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Protein

Metallothionein-1E

Gene

MT1E

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi5 – 51Divalent metal cation; cluster BBy similarity
Metal bindingi7 – 71Divalent metal cation; cluster BBy similarity
Metal bindingi13 – 131Divalent metal cation; cluster BBy similarity
Metal bindingi15 – 151Divalent metal cation; cluster BBy similarity
Metal bindingi19 – 191Divalent metal cation; cluster BBy similarity
Metal bindingi21 – 211Divalent metal cation; cluster BBy similarity
Metal bindingi24 – 241Divalent metal cation; cluster BBy similarity
Metal bindingi26 – 261Divalent metal cation; cluster BBy similarity
Metal bindingi29 – 291Divalent metal cation; cluster BBy similarity
Metal bindingi33 – 331Divalent metal cation; cluster ABy similarity
Metal bindingi34 – 341Divalent metal cation; cluster ABy similarity
Metal bindingi36 – 361Divalent metal cation; cluster ABy similarity
Metal bindingi37 – 371Divalent metal cation; cluster ABy similarity
Metal bindingi41 – 411Divalent metal cation; cluster ABy similarity
Metal bindingi44 – 441Divalent metal cation; cluster ABy similarity
Metal bindingi48 – 481Divalent metal cation; cluster ABy similarity
Metal bindingi50 – 501Divalent metal cation; cluster ABy similarity
Metal bindingi57 – 571Divalent metal cation; cluster ABy similarity
Metal bindingi59 – 591Divalent metal cation; cluster ABy similarity
Metal bindingi60 – 601Divalent metal cation; cluster ABy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Metal-thiolate cluster

Names & Taxonomyi

Protein namesi
Recommended name:
Metallothionein-1E
Short name:
MT-1E
Alternative name(s):
Metallothionein-IE
Short name:
MT-IE
Gene namesi
Name:MT1E
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 6161Metallothionein-1EPRO_0000197211Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity

Keywords - PTMi

Acetylation

Interactioni

Subunit structurei

Monomer.By similarity

Structurei

3D structure databases

ProteinModelPortaliP79431.
SMRiP79431. Positions 1-61.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 2929BetaAdd
BLAST
Regioni30 – 6132AlphaAdd
BLAST

Domaini

Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines.

Sequence similaritiesi

Phylogenomic databases

HOVERGENiHBG009063.
InParanoidiP79431.

Family and domain databases

Gene3Di4.10.10.10. 1 hit.
InterProiIPR003019. Metalthion.
IPR017854. Metalthion_dom.
IPR023587. Metalthion_dom_vert.
IPR000006. Metalthion_vert.
IPR018064. Metalthion_vert_metal_BS.
[Graphical view]
PANTHERiPTHR23299. PTHR23299. 1 hit.
PfamiPF00131. Metallothio. 1 hit.
[Graphical view]
PRINTSiPR00860. MTVERTEBRATE.
SUPFAMiSSF57868. SSF57868. 1 hit.
PROSITEiPS00203. METALLOTHIONEIN_VRT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P79431-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPNCSCPTG GSCSCAGSCT CKACRCTSCK KSCCSCCPVG CAKCAQGCIC
60
KGASDKCSCC A
Length:61
Mass (Da):5,969
Last modified:May 1, 1997 - v1
Checksum:iCB5651A66BDF6995
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB000790 mRNA. Translation: BAA19180.1.
AB000791 mRNA. Translation: BAA19181.1.
UniGeneiSsc.15694.
Ssc.9079.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB000790 mRNA. Translation: BAA19180.1.
AB000791 mRNA. Translation: BAA19181.1.
UniGeneiSsc.15694.
Ssc.9079.

3D structure databases

ProteinModelPortaliP79431.
SMRiP79431. Positions 1-61.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG009063.
InParanoidiP79431.

Family and domain databases

Gene3Di4.10.10.10. 1 hit.
InterProiIPR003019. Metalthion.
IPR017854. Metalthion_dom.
IPR023587. Metalthion_dom_vert.
IPR000006. Metalthion_vert.
IPR018064. Metalthion_vert_metal_BS.
[Graphical view]
PANTHERiPTHR23299. PTHR23299. 1 hit.
PfamiPF00131. Metallothio. 1 hit.
[Graphical view]
PRINTSiPR00860. MTVERTEBRATE.
SUPFAMiSSF57868. SSF57868. 1 hit.
PROSITEiPS00203. METALLOTHIONEIN_VRT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMT1E_PIG
AccessioniPrimary (citable) accession number: P79431
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: May 1, 1997
Last modified: December 9, 2015
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Metallothioneins
    Classification of metallothioneins and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.