Histone demethylase UTY - Mus musculus (Mouse)

Preferred order of sections

Names and origin

Protein names

Recommended name:
Histone demethylase UTY
EC=1.14.11.-

Alternative name(s):
Male-specific histocompatibility antigen H-YDB
Ubiquitously transcribed TPR protein on the Y chromosome
Ubiquitously transcribed Y chromosome tetratricopeptide repeat protein

Gene names

Name:

Uty

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	1212 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Histone demethylase By similarity.
Cofactor	Ascorbate By similarity. Fe²⁺ By similarity.
Subunit structure	Binds TLE1 and TLE2.
Subcellular location	Nucleus Potential.
Sequence similarities	Belongs to the UTX family. Contains 1 JmjC domain. Contains 8 TPR repeats.

Ontologies

Keywords
Cellular component	Nucleus
Domain	Repeat TPR repeat
Ligand	Iron Metal-binding
Molecular function	Chromatin regulator Dioxygenase Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	canonical Wnt receptor signaling pathway Inferred from direct assay PubMed 22949634. Source: MGI cardiac muscle cell contraction Inferred from mutant phenotype PubMed 22192413. Source: MGI establishment of protein localization Inferred from direct assay PubMed 22192413. Source: MGI heart development Inferred from mutant phenotype PubMed 22192413. Source: MGI in utero embryonic development Inferred from mutant phenotype PubMed 22192413. Source: MGI regulation of chromatin silencing Inferred from mutant phenotype PubMed 22192413. Source: MGI
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	RNA polymerase II core promoter proximal region sequence-specific DNA binding Inferred from direct assay PubMed 22949634. Source: MGI histone demethylase activity (H3-K36 specific) Inferred from mutant phenotype PubMed 22192413. Source: MGI metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 1212

1212

Histone demethylase UTY

PRO_0000106413

Regions

Repeat

88 – 121

34

TPR 1

Repeat

125 – 158

34

TPR 2

Repeat

165 – 193

29

TPR 3

Repeat

200 – 233

34

TPR 4

Repeat

245 – 278

34

TPR 5

Repeat

279 – 312

34

TPR 6

Repeat

313 – 346

34

TPR 7

Repeat

347 – 380

34

TPR 8

Domain

907 – 1070

164

JmjC

Sites

Metal binding

958

1

Iron By similarity

Metal binding

960

1

Iron By similarity

Experimental info

Sequence conflict

1069

1

E → Q in CAA70422. Ref.2

Sequence conflict

1149 – 1212

64

EVFNL…LSSAS → STRDLLPQLHLRQCHLQGPT DKAAILEFHLTEGSGDMH in CAA70422. Ref.2

Sequences

Sequence

Length

Mass (Da)

Tools

P79457 [UniParc].

Last modified July 15, 1999. Version 2.
Checksum: 2AE1A816F3D6ACB5
Show »

FASTA

1,212

136,737

        10         20         30         40         50         60 
MKSYGLSLTT AALGNEEKKM AAEKARGEGE EGSFSLTVEE KKALCGLDSS FFGFLTRCKD 

        70         80         90        100        110        120 
GAKMKTLLNK AIHFYESLIV KAEGKVESDF FCQLGHFNLL LEDYSKALSS YQRYYSLQTD 

       130        140        150        160        170        180 
YWKNAAFLYG LGLVYFYYNA FQWAIRAFQE VLYVDPNFCR AKEIHLRLGF MFKMNTDYES 

       190        200        210        220        230        240 
SLKHFQLALI DCNVCTLSSV EIQFHIAHLY ETQRKYHSAK AAYEQLLQIE SLPSQVKATV 

       250        260        270        280        290        300 
LQQLGWMHHN MDLIGDNTTK ERYAIQYLQK SLEEDPNSGQ SWYFLGRCYS CIGKVQDAFV 

       310        320        330        340        350        360 
SYRQSIDKSE ASADTWCSIG VLYQQQNQPM DALQAYICAV QLDHGHAAAW MDLGILYESC 

       370        380        390        400        410        420 
NQPQDAIKCY LNAARSKSCN NTSALTSRIK FLQAQLCNLP QSSLQNKTKL LPSIEEAWSL 

       430        440        450        460        470        480 
PIPAELTSRQ GAMNTAQQSV SDTWNSVQTA SHHSVQQKVY TQCFTAQKLQ SFGKDQQPPF 

       490        500        510        520        530        540 
QTGSTRYLQA ASTNDQNQNG NHTLPQNSKG DAQNHFLRIP TSEEQKIINF TKESKDSRSK 

       550        560        570        580        590        600 
SLTSKTSRKD RDTSNICVNA KKHSNHIYQI SSVPISSLNN KESVSPDLII VDNPQLSVLV 

       610        620        630        640        650        660 
GETIDNVDHD IGTCNKVNNV HLAIHKKPDN LSASSPSSAI STETLSLKLT EQTHIVTSFI 

       670        680        690        700        710        720 
SPHSGLHTIN GEGHENLESS ASVNVGLRPR SQIIPSMSVS IYSSSTEVLK ACRSLGKNGL 

       730        740        750        760        770        780 
SNGHILLDIC PPPRPPTSPY PPLPKEKLNP PTPSIYLENK RDAFFPPLHQ FCINPKNPVT 

       790        800        810        820        830        840 
VIRGLAGALK LDLGLFSTKT LVEANNEHIV EVRTQLLQPA DENWDPSGTK KIWRYENKSS 

       850        860        870        880        890        900 
HTTIAKYAQY QACSFQESLR EENERRTQVK DYSDNESTCS DNSGRRQKAP FKTIKCGINI 

       910        920        930        940        950        960 
DLSDNKKWKL QLHELTKLPA FVRVVSAGNL LSHVGYTILG MNSVQLCMKV PGSRIPGHQE 

       970        980        990       1000       1010       1020 
NNNFCSVNIN IGPGDCEWFV VPEDYWGVLN DFCEKNNLNF LMSSWWPNLE DLYEANVPVY 

      1030       1040       1050       1060       1070       1080 
RFIQRPGDLV WINAGTVHWV QAIGWCNNIT WNVGPLTAFQ YKLAVERYEW NKLQSVKSVV 

      1090       1100       1110       1120       1130       1140 
PMVHLSWNMA RNIKVSDPKL FEMIKYCLLK ILKHCQTLRE ALVAAGKEVL WHGRINDEPA 

      1150       1160       1170       1180       1190       1200 
PYCSICEVEV FNLLFVTNES NSQKTYIVHC QNCARKTSGN LENFVVLEQY KMEDLIQVYD 

      1210 
QFTLAPSLSS AS

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References

[1]	"The mouse Y chromosome interval necessary for spermatogonial proliferation is gene dense with syntenic homology to the human AZFa region." Mazeyrat S., Saut N., Sargent C.A., Grimmond S., Longepied G., Ehrmann I.E., Ellis P.S., Greenfield A., Affara N.A., Mitchell M.J. Hum. Mol. Genet. 7:1713-1724(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: RIII. Tissue: Testis.
[2]	"An H-YDb epitope is encoded by a novel mouse Y chromosome gene." Greenfield A., Scott D., Pennisi D., Ehrmann I., Ellis P.S., Cooper L., Simpson E., Koopman P. Nat. Genet. 14:474-478(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Swiss.
[3]	"Groucho/transducin-like enhancer of split (TLE) family members interact with the yeast transcriptional co-repressor SSN6 and mammalian SSN6-related proteins: implications for evolutionary conservation of transcription repression mechanisms." Grbavec D., Lo R., Liu Y., Greenfield A., Stifani S. Biochem. J. 337:13-17(1999) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH TLE1 AND TLE2.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF057367 mRNA. Translation: AAC67385.1. Y09222 mRNA. Translation: CAA70422.1.
IPI	IPI00114302.
PIR	T42387. T42729.
UniGene	Mm.20477.
3D structure databases
ProteinModelPortal	P79457.
SMR	P79457. Positions 64-194, 199-373, 698-1206.
ModBase	Search...
PTM databases
PhosphoSite	P79457.
Proteomic databases
PRIDE	P79457.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
MGI	MGI:894810. Uty.
Phylogenomic databases
eggNOG	COG0457.
HOGENOM	HOG000220834.
HOVERGEN	HBG018063.
InParanoid	P79457.
Gene expression databases
Genevestigator	P79457.
GermOnline	ENSMUSG00000068457. Mus musculus.
Family and domain databases
Gene3D	1.25.40.10. 1 hit.
InterPro	IPR003347. JmjC_dom. IPR001440. TPR-1. IPR013026. TPR-contain_dom. IPR011990. TPR-like_helical. IPR019734. TPR_repeat. [Graphical view]
Pfam	PF02373. JmjC. 1 hit. PF00515. TPR_1. 3 hits. PF13181. TPR_8. 1 hit. [Graphical view]
SMART	SM00558. JmjC. 1 hit. SM00028. TPR. 6 hits. [Graphical view]
PROSITE	PS51184. JMJC. 1 hit. PS50005. TPR. 7 hits. PS50293. TPR_REGION. 1 hit. [Graphical view]
ProtoNet	Search...
Other
SOURCE	Search...

Entry information

Entry name

UTY_MOUSE

Accession

Primary (citable) accession number: P79457
Secondary accession number(s): O97979

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
Last sequence update:	July 15, 1999
Last modified:	May 29, 2013
This is version 105 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sites

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

PTM databases

Proteomic databases

Protocols and materials databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents