, allele DRB3*02:07, allele DRB3*02:08, allele DRB3*02:11, allele DRB3*02:12, allele DRB3*02:13, allele DRB3*02:14, allele DRB3*02:15, allele DRB3*02:16, allele DRB3*02:17, allele DRB3*02:18, allele DRB3*02:19, allele DRB3*02:20, allele DRB3*02:21, allele DRB3*02:22, allele DRB3*02:23, allele DRB3*02:24 and allele DRB3*02:25.
VAR_060758
Natural variant841R → L in allele DRB3*02:23.
VAR_060759
Natural variant861V → A in allele DRB3*02:16.
VAR_060760
Natural variant861V → D in allele DRB3*01:07, allele DRB3*02:01, allele DRB3*02:02, allele DRB3*02:03, allele DRB3*02:04, allele DRB3*02:05, allele DRB3*02:06, allele DRB3*02:10, allele DRB3*02:11, allele DRB3*02:12, allele DRB3*02:13, allele DRB3*02:14, allele DRB3*02:15, allele DRB3*02:17, allele DRB3*02:18, allele DRB3*02:19, allele DRB3*02:20, allele DRB3*02:22, allele DRB3*02:23, allele DRB3*02:24 and allele DRB3*02:25.
VAR_060762
Natural variant861V → S in allele DRB3*02:08; requires 2 nucleotide substitutions.
VAR_060761
Natural variant871A → E in allele DRB3*02:18.
VAR_060763
Natural variant891S → H in allele DRB3*02:16; requires 2 nucleotide substitutions.
VAR_060764
Natural variant891S → Y in allele DRB3*01:07, allele DRB3*02:01, allele DRB3*02:02, allele DRB3*02:03, allele DRB3*02:04, allele DRB3*02:05, allele DRB3*02:06, allele DRB3*02:07, allele DRB3*02:08, allele DRB3*02:10, allele DRB3*02:11, allele DRB3*02:12, allele DRB3*02:13, allele DRB3*02:14, allele DRB3*02:15, allele DRB3*02:17, allele DRB3*02:18, allele DRB3*02:20, allele DRB3*02:22, allele DRB3*02:23 and allele DRB3*02:24.
VAR_060765
Natural variant961L → F in allele DRB3*02:17.
VAR_060766
Natural variant961L → I in allele DRB3*02:11.
VAR_060767
Natural variant1021G → A.
Corresponds to variant rs17878857 [ dbSNP | Ensembl ].
VAR_033396
Natural variant1031R → Q in allele DRB3*01:07, allele DRB3*02:01, allele DRB3*02:02, allele DRB3*02:03, allele DRB3*02:05, allele DRB3*02:06, allele DRB3*02:07, allele DRB3*02:08, allele DRB3*02:09, allele DRB3*02:10, allele DRB3*02:11, allele DRB3*02:12, allele DRB3*02:13, allele DRB3*02:14, allele DRB3*02:15, allele DRB3*02:16, allele DRB3*02:17, allele DRB3*02:18, allele DRB3*02:20, allele DRB3*02:21, allele DRB3*02:23, allele DRB3*02:24, allele DRB3*02:25, allele DRB3*03:01 and allele DRB3*03:02.
VAR_060768
Natural variant1061N → T in allele DRB3*02:15.
VAR_060769
Natural variant1131G → R in allele DRB3*01:12.
VAR_060770
Natural variant1141V → A.
Corresponds to variant rs17424145 [ dbSNP | Ensembl ].
VAR_033397
Natural variant1151G → A in allele DRB3*02:14.
VAR_060771
Natural variant1151G → V in allele DRB3*02:01, allele DRB3*02:04, allele DRB3*02:24, allele DRB3*03:01 and allele DRB3*03:02.
VAR_060772
Natural variant1691A → T in allele DRB3*03:01.
VAR_060773
Natural variant1781Q → H in allele DRB3*03:01.
VAR_060774
Natural variant1931V → F in allele DRB3*02:01.
VAR_060775
Natural variant2121A → P in allele DRB3*02:01, allele DRB3*02:02, allele DRB3*02:10, allele DRB3*02:11, allele DRB3*02:24 and allele DRB3*03:01.
VAR_060776
Natural variant2181R → S in allele DRB3*02:01, allele DRB3*02:02, allele DRB3*02:10 and allele DRB3*02:11.
VAR_060777
Natural variant2361V → M.
Corresponds to variant rs2230816 [ dbSNP | Ensembl ].
VAR_033398

Secondary structure

.................................... 266
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P79483 [UniParc].

Last modified May 1, 1997. Version 1.
Checksum: 2FC3AE68D3B10EAD

FASTA26629,962
        10         20         30         40         50         60 
MVCLKLPGGS SLAALTVTLM VLSSRLAFAG DTRPRFLELR KSECHFFNGT ERVRYLDRYF 

        70         80         90        100        110        120 
HNQEEFLRFD SDVGEYRAVT ELGRPVAESW NSQKDLLEQK RGRVDNYCRH NYGVGESFTV 

       130        140        150        160        170        180 
QRRVHPQVTV YPAKTQPLQH HNLLVCSVSG FYPGSIEVRW FRNGQEEKAG VVSTGLIQNG 

       190        200        210        220        230        240 
DWTFQTLVML ETVPRSGEVY TCQVEHPSVT SALTVEWRAR SESAQSKMLS GVGGFVLGLL 

       250        260 
FLGAGLFIYF RNQKGHSGLQ PTGFLS 

« Hide

References

« Hide 'large scale' references
[1]"Complete sequence of an HLA-DR beta chain deduced from a cDNA clone and identification of multiple non-allelic DR beta chain genes."
Long E.O., Wake C.T., Gorski J., Mach B.
EMBO J. 2:389-394(1983) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE DRB3*02:01).
[2]"Polymorphism of human Ia antigens: gene conversion between two DR beta loci results in a new HLA-D/DR specificity."
Gorski J., Mach B.
Nature 322:67-70(1986) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE DRB3*01:01).
[3]"Description of two new HLA-DRB alleles (DRB1*0310 and DRB3*01012) found in a Spanish infant."
Martinez-Quiles N., Martin-Villa J.M., Martinez-Laso J., Perez-Blas M., Ferre-Lopez S., Moreno-Pelayo M.A., Alvarez-Tejado M., Arnaiz-Villena A.
Tissue Antigens 49:658-661(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE DRB3*01:01).
Tissue: Blood.
[4]"DRB3 alleles with variations in the annealing sites of commonly used amplification primers."
Coquillard G.J., Tang T.F., Steiner N., Perlee L., Ng J., Hartzman R.J., Hurley C.K.
Tissue Antigens 55:558-563(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE DRB3*01:01), NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-119 (ALLELE DRB3*01:04).
Tissue: Blood.
[5]"Cloning and nucleotide sequence analysis of HLA-DRB3*01012 from EBV-transformed Korean B-cell line by sequence based typing."
Kim K.H., Kang J.H., Maeng C.Y., Han H., Park J.H., Hahm K.S., Kim K.L.
Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE DRB3*01:01).
[6]"HLA-DRB3*03011 sequence complete mRNA."
Spierings E., Zegveld S.T., Goulmy E.
Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE DRB3*03:01).
[7]"DNA sequences coding for the DR beta-chain locus of the human lymphocyte antigen complex and polypeptides, diagnostic typing processes and products related thereto."
Mach B.F., Long E.O., Wake C.T.
Patent number EP0103960, 28-MAR-1984
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE DRB3*02:01).
[8]"The DNA sequence and analysis of human chromosome 6."
Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. expand/collapse author list , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ALLELES DRB3*01:01 AND DRB3*02:02).
[9]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ALLELES DRB3*01:01 AND DRB3*02:02).
Tissue: Brain.
[10]"Molecular analysis of the genes for human class II antigens of the major histocompatibility complex."
Long E.O., Gorski J., Rollini P., Wake C.T., Strubin M., Rabourdin-Combe C., Mach B.
Hum. Immunol. 8:113-121(1983) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 30-266 (ALLELE DRB3*02:01).
[11]"Allelic variation in the DR subregion of the human major histocompatibility complex."
Bell J.I., Denney D. Jr., Foster L., Belt T.K., Todd J.A., McDevitt H.O.
Proc. Natl. Acad. Sci. U.S.A. 84:6234-6238(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 30-266 (ALLELE DRB3*02:01).
[12]"Identification by sequencing based typing and complete coding region analysis of three new HLA class II alleles: DRB3*0210, DRB3*0211 and DQB1*0310."
Balas A., Santos S., Aviles M.J., Garcia-Sanchez F., Lillo R., Vicario J.L.
Tissue Antigens 56:380-384(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 30-266 (ALLELES DRB3*02:10 AND DRB3*02:11).
[13]"A new HLA-DRB3*02 allele identified by sequencing based typing."
Westerink N., Bacelar M., Arts-Hilkes Y., Mulder W., Rozemuller E.H.
Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-217 (ALLELE DRB3*02:24).
[14]"Sequencing of two new HLA class II alleles: DRB3*0218 and DQB1*030202."
Balas A., Aviles M.J., Lillo R., Alonso-Nieto M., Zarapuz L., Garcia-Villaescusa R., Garcia-Sanchez F., Vicario J.L.
Tissue Antigens 63:614-616(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-124 (ALLELE DRB3*02:18).
[15]"Identification of a new DRB3*02 allelic variant (DRB3*0209) by high-resolution sequence-based typing."
Morabito A., Pera C., Longo A., Delfino L., Ferrara G.B.
Tissue Antigens 56:90-94(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB3*02:09).
[16]"Description of fourteen new DRB alleles found in a stem cell donor registry."
Tang T.F., Lin Y.-S., Robbins F.M., Li L., Sintasath D., Coquillard G., Huang A., Heine U., Ng J., Hartzman R.J., Hurley C.K.
Tissue Antigens 59:63-65(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB3*01:05).
[17]"Three new DRB alleles routinely identified by sequence-based typing: DRB1*010103, DRB1*0326 and DRB3*0219."
Dubois V., Favre-Victoire I., Gebuhrer L.
Tissue Antigens 64:621-623(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB3*02:19).
[18]"Characterisation of two novel HLA alleles, HLA-Cw*0429 and HLA-DRB3*0223."
Danzer M., Polin H., Hofer K., Proll J., Gabriel C.
Tissue Antigens 72:498-499(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB3*02:23).
Tissue: Peripheral blood.
[19]"Description of three novel HLA-DRB3 alleles: DRB3*010105, DRB3*0112 and DRB3*0113."
Lee K.W., Jung Y.A.
Tissue Antigens 73:83-84(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELES DRB3*01:01; DRB3*01:12 AND DRB3*01:13).
[20]"New DRB3*02 variant."
Keller E.
Submitted (APR-1996) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB3*02:04).
[21]"An HLA-DRB3 allele detected by SBT."
Greville W.D., Ng G., Kennedy A., Dunckley H.
Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELES DRB3*02:12 AND DRB3*02:13).
[22]"A new HLA DRB3* allele very similar to DRB3*02021 and DRB3*0212 alleles."
Moine A.
Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB3*02:14).
[23]"A novel DRB3 allele."
Varney M.
Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB3*02:15).
[24]"Identification of a novel DRB3*0216 allele."
Avergas C.U., Iglehart B.A., Leffell M.S.
Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB3*02:16).
[25]"Novel HLA-DRB3 allele revealed by sequencing based typing."
Hogbin J.-P., Chapman G., Greville W.D.
Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB3*02:17).
[26]"Description of a new DRB3* allele."
Perasaari J., Egle Jansson I., Partanen J., Bengtsson M.
Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB3*01:11).
[27]"New HLA-DRB3*02 allele."
Colombini I., Malagoli A., Carella G.
Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB3*02:20).
[28]"New HLA-DRB3*02 allelic variant identified by high resolution sequence-based typing."
Garino E., Berrino M., Bertinetto F., Brancatello F., Caropreso P., Chidichimo R., Frisaldi E., Mazzola G., Panniello M., Tondat F., Locatelli F., Amoroso A.
Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB3*02:21).
[29]"The DRB3 new allele is identical to the current HLA-DRB3*020201 allele except a point substitution at codon 74 where a G is found in place of A."
Dormoy A., Froelich N.
Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELES DRB3*02:22).
[30]"The new DRB3 allele is identical to the DRB3*020201 allele except a mutation at position 266 leading to the change of the amino acid 65 (Tyr (TAC) -> Ser(TCC)."
Dormoy A., Derin R., Jollet I., Weschler B., Leisenbach R.
Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB3*02:25).
Tissue: Peripheral blood.
[31]"Identification of a novel HLA-DRB3*01 allele containing a DRB1 sequence motive by micro-TGGE and confirmed by cloning and direct sequencing."
Garritsen H.S.P., Fae I., Legath N., Hannig H., Fischer G.F.
Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (ALLELE DRB3*01:14).
[32]"New HLA class II (DRB3) allele detected by sequencing-based typing."
Greville W.D., Ng G., Kennedy A., Dunckley H.
Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-122 (ALLELE DRB3*02:02).
[33]"Description of a new HLA-DRB3 allele in a Spanish bone marrow donor."
Loeliger C.
Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-122 (ALLELE DRB3*01:08).
Tissue: Bone marrow.
[34]"Novel HLA*DRB3 allele."
Li L., Hurley C.K.
Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-122 (ALLELE DRB3*01:09).
[35]"Diversity associated with the second expressed HLA-DRB locus in the human population."
Robbins F., Hurley C.K., Tang T., Yao H., Lin Y.S., Wade J., Goeken N., Hartzman R.J.
Immunogenetics 46:104-110(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-121 (ALLELE DRB3*02:05).
[36]Olerup O.
Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-117 (ALLELE DRB3*01:03).
[37]"Identification of new DRB1*01 (DRB1*01022), DRB1*14 (DRB1*1428) and DRB3* (DRB3*0206) alleles."
Hashemi-Tavoularis S., Couture C., Buyse I.M.
Tissue Antigens 50:89-93(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-115 (ALLELE DRB3*02:06).
[38]"A novel DRB3 allele (DRB3*0208), a new allelic variant of DRB1*1502 (DRB1*15023) and two new DQB1 (DQB1*03012 and DQB1*0614) alleles."
Hashemi-tavoularis S., Ouellet S., Sengar D.P.S., Buyse I.M.
Tissue Antigens 52:294-299(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-115 (ALLELES DRB3*02:08 AND DRB3*03:02).
Tissue: Blood.
[39]"Identification of three new DRB3* (DRB3*0106, DRB3*0107 and DRB3*02022) alleles."
Tavoularis S., Ouellet S., Stephens S.
Tissue Antigens 57:390-393(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-115 (ALLELES DRB3*01:06 AND DRB3*01:07).
Tissue: Peripheral blood.
[40]"Identification of three novel alleles: DRB3*0110, DRB1*1140, and DRB1*140102."
Tavoularis S., Couture C., Ribeiro-Barros E.
Tissue Antigens 63:496-500(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-115 (ALLELE DRB3*01:10).
Tissue: Peripheral blood.
[41]"New HLA class II alleles in the Indonesian population."
Panigoro R., Greville W.D., Kennedy A., Trejaut J., Dunckley H.
Tissue Antigens 54:521-523(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 36-119 (ALLELE DRB3*03:03).
[42]"Identification and nucleotide sequence of two novel DRB3 alleles, DRB3*0102 and DRB3*010133."
Guttridge M.G., Hudson L., Williams H., Dunn P., Duy S., Darke C.
Tissue Antigens 49:665-667(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 36-117 (ALLELE DRB3*01:02).
[43]"Identification of a new DRB3*02 allele (DRB3*0207) by sequence-based typing."
Voorter C.E., Hentges F., van den Berg-Loonen E.M.
Tissue Antigens 50:552-554(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 37-116 (ALLELE DRB3*02:07).
[44]"Five new DRB1 alleles found during routine DRB oligotyping."
Anholts J.D.H., Verduijn W., Schreuder G.M.T.
Submitted (MAY-1995) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 37-116 (ALLELE DRB3*02:03).
[45]"Identification of a putative DR8 founder haplotype containing a novel DRB1*0801 allele."
Eberle M., Asu U., Taylor M., Hunter J.B., Fuller T.C., Maurer D.
Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 43-120 (ALLELE DRB3*02:02).
[46]"HLA-DR beta-chain polymorphism. Second domain polymorphism reflects evolutionary relatedness of alleles and may explain public serologic epitopes."
Gorski J.
J. Immunol. 143:329-333(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 124-217 (ALLELE DRB3*01:01/DRB3*01:02).
[47]"Naturally processed peptides spanning the HPA-1a polymorphism are efficiently generated and displayed from platelet glycoprotein by HLA-DRB3*0101-positive antigen-presenting cells."
Anani Sarab G., Moss M., Barker R.N., Urbaniak S.J.
Blood 114:1954-1957(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION OF THE ALLOANTIGEN HPA-1A BY MASS SPECTROMETRY, ASSOCIATION TO ALLELE HLA-DRB3*01:01.
[48]"Invariant chain structure and MHC class II function."
Cresswell P.
Cell 84:505-507(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: REVIEW.
[49]"Presentation of antigens by MHC class II molecules: getting the most out of them."
Villadangos J.A.
Mol. Immunol. 38:329-346(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: REVIEW.
[50]"Autophagy in MHC class II presentation: sampling from within."
Menendez-Benito V., Neefjes J.
Immunity 26:1-3(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: REVIEW.
[51]"MHC class II molecules on the move for successful antigen presentation."
Rocha N., Neefjes J.
EMBO J. 27:1-5(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: REVIEW.
[52]"MHC class II stabilization at the surface of human dendritic cells is the result of maturation-dependent MARCH I down-regulation."
De Gassart A., Camosseto V., Thibodeau J., Ceppi M., Catalan N., Pierre P., Gatti E.
Proc. Natl. Acad. Sci. U.S.A. 105:3491-3496(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: UBIQUITINATION BY MARCH1, SUBCELLULAR LOCATION.
[53]"MHC class II transport at a glance."
Berger A.C., Roche P.A.
J. Cell Sci. 122:1-4(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: REVIEW.
[54]"CD74 in antigen presentation, inflammation, and cancers of the gastrointestinal tract."
Beswick E.J., Reyes V.E.
World J. Gastroenterol. 15:2855-2861(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: REVIEW.
[55]"Crystallographic structure of the human leukocyte antigen DRA, DRB3*0101: models of a directional alloimmune response and autoimmunity."
Parry C.S., Gorski J., Stern L.J.
J. Mol. Biol. 371:435-446(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.25 ANGSTROMS) OF 30-219 OF HLA-DRA/HLA-DRB3 HETERODIMER IN COMPLEX WITH ITGB3 PEPTIDE (ALLOANTIGEN HPA-1A), SUBUNIT, DISULFIDE BOND.
[56]"The structure of HLA-DR52c: comparison to other HLA-DRB3 alleles."
Dai S., Crawford F., Marrack P., Kappler J.W.
Proc. Natl. Acad. Sci. U.S.A. 105:11893-11897(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 30-219 OF HLA-DRA/HLA-DRB3 HETERODIMER IN COMPLEX WITH EEF1A2 PEPTIDE, GLYCOSYLATION AT ASN-48, DISULFIDE BOND.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
V00522 mRNA. Translation: CAA23781.1.
X04055 Genomic DNA. No translation available.
X04058 Genomic DNA. No translation available.
U66825 mRNA. Translation: AAD43828.1.
AF026467 Genomic DNA. Translation: AAC05599.1.
AF199236 mRNA. Translation: AAF13065.2.
U95819 mRNA. Translation: AAD00819.1.
AY138123 mRNA. Translation: AAN15205.1.
A06800 mRNA. Translation: CAA00596.1.
AL662842 Genomic DNA. Translation: CAI17549.1.
AL929581 Genomic DNA. Translation: CAI18691.1.
CR788283 Genomic DNA. Translation: CAQ11026.1.
Z84814 Genomic DNA. Translation: CAB06607.1.
BC008987 mRNA. Translation: AAH08987.1.
BC106057 mRNA. Translation: AAI06058.1.
M17380 mRNA. Translation: AAA59804.1.
AF192258 mRNA. Translation: AAF26358.1.
AF192259 mRNA. Translation: AAF26359.1.
FJ515276 Genomic DNA. Translation: ACL50609.1.
AY291205 Genomic DNA. Translation: AAP43643.1.
AF148518 Genomic DNA. Translation: AAF67837.1.
AF081677 Genomic DNA. Translation: AAC32202.1.
AY271986 Genomic DNA. Translation: AAP23230.1.
AM747470 Genomic DNA. Translation: CAO00528.1.
EU873151 Genomic DNA. Translation: ACF33221.1.
EU873152 Genomic DNA. Translation: ACF33222.1.
EU873153 Genomic DNA. Translation: ACF33223.1.
X91639 Genomic DNA. No translation available.
AF208484 Genomic DNA. Translation: AAF23165.1.
AF208485 Genomic DNA. Translation: AAF23166.1.
AJ290395 Genomic DNA. Translation: CAC27417.1.
AF427138 Genomic DNA. Translation: AAL26538.1.
AF455114 Genomic DNA. Translation: AAL57866.1.
AF461431 Genomic DNA. Translation: AAL66370.1.
AJ564210 Genomic DNA. Translation: CAD91915.2.
AY958608 Genomic DNA. Translation: AAY28717.1.
DQ311653 Genomic DNA. Translation: ABC33924.1.
AM413002 Genomic DNA. Translation: CAL85628.1.
FN424163 Genomic DNA. Translation: CAZ66795.1.
FN424162 Genomic DNA. Translation: CAZ66766.1.
AF177216 Genomic DNA. Translation: AAD53911.1.
AF361865 Genomic DNA. Translation: AAK38297.1.
AY042679 Genomic DNA. Translation: AAK94514.1.
U36826 Genomic DNA. Translation: AAB63531.1.
U94590 Genomic DNA. Translation: AAB53324.1.
X95760 Genomic DNA. Translation: CAA65066.1.
Y13715 Genomic DNA. Translation: CAA74043.1.
AJ001255 Genomic DNA. Translation: CAA04629.1.
AJ242860 Genomic DNA. Translation: CAB62390.1.
AJ242862 Genomic DNA. Translation: CAB62392.1.
AJ315477 Genomic DNA. Translation: CAC86562.1.
AF028012 Genomic DNA. Translation: AAB94614.1.
Y08063 Genomic DNA. Translation: CAA69301.1.
Y10180 Genomic DNA. Translation: CAA71253.1.
X86977 Genomic DNA. No translation available.
AF152845 Genomic DNA. Translation: AAD45286.1.
PIRB60748.
E28043.
HLHU5D. I37469.
PT0164.
PT0165.
PT0166.
S03442.
RefSeqNP_072049.2. NM_022555.3.
UniGeneHs.696211.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2Q6WX-ray2.25B/E30-219[»]
3C5JX-ray1.80B30-219[»]
4H1LX-ray3.30B/E33-219[»]
ProteinModelPortalP79483.
SMRP79483. Positions 32-218.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid109370. 11 interactions.
IntActP79483. 2 interactions.

Chemistry

BindingDBP79483.
ChEMBLCHEMBL3460.

Polymorphism databases

DMDM34395491.

Proteomic databases

PaxDbP79483.
PRIDEP79483.

Protocols and materials databases

DNASU3125.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000307137; ENSP00000302517; ENSG00000196101.
GeneID3125.
KEGGhsa:3125.
UCSCuc011fni.1. human.

Organism-specific databases

CTD3125.
GeneCardsGC06M8T3720.
GC06Mi32470.
GC06Mj32412.
HGNCHGNC:4951. HLA-DRB3.
MIM612735. gene.
neXtProtNX_P79483.
PharmGKBPA35074.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG68200.
HOVERGENHBG012730.
InParanoidP01913.
KOK06752.
OMANQKGHAG.
OrthoDBEOG7PS1GV.
PhylomeDBP79483.

Enzyme and pathway databases

ReactomeREACT_6900. Immune System.

Gene expression databases

GenevestigatorP79483.

Family and domain databases

Gene3D2.60.40.10. 1 hit.
3.10.320.10. 1 hit.
InterProIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011162. MHC_I/II-like_Ag-recog.
IPR014745. MHC_II_a/b_N.
IPR000353. MHC_II_b_N.
[Graphical view]
PfamPF07654. C1-set. 1 hit.
PF00969. MHC_II_beta. 1 hit.
[Graphical view]
ProDomPD000328. MHC_II_b_N. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTSM00407. IGc1. 1 hit.
SM00921. MHC_II_beta. 1 hit.
[Graphical view]
SUPFAMSSF54452. SSF54452. 1 hit.
PROSITEPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP79483.
GeneWikiHLA-DRB3_(gene).
GenomeRNAi3125.
NextBio12400.
PROP79483.
SOURCESearch...

Entry information

Entry nameDRB3_HUMAN
AccessionPrimary (citable) accession number: P79483
Secondary accession number(s): A0ZXY9 expand/collapse secondary AC list , A7MA46, B5AU12, B5AU13, B5AU14, B8YAC6, C6H115, C6H116, O02875, O19590, O46701, O46794, O78049, O78162, P01913, P79663, Q29721, Q29809, Q2PPD0, Q30144, Q507L8, Q5SP44, Q5STE0, Q6YJU6, Q70M87, Q7YQ62, Q860I9, Q8SP69, Q8WLT7, Q8WLT8, Q95359, Q95HM8, Q95IE5, Q96H16, Q9BCP3, Q9BD18, Q9MYA4, Q9MYH3, Q9MYH4, Q9TP01, Q9TP02, Q9TPB5, Q9TQ21, Q9UIN3, Q9UIN5
Entry history
Integrated into UniProtKB/Swiss-Prot: August 29, 2003
Last sequence update: May 1, 1997
Last modified: April 16, 2014
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 6

Human chromosome 6: entries, gene names and cross-references to MIM