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Protein

Histone demethylase UTY

Gene

Uty

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Male-specific histone demethylase that catalyzes trimethylated 'Lys-27' (H3K27me3) demethylation in histone H3. Has relatively low KDM activity.By similarity

Cofactori

Protein has several cofactor binding sites:

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi958 – 9581IronBy similarity
Metal bindingi960 – 9601IronBy similarity
Metal bindingi1038 – 10381IronBy similarity
Metal bindingi1143 – 11431ZincBy similarity
Metal bindingi1146 – 11461ZincBy similarity
Metal bindingi1170 – 11701ZincBy similarity
Metal bindingi1173 – 11731ZincBy similarity

GO - Molecular functioni

  1. histone demethylase activity (H3-K27 specific) Source: InterPro
  2. histone demethylase activity (H3-K36 specific) Source: MGI
  3. metal ion binding Source: UniProtKB-KW
  4. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: MGI

GO - Biological processi

  1. canonical Wnt signaling pathway Source: MGI
  2. cardiac muscle cell contraction Source: MGI
  3. embryonic organ development Source: MGI
  4. establishment of protein localization Source: MGI
  5. heart development Source: MGI
  6. heart morphogenesis Source: MGI
  7. histone H3-K36 demethylation Source: GOC
  8. in utero embryonic development Source: MGI
  9. regulation of chromatin silencing Source: MGI
  10. regulation of gene expression Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Dioxygenase, Oxidoreductase

Keywords - Ligandi

Iron, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Histone demethylase UTY (EC:1.14.11.-)
Alternative name(s):
Male-specific histocompatibility antigen H-YDB
Ubiquitously transcribed TPR protein on the Y chromosome
Ubiquitously transcribed Y chromosome tetratricopeptide repeat protein
Gene namesi
Name:Uty
Synonyms:Kdm6c
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:894810. Uty.

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
  2. protein complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12121212Histone demethylase UTYPRO_0000106413Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei752 – 7521PhosphothreonineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiP79457.

PTM databases

PhosphoSiteiP79457.

Expressioni

Gene expression databases

GenevestigatoriP79457.

Interactioni

Subunit structurei

Binds TLE1 and TLE2.

Structurei

3D structure databases

ProteinModelPortaliP79457.
SMRiP79457. Positions 698-1209.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati88 – 12134TPR 1Add
BLAST
Repeati125 – 15834TPR 2Add
BLAST
Repeati165 – 19329TPR 3Add
BLAST
Repeati200 – 23334TPR 4Add
BLAST
Repeati245 – 27834TPR 5Add
BLAST
Repeati279 – 31234TPR 6Add
BLAST
Repeati313 – 34634TPR 7Add
BLAST
Repeati347 – 38034TPR 8Add
BLAST
Domaini907 – 1070164JmjCPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the UTX family.Curated
Contains 1 JmjC domain.PROSITE-ProRule annotation
Contains 8 TPR repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiCOG0457.
HOGENOMiHOG000220834.
HOVERGENiHBG018063.
InParanoidiP79457.
PhylomeDBiP79457.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
InterProiIPR003347. JmjC_dom.
IPR029516. KDM6C.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR001440. TPR_1.
IPR019734. TPR_repeat.
[Graphical view]
PANTHERiPTHR14017:SF17. PTHR14017:SF17. 1 hit.
PfamiPF02373. JmjC. 1 hit.
PF00515. TPR_1. 3 hits.
PF13181. TPR_8. 1 hit.
[Graphical view]
SMARTiSM00558. JmjC. 1 hit.
SM00028. TPR. 6 hits.
[Graphical view]
PROSITEiPS51184. JMJC. 1 hit.
PS50005. TPR. 7 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P79457-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSYGLSLTT AALGNEEKKM AAEKARGEGE EGSFSLTVEE KKALCGLDSS
60 70 80 90 100
FFGFLTRCKD GAKMKTLLNK AIHFYESLIV KAEGKVESDF FCQLGHFNLL
110 120 130 140 150
LEDYSKALSS YQRYYSLQTD YWKNAAFLYG LGLVYFYYNA FQWAIRAFQE
160 170 180 190 200
VLYVDPNFCR AKEIHLRLGF MFKMNTDYES SLKHFQLALI DCNVCTLSSV
210 220 230 240 250
EIQFHIAHLY ETQRKYHSAK AAYEQLLQIE SLPSQVKATV LQQLGWMHHN
260 270 280 290 300
MDLIGDNTTK ERYAIQYLQK SLEEDPNSGQ SWYFLGRCYS CIGKVQDAFV
310 320 330 340 350
SYRQSIDKSE ASADTWCSIG VLYQQQNQPM DALQAYICAV QLDHGHAAAW
360 370 380 390 400
MDLGILYESC NQPQDAIKCY LNAARSKSCN NTSALTSRIK FLQAQLCNLP
410 420 430 440 450
QSSLQNKTKL LPSIEEAWSL PIPAELTSRQ GAMNTAQQSV SDTWNSVQTA
460 470 480 490 500
SHHSVQQKVY TQCFTAQKLQ SFGKDQQPPF QTGSTRYLQA ASTNDQNQNG
510 520 530 540 550
NHTLPQNSKG DAQNHFLRIP TSEEQKIINF TKESKDSRSK SLTSKTSRKD
560 570 580 590 600
RDTSNICVNA KKHSNHIYQI SSVPISSLNN KESVSPDLII VDNPQLSVLV
610 620 630 640 650
GETIDNVDHD IGTCNKVNNV HLAIHKKPDN LSASSPSSAI STETLSLKLT
660 670 680 690 700
EQTHIVTSFI SPHSGLHTIN GEGHENLESS ASVNVGLRPR SQIIPSMSVS
710 720 730 740 750
IYSSSTEVLK ACRSLGKNGL SNGHILLDIC PPPRPPTSPY PPLPKEKLNP
760 770 780 790 800
PTPSIYLENK RDAFFPPLHQ FCINPKNPVT VIRGLAGALK LDLGLFSTKT
810 820 830 840 850
LVEANNEHIV EVRTQLLQPA DENWDPSGTK KIWRYENKSS HTTIAKYAQY
860 870 880 890 900
QACSFQESLR EENERRTQVK DYSDNESTCS DNSGRRQKAP FKTIKCGINI
910 920 930 940 950
DLSDNKKWKL QLHELTKLPA FVRVVSAGNL LSHVGYTILG MNSVQLCMKV
960 970 980 990 1000
PGSRIPGHQE NNNFCSVNIN IGPGDCEWFV VPEDYWGVLN DFCEKNNLNF
1010 1020 1030 1040 1050
LMSSWWPNLE DLYEANVPVY RFIQRPGDLV WINAGTVHWV QAIGWCNNIT
1060 1070 1080 1090 1100
WNVGPLTAFQ YKLAVERYEW NKLQSVKSVV PMVHLSWNMA RNIKVSDPKL
1110 1120 1130 1140 1150
FEMIKYCLLK ILKHCQTLRE ALVAAGKEVL WHGRINDEPA PYCSICEVEV
1160 1170 1180 1190 1200
FNLLFVTNES NSQKTYIVHC QNCARKTSGN LENFVVLEQY KMEDLIQVYD
1210
QFTLAPSLSS AS
Length:1,212
Mass (Da):136,737
Last modified:July 15, 1999 - v2
Checksum:i2AE1A816F3D6ACB5
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1069 – 10691E → Q in CAA70422 (PubMed:8944031).Curated
Sequence conflicti1149 – 121264EVFNL…LSSAS → STRDLLPQLHLRQCHLQGPT DKAAILEFHLTEGSGDMH in CAA70422 (PubMed:8944031).CuratedAdd
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF057367 mRNA. Translation: AAC67385.1.
Y09222 mRNA. Translation: CAA70422.1.
CCDSiCCDS41216.1.
PIRiT42387.
T42729.
UniGeneiMm.20477.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF057367 mRNA. Translation: AAC67385.1.
Y09222 mRNA. Translation: CAA70422.1.
CCDSiCCDS41216.1.
PIRiT42387.
T42729.
UniGeneiMm.20477.

3D structure databases

ProteinModelPortaliP79457.
SMRiP79457. Positions 698-1209.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiP79457.

Proteomic databases

PRIDEiP79457.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:894810. Uty.

Phylogenomic databases

eggNOGiCOG0457.
HOGENOMiHOG000220834.
HOVERGENiHBG018063.
InParanoidiP79457.
PhylomeDBiP79457.

Miscellaneous databases

PROiP79457.
SOURCEiSearch...

Gene expression databases

GenevestigatoriP79457.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
InterProiIPR003347. JmjC_dom.
IPR029516. KDM6C.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR001440. TPR_1.
IPR019734. TPR_repeat.
[Graphical view]
PANTHERiPTHR14017:SF17. PTHR14017:SF17. 1 hit.
PfamiPF02373. JmjC. 1 hit.
PF00515. TPR_1. 3 hits.
PF13181. TPR_8. 1 hit.
[Graphical view]
SMARTiSM00558. JmjC. 1 hit.
SM00028. TPR. 6 hits.
[Graphical view]
PROSITEiPS51184. JMJC. 1 hit.
PS50005. TPR. 7 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The mouse Y chromosome interval necessary for spermatogonial proliferation is gene dense with syntenic homology to the human AZFa region."
    Mazeyrat S., Saut N., Sargent C.A., Grimmond S., Longepied G., Ehrmann I.E., Ellis P.S., Greenfield A., Affara N.A., Mitchell M.J.
    Hum. Mol. Genet. 7:1713-1724(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: RIII.
    Tissue: Testis.
  2. "An H-YDb epitope is encoded by a novel mouse Y chromosome gene."
    Greenfield A., Scott D., Pennisi D., Ehrmann I., Ellis P.S., Cooper L., Simpson E., Koopman P.
    Nat. Genet. 14:474-478(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Swiss.
  3. "Groucho/transducin-like enhancer of split (TLE) family members interact with the yeast transcriptional co-repressor SSN6 and mammalian SSN6-related proteins: implications for evolutionary conservation of transcription repression mechanisms."
    Grbavec D., Lo R., Liu Y., Greenfield A., Stifani S.
    Biochem. J. 337:13-17(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH TLE1 AND TLE2.

Entry informationi

Entry nameiUTY_MOUSE
AccessioniPrimary (citable) accession number: P79457
Secondary accession number(s): O97979
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: July 15, 1999
Last modified: January 7, 2015
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.