P79393 (PI2R_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Prostacyclin receptor

Alternative name(s):
Prostaglandin I2 receptor
Short name=PGI receptor
Short name=PGI2 receptor
Prostanoid IP receptor

Gene names

Name:

PTGIR

Organism

Bos taurus (Bovine) [Reference proteome]

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	385 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Receptor for prostacyclin (prostaglandin I2 or PGI2). The activity of this receptor is mediated by G(s) proteins which activate adenylate cyclase.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Post-translational modification	Isoprenylation does not influence ligand binding but is required for efficient coupling to the effectors adenylyl cyclase and phospholipase C By similarity.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein Lipoprotein Methylation Palmitate Prenylation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	G-protein coupled receptor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 382	382	Prostacyclin receptor		PRO_0000070074
	Propeptide	383 – 385	3	Removed in mature form Potential		PRO_0000240003
Regions
	Topological domain	1 – 16	16	Extracellular Potential
	Transmembrane	17 – 38	22	Helical; Name=1; Potential
	Topological domain	39 – 51	13	Cytoplasmic Potential
	Transmembrane	52 – 76	25	Helical; Name=2; Potential
	Topological domain	77 – 94	18	Extracellular Potential
	Transmembrane	95 – 115	21	Helical; Name=3; Potential
	Topological domain	116 – 134	19	Cytoplasmic Potential
	Transmembrane	135 – 158	24	Helical; Name=4; Potential
	Topological domain	159 – 181	23	Extracellular Potential
	Transmembrane	182 – 208	27	Helical; Name=5; Potential
	Topological domain	209 – 234	26	Cytoplasmic Potential
	Transmembrane	235 – 259	25	Helical; Name=6; Potential
	Topological domain	260 – 273	14	Extracellular Potential
	Transmembrane	274 – 294	21	Helical; Name=7; Potential
	Topological domain	295 – 385	91	Cytoplasmic Potential
Amino acid modifications
	Modified residue	382	1	Cysteine methyl ester By similarity
	Lipidation	308	1	S-palmitoyl cysteine By similarity
	Lipidation	382	1	S-farnesyl cysteine By similarity
	Glycosylation	7	1	N-linked (GlcNAc...) Potential
	Disulfide bond	5 ↔ 165		By similarity
	Disulfide bond	92 ↔ 170		By similarity

Sequences

	Sequence		Length	Mass (Da)
	P79393 [UniParc]. Last modified May 1, 1997. Version 1. Checksum: 0CDA5A4D18E035C7	FASTA	385	41,247
	10 20 30 40 50 60 MADSCRNLTY VRDSVGPATS TLMFVAGVVG NGLALGILGA RRHSRPSAFA VLVTGLGVTD 70 80 90 100 110 120 LLGTCFLSPA VFAAYARNSS LLGLARGRPA LCDAFAFAMT FFGLASTLIL FAMAVERCLA 130 140 150 160 170 180 LSHPYLYAQL DGPRRARLAL PAIYAFCTIF CSLPFLGLGQ HQQYCPGSWC FIRMRSAEPG 190 200 210 220 230 240 GCAFLLAYAS LVALLVAAIV LCNGSVTLSL CRMYRQQRRH QARCPRPRAG EDEVDHLILL 250 260 270 280 290 300 ALMTGIMAVC SLPLTPQIRG FTQAIAPDSS EMGDLLAFRF NAFNPILDPW VFILFRKSVF 310 320 330 340 350 360 QRLKLWFCCL YSRPAQGDSR TSLSQSASGR KDSSAPPALE GKKGNWVPLS AWGEGQGGPL 370 380 PAVQLPTSTV GTPSKAGSEA ACSLC

References

[1]	"Cloning and sequencing of the bovine prostacyclin receptor gene." Hasse A., Schroer K. Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z93039, Z93040 Genomic DNA. Translation: CAB07510.1.
IPI	IPI00907733.
UniGene	Bt.108623.
3D structure databases
ProteinModelPortal	P79393.
ModBase	Search...
Protein-protein interaction databases
STRING	9913.ENSBTAP00000019413.
Protein family/group databases
GPCRDB	Search...
Proteomic databases
PRIDE	P79393.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
eggNOG	NOG305292.
HOGENOM	HOG000115475.
HOVERGEN	HBG003074.
Enzyme and pathway databases
BioCyc	CATTLE:520278-MONOMER.
Family and domain databases
InterPro	IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR008365. Prostanoid_rcpt. IPR000370. Prostglndn_IP_rcpt. [Graphical view]
PANTHER	PTHR11866. PTHR11866. 1 hit. PTHR11866:SF7. PTHR11866:SF7. 1 hit.
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN. PR01788. PROSTANOIDR. PR00856. PRSTNOIDIPR.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	20873069.

Entry information

Entry name

PI2R_BOVIN

Accession

Primary (citable) accession number: P79393

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	May 1, 1997
Last modified:	May 29, 2013
This is version 93 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program