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P79457 (UTY_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 111. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Histone demethylase UTY

EC=1.14.11.-
Alternative name(s):
Male-specific histocompatibility antigen H-YDB
Ubiquitously transcribed TPR protein on the Y chromosome
Ubiquitously transcribed Y chromosome tetratricopeptide repeat protein
Gene names
Name:Uty
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length1212 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Histone demethylase By similarity.

Cofactor

Ascorbate By similarity.

Fe2+ By similarity.

Subunit structure

Binds TLE1 and TLE2.

Subcellular location

Nucleus Potential.

Sequence similarities

Belongs to the UTX family.

Contains 1 JmjC domain.

Contains 8 TPR repeats.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 12121212Histone demethylase UTY
PRO_0000106413

Regions

Repeat88 – 12134TPR 1
Repeat125 – 15834TPR 2
Repeat165 – 19329TPR 3
Repeat200 – 23334TPR 4
Repeat245 – 27834TPR 5
Repeat279 – 31234TPR 6
Repeat313 – 34634TPR 7
Repeat347 – 38034TPR 8
Domain907 – 1070164JmjC

Sites

Metal binding9581Iron By similarity
Metal binding9601Iron By similarity

Experimental info

Sequence conflict10691E → Q in CAA70422. Ref.2
Sequence conflict1149 – 121264EVFNL…LSSAS → STRDLLPQLHLRQCHLQGPT DKAAILEFHLTEGSGDMH in CAA70422. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P79457 [UniParc].

Last modified July 15, 1999. Version 2.
Checksum: 2AE1A816F3D6ACB5

FASTA1,212136,737
        10         20         30         40         50         60 
MKSYGLSLTT AALGNEEKKM AAEKARGEGE EGSFSLTVEE KKALCGLDSS FFGFLTRCKD 

        70         80         90        100        110        120 
GAKMKTLLNK AIHFYESLIV KAEGKVESDF FCQLGHFNLL LEDYSKALSS YQRYYSLQTD 

       130        140        150        160        170        180 
YWKNAAFLYG LGLVYFYYNA FQWAIRAFQE VLYVDPNFCR AKEIHLRLGF MFKMNTDYES 

       190        200        210        220        230        240 
SLKHFQLALI DCNVCTLSSV EIQFHIAHLY ETQRKYHSAK AAYEQLLQIE SLPSQVKATV 

       250        260        270        280        290        300 
LQQLGWMHHN MDLIGDNTTK ERYAIQYLQK SLEEDPNSGQ SWYFLGRCYS CIGKVQDAFV 

       310        320        330        340        350        360 
SYRQSIDKSE ASADTWCSIG VLYQQQNQPM DALQAYICAV QLDHGHAAAW MDLGILYESC 

       370        380        390        400        410        420 
NQPQDAIKCY LNAARSKSCN NTSALTSRIK FLQAQLCNLP QSSLQNKTKL LPSIEEAWSL 

       430        440        450        460        470        480 
PIPAELTSRQ GAMNTAQQSV SDTWNSVQTA SHHSVQQKVY TQCFTAQKLQ SFGKDQQPPF 

       490        500        510        520        530        540 
QTGSTRYLQA ASTNDQNQNG NHTLPQNSKG DAQNHFLRIP TSEEQKIINF TKESKDSRSK 

       550        560        570        580        590        600 
SLTSKTSRKD RDTSNICVNA KKHSNHIYQI SSVPISSLNN KESVSPDLII VDNPQLSVLV 

       610        620        630        640        650        660 
GETIDNVDHD IGTCNKVNNV HLAIHKKPDN LSASSPSSAI STETLSLKLT EQTHIVTSFI 

       670        680        690        700        710        720 
SPHSGLHTIN GEGHENLESS ASVNVGLRPR SQIIPSMSVS IYSSSTEVLK ACRSLGKNGL 

       730        740        750        760        770        780 
SNGHILLDIC PPPRPPTSPY PPLPKEKLNP PTPSIYLENK RDAFFPPLHQ FCINPKNPVT 

       790        800        810        820        830        840 
VIRGLAGALK LDLGLFSTKT LVEANNEHIV EVRTQLLQPA DENWDPSGTK KIWRYENKSS 

       850        860        870        880        890        900 
HTTIAKYAQY QACSFQESLR EENERRTQVK DYSDNESTCS DNSGRRQKAP FKTIKCGINI 

       910        920        930        940        950        960 
DLSDNKKWKL QLHELTKLPA FVRVVSAGNL LSHVGYTILG MNSVQLCMKV PGSRIPGHQE 

       970        980        990       1000       1010       1020 
NNNFCSVNIN IGPGDCEWFV VPEDYWGVLN DFCEKNNLNF LMSSWWPNLE DLYEANVPVY 

      1030       1040       1050       1060       1070       1080 
RFIQRPGDLV WINAGTVHWV QAIGWCNNIT WNVGPLTAFQ YKLAVERYEW NKLQSVKSVV 

      1090       1100       1110       1120       1130       1140 
PMVHLSWNMA RNIKVSDPKL FEMIKYCLLK ILKHCQTLRE ALVAAGKEVL WHGRINDEPA 

      1150       1160       1170       1180       1190       1200 
PYCSICEVEV FNLLFVTNES NSQKTYIVHC QNCARKTSGN LENFVVLEQY KMEDLIQVYD 

      1210 
QFTLAPSLSS AS 

« Hide

References

[1]"The mouse Y chromosome interval necessary for spermatogonial proliferation is gene dense with syntenic homology to the human AZFa region."
Mazeyrat S., Saut N., Sargent C.A., Grimmond S., Longepied G., Ehrmann I.E., Ellis P.S., Greenfield A., Affara N.A., Mitchell M.J.
Hum. Mol. Genet. 7:1713-1724(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: RIII.
Tissue: Testis.
[2]"An H-YDb epitope is encoded by a novel mouse Y chromosome gene."
Greenfield A., Scott D., Pennisi D., Ehrmann I., Ellis P.S., Cooper L., Simpson E., Koopman P.
Nat. Genet. 14:474-478(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Swiss.
[3]"Groucho/transducin-like enhancer of split (TLE) family members interact with the yeast transcriptional co-repressor SSN6 and mammalian SSN6-related proteins: implications for evolutionary conservation of transcription repression mechanisms."
Grbavec D., Lo R., Liu Y., Greenfield A., Stifani S.
Biochem. J. 337:13-17(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH TLE1 AND TLE2.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF057367 mRNA. Translation: AAC67385.1.
Y09222 mRNA. Translation: CAA70422.1.
PIRT42387.
T42729.
UniGeneMm.20477.

3D structure databases

ProteinModelPortalP79457.
SMRP79457. Positions 698-1209.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteP79457.

Proteomic databases

PRIDEP79457.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

MGIMGI:894810. Uty.

Phylogenomic databases

eggNOGCOG0457.
HOGENOMHOG000220834.
HOVERGENHBG018063.
InParanoidP79457.
PhylomeDBP79457.

Gene expression databases

GenevestigatorP79457.

Family and domain databases

Gene3D1.25.40.10. 1 hit.
InterProIPR003347. JmjC_dom.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical.
IPR001440. TPR_1.
IPR019734. TPR_repeat.
[Graphical view]
PfamPF02373. JmjC. 1 hit.
PF00515. TPR_1. 3 hits.
PF13181. TPR_8. 1 hit.
[Graphical view]
SMARTSM00558. JmjC. 1 hit.
SM00028. TPR. 6 hits.
[Graphical view]
PROSITEPS51184. JMJC. 1 hit.
PS50005. TPR. 7 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

PROP79457.
SOURCESearch...

Entry information

Entry nameUTY_MOUSE
AccessionPrimary (citable) accession number: P79457
Secondary accession number(s): O97979
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: July 15, 1999
Last modified: April 16, 2014
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot