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Protein

Cytochrome P450 2E1

Gene

CYP2E1

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Metabolizes several precarcinogens, drugs, and solvents to reactive metabolites.By similarity

Catalytic activityi

4-nitrophenol + NADPH + O2 = 4-nitrocatechol + NADP+ + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi437 – 4371Iron (heme axial ligand)By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding, NADP

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 2E1 (EC:1.14.13.-)
Alternative name(s):
4-nitrophenol 2-hydroxylase (EC:1.14.13.n7)
CYPIIE1
Cytochrome P-450-J
Short name:
Cytochrome P450-J
Gene namesi
Name:CYP2E1
Synonyms:CYP2E
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 495494Cytochrome P450 2E1PRO_0000051756Add
BLAST

Proteomic databases

PaxDbiP79383.

Interactioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000011493.

Structurei

3D structure databases

ProteinModelPortaliP79383.
SMRiP79383. Positions 33-493.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni298 – 3036Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiKOG0156. Eukaryota.
COG2124. LUCA.
HOGENOMiHOG000036992.
HOVERGENiHBG015789.
InParanoidiP79383.
KOiK07415.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008070. Cyt_P450_E_grp-I_CYP2E-like.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR01687. EP450ICYP2E.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P79383-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTALGITVAL LVWLVTLLLI SIWKHIHSSW KLPPGPFPLP IVGNIFQLDL
60 70 80 90 100
KNIPKSFTML AERYGPVFTV YLGSRRIVVL HGYKAVKEVL LHYKNEFSGR
110 120 130 140 150
GEIPTFQVHK DKGVIFNNGP TWRDTRRFSL TTLRDFGMGK QGNEQRIQRE
160 170 180 190 200
AHFLLEALRK THGQPFDPTF LIGCAPCNVI SDILFRQHFD YNDKTCLRLM
210 220 230 240 250
SMFNENFYLL STGWIQLYNN FSGYLRYLPG SHRKLMKNIS EIKDYALERV
260 270 280 290 300
KDHRDSLEPS CPRDFTDTLL MEMEKEKYSA EPIYTLDNIA VTVADMFFAG
310 320 330 340 350
TETTSTTLRY GLLILMKYPE VEEKLHEEID RVIGPNRIPA IKDRLVMPYL
360 370 380 390 400
DAVVHEIQRF IDLIPSNLPH EATRDTDFRD YIIPKGTVVI PTLDSVLYDS
410 420 430 440 450
QEFPEPEKFK PEHFLNENGK FKYSDHFKAF SAGKRVCVGE GLARMELFLF
460 470 480 490
MAAILQHFNL KSLVDPKDID LSPIAIGFAK IPPHYKLCVI PRSQV
Length:495
Mass (Da):57,095
Last modified:May 1, 1997 - v1
Checksum:i4D81555E4F225F80
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB000885 mRNA. Translation: BAA19202.1.
RefSeqiNP_999586.1. NM_214421.1.
UniGeneiSsc.15741.

Genome annotation databases

GeneIDi403216.
KEGGissc:403216.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB000885 mRNA. Translation: BAA19202.1.
RefSeqiNP_999586.1. NM_214421.1.
UniGeneiSsc.15741.

3D structure databases

ProteinModelPortaliP79383.
SMRiP79383. Positions 33-493.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000011493.

Proteomic databases

PaxDbiP79383.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi403216.
KEGGissc:403216.

Organism-specific databases

CTDi1571.

Phylogenomic databases

eggNOGiKOG0156. Eukaryota.
COG2124. LUCA.
HOGENOMiHOG000036992.
HOVERGENiHBG015789.
InParanoidiP79383.
KOiK07415.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008070. Cyt_P450_E_grp-I_CYP2E-like.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR01687. EP450ICYP2E.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning of the pig cytochrome P-450-j gene."
    Kimura M., Kawakami K., Suzuki H., Hamasima N.
    Submitted (FEB-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiCP2E1_PIG
AccessioniPrimary (citable) accession number: P79383
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 1, 1997
Last modified: February 17, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.