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P79430

- CP192_PIG

UniProt

P79430 - CP192_PIG

Protein

Aromatase 2

Gene

CYP19A2

Organism
Sus scrofa (Pig)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 1 (01 May 1997)
      Previous versions | rss
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    Functioni

    Catalyzes the formation of aromatic C18 estrogens from C19 androgens.

    Catalytic activityi

    Testosterone + 3 O2 + 3 reduced flavoproteins = 17-beta-estradiol + formate + 4 H2O + 3 oxidized flavoproteins.
    Androst-4-ene-3,17-dione + 3 O2 + 3 reduced flavoproteins = estrone + formate + 4 H2O + 3 oxidized flavoproteins.

    Cofactori

    Heme group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi437 – 4371Iron (heme axial ligand)By similarity

    GO - Molecular functioni

    1. heme binding Source: InterPro
    2. iron ion binding Source: InterPro
    3. monooxygenase activity Source: UniProtKB-KW
    4. oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen Source: InterPro

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Aromatase 2 (EC:1.14.14.14)
    Alternative name(s):
    CYPXIXA2
    Cytochrome P-450AROM
    Cytochrome P450 19 type II
    Estrogen synthase
    Gene namesi
    Name:CYP19A2
    OrganismiSus scrofa (Pig)
    Taxonomic identifieri9823 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
    ProteomesiUP000008227: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 503503Aromatase 2PRO_0000051959Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP79430.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Phylogenomic databases

    HOVERGENiHBG050750.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00463. EP450I.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P79430-1 [UniParc]FASTAAdd to Basket

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    MVLEMLNPMY YKITSMVSEV VPFASIAVLL LTGFLLLLWN YENTSSIPSP    50
    GYFLGIGPLI SHFRFLWMGI GSACNYYNEM YGEFMRVWIG GEETLIISKS 100
    SSVFHVMKHS HYTSRFGSKP GLECIGMYEK GIIFNNDPAL WKAVRTYFMK 150
    ALSGPGLVRM VTVCADSITK HLDKLEEVRN DLGYVDVLTL MRRIMLDTSN 200
    NLFLGIPLDE KAIVCKIQGY FDAWQALLLK PEFFFKFSWL YKKHKESVKD 250
    LKENMEILIE KKRCSIITAE KLEDCMDFAT ELILAEKRGE LTKENVNQCI 300
    LEMLIAAPDT LSVTVFFMLF LIAKHPQVEE AIVKEIQTVI GERDIRNDDM 350
    QKLKVVENFI YESMRYQPVV DLVMRKALED DVIDGYPVKK GTNIILNIGR 400
    MHRLEFFPKP NEFTLENFAK NVPYRYFQPF GFGPRACAGK YIAMVMMKVT 450
    LVILLRRFQV QTPQDRCVEK MQKKNDLSLH PDETSGLLEM IFIPRNSDKS 500
    LDH 503
    Length:503
    Mass (Da):58,063
    Last modified:May 1, 1997 - v1
    Checksum:iFAC8821A68AC5F77
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti79 – 791E → K in AAB51387. (PubMed:8674811)Curated
    Sequence conflicti502 – 5021D → E in AAB51387. (PubMed:8674811)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U92245 mRNA. Translation: AAB51387.1.
    AH006583 Genomic DNA. Translation: AAC48732.1.
    U52142 mRNA. Translation: AAB61697.1.
    RefSeqiNP_999595.1. NM_214430.1.
    UniGeneiSsc.26327.

    Genome annotation databases

    GeneIDi403332.
    KEGGissc:403332.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U92245 mRNA. Translation: AAB51387.1 .
    AH006583 Genomic DNA. Translation: AAC48732.1 .
    U52142 mRNA. Translation: AAB61697.1 .
    RefSeqi NP_999595.1. NM_214430.1.
    UniGenei Ssc.26327.

    3D structure databases

    ProteinModelPortali P79430.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 403332.
    KEGGi ssc:403332.

    Organism-specific databases

    CTDi 403332.

    Phylogenomic databases

    HOVERGENi HBG050750.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00463. EP450I.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Functional ovarian and placental isoforms of porcine aromatase."
      Corbin C.J., Khalil M.W., Conley A.J.
      Mol. Cell. Endocrinol. 113:29-37(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: Placenta.
    2. "Closely related genes encode developmental and tissue isoforms of porcine cytochrome P450 aromatase."
      Choi I., Troyer D.L., Cornwell D.L., Kirby-Dobbels K.R., Collante W.R., Simmen F.A.
      DNA Cell Biol. 16:769-777(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: Liver and Placenta.

    Entry informationi

    Entry nameiCP192_PIG
    AccessioniPrimary (citable) accession number: P79430
    Secondary accession number(s): O02847
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: May 1, 1997
    Last modified: October 1, 2014
    This is version 84 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3