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P79381

- HYEP_PIG

UniProt

P79381 - HYEP_PIG

Protein

Epoxide hydrolase 1

Gene

EPHX1

Organism
Sus scrofa (Pig)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 1 (01 May 1997)
      Previous versions | rss
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    Functioni

    Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water.By similarity

    Catalytic activityi

    Cis-stilbene oxide + H2O = (+)-(1R,2R)-1,2-diphenylethane-1,2-diol.

    GO - Molecular functioni

    1. cis-stilbene-oxide hydrolase activity Source: UniProtKB-EC

    GO - Biological processi

    1. aromatic compound catabolic process Source: UniProtKB-KW
    2. response to organic cyclic compound Source: Ensembl
    3. response to toxic substance Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Aromatic hydrocarbons catabolism, Detoxification

    Protein family/group databases

    MEROPSiS33.971.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Epoxide hydrolase 1 (EC:3.3.2.9)
    Alternative name(s):
    Epoxide hydratase
    Microsomal epoxide hydrolase
    Gene namesi
    Name:EPHX1
    OrganismiSus scrofa (Pig)
    Taxonomic identifieri9823 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
    ProteomesiUP000008227: Chromosome 10

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 454454Epoxide hydrolase 1PRO_0000080857Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei294 – 2941Omega-N-methylated arginineBy similarity

    Keywords - PTMi

    Methylation

    Proteomic databases

    PaxDbiP79381.
    PRIDEiP79381.

    Interactioni

    Protein-protein interaction databases

    STRINGi9823.ENSSSCP00000011571.

    Structurei

    3D structure databases

    ProteinModelPortaliP79381.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei2 – 2019Helical; Signal-anchorSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase S33 family.Curated

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0596.
    GeneTreeiENSGT00390000002210.
    HOGENOMiHOG000132894.
    HOVERGENiHBG002366.
    KOiK01253.
    OMAiIISYWRN.
    OrthoDBiEOG7B5WZH.
    TreeFamiTF313813.

    Family and domain databases

    Gene3Di3.40.50.1820. 1 hit.
    InterProiIPR029058. AB_hydrolase.
    IPR000073. AB_hydrolase_1.
    IPR000639. Epox_hydrolase-like.
    IPR010497. Epoxide_hydro_N.
    IPR016292. Epoxide_hydrolase.
    [Graphical view]
    PfamiPF00561. Abhydrolase_1. 1 hit.
    PF06441. EHN. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001112. Epoxide_hydrolase. 1 hit.
    PRINTSiPR00412. EPOXHYDRLASE.
    SUPFAMiSSF53474. SSF53474. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P79381-1 [UniParc]FASTAAdd to Basket

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    MWLEILLASV LGFVIYWFVS KDKEETLLLG DGWWGPGSRP AAAEDESIRP    50
    FKVETSDEEI NDLHQRIEKF RLTPPLEDSR FHYGFNSNYL KKIISYWRNT 100
    FDWRKQVEVL NKYPHFKTKI EGLDIHFIHV KPPQLPSGRT AKPLLMVHGW 150
    PGCFYEFYKI IPLLTDPKNH GLSDEHVFEV ICPSIPGYGF SEASSKKGFN 200
    SVAAARIFYK LMLRLGFQEF YLQGGDWGSL ICTNMAQLVP SHVKGLHLNV 250
    ALVLRNVYTL TFFLGRRLGR LFGYTERDLE LLYPFKKTFY TLMRESGYMH 300
    IQSTKPDTVG CALNDSPVGL AAYILEKFST WTNEEFRDLE DGGLERKFSL 350
    DELLTVIMLY WTTGTITSSQ RFYKENLGQG VMANKHEAIK VHVPTGFAAF 400
    PSEVLHCPEK WVKNKYPKLI SYSYMARGGH FAAFEEPELL AQDIRKFMGL 450
    LEQQ 454
    Length:454
    Mass (Da):52,394
    Last modified:May 1, 1997 - v1
    Checksum:iBF3D34884565E092
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB000883 mRNA. Translation: BAA19200.1.
    RefSeqiNP_999520.1. NM_214355.1.
    XP_005653835.1. XM_005653778.1.
    XP_005653836.1. XM_005653779.1.
    XP_005653837.1. XM_005653780.1.
    XP_005653838.1. XM_005653781.1.
    XP_005653839.1. XM_005653782.1.
    XP_005653840.1. XM_005653783.1.
    UniGeneiSsc.53710.

    Genome annotation databases

    EnsembliENSSSCT00000011875; ENSSSCP00000011571; ENSSSCG00000010853.
    GeneIDi397639.
    KEGGissc:397639.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB000883 mRNA. Translation: BAA19200.1 .
    RefSeqi NP_999520.1. NM_214355.1.
    XP_005653835.1. XM_005653778.1.
    XP_005653836.1. XM_005653779.1.
    XP_005653837.1. XM_005653780.1.
    XP_005653838.1. XM_005653781.1.
    XP_005653839.1. XM_005653782.1.
    XP_005653840.1. XM_005653783.1.
    UniGenei Ssc.53710.

    3D structure databases

    ProteinModelPortali P79381.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9823.ENSSSCP00000011571.

    Protein family/group databases

    MEROPSi S33.971.

    Proteomic databases

    PaxDbi P79381.
    PRIDEi P79381.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSSSCT00000011875 ; ENSSSCP00000011571 ; ENSSSCG00000010853 .
    GeneIDi 397639.
    KEGGi ssc:397639.

    Organism-specific databases

    CTDi 2052.

    Phylogenomic databases

    eggNOGi COG0596.
    GeneTreei ENSGT00390000002210.
    HOGENOMi HOG000132894.
    HOVERGENi HBG002366.
    KOi K01253.
    OMAi IISYWRN.
    OrthoDBi EOG7B5WZH.
    TreeFami TF313813.

    Family and domain databases

    Gene3Di 3.40.50.1820. 1 hit.
    InterProi IPR029058. AB_hydrolase.
    IPR000073. AB_hydrolase_1.
    IPR000639. Epox_hydrolase-like.
    IPR010497. Epoxide_hydro_N.
    IPR016292. Epoxide_hydrolase.
    [Graphical view ]
    Pfami PF00561. Abhydrolase_1. 1 hit.
    PF06441. EHN. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001112. Epoxide_hydrolase. 1 hit.
    PRINTSi PR00412. EPOXHYDRLASE.
    SUPFAMi SSF53474. SSF53474. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of the pig epoxide hydrolase gene."
      Kawakami K., Kimura M., Suzuki H., Hamasima N.
      Submitted (FEB-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiHYEP_PIG
    AccessioniPrimary (citable) accession number: P79381
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 20, 2005
    Last sequence update: May 1, 1997
    Last modified: October 1, 2014
    This is version 85 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3