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P79401 (CP3AT_PIG) Reviewed, UniProtKB/Swiss-Prot

Last modified December 11, 2013. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome P450 3A29

EC=1.14.14.1
Alternative name(s):
CYPIIIA29
Gene names
Name:CYP3A29
OrganismSus scrofa (Pig) [Reference proteome]
Taxonomic identifier9823 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus

Protein attributes

Sequence length503 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activity

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactor

Heme group By similarity.

Subcellular location

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Induction

P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

Sequence similarities

Belongs to the cytochrome P450 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 503503Cytochrome P450 3A29
PRO_0000051808

Sites

Metal binding4421Iron (heme axial ligand) By similarity

Sequences

Sequence LengthMass (Da)Tools
P79401 [UniParc].

Last modified May 1, 1997. Version 1.
Checksum: E3D411B2674FD17F

FASTA50357,199
        10         20         30         40         50         60 
MDLIPGFSTE TWVLLATSLV LLYLYGTYSH GLFKKLGIPG PRPLPYFGNI LGYRKGVDHF 

        70         80         90        100        110        120 
DKKCFQQYGK MWGVYDGRQP LLAVTDPNMI KSVLVKECYS VFTNRRSFGP LGAMRNALSL 

       130        140        150        160        170        180 
AEDEEWKRIR TLLSPTFTSG KLKEMFPIIS HYGDLLVSNL RKEAEKGKPV TMKDIFGAYS 

       190        200        210        220        230        240 
MDVITSTAFG VNIDSLNNPQ DPFVENSKKL LKFSFFDPFL LSLIFFPFLT PIFEVLNITL 

       250        260        270        280        290        300 
FPKSSVNFFT KSVKRMKESR LTDQQKRRVD LLQLMINSQN SKEMDPHKSL SNEELVAQGI 

       310        320        330        340        350        360 
IFIFAGYETT SSALSLLAYE LATHPDVQQK LQEEIEATFP NKAPPTYDAL AQMEYLDMVV 

       370        380        390        400        410        420 
NETLRLYPIA ARLERACKKD VEIHGVFVPK GTVVVVPVFV LHRDPDLWPE PEEFRPERFS 

       430        440        450        460        470        480 
KKHKDTINPY TYLPFGTGPR NCIGMRFALM NMKLALVRVL QNFSFKPCKE TQIPLKLTTQ 

       490        500 
GLTQPEKPVV LKILPRDGTV SGA 

« Hide

References

[1]"Mapping of porcine genes belonging to two different cytochrome P450 subfamilies."
Nissen P.H., Winteroe A.K., Fredholm M.
Anim. Genet. 29:7-11(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Small intestine.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z93099 mRNA. Translation: CAB07513.1.
RefSeqNP_999588.1. NM_214423.1.
UniGeneSsc.204.

3D structure databases

ProteinModelPortalP79401.
SMRP79401. Positions 30-496.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID403324.
KEGGssc:403324.

Organism-specific databases

CTD403324.

Phylogenomic databases

HOVERGENHBG108567.
KOK07424.

Family and domain databases

Gene3D1.10.630.10. 1 hit.
InterProIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR008072. Cyt_P450_E_CYP3A.
IPR002402. Cyt_P450_E_grp-II.
[Graphical view]
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00464. EP450II.
PR01689. EP450IICYP3A.
PR00385. P450.
SUPFAMSSF48264. SSF48264. 1 hit.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCP3AT_PIG
AccessionPrimary (citable) accession number: P79401
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: May 1, 1997
Last modified: December 11, 2013
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families