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Protein

Histone demethylase UTY

Gene

Uty

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Male-specific histone demethylase that catalyzes trimethylated 'Lys-27' (H3K27me3) demethylation in histone H3. Has relatively low KDM activity.By similarity

Cofactori

Protein has several cofactor binding sites:

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi958IronBy similarity1
Metal bindingi960IronBy similarity1
Metal bindingi1038IronBy similarity1
Metal bindingi1143ZincBy similarity1
Metal bindingi1146ZincBy similarity1
Metal bindingi1170ZincBy similarity1
Metal bindingi1173ZincBy similarity1

GO - Molecular functioni

  • histone demethylase activity (H3-K36 specific) Source: MGI
  • metal ion binding Source: UniProtKB-KW
  • RNA polymerase II proximal promoter sequence-specific DNA binding Source: MGI

GO - Biological processi

  • canonical Wnt signaling pathway Source: MGI
  • cardiac muscle cell contraction Source: MGI
  • embryonic organ development Source: MGI
  • establishment of protein localization Source: MGI
  • heart development Source: MGI
  • heart morphogenesis Source: MGI
  • in utero embryonic development Source: MGI
  • regulation of chromatin silencing Source: MGI
  • regulation of gene expression Source: MGI

Keywordsi

Molecular functionChromatin regulator, Dioxygenase, Oxidoreductase
LigandIron, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Histone demethylase UTY (EC:1.14.11.-)
Alternative name(s):
Male-specific histocompatibility antigen H-YDB
Ubiquitously transcribed TPR protein on the Y chromosome
Ubiquitously transcribed Y chromosome tetratricopeptide repeat protein
Gene namesi
Name:Uty
Synonyms:Kdm6c
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:894810 Uty

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001064131 – 1212Histone demethylase UTYAdd BLAST1212

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei585PhosphoserineBy similarity1
Modified residuei644PhosphothreonineBy similarity1
Modified residuei646PhosphoserineBy similarity1
Modified residuei752PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP79457
PaxDbiP79457
PRIDEiP79457

PTM databases

iPTMnetiP79457
PhosphoSitePlusiP79457

Interactioni

Subunit structurei

Binds TLE1 and TLE2.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000070012

Structurei

3D structure databases

ProteinModelPortaliP79457
SMRiP79457
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati88 – 121TPR 1Add BLAST34
Repeati125 – 158TPR 2Add BLAST34
Repeati165 – 193TPR 3Add BLAST29
Repeati200 – 233TPR 4Add BLAST34
Repeati245 – 278TPR 5Add BLAST34
Repeati279 – 312TPR 6Add BLAST34
Repeati313 – 346TPR 7Add BLAST34
Repeati347 – 380TPR 8Add BLAST34
Domaini907 – 1070JmjCPROSITE-ProRule annotationAdd BLAST164

Sequence similaritiesi

Belongs to the UTX family.Curated

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG1124 Eukaryota
KOG1246 Eukaryota
COG0457 LUCA
ENOG410XR9J LUCA
HOGENOMiHOG000220834
HOVERGENiHBG018063
InParanoidiP79457
PhylomeDBiP79457

Family and domain databases

Gene3Di1.25.40.10, 2 hits
InterProiView protein in InterPro
IPR003347 JmjC_dom
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat
PfamiView protein in Pfam
PF02373 JmjC, 1 hit
PF13181 TPR_8, 1 hit
SMARTiView protein in SMART
SM00558 JmjC, 1 hit
SM00028 TPR, 7 hits
SUPFAMiSSF48452 SSF48452, 1 hit
PROSITEiView protein in PROSITE
PS51184 JMJC, 1 hit
PS50005 TPR, 7 hits
PS50293 TPR_REGION, 1 hit

Sequencei

Sequence statusi: Complete.

P79457-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSYGLSLTT AALGNEEKKM AAEKARGEGE EGSFSLTVEE KKALCGLDSS
60 70 80 90 100
FFGFLTRCKD GAKMKTLLNK AIHFYESLIV KAEGKVESDF FCQLGHFNLL
110 120 130 140 150
LEDYSKALSS YQRYYSLQTD YWKNAAFLYG LGLVYFYYNA FQWAIRAFQE
160 170 180 190 200
VLYVDPNFCR AKEIHLRLGF MFKMNTDYES SLKHFQLALI DCNVCTLSSV
210 220 230 240 250
EIQFHIAHLY ETQRKYHSAK AAYEQLLQIE SLPSQVKATV LQQLGWMHHN
260 270 280 290 300
MDLIGDNTTK ERYAIQYLQK SLEEDPNSGQ SWYFLGRCYS CIGKVQDAFV
310 320 330 340 350
SYRQSIDKSE ASADTWCSIG VLYQQQNQPM DALQAYICAV QLDHGHAAAW
360 370 380 390 400
MDLGILYESC NQPQDAIKCY LNAARSKSCN NTSALTSRIK FLQAQLCNLP
410 420 430 440 450
QSSLQNKTKL LPSIEEAWSL PIPAELTSRQ GAMNTAQQSV SDTWNSVQTA
460 470 480 490 500
SHHSVQQKVY TQCFTAQKLQ SFGKDQQPPF QTGSTRYLQA ASTNDQNQNG
510 520 530 540 550
NHTLPQNSKG DAQNHFLRIP TSEEQKIINF TKESKDSRSK SLTSKTSRKD
560 570 580 590 600
RDTSNICVNA KKHSNHIYQI SSVPISSLNN KESVSPDLII VDNPQLSVLV
610 620 630 640 650
GETIDNVDHD IGTCNKVNNV HLAIHKKPDN LSASSPSSAI STETLSLKLT
660 670 680 690 700
EQTHIVTSFI SPHSGLHTIN GEGHENLESS ASVNVGLRPR SQIIPSMSVS
710 720 730 740 750
IYSSSTEVLK ACRSLGKNGL SNGHILLDIC PPPRPPTSPY PPLPKEKLNP
760 770 780 790 800
PTPSIYLENK RDAFFPPLHQ FCINPKNPVT VIRGLAGALK LDLGLFSTKT
810 820 830 840 850
LVEANNEHIV EVRTQLLQPA DENWDPSGTK KIWRYENKSS HTTIAKYAQY
860 870 880 890 900
QACSFQESLR EENERRTQVK DYSDNESTCS DNSGRRQKAP FKTIKCGINI
910 920 930 940 950
DLSDNKKWKL QLHELTKLPA FVRVVSAGNL LSHVGYTILG MNSVQLCMKV
960 970 980 990 1000
PGSRIPGHQE NNNFCSVNIN IGPGDCEWFV VPEDYWGVLN DFCEKNNLNF
1010 1020 1030 1040 1050
LMSSWWPNLE DLYEANVPVY RFIQRPGDLV WINAGTVHWV QAIGWCNNIT
1060 1070 1080 1090 1100
WNVGPLTAFQ YKLAVERYEW NKLQSVKSVV PMVHLSWNMA RNIKVSDPKL
1110 1120 1130 1140 1150
FEMIKYCLLK ILKHCQTLRE ALVAAGKEVL WHGRINDEPA PYCSICEVEV
1160 1170 1180 1190 1200
FNLLFVTNES NSQKTYIVHC QNCARKTSGN LENFVVLEQY KMEDLIQVYD
1210
QFTLAPSLSS AS
Length:1,212
Mass (Da):136,737
Last modified:July 15, 1999 - v2
Checksum:i2AE1A816F3D6ACB5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1069E → Q in CAA70422 (PubMed:8944031).Curated1
Sequence conflicti1149 – 1212EVFNL…LSSAS → STRDLLPQLHLRQCHLQGPT DKAAILEFHLTEGSGDMH in CAA70422 (PubMed:8944031).CuratedAdd BLAST64

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF057367 mRNA Translation: AAC67385.1
Y09222 mRNA Translation: CAA70422.1
CCDSiCCDS41216.1
PIRiT42387
T42729
UniGeneiMm.20477

Similar proteinsi

Entry informationi

Entry nameiUTY_MOUSE
AccessioniPrimary (citable) accession number: P79457
Secondary accession number(s): O97979
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: July 15, 1999
Last modified: April 25, 2018
This is version 139 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health