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P79401

- CP3AT_PIG

UniProt

P79401 - CP3AT_PIG

Protein

Cytochrome P450 3A29

Gene

CYP3A29

Organism
Sus scrofa (Pig)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 86 (01 Oct 2014)
      Sequence version 1 (01 May 1997)
      Previous versions | rss
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    Functioni

    Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

    Catalytic activityi

    RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

    Cofactori

    Heme group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi442 – 4421Iron (heme axial ligand)By similarity

    GO - Molecular functioni

    1. aromatase activity Source: UniProtKB-EC
    2. heme binding Source: InterPro
    3. iron ion binding Source: InterPro
    4. monooxygenase activity Source: UniProtKB

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome P450 3A29 (EC:1.14.14.1)
    Alternative name(s):
    CYPIIIA29
    Gene namesi
    Name:CYP3A29
    OrganismiSus scrofa (Pig)
    Taxonomic identifieri9823 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
    ProteomesiUP000008227: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 503503Cytochrome P450 3A29PRO_0000051808Add
    BLAST

    Expressioni

    Inductioni

    P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

    Structurei

    3D structure databases

    ProteinModelPortaliP79401.
    SMRiP79401. Positions 30-496.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Phylogenomic databases

    HOVERGENiHBG108567.
    KOiK07424.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR008072. Cyt_P450_E_CYP3A.
    IPR002402. Cyt_P450_E_grp-II.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00464. EP450II.
    PR01689. EP450IICYP3A.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P79401-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDLIPGFSTE TWVLLATSLV LLYLYGTYSH GLFKKLGIPG PRPLPYFGNI    50
    LGYRKGVDHF DKKCFQQYGK MWGVYDGRQP LLAVTDPNMI KSVLVKECYS 100
    VFTNRRSFGP LGAMRNALSL AEDEEWKRIR TLLSPTFTSG KLKEMFPIIS 150
    HYGDLLVSNL RKEAEKGKPV TMKDIFGAYS MDVITSTAFG VNIDSLNNPQ 200
    DPFVENSKKL LKFSFFDPFL LSLIFFPFLT PIFEVLNITL FPKSSVNFFT 250
    KSVKRMKESR LTDQQKRRVD LLQLMINSQN SKEMDPHKSL SNEELVAQGI 300
    IFIFAGYETT SSALSLLAYE LATHPDVQQK LQEEIEATFP NKAPPTYDAL 350
    AQMEYLDMVV NETLRLYPIA ARLERACKKD VEIHGVFVPK GTVVVVPVFV 400
    LHRDPDLWPE PEEFRPERFS KKHKDTINPY TYLPFGTGPR NCIGMRFALM 450
    NMKLALVRVL QNFSFKPCKE TQIPLKLTTQ GLTQPEKPVV LKILPRDGTV 500
    SGA 503
    Length:503
    Mass (Da):57,199
    Last modified:May 1, 1997 - v1
    Checksum:iE3D411B2674FD17F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z93099 mRNA. Translation: CAB07513.1.
    RefSeqiNP_999588.1. NM_214423.1.
    UniGeneiSsc.204.

    Genome annotation databases

    GeneIDi403324.
    KEGGissc:403324.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z93099 mRNA. Translation: CAB07513.1 .
    RefSeqi NP_999588.1. NM_214423.1.
    UniGenei Ssc.204.

    3D structure databases

    ProteinModelPortali P79401.
    SMRi P79401. Positions 30-496.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 403324.
    KEGGi ssc:403324.

    Organism-specific databases

    CTDi 403324.

    Phylogenomic databases

    HOVERGENi HBG108567.
    KOi K07424.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR008072. Cyt_P450_E_CYP3A.
    IPR002402. Cyt_P450_E_grp-II.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00464. EP450II.
    PR01689. EP450IICYP3A.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Mapping of porcine genes belonging to two different cytochrome P450 subfamilies."
      Nissen P.H., Winteroe A.K., Fredholm M.
      Anim. Genet. 29:7-11(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Small intestine.

    Entry informationi

    Entry nameiCP3AT_PIG
    AccessioniPrimary (citable) accession number: P79401
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: May 1, 1997
    Last modified: October 1, 2014
    This is version 86 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3