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Protein

5-hydroxytryptamine receptor 1D

Gene

HTR1D

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Regulates the release of 5-hydroxytryptamine in the brain, and thereby affects neural activity. May also play a role in regulating the release of other neurotransmitters. May play a role in vasoconstriction (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
5-hydroxytryptamine receptor 1D
Short name:
5-HT-1D
Short name:
5-HT1D
Alternative name(s):
Serotonin receptor 1D
Gene namesi
Name:HTR1D
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei‹1 – 18Helical; Name=2Sequence analysisAdd BLAST›18
Topological domaini19 – 32ExtracellularBy similarityAdd BLAST14
Transmembranei33 – 54Helical; Name=3By similarityAdd BLAST22
Topological domaini55 – 74CytoplasmicBy similarityAdd BLAST20
Transmembranei75 – 96Helical; Name=4By similarityAdd BLAST22
Topological domaini97 – 114ExtracellularBy similarityAdd BLAST18
Transmembranei115 – 137Helical; Name=5By similarityAdd BLAST23
Topological domaini138 – 222CytoplasmicBy similarityAdd BLAST85
Transmembranei223 – 246Helical; Name=6By similarityAdd BLAST24
Topological domaini247 – 255ExtracellularBy similarity9
Transmembranei256 – 280Helical; Name=7By similarityAdd BLAST25
Topological domaini281 – ›291CytoplasmicBy similarityAdd BLAST›11

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL4105.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000068929‹1 – ›2915-hydroxytryptamine receptor 1DAdd BLAST›291

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi31 ↔ 108PROSITE-ProRule annotation
Glycosylationi111N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP79400.

Interactioni

Subunit structurei

Homodimer. Heterodimer with HTR1B (By similarity).By similarity

Chemistry databases

BindingDBiP79400.

Structurei

3D structure databases

ProteinModelPortaliP79400.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni34 – 43Agonist bindingBy similarity10
Regioni234 – 238Agonist bindingBy similarity5

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi55 – 57DRY motif; important for ligand-induced conformation changesBy similarity3
Motifi272 – 276NPxxY motif; important for ligand-induced conformation changes and signalingBy similarity5

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOVERGENiHBG106962.
InParanoidiP79400.

Family and domain databases

InterProiView protein in InterPro
IPR000505. 5HT1D_rcpt.
IPR002231. 5HT_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
PANTHERiPTHR24247:SF136. PTHR24247:SF136. 1 hit.
PfamiView protein in Pfam
PF00001. 7tm_1. 1 hit.
PRINTSiPR00514. 5HT1DRECEPTR.
PR01101. 5HTRECEPTOR.
PR00237. GPCRRHODOPSN.
PROSITEiView protein in PROSITE
PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.

Sequencei

Sequence statusi: Fragment.

P79400-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
AMTDLLVSIL VMPISIPYTI TQTWSFGQLL CDIWLSSDIT CCTASILHLC
60 70 80 90 100
VIALDRYWAI TDALEYSKRR TAGHAAAMIA IVWAISICIS IPPLFWRQAR
110 120 130 140 150
AHEEISDCLV NTSQISYTIY STCGAFYIPS LLLIILYGRI YRAARNRILN
160 170 180 190 200
PPSLYGKRFT TAHLITGSAG SSLCSLNPSL HEGHSHSAGS PLFFNHVKIK
210 220 230 240 250
LADSVLERKR ISAARERKAT KTLGIILGAF IICWLPFFVA SLVLPICRDS
260 270 280 290
CWIHPALFDF FTWLGYLNSL INPIIYTVFN EEFRQAFQKV V
Length:291
Mass (Da):32,669
Last modified:May 1, 1997 - v1
Checksum:i71E798F3652651CB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11
Non-terminal residuei2911

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y11868 mRNA. Translation: CAA72616.1.
UniGeneiSsc.15993.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry namei5HT1D_PIG
AccessioniPrimary (citable) accession number: P79400
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 1, 1997
Last modified: July 5, 2017
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families