Reviewed, UniProtKB/Swiss-Prot P79402 (CP242_PIG)

Names and origin

Protein names

Recommended name:
    Cytochrome P450 2C42
    EC=1.14.14.1
Alternative name(s):
    CYPIIC42

Gene names

Name:

CYP2C42

Organism

Sus scrofa (Pig)

Taxonomic identifier

9823 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Suina › Suidae › Sus

Protein attributes

Sequence length	327 AA.
Sequence status	Fragment.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Catalytic activity	RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.
Cofactor	Heme group By similarity.
Subcellular location	Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Induction	P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.
Sequence similarities	Belongs to the cytochrome P450 family.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum Membrane Microsome
Ligand	Heme Iron Metal-binding
Molecular function	Monooxygenase Oxidoreductase
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell microsome Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	aromatase activity Inferred from electronic annotation. Source: EC electron carrier activity Inferred from electronic annotation. Source: InterPro heme binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – 327	›327	Cytochrome P450 2C42		PRO_0000051725
Sites
	Metal binding	272	1	Iron (heme axial ligand) By similarity
Experimental info
	Non-terminal residue	1	1

Sequences

	Sequence		Length	Mass (Da)
	P79402-1 [UniParc]. Last modified May 1, 1997. Version 1. Checksum: 0EA0CA0E1B9B94D9	FASTA	327	37,458
	10 20 30 40 50 60 CDPTFILDCA PCNVICSIIF QNRFDYTDQD FLTLLEKFHE NLNILSSPWI QVCNNFPALI 70 80 90 100 110 120 DYSPGIHNKL LKNIAYLKSY VLKKVKEHQE SLDINNPRDF IDCFLIKMEQ EKHNQQSEYT 130 140 150 160 170 180 IENLIATVSD MFSAGTETTS TTMRYGLLLL LKHPEVTAKV QEEIDRVIGR HRSACMQDRS 190 200 210 220 230 240 HMPYTDAVVH EIQRYIDLVP TNLPHAVTCD IKFRNYLIPK GTTILTSLTS VLYDCKAFPN 250 260 270 280 290 300 PEVFDPGHFL DESGNFKKSD YFMPFSTGKR ICVGEGLARM ELFLFLTTIL QKFNLKSVVD 310 320 PKDIDTTPVA NGFASVPPFY QICFIPL

References

[1]	"Mapping of porcine genes belonging to two different cytochrome P450 subfamilies." Nissen P.H., Winteroe A.K., Fredholm M. Anim. Genet. 29:7-11(1998) [PubMed: 9682441] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Small intestine.

Cross-references

Sequence databases
EMBLGenBankDDBJ	Z93098 mRNA. Translation: CAB07512.1.
UniGene	Ssc.16124
3D structure databases
HSSP	HSSP built from PDB template 1OG2 based on UniProtKB P11712.
SMR	P79402. Positions 1-327.
ModBase	Search...
Phylogenomic databases
HOVERGEN	P79402.
Enzyme and pathway databases
BRENDA	1.14.14.1. 249.
Family and domain databases
InterPro	IPR001128. Cyt_P450. IPR017973. Cyt_P450_C. IPR017972. Cyt_P450_CS. IPR002401. Cyt_P450_E_grp-I. [Graphical view]
Gene3D	G3DSA:1.10.630.10. Cyt_P450. 1 hit.
PANTHER	PTHR19383. Cyt_P450. 1 hit.
Pfam	PF00067. p450. 1 hit. [Graphical view]
PRINTS	PR00463. EP450I. PR00385. P450.
PROSITE	PS00086. CYTOCHROME_P450. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CP242_PIG

Accession

Primary (citable) accession number: P79402

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
Last sequence update:	May 1, 1997
Last modified:	June 16, 2009
This is version 57 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)