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Protein

Cytochrome P450 2E1

Gene

CYP2E1

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Metabolizes several precarcinogens, drugs, and solvents to reactive metabolites.By similarity

Catalytic activityi

4-nitrophenol + NADPH + O2 = 4-nitrocatechol + NADP+ + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi437Iron (heme axial ligand)By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
LigandHeme, Iron, Metal-binding, NADP

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 2E1 (EC:1.14.13.-)
Alternative name(s):
4-nitrophenol 2-hydroxylase (EC:1.14.13.n7)
CYPIIE1
Cytochrome P-450-J
Short name:
Cytochrome P450-J
Gene namesi
Name:CYP2E1
Synonyms:CYP2E
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000517561 – 495Cytochrome P450 2E1Add BLAST495

Proteomic databases

PaxDbiP79383.
PeptideAtlasiP79383.
PRIDEiP79383.

Interactioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000011493.

Structurei

3D structure databases

ProteinModelPortaliP79383.
SMRiP79383.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni298 – 303Substrate bindingBy similarity6

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiKOG0156. Eukaryota.
COG2124. LUCA.
HOGENOMiHOG000036992.
HOVERGENiHBG015789.
InParanoidiP79383.
KOiK07415.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiView protein in InterPro
IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008070. Cyt_P450_E_grp-I_CYP2E-like.
IPR036396. Cyt_P450_sf.
PfamiView protein in Pfam
PF00067. p450. 1 hit.
PRINTSiPR00463. EP450I.
PR01687. EP450ICYP2E.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiView protein in PROSITE
PS00086. CYTOCHROME_P450. 1 hit.

Sequencei

Sequence statusi: Complete.

P79383-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTALGITVAL LVWLVTLLLI SIWKHIHSSW KLPPGPFPLP IVGNIFQLDL
60 70 80 90 100
KNIPKSFTML AERYGPVFTV YLGSRRIVVL HGYKAVKEVL LHYKNEFSGR
110 120 130 140 150
GEIPTFQVHK DKGVIFNNGP TWRDTRRFSL TTLRDFGMGK QGNEQRIQRE
160 170 180 190 200
AHFLLEALRK THGQPFDPTF LIGCAPCNVI SDILFRQHFD YNDKTCLRLM
210 220 230 240 250
SMFNENFYLL STGWIQLYNN FSGYLRYLPG SHRKLMKNIS EIKDYALERV
260 270 280 290 300
KDHRDSLEPS CPRDFTDTLL MEMEKEKYSA EPIYTLDNIA VTVADMFFAG
310 320 330 340 350
TETTSTTLRY GLLILMKYPE VEEKLHEEID RVIGPNRIPA IKDRLVMPYL
360 370 380 390 400
DAVVHEIQRF IDLIPSNLPH EATRDTDFRD YIIPKGTVVI PTLDSVLYDS
410 420 430 440 450
QEFPEPEKFK PEHFLNENGK FKYSDHFKAF SAGKRVCVGE GLARMELFLF
460 470 480 490
MAAILQHFNL KSLVDPKDID LSPIAIGFAK IPPHYKLCVI PRSQV
Length:495
Mass (Da):57,095
Last modified:May 1, 1997 - v1
Checksum:i4D81555E4F225F80
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB000885 mRNA. Translation: BAA19202.1.
RefSeqiNP_999586.1. NM_214421.1.
UniGeneiSsc.15741.

Genome annotation databases

GeneIDi403216.
KEGGissc:403216.

Similar proteinsi

Entry informationi

Entry nameiCP2E1_PIG
AccessioniPrimary (citable) accession number: P79383
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 1, 1997
Last modified: October 25, 2017
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families