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P79402

- CP242_PIG

UniProt

P79402 - CP242_PIG

Protein

Cytochrome P450 2C42

Gene

CYP2C42

Organism
Sus scrofa (Pig)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 1 (01 May 1997)
      Previous versions | rss
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    Functioni

    Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

    Catalytic activityi

    RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

    Cofactori

    Heme group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi272 – 2721Iron (heme axial ligand)By similarity

    GO - Molecular functioni

    1. aromatase activity Source: UniProtKB-EC
    2. heme binding Source: InterPro
    3. iron ion binding Source: InterPro

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Enzyme and pathway databases

    ReactomeiREACT_202610. Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET).
    REACT_205311. Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE).

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome P450 2C42 (EC:1.14.14.1)
    Alternative name(s):
    CYPIIC42
    Gene namesi
    Name:CYP2C42
    OrganismiSus scrofa (Pig)
    Taxonomic identifieri9823 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
    ProteomesiUP000008227: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini‹1 – 327›327Cytochrome P450 2C42PRO_0000051725Add
    BLAST

    Proteomic databases

    PaxDbiP79402.

    Expressioni

    Inductioni

    P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

    Interactioni

    Protein-protein interaction databases

    STRINGi9823.ENSSSCP00000011178.

    Structurei

    3D structure databases

    ProteinModelPortaliP79402.
    SMRiP79402. Positions 1-327.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Phylogenomic databases

    eggNOGiCOG2124.
    HOGENOMiHOG000036992.
    HOVERGENiHBG015789.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00463. EP450I.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    P79402-1 [UniParc]FASTAAdd to Basket

    « Hide

    CDPTFILDCA PCNVICSIIF QNRFDYTDQD FLTLLEKFHE NLNILSSPWI    50
    QVCNNFPALI DYSPGIHNKL LKNIAYLKSY VLKKVKEHQE SLDINNPRDF 100
    IDCFLIKMEQ EKHNQQSEYT IENLIATVSD MFSAGTETTS TTMRYGLLLL 150
    LKHPEVTAKV QEEIDRVIGR HRSACMQDRS HMPYTDAVVH EIQRYIDLVP 200
    TNLPHAVTCD IKFRNYLIPK GTTILTSLTS VLYDCKAFPN PEVFDPGHFL 250
    DESGNFKKSD YFMPFSTGKR ICVGEGLARM ELFLFLTTIL QKFNLKSVVD 300
    PKDIDTTPVA NGFASVPPFY QICFIPL 327
    Length:327
    Mass (Da):37,458
    Last modified:May 1, 1997 - v1
    Checksum:i0EA0CA0E1B9B94D9
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z93098 mRNA. Translation: CAB07512.1.
    UniGeneiSsc.16124.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z93098 mRNA. Translation: CAB07512.1 .
    UniGenei Ssc.16124.

    3D structure databases

    ProteinModelPortali P79402.
    SMRi P79402. Positions 1-327.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9823.ENSSSCP00000011178.

    Proteomic databases

    PaxDbi P79402.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    eggNOGi COG2124.
    HOGENOMi HOG000036992.
    HOVERGENi HBG015789.

    Enzyme and pathway databases

    Reactomei REACT_202610. Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET).
    REACT_205311. Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE).

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00463. EP450I.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Mapping of porcine genes belonging to two different cytochrome P450 subfamilies."
      Nissen P.H., Winteroe A.K., Fredholm M.
      Anim. Genet. 29:7-11(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Small intestine.

    Entry informationi

    Entry nameiCP242_PIG
    AccessioniPrimary (citable) accession number: P79402
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1999
    Last sequence update: May 1, 1997
    Last modified: October 1, 2014
    This is version 81 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3