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P79430 (CP192_PIG) Reviewed, UniProtKB/Swiss-Prot

Last modified January 22, 2014. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Aromatase 2

EC=1.14.14.14
Alternative name(s):
CYPXIXA2
Cytochrome P-450AROM
Cytochrome P450 19 type II
Estrogen synthase
Gene names
Name:CYP19A2
OrganismSus scrofa (Pig) [Reference proteome]
Taxonomic identifier9823 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus

Protein attributes

Sequence length503 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Catalyzes the formation of aromatic C18 estrogens from C19 androgens.

Catalytic activity

Testosterone + 3 O2 + 3 reduced flavoproteins = 17-beta-estradiol + formate + 4 H2O + 3 oxidized flavoproteins.

Androst-4-ene-3,17-dione + 3 O2 + 3 reduced flavoproteins = estrone + formate + 4 H2O + 3 oxidized flavoproteins.

Cofactor

Heme group By similarity.

Subcellular location

Membrane; Peripheral membrane protein.

Sequence similarities

Belongs to the cytochrome P450 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 503503Aromatase 2
PRO_0000051959

Sites

Metal binding4371Iron (heme axial ligand) By similarity

Experimental info

Sequence conflict791E → K in AAB51387. Ref.1
Sequence conflict5021D → E in AAB51387. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P79430 [UniParc].

Last modified May 1, 1997. Version 1.
Checksum: FAC8821A68AC5F77

FASTA50358,063
        10         20         30         40         50         60 
MVLEMLNPMY YKITSMVSEV VPFASIAVLL LTGFLLLLWN YENTSSIPSP GYFLGIGPLI 

        70         80         90        100        110        120 
SHFRFLWMGI GSACNYYNEM YGEFMRVWIG GEETLIISKS SSVFHVMKHS HYTSRFGSKP 

       130        140        150        160        170        180 
GLECIGMYEK GIIFNNDPAL WKAVRTYFMK ALSGPGLVRM VTVCADSITK HLDKLEEVRN 

       190        200        210        220        230        240 
DLGYVDVLTL MRRIMLDTSN NLFLGIPLDE KAIVCKIQGY FDAWQALLLK PEFFFKFSWL 

       250        260        270        280        290        300 
YKKHKESVKD LKENMEILIE KKRCSIITAE KLEDCMDFAT ELILAEKRGE LTKENVNQCI 

       310        320        330        340        350        360 
LEMLIAAPDT LSVTVFFMLF LIAKHPQVEE AIVKEIQTVI GERDIRNDDM QKLKVVENFI 

       370        380        390        400        410        420 
YESMRYQPVV DLVMRKALED DVIDGYPVKK GTNIILNIGR MHRLEFFPKP NEFTLENFAK 

       430        440        450        460        470        480 
NVPYRYFQPF GFGPRACAGK YIAMVMMKVT LVILLRRFQV QTPQDRCVEK MQKKNDLSLH 

       490        500 
PDETSGLLEM IFIPRNSDKS LDH 

« Hide

References

[1]"Functional ovarian and placental isoforms of porcine aromatase."
Corbin C.J., Khalil M.W., Conley A.J.
Mol. Cell. Endocrinol. 113:29-37(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Tissue: Placenta.
[2]"Closely related genes encode developmental and tissue isoforms of porcine cytochrome P450 aromatase."
Choi I., Troyer D.L., Cornwell D.L., Kirby-Dobbels K.R., Collante W.R., Simmen F.A.
DNA Cell Biol. 16:769-777(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Tissue: Liver and Placenta.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U92245 mRNA. Translation: AAB51387.1.
AH006583 Genomic DNA. Translation: AAC48732.1.
U52142 mRNA. Translation: AAB61697.1.
RefSeqNP_999595.1. NM_214430.1.
UniGeneSsc.26327.

3D structure databases

ProteinModelPortalP79430.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID403332.
KEGGssc:403332.

Organism-specific databases

CTD403332.

Phylogenomic databases

HOVERGENHBG050750.

Family and domain databases

Gene3D1.10.630.10. 1 hit.
InterProIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00463. EP450I.
PR00385. P450.
SUPFAMSSF48264. SSF48264. 1 hit.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCP192_PIG
AccessionPrimary (citable) accession number: P79430
Secondary accession number(s): O02847
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1997
Last modified: January 22, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families