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P79402 (CP242_PIG) Reviewed, UniProtKB/Swiss-Prot

Last modified December 11, 2013. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome P450 2C42

EC=1.14.14.1
Alternative name(s):
CYPIIC42
Gene names
Name:CYP2C42
OrganismSus scrofa (Pig) [Reference proteome]
Taxonomic identifier9823 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus

Protein attributes

Sequence length327 AA.
Sequence statusFragment.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activity

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactor

Heme group By similarity.

Subcellular location

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Induction

P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

Sequence similarities

Belongs to the cytochrome P450 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain‹1 – 327›327Cytochrome P450 2C42
PRO_0000051725

Sites

Metal binding2721Iron (heme axial ligand) By similarity

Experimental info

Non-terminal residue11

Sequences

Sequence LengthMass (Da)Tools
P79402 [UniParc].

Last modified May 1, 1997. Version 1.
Checksum: 0EA0CA0E1B9B94D9

FASTA32737,458
        10         20         30         40         50         60 
CDPTFILDCA PCNVICSIIF QNRFDYTDQD FLTLLEKFHE NLNILSSPWI QVCNNFPALI 

        70         80         90        100        110        120 
DYSPGIHNKL LKNIAYLKSY VLKKVKEHQE SLDINNPRDF IDCFLIKMEQ EKHNQQSEYT 

       130        140        150        160        170        180 
IENLIATVSD MFSAGTETTS TTMRYGLLLL LKHPEVTAKV QEEIDRVIGR HRSACMQDRS 

       190        200        210        220        230        240 
HMPYTDAVVH EIQRYIDLVP TNLPHAVTCD IKFRNYLIPK GTTILTSLTS VLYDCKAFPN 

       250        260        270        280        290        300 
PEVFDPGHFL DESGNFKKSD YFMPFSTGKR ICVGEGLARM ELFLFLTTIL QKFNLKSVVD 

       310        320 
PKDIDTTPVA NGFASVPPFY QICFIPL 

« Hide

References

[1]"Mapping of porcine genes belonging to two different cytochrome P450 subfamilies."
Nissen P.H., Winteroe A.K., Fredholm M.
Anim. Genet. 29:7-11(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Small intestine.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z93098 mRNA. Translation: CAB07512.1.
UniGeneSsc.16124.

3D structure databases

ProteinModelPortalP79402.
SMRP79402. Positions 1-327.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9823.ENSSSCP00000011178.

Proteomic databases

PaxDbP79402.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

eggNOGCOG2124.
HOGENOMHOG000036992.
HOVERGENHBG015789.

Family and domain databases

Gene3D1.10.630.10. 1 hit.
InterProIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00463. EP450I.
PR00385. P450.
SUPFAMSSF48264. SSF48264. 1 hit.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCP242_PIG
AccessionPrimary (citable) accession number: P79402
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: May 1, 1997
Last modified: December 11, 2013
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families