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Protein

Aromatase 2

Gene

CYP19A2

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the formation of aromatic C18 estrogens from C19 androgens.

Catalytic activityi

Testosterone + 3 O2 + 3 reduced flavoproteins = 17-beta-estradiol + formate + 4 H2O + 3 oxidized flavoproteins.
Androst-4-ene-3,17-dione + 3 O2 + 3 reduced flavoproteins = estrone + formate + 4 H2O + 3 oxidized flavoproteins.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi437 – 4371Iron (heme axial ligand)By similarity

GO - Molecular functioni

  1. heme binding Source: InterPro
  2. iron ion binding Source: InterPro
  3. monooxygenase activity Source: UniProtKB-KW
  4. oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Aromatase 2 (EC:1.14.14.14)
Alternative name(s):
CYPXIXA2
Cytochrome P-450AROM
Cytochrome P450 19 type II
Estrogen synthase
Gene namesi
Name:CYP19A2
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
ProteomesiUP000008227: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 503503Aromatase 2PRO_0000051959Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP79430.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

HOVERGENiHBG050750.
InParanoidiP79430.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P79430-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVLEMLNPMY YKITSMVSEV VPFASIAVLL LTGFLLLLWN YENTSSIPSP
60 70 80 90 100
GYFLGIGPLI SHFRFLWMGI GSACNYYNEM YGEFMRVWIG GEETLIISKS
110 120 130 140 150
SSVFHVMKHS HYTSRFGSKP GLECIGMYEK GIIFNNDPAL WKAVRTYFMK
160 170 180 190 200
ALSGPGLVRM VTVCADSITK HLDKLEEVRN DLGYVDVLTL MRRIMLDTSN
210 220 230 240 250
NLFLGIPLDE KAIVCKIQGY FDAWQALLLK PEFFFKFSWL YKKHKESVKD
260 270 280 290 300
LKENMEILIE KKRCSIITAE KLEDCMDFAT ELILAEKRGE LTKENVNQCI
310 320 330 340 350
LEMLIAAPDT LSVTVFFMLF LIAKHPQVEE AIVKEIQTVI GERDIRNDDM
360 370 380 390 400
QKLKVVENFI YESMRYQPVV DLVMRKALED DVIDGYPVKK GTNIILNIGR
410 420 430 440 450
MHRLEFFPKP NEFTLENFAK NVPYRYFQPF GFGPRACAGK YIAMVMMKVT
460 470 480 490 500
LVILLRRFQV QTPQDRCVEK MQKKNDLSLH PDETSGLLEM IFIPRNSDKS

LDH
Length:503
Mass (Da):58,063
Last modified:May 1, 1997 - v1
Checksum:iFAC8821A68AC5F77
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti79 – 791E → K in AAB51387. (PubMed:8674811)Curated
Sequence conflicti502 – 5021D → E in AAB51387. (PubMed:8674811)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U92245 mRNA. Translation: AAB51387.1.
AH006583 Genomic DNA. Translation: AAC48732.1.
U52142 mRNA. Translation: AAB61697.1.
RefSeqiNP_999595.1. NM_214430.1.
UniGeneiSsc.26327.

Genome annotation databases

GeneIDi403332.
KEGGissc:403332.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U92245 mRNA. Translation: AAB51387.1.
AH006583 Genomic DNA. Translation: AAC48732.1.
U52142 mRNA. Translation: AAB61697.1.
RefSeqiNP_999595.1. NM_214430.1.
UniGeneiSsc.26327.

3D structure databases

ProteinModelPortaliP79430.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi403332.
KEGGissc:403332.

Organism-specific databases

CTDi403332.

Phylogenomic databases

HOVERGENiHBG050750.
InParanoidiP79430.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Functional ovarian and placental isoforms of porcine aromatase."
    Corbin C.J., Khalil M.W., Conley A.J.
    Mol. Cell. Endocrinol. 113:29-37(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Placenta.
  2. "Closely related genes encode developmental and tissue isoforms of porcine cytochrome P450 aromatase."
    Choi I., Troyer D.L., Cornwell D.L., Kirby-Dobbels K.R., Collante W.R., Simmen F.A.
    DNA Cell Biol. 16:769-777(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Liver and Placenta.

Entry informationi

Entry nameiCP192_PIG
AccessioniPrimary (citable) accession number: P79430
Secondary accession number(s): O02847
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1997
Last modified: January 7, 2015
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.