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P79457

- UTY_MOUSE

UniProt

P79457 - UTY_MOUSE

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Protein
Histone demethylase UTY
Gene
Uty
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Histone demethylase By similarity.

Cofactori

Ascorbate By similarity.
Fe2+ By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi958 – 9581Iron By similarity
Metal bindingi960 – 9601Iron By similarity

GO - Molecular functioni

  1. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: MGI
  2. histone demethylase activity (H3-K36 specific) Source: MGI
  3. metal ion binding Source: UniProtKB-KW
  4. protein binding Source: MGI

GO - Biological processi

  1. canonical Wnt signaling pathway Source: MGI
  2. cardiac muscle cell contraction Source: MGI
  3. embryonic organ development Source: MGI
  4. establishment of protein localization Source: MGI
  5. heart development Source: MGI
  6. heart morphogenesis Source: MGI
  7. histone H3-K36 demethylation Source: GOC
  8. in utero embryonic development Source: MGI
  9. regulation of chromatin silencing Source: MGI
  10. regulation of gene expression Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Dioxygenase, Oxidoreductase

Keywords - Ligandi

Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Histone demethylase UTY (EC:1.14.11.-)
Alternative name(s):
Male-specific histocompatibility antigen H-YDB
Ubiquitously transcribed TPR protein on the Y chromosome
Ubiquitously transcribed Y chromosome tetratricopeptide repeat protein
Gene namesi
Name:Uty
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:894810. Uty.

Subcellular locationi

Nucleus Reviewed prediction

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
  2. protein complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12121212Histone demethylase UTY
PRO_0000106413Add
BLAST

Proteomic databases

PRIDEiP79457.

PTM databases

PhosphoSiteiP79457.

Expressioni

Gene expression databases

GenevestigatoriP79457.

Interactioni

Subunit structurei

Binds TLE1 and TLE2.

Structurei

3D structure databases

ProteinModelPortaliP79457.
SMRiP79457. Positions 698-1209.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati88 – 12134TPR 1
Add
BLAST
Repeati125 – 15834TPR 2
Add
BLAST
Repeati165 – 19329TPR 3
Add
BLAST
Repeati200 – 23334TPR 4
Add
BLAST
Repeati245 – 27834TPR 5
Add
BLAST
Repeati279 – 31234TPR 6
Add
BLAST
Repeati313 – 34634TPR 7
Add
BLAST
Repeati347 – 38034TPR 8
Add
BLAST
Domaini907 – 1070164JmjC
Add
BLAST

Sequence similaritiesi

Belongs to the UTX family.
Contains 1 JmjC domain.
Contains 8 TPR repeats.

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiCOG0457.
HOGENOMiHOG000220834.
HOVERGENiHBG018063.
InParanoidiP79457.
PhylomeDBiP79457.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
InterProiIPR003347. JmjC_dom.
IPR029516. KDM6C.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical.
IPR001440. TPR_1.
IPR019734. TPR_repeat.
[Graphical view]
PANTHERiPTHR14017:SF17. PTHR14017:SF17. 1 hit.
PfamiPF02373. JmjC. 1 hit.
PF00515. TPR_1. 3 hits.
PF13181. TPR_8. 1 hit.
[Graphical view]
SMARTiSM00558. JmjC. 1 hit.
SM00028. TPR. 6 hits.
[Graphical view]
PROSITEiPS51184. JMJC. 1 hit.
PS50005. TPR. 7 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P79457-1 [UniParc]FASTAAdd to Basket

« Hide

MKSYGLSLTT AALGNEEKKM AAEKARGEGE EGSFSLTVEE KKALCGLDSS     50
FFGFLTRCKD GAKMKTLLNK AIHFYESLIV KAEGKVESDF FCQLGHFNLL 100
LEDYSKALSS YQRYYSLQTD YWKNAAFLYG LGLVYFYYNA FQWAIRAFQE 150
VLYVDPNFCR AKEIHLRLGF MFKMNTDYES SLKHFQLALI DCNVCTLSSV 200
EIQFHIAHLY ETQRKYHSAK AAYEQLLQIE SLPSQVKATV LQQLGWMHHN 250
MDLIGDNTTK ERYAIQYLQK SLEEDPNSGQ SWYFLGRCYS CIGKVQDAFV 300
SYRQSIDKSE ASADTWCSIG VLYQQQNQPM DALQAYICAV QLDHGHAAAW 350
MDLGILYESC NQPQDAIKCY LNAARSKSCN NTSALTSRIK FLQAQLCNLP 400
QSSLQNKTKL LPSIEEAWSL PIPAELTSRQ GAMNTAQQSV SDTWNSVQTA 450
SHHSVQQKVY TQCFTAQKLQ SFGKDQQPPF QTGSTRYLQA ASTNDQNQNG 500
NHTLPQNSKG DAQNHFLRIP TSEEQKIINF TKESKDSRSK SLTSKTSRKD 550
RDTSNICVNA KKHSNHIYQI SSVPISSLNN KESVSPDLII VDNPQLSVLV 600
GETIDNVDHD IGTCNKVNNV HLAIHKKPDN LSASSPSSAI STETLSLKLT 650
EQTHIVTSFI SPHSGLHTIN GEGHENLESS ASVNVGLRPR SQIIPSMSVS 700
IYSSSTEVLK ACRSLGKNGL SNGHILLDIC PPPRPPTSPY PPLPKEKLNP 750
PTPSIYLENK RDAFFPPLHQ FCINPKNPVT VIRGLAGALK LDLGLFSTKT 800
LVEANNEHIV EVRTQLLQPA DENWDPSGTK KIWRYENKSS HTTIAKYAQY 850
QACSFQESLR EENERRTQVK DYSDNESTCS DNSGRRQKAP FKTIKCGINI 900
DLSDNKKWKL QLHELTKLPA FVRVVSAGNL LSHVGYTILG MNSVQLCMKV 950
PGSRIPGHQE NNNFCSVNIN IGPGDCEWFV VPEDYWGVLN DFCEKNNLNF 1000
LMSSWWPNLE DLYEANVPVY RFIQRPGDLV WINAGTVHWV QAIGWCNNIT 1050
WNVGPLTAFQ YKLAVERYEW NKLQSVKSVV PMVHLSWNMA RNIKVSDPKL 1100
FEMIKYCLLK ILKHCQTLRE ALVAAGKEVL WHGRINDEPA PYCSICEVEV 1150
FNLLFVTNES NSQKTYIVHC QNCARKTSGN LENFVVLEQY KMEDLIQVYD 1200
QFTLAPSLSS AS 1212
Length:1,212
Mass (Da):136,737
Last modified:July 15, 1999 - v2
Checksum:i2AE1A816F3D6ACB5
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1069 – 10691E → Q in CAA70422. 1 Publication
Sequence conflicti1149 – 121264EVFNL…LSSAS → STRDLLPQLHLRQCHLQGPT DKAAILEFHLTEGSGDMH in CAA70422. 1 Publication
Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF057367 mRNA. Translation: AAC67385.1.
Y09222 mRNA. Translation: CAA70422.1.
CCDSiCCDS41216.1.
PIRiT42387.
T42729.
UniGeneiMm.20477.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF057367 mRNA. Translation: AAC67385.1 .
Y09222 mRNA. Translation: CAA70422.1 .
CCDSi CCDS41216.1.
PIRi T42387.
T42729.
UniGenei Mm.20477.

3D structure databases

ProteinModelPortali P79457.
SMRi P79457. Positions 698-1209.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei P79457.

Proteomic databases

PRIDEi P79457.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

MGIi MGI:894810. Uty.

Phylogenomic databases

eggNOGi COG0457.
HOGENOMi HOG000220834.
HOVERGENi HBG018063.
InParanoidi P79457.
PhylomeDBi P79457.

Miscellaneous databases

PROi P79457.
SOURCEi Search...

Gene expression databases

Genevestigatori P79457.

Family and domain databases

Gene3Di 1.25.40.10. 1 hit.
InterProi IPR003347. JmjC_dom.
IPR029516. KDM6C.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical.
IPR001440. TPR_1.
IPR019734. TPR_repeat.
[Graphical view ]
PANTHERi PTHR14017:SF17. PTHR14017:SF17. 1 hit.
Pfami PF02373. JmjC. 1 hit.
PF00515. TPR_1. 3 hits.
PF13181. TPR_8. 1 hit.
[Graphical view ]
SMARTi SM00558. JmjC. 1 hit.
SM00028. TPR. 6 hits.
[Graphical view ]
PROSITEi PS51184. JMJC. 1 hit.
PS50005. TPR. 7 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The mouse Y chromosome interval necessary for spermatogonial proliferation is gene dense with syntenic homology to the human AZFa region."
    Mazeyrat S., Saut N., Sargent C.A., Grimmond S., Longepied G., Ehrmann I.E., Ellis P.S., Greenfield A., Affara N.A., Mitchell M.J.
    Hum. Mol. Genet. 7:1713-1724(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: RIII.
    Tissue: Testis.
  2. "An H-YDb epitope is encoded by a novel mouse Y chromosome gene."
    Greenfield A., Scott D., Pennisi D., Ehrmann I., Ellis P.S., Cooper L., Simpson E., Koopman P.
    Nat. Genet. 14:474-478(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Swiss.
  3. "Groucho/transducin-like enhancer of split (TLE) family members interact with the yeast transcriptional co-repressor SSN6 and mammalian SSN6-related proteins: implications for evolutionary conservation of transcription repression mechanisms."
    Grbavec D., Lo R., Liu Y., Greenfield A., Stifani S.
    Biochem. J. 337:13-17(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH TLE1 AND TLE2.

Entry informationi

Entry nameiUTY_MOUSE
AccessioniPrimary (citable) accession number: P79457
Secondary accession number(s): O97979
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: July 15, 1999
Last modified: September 3, 2014
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi