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P79401

- CP3AT_PIG

UniProt

P79401 - CP3AT_PIG

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Protein

Cytochrome P450 3A29

Gene

CYP3A29

Organism
Sus scrofa (Pig)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi442 – 4421Iron (heme axial ligand)By similarity

GO - Molecular functioni

  1. aromatase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro
  4. monooxygenase activity Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 3A29 (EC:1.14.14.1)
Alternative name(s):
CYPIIIA29
Gene namesi
Name:CYP3A29
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
ProteomesiUP000008227: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 503503Cytochrome P450 3A29PRO_0000051808Add
BLAST

Expressioni

Inductioni

P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

Structurei

3D structure databases

ProteinModelPortaliP79401.
SMRiP79401. Positions 30-496.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

HOVERGENiHBG108567.
InParanoidiP79401.
KOiK07424.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR008072. Cyt_P450_E_CYP3A.
IPR002402. Cyt_P450_E_grp-II.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00464. EP450II.
PR01689. EP450IICYP3A.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P79401-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDLIPGFSTE TWVLLATSLV LLYLYGTYSH GLFKKLGIPG PRPLPYFGNI
60 70 80 90 100
LGYRKGVDHF DKKCFQQYGK MWGVYDGRQP LLAVTDPNMI KSVLVKECYS
110 120 130 140 150
VFTNRRSFGP LGAMRNALSL AEDEEWKRIR TLLSPTFTSG KLKEMFPIIS
160 170 180 190 200
HYGDLLVSNL RKEAEKGKPV TMKDIFGAYS MDVITSTAFG VNIDSLNNPQ
210 220 230 240 250
DPFVENSKKL LKFSFFDPFL LSLIFFPFLT PIFEVLNITL FPKSSVNFFT
260 270 280 290 300
KSVKRMKESR LTDQQKRRVD LLQLMINSQN SKEMDPHKSL SNEELVAQGI
310 320 330 340 350
IFIFAGYETT SSALSLLAYE LATHPDVQQK LQEEIEATFP NKAPPTYDAL
360 370 380 390 400
AQMEYLDMVV NETLRLYPIA ARLERACKKD VEIHGVFVPK GTVVVVPVFV
410 420 430 440 450
LHRDPDLWPE PEEFRPERFS KKHKDTINPY TYLPFGTGPR NCIGMRFALM
460 470 480 490 500
NMKLALVRVL QNFSFKPCKE TQIPLKLTTQ GLTQPEKPVV LKILPRDGTV

SGA
Length:503
Mass (Da):57,199
Last modified:May 1, 1997 - v1
Checksum:iE3D411B2674FD17F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z93099 mRNA. Translation: CAB07513.1.
RefSeqiNP_999588.1. NM_214423.1.
UniGeneiSsc.204.

Genome annotation databases

GeneIDi403324.
KEGGissc:403324.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z93099 mRNA. Translation: CAB07513.1 .
RefSeqi NP_999588.1. NM_214423.1.
UniGenei Ssc.204.

3D structure databases

ProteinModelPortali P79401.
SMRi P79401. Positions 30-496.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 403324.
KEGGi ssc:403324.

Organism-specific databases

CTDi 403324.

Phylogenomic databases

HOVERGENi HBG108567.
InParanoidi P79401.
KOi K07424.

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR008072. Cyt_P450_E_CYP3A.
IPR002402. Cyt_P450_E_grp-II.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00464. EP450II.
PR01689. EP450IICYP3A.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Mapping of porcine genes belonging to two different cytochrome P450 subfamilies."
    Nissen P.H., Winteroe A.K., Fredholm M.
    Anim. Genet. 29:7-11(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Small intestine.

Entry informationi

Entry nameiCP3AT_PIG
AccessioniPrimary (citable) accession number: P79401
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: May 1, 1997
Last modified: November 26, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3