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Protein

Cytochrome P450 2C42

Gene

CYP2C42

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi272 – 2721Iron (heme axial ligand)By similarity

GO - Molecular functioni

  1. aromatase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_202610. Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET).
REACT_205311. Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE).
REACT_255141. Xenobiotics.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 2C42 (EC:1.14.14.1)
Alternative name(s):
CYPIIC42
Gene namesi
Name:CYP2C42
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
ProteomesiUP000008227: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – 327›327Cytochrome P450 2C42PRO_0000051725Add
BLAST

Proteomic databases

PaxDbiP79402.

Expressioni

Inductioni

P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

Interactioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000011178.

Structurei

3D structure databases

ProteinModelPortaliP79402.
SMRiP79402. Positions 1-327.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiCOG2124.
HOGENOMiHOG000036992.
HOVERGENiHBG015789.
InParanoidiP79402.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

P79402-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
CDPTFILDCA PCNVICSIIF QNRFDYTDQD FLTLLEKFHE NLNILSSPWI
60 70 80 90 100
QVCNNFPALI DYSPGIHNKL LKNIAYLKSY VLKKVKEHQE SLDINNPRDF
110 120 130 140 150
IDCFLIKMEQ EKHNQQSEYT IENLIATVSD MFSAGTETTS TTMRYGLLLL
160 170 180 190 200
LKHPEVTAKV QEEIDRVIGR HRSACMQDRS HMPYTDAVVH EIQRYIDLVP
210 220 230 240 250
TNLPHAVTCD IKFRNYLIPK GTTILTSLTS VLYDCKAFPN PEVFDPGHFL
260 270 280 290 300
DESGNFKKSD YFMPFSTGKR ICVGEGLARM ELFLFLTTIL QKFNLKSVVD
310 320
PKDIDTTPVA NGFASVPPFY QICFIPL
Length:327
Mass (Da):37,458
Last modified:May 1, 1997 - v1
Checksum:i0EA0CA0E1B9B94D9
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z93098 mRNA. Translation: CAB07512.1.
UniGeneiSsc.16124.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z93098 mRNA. Translation: CAB07512.1.
UniGeneiSsc.16124.

3D structure databases

ProteinModelPortaliP79402.
SMRiP79402. Positions 1-327.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000011178.

Proteomic databases

PaxDbiP79402.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiCOG2124.
HOGENOMiHOG000036992.
HOVERGENiHBG015789.
InParanoidiP79402.

Enzyme and pathway databases

ReactomeiREACT_202610. Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET).
REACT_205311. Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE).
REACT_255141. Xenobiotics.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Mapping of porcine genes belonging to two different cytochrome P450 subfamilies."
    Nissen P.H., Winteroe A.K., Fredholm M.
    Anim. Genet. 29:7-11(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Small intestine.

Entry informationi

Entry nameiCP242_PIG
AccessioniPrimary (citable) accession number: P79402
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: May 1, 1997
Last modified: January 7, 2015
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.