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P79457

- UTY_MOUSE

UniProt

P79457 - UTY_MOUSE

Protein

Histone demethylase UTY

Gene

Uty

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 115 (01 Oct 2014)
      Sequence version 2 (15 Jul 1999)
      Previous versions | rss
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    Functioni

    Histone demethylase.By similarity

    Cofactori

    Ascorbate.By similarity
    Fe2+.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi958 – 9581IronBy similarity
    Metal bindingi960 – 9601IronBy similarity

    GO - Molecular functioni

    1. histone demethylase activity (H3-K36 specific) Source: MGI
    2. metal ion binding Source: UniProtKB-KW
    3. protein binding Source: MGI
    4. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: MGI

    GO - Biological processi

    1. canonical Wnt signaling pathway Source: MGI
    2. cardiac muscle cell contraction Source: MGI
    3. embryonic organ development Source: MGI
    4. establishment of protein localization Source: MGI
    5. heart development Source: MGI
    6. heart morphogenesis Source: MGI
    7. histone H3-K36 demethylation Source: GOC
    8. in utero embryonic development Source: MGI
    9. regulation of chromatin silencing Source: MGI
    10. regulation of gene expression Source: MGI

    Keywords - Molecular functioni

    Chromatin regulator, Dioxygenase, Oxidoreductase

    Keywords - Ligandi

    Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histone demethylase UTY (EC:1.14.11.-)
    Alternative name(s):
    Male-specific histocompatibility antigen H-YDB
    Ubiquitously transcribed TPR protein on the Y chromosome
    Ubiquitously transcribed Y chromosome tetratricopeptide repeat protein
    Gene namesi
    Name:Uty
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    Organism-specific databases

    MGIiMGI:894810. Uty.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell
    2. protein complex Source: MGI

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 12121212Histone demethylase UTYPRO_0000106413Add
    BLAST

    Proteomic databases

    PRIDEiP79457.

    PTM databases

    PhosphoSiteiP79457.

    Expressioni

    Gene expression databases

    GenevestigatoriP79457.

    Interactioni

    Subunit structurei

    Binds TLE1 and TLE2.

    Structurei

    3D structure databases

    ProteinModelPortaliP79457.
    SMRiP79457. Positions 698-1209.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati88 – 12134TPR 1Add
    BLAST
    Repeati125 – 15834TPR 2Add
    BLAST
    Repeati165 – 19329TPR 3Add
    BLAST
    Repeati200 – 23334TPR 4Add
    BLAST
    Repeati245 – 27834TPR 5Add
    BLAST
    Repeati279 – 31234TPR 6Add
    BLAST
    Repeati313 – 34634TPR 7Add
    BLAST
    Repeati347 – 38034TPR 8Add
    BLAST
    Domaini907 – 1070164JmjCPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the UTX family.Curated
    Contains 1 JmjC domain.PROSITE-ProRule annotation
    Contains 8 TPR repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, TPR repeat

    Phylogenomic databases

    eggNOGiCOG0457.
    HOGENOMiHOG000220834.
    HOVERGENiHBG018063.
    InParanoidiP79457.
    PhylomeDBiP79457.

    Family and domain databases

    Gene3Di1.25.40.10. 1 hit.
    InterProiIPR003347. JmjC_dom.
    IPR029516. KDM6C.
    IPR013026. TPR-contain_dom.
    IPR011990. TPR-like_helical.
    IPR001440. TPR_1.
    IPR019734. TPR_repeat.
    [Graphical view]
    PANTHERiPTHR14017:SF17. PTHR14017:SF17. 1 hit.
    PfamiPF02373. JmjC. 1 hit.
    PF00515. TPR_1. 3 hits.
    PF13181. TPR_8. 1 hit.
    [Graphical view]
    SMARTiSM00558. JmjC. 1 hit.
    SM00028. TPR. 6 hits.
    [Graphical view]
    PROSITEiPS51184. JMJC. 1 hit.
    PS50005. TPR. 7 hits.
    PS50293. TPR_REGION. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P79457-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKSYGLSLTT AALGNEEKKM AAEKARGEGE EGSFSLTVEE KKALCGLDSS     50
    FFGFLTRCKD GAKMKTLLNK AIHFYESLIV KAEGKVESDF FCQLGHFNLL 100
    LEDYSKALSS YQRYYSLQTD YWKNAAFLYG LGLVYFYYNA FQWAIRAFQE 150
    VLYVDPNFCR AKEIHLRLGF MFKMNTDYES SLKHFQLALI DCNVCTLSSV 200
    EIQFHIAHLY ETQRKYHSAK AAYEQLLQIE SLPSQVKATV LQQLGWMHHN 250
    MDLIGDNTTK ERYAIQYLQK SLEEDPNSGQ SWYFLGRCYS CIGKVQDAFV 300
    SYRQSIDKSE ASADTWCSIG VLYQQQNQPM DALQAYICAV QLDHGHAAAW 350
    MDLGILYESC NQPQDAIKCY LNAARSKSCN NTSALTSRIK FLQAQLCNLP 400
    QSSLQNKTKL LPSIEEAWSL PIPAELTSRQ GAMNTAQQSV SDTWNSVQTA 450
    SHHSVQQKVY TQCFTAQKLQ SFGKDQQPPF QTGSTRYLQA ASTNDQNQNG 500
    NHTLPQNSKG DAQNHFLRIP TSEEQKIINF TKESKDSRSK SLTSKTSRKD 550
    RDTSNICVNA KKHSNHIYQI SSVPISSLNN KESVSPDLII VDNPQLSVLV 600
    GETIDNVDHD IGTCNKVNNV HLAIHKKPDN LSASSPSSAI STETLSLKLT 650
    EQTHIVTSFI SPHSGLHTIN GEGHENLESS ASVNVGLRPR SQIIPSMSVS 700
    IYSSSTEVLK ACRSLGKNGL SNGHILLDIC PPPRPPTSPY PPLPKEKLNP 750
    PTPSIYLENK RDAFFPPLHQ FCINPKNPVT VIRGLAGALK LDLGLFSTKT 800
    LVEANNEHIV EVRTQLLQPA DENWDPSGTK KIWRYENKSS HTTIAKYAQY 850
    QACSFQESLR EENERRTQVK DYSDNESTCS DNSGRRQKAP FKTIKCGINI 900
    DLSDNKKWKL QLHELTKLPA FVRVVSAGNL LSHVGYTILG MNSVQLCMKV 950
    PGSRIPGHQE NNNFCSVNIN IGPGDCEWFV VPEDYWGVLN DFCEKNNLNF 1000
    LMSSWWPNLE DLYEANVPVY RFIQRPGDLV WINAGTVHWV QAIGWCNNIT 1050
    WNVGPLTAFQ YKLAVERYEW NKLQSVKSVV PMVHLSWNMA RNIKVSDPKL 1100
    FEMIKYCLLK ILKHCQTLRE ALVAAGKEVL WHGRINDEPA PYCSICEVEV 1150
    FNLLFVTNES NSQKTYIVHC QNCARKTSGN LENFVVLEQY KMEDLIQVYD 1200
    QFTLAPSLSS AS 1212
    Length:1,212
    Mass (Da):136,737
    Last modified:July 15, 1999 - v2
    Checksum:i2AE1A816F3D6ACB5
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti1069 – 10691E → Q in CAA70422. (PubMed:8944031)Curated
    Sequence conflicti1149 – 121264EVFNL…LSSAS → STRDLLPQLHLRQCHLQGPT DKAAILEFHLTEGSGDMH in CAA70422. (PubMed:8944031)CuratedAdd
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF057367 mRNA. Translation: AAC67385.1.
    Y09222 mRNA. Translation: CAA70422.1.
    CCDSiCCDS41216.1.
    PIRiT42387.
    T42729.
    UniGeneiMm.20477.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF057367 mRNA. Translation: AAC67385.1 .
    Y09222 mRNA. Translation: CAA70422.1 .
    CCDSi CCDS41216.1.
    PIRi T42387.
    T42729.
    UniGenei Mm.20477.

    3D structure databases

    ProteinModelPortali P79457.
    SMRi P79457. Positions 698-1209.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei P79457.

    Proteomic databases

    PRIDEi P79457.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    MGIi MGI:894810. Uty.

    Phylogenomic databases

    eggNOGi COG0457.
    HOGENOMi HOG000220834.
    HOVERGENi HBG018063.
    InParanoidi P79457.
    PhylomeDBi P79457.

    Miscellaneous databases

    PROi P79457.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori P79457.

    Family and domain databases

    Gene3Di 1.25.40.10. 1 hit.
    InterProi IPR003347. JmjC_dom.
    IPR029516. KDM6C.
    IPR013026. TPR-contain_dom.
    IPR011990. TPR-like_helical.
    IPR001440. TPR_1.
    IPR019734. TPR_repeat.
    [Graphical view ]
    PANTHERi PTHR14017:SF17. PTHR14017:SF17. 1 hit.
    Pfami PF02373. JmjC. 1 hit.
    PF00515. TPR_1. 3 hits.
    PF13181. TPR_8. 1 hit.
    [Graphical view ]
    SMARTi SM00558. JmjC. 1 hit.
    SM00028. TPR. 6 hits.
    [Graphical view ]
    PROSITEi PS51184. JMJC. 1 hit.
    PS50005. TPR. 7 hits.
    PS50293. TPR_REGION. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The mouse Y chromosome interval necessary for spermatogonial proliferation is gene dense with syntenic homology to the human AZFa region."
      Mazeyrat S., Saut N., Sargent C.A., Grimmond S., Longepied G., Ehrmann I.E., Ellis P.S., Greenfield A., Affara N.A., Mitchell M.J.
      Hum. Mol. Genet. 7:1713-1724(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: RIII.
      Tissue: Testis.
    2. "An H-YDb epitope is encoded by a novel mouse Y chromosome gene."
      Greenfield A., Scott D., Pennisi D., Ehrmann I., Ellis P.S., Cooper L., Simpson E., Koopman P.
      Nat. Genet. 14:474-478(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Swiss.
    3. "Groucho/transducin-like enhancer of split (TLE) family members interact with the yeast transcriptional co-repressor SSN6 and mammalian SSN6-related proteins: implications for evolutionary conservation of transcription repression mechanisms."
      Grbavec D., Lo R., Liu Y., Greenfield A., Stifani S.
      Biochem. J. 337:13-17(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH TLE1 AND TLE2.

    Entry informationi

    Entry nameiUTY_MOUSE
    AccessioniPrimary (citable) accession number: P79457
    Secondary accession number(s): O97979
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1999
    Last sequence update: July 15, 1999
    Last modified: October 1, 2014
    This is version 115 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3