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Protein

Prostacyclin receptor

Gene

PTGIR

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Receptor for prostacyclin (prostaglandin I2 or PGI2). The activity of this receptor is mediated by G(s) proteins which activate adenylate cyclase.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Prostacyclin receptor
Alternative name(s):
Prostaglandin I2 receptor
Short name:
PGI receptor
Short name:
PGI2 receptor
Prostanoid IP receptor
Gene namesi
Name:PTGIR
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1616ExtracellularSequence analysisAdd
BLAST
Transmembranei17 – 3822Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini39 – 5113CytoplasmicSequence analysisAdd
BLAST
Transmembranei52 – 7625Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini77 – 9418ExtracellularSequence analysisAdd
BLAST
Transmembranei95 – 11521Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini116 – 13419CytoplasmicSequence analysisAdd
BLAST
Transmembranei135 – 15824Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini159 – 18123ExtracellularSequence analysisAdd
BLAST
Transmembranei182 – 20827Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini209 – 23426CytoplasmicSequence analysisAdd
BLAST
Transmembranei235 – 25925Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini260 – 27314ExtracellularSequence analysisAdd
BLAST
Transmembranei274 – 29421Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini295 – 38591CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 382382Prostacyclin receptorPRO_0000070074Add
BLAST
Propeptidei383 – 3853Removed in mature formSequence analysisPRO_0000240003

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi5 ↔ 165PROSITE-ProRule annotation
Glycosylationi7 – 71N-linked (GlcNAc...)Sequence analysis
Disulfide bondi92 ↔ 170PROSITE-ProRule annotation
Lipidationi308 – 3081S-palmitoyl cysteineBy similarity
Modified residuei382 – 3821Cysteine methyl esterBy similarity
Lipidationi382 – 3821S-farnesyl cysteineBy similarity

Post-translational modificationi

Isoprenylation does not influence ligand binding but is required for efficient coupling to the effectors adenylyl cyclase and phospholipase C.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Methylation, Palmitate, Prenylation

Proteomic databases

PaxDbiP79393.
PRIDEiP79393.

Interactioni

Subunit structurei

Interacts (non-isoprenylated C-terminus) with PDZK1.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000019413.

Structurei

3D structure databases

ProteinModelPortaliP79393.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOGENOMiHOG000115475.
HOVERGENiHBG003074.
InParanoidiP79393.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR008365. Prostanoid_rcpt.
IPR000370. Prostglndn_IP_rcpt.
[Graphical view]
PANTHERiPTHR11866. PTHR11866. 1 hit.
PTHR11866:SF7. PTHR11866:SF7. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01788. PROSTANOIDR.
PR00856. PRSTNOIDIPR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P79393-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADSCRNLTY VRDSVGPATS TLMFVAGVVG NGLALGILGA RRHSRPSAFA
60 70 80 90 100
VLVTGLGVTD LLGTCFLSPA VFAAYARNSS LLGLARGRPA LCDAFAFAMT
110 120 130 140 150
FFGLASTLIL FAMAVERCLA LSHPYLYAQL DGPRRARLAL PAIYAFCTIF
160 170 180 190 200
CSLPFLGLGQ HQQYCPGSWC FIRMRSAEPG GCAFLLAYAS LVALLVAAIV
210 220 230 240 250
LCNGSVTLSL CRMYRQQRRH QARCPRPRAG EDEVDHLILL ALMTGIMAVC
260 270 280 290 300
SLPLTPQIRG FTQAIAPDSS EMGDLLAFRF NAFNPILDPW VFILFRKSVF
310 320 330 340 350
QRLKLWFCCL YSRPAQGDSR TSLSQSASGR KDSSAPPALE GKKGNWVPLS
360 370 380
AWGEGQGGPL PAVQLPTSTV GTPSKAGSEA ACSLC
Length:385
Mass (Da):41,247
Last modified:May 1, 1997 - v1
Checksum:i0CDA5A4D18E035C7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z93039, Z93040 Genomic DNA. Translation: CAB07510.1.
UniGeneiBt.108623.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z93039, Z93040 Genomic DNA. Translation: CAB07510.1.
UniGeneiBt.108623.

3D structure databases

ProteinModelPortaliP79393.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000019413.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PaxDbiP79393.
PRIDEiP79393.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOGENOMiHOG000115475.
HOVERGENiHBG003074.
InParanoidiP79393.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR008365. Prostanoid_rcpt.
IPR000370. Prostglndn_IP_rcpt.
[Graphical view]
PANTHERiPTHR11866. PTHR11866. 1 hit.
PTHR11866:SF7. PTHR11866:SF7. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01788. PROSTANOIDR.
PR00856. PRSTNOIDIPR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning and sequencing of the bovine prostacyclin receptor gene."
    Hasse A., Schroer K.
    Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiPI2R_BOVIN
AccessioniPrimary (citable) accession number: P79393
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 1, 1997
Last modified: June 8, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.