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P79381

- HYEP_PIG

UniProt

P79381 - HYEP_PIG

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Protein

Epoxide hydrolase 1

Gene

EPHX1

Organism
Sus scrofa (Pig)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water.By similarity

Catalytic activityi

Cis-stilbene oxide + H2O = (+)-(1R,2R)-1,2-diphenylethane-1,2-diol.

GO - Molecular functioni

  1. cis-stilbene-oxide hydrolase activity Source: UniProtKB-EC

GO - Biological processi

  1. aromatic compound catabolic process Source: UniProtKB-KW
  2. response to organic cyclic compound Source: Ensembl
  3. response to toxic substance Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Aromatic hydrocarbons catabolism, Detoxification

Protein family/group databases

MEROPSiS33.971.

Names & Taxonomyi

Protein namesi
Recommended name:
Epoxide hydrolase 1 (EC:3.3.2.9)
Alternative name(s):
Epoxide hydratase
Microsomal epoxide hydrolase
Gene namesi
Name:EPHX1
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
ProteomesiUP000008227: Chromosome 10

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 454454Epoxide hydrolase 1PRO_0000080857Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei294 – 2941Omega-N-methylated arginineBy similarity

Keywords - PTMi

Methylation

Proteomic databases

PaxDbiP79381.
PRIDEiP79381.

Interactioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000011571.

Structurei

3D structure databases

ProteinModelPortaliP79381.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei2 – 2019Helical; Signal-anchorSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S33 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0596.
GeneTreeiENSGT00390000002210.
HOGENOMiHOG000132894.
HOVERGENiHBG002366.
InParanoidiP79381.
KOiK01253.
OMAiIISYWRN.
OrthoDBiEOG7B5WZH.
TreeFamiTF313813.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR000073. AB_hydrolase_1.
IPR000639. Epox_hydrolase-like.
IPR010497. Epoxide_hydro_N.
IPR016292. Epoxide_hydrolase.
[Graphical view]
PfamiPF00561. Abhydrolase_1. 1 hit.
PF06441. EHN. 1 hit.
[Graphical view]
PIRSFiPIRSF001112. Epoxide_hydrolase. 1 hit.
PRINTSiPR00412. EPOXHYDRLASE.
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Complete.

P79381-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MWLEILLASV LGFVIYWFVS KDKEETLLLG DGWWGPGSRP AAAEDESIRP
60 70 80 90 100
FKVETSDEEI NDLHQRIEKF RLTPPLEDSR FHYGFNSNYL KKIISYWRNT
110 120 130 140 150
FDWRKQVEVL NKYPHFKTKI EGLDIHFIHV KPPQLPSGRT AKPLLMVHGW
160 170 180 190 200
PGCFYEFYKI IPLLTDPKNH GLSDEHVFEV ICPSIPGYGF SEASSKKGFN
210 220 230 240 250
SVAAARIFYK LMLRLGFQEF YLQGGDWGSL ICTNMAQLVP SHVKGLHLNV
260 270 280 290 300
ALVLRNVYTL TFFLGRRLGR LFGYTERDLE LLYPFKKTFY TLMRESGYMH
310 320 330 340 350
IQSTKPDTVG CALNDSPVGL AAYILEKFST WTNEEFRDLE DGGLERKFSL
360 370 380 390 400
DELLTVIMLY WTTGTITSSQ RFYKENLGQG VMANKHEAIK VHVPTGFAAF
410 420 430 440 450
PSEVLHCPEK WVKNKYPKLI SYSYMARGGH FAAFEEPELL AQDIRKFMGL

LEQQ
Length:454
Mass (Da):52,394
Last modified:May 1, 1997 - v1
Checksum:iBF3D34884565E092
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB000883 mRNA. Translation: BAA19200.1.
RefSeqiNP_999520.1. NM_214355.1.
XP_005653835.1. XM_005653778.1.
XP_005653836.1. XM_005653779.1.
XP_005653837.1. XM_005653780.1.
XP_005653838.1. XM_005653781.1.
XP_005653839.1. XM_005653782.1.
XP_005653840.1. XM_005653783.1.
UniGeneiSsc.53710.

Genome annotation databases

EnsembliENSSSCT00000011875; ENSSSCP00000011571; ENSSSCG00000010853.
GeneIDi397639.
KEGGissc:397639.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB000883 mRNA. Translation: BAA19200.1 .
RefSeqi NP_999520.1. NM_214355.1.
XP_005653835.1. XM_005653778.1.
XP_005653836.1. XM_005653779.1.
XP_005653837.1. XM_005653780.1.
XP_005653838.1. XM_005653781.1.
XP_005653839.1. XM_005653782.1.
XP_005653840.1. XM_005653783.1.
UniGenei Ssc.53710.

3D structure databases

ProteinModelPortali P79381.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9823.ENSSSCP00000011571.

Protein family/group databases

MEROPSi S33.971.

Proteomic databases

PaxDbi P79381.
PRIDEi P79381.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSSSCT00000011875 ; ENSSSCP00000011571 ; ENSSSCG00000010853 .
GeneIDi 397639.
KEGGi ssc:397639.

Organism-specific databases

CTDi 2052.

Phylogenomic databases

eggNOGi COG0596.
GeneTreei ENSGT00390000002210.
HOGENOMi HOG000132894.
HOVERGENi HBG002366.
InParanoidi P79381.
KOi K01253.
OMAi IISYWRN.
OrthoDBi EOG7B5WZH.
TreeFami TF313813.

Family and domain databases

Gene3Di 3.40.50.1820. 1 hit.
InterProi IPR029058. AB_hydrolase.
IPR000073. AB_hydrolase_1.
IPR000639. Epox_hydrolase-like.
IPR010497. Epoxide_hydro_N.
IPR016292. Epoxide_hydrolase.
[Graphical view ]
Pfami PF00561. Abhydrolase_1. 1 hit.
PF06441. EHN. 1 hit.
[Graphical view ]
PIRSFi PIRSF001112. Epoxide_hydrolase. 1 hit.
PRINTSi PR00412. EPOXHYDRLASE.
SUPFAMi SSF53474. SSF53474. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Cloning of the pig epoxide hydrolase gene."
    Kawakami K., Kimura M., Suzuki H., Hamasima N.
    Submitted (FEB-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiHYEP_PIG
AccessioniPrimary (citable) accession number: P79381
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: May 1, 1997
Last modified: October 29, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3