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Protein

Epoxide hydrolase 1

Gene

EPHX1

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water. May play a role in the metabolism of endogenous lipids such as epoxide-containing fatty acids.By similarity

Catalytic activityi

Cis-stilbene oxide + H2O = (1R,2R)-1,2-diphenylethane-1,2-diol.By similarity
1-(4-methoxyphenyl)-N-methyl-N-((3-methyloxetan-3-yl)methyl)methanamine + H2O = 2-((((4-methoxyphenyl)methyl)(methyl)amino)methyl)-2-methylpropane-1,3-diol.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei226NucleophileBy similarity1
Active sitei373Proton donorBy similarity1
Active sitei430Proton acceptorBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processAromatic hydrocarbons catabolism, Detoxification

Enzyme and pathway databases

ReactomeiR-SSC-211945 Phase I - Functionalization of compounds

Protein family/group databases

ESTHERisussc-hyep Epoxide_hydrolase
MEROPSiS33.971

Names & Taxonomyi

Protein namesi
Recommended name:
Epoxide hydrolase 1 (EC:3.3.2.9By similarity)
Alternative name(s):
Epoxide hydratase
Microsomal epoxide hydrolase
Short name:
mEHCurated
Gene namesi
Name:EPHX1
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei1 – 21HelicalBy similarityAdd BLAST21
Topological domaini22 – 454CytoplasmicBy similarityAdd BLAST433

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000808571 – 454Epoxide hydrolase 1Add BLAST454

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei294Dimethylated arginine; alternateBy similarity1
Modified residuei294Omega-N-methylated arginine; alternateBy similarity1

Keywords - PTMi

Methylation

Proteomic databases

PaxDbiP79381
PeptideAtlasiP79381
PRIDEiP79381

Expressioni

Gene expression databases

BgeeiENSSSCG00000010853
GenevisibleiP79381 SS

Interactioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000011571

Structurei

3D structure databases

ProteinModelPortaliP79381
SMRiP79381
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S33 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2565 Eukaryota
COG0596 LUCA
HOGENOMiHOG000132894
HOVERGENiHBG002366
InParanoidiP79381
KOiK01253
OMAiYSLMRES
OrthoDBiEOG091G0B5A
TreeFamiTF313813

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR000639 Epox_hydrolase-like
IPR010497 Epoxide_hydro_N
IPR016292 Epoxide_hydrolase
PfamiView protein in Pfam
PF06441 EHN, 1 hit
PIRSFiPIRSF001112 Epoxide_hydrolase, 1 hit
PRINTSiPR00412 EPOXHYDRLASE
SUPFAMiSSF53474 SSF53474, 1 hit

Sequencei

Sequence statusi: Complete.

P79381-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWLEILLASV LGFVIYWFVS KDKEETLLLG DGWWGPGSRP AAAEDESIRP
60 70 80 90 100
FKVETSDEEI NDLHQRIEKF RLTPPLEDSR FHYGFNSNYL KKIISYWRNT
110 120 130 140 150
FDWRKQVEVL NKYPHFKTKI EGLDIHFIHV KPPQLPSGRT AKPLLMVHGW
160 170 180 190 200
PGCFYEFYKI IPLLTDPKNH GLSDEHVFEV ICPSIPGYGF SEASSKKGFN
210 220 230 240 250
SVAAARIFYK LMLRLGFQEF YLQGGDWGSL ICTNMAQLVP SHVKGLHLNV
260 270 280 290 300
ALVLRNVYTL TFFLGRRLGR LFGYTERDLE LLYPFKKTFY TLMRESGYMH
310 320 330 340 350
IQSTKPDTVG CALNDSPVGL AAYILEKFST WTNEEFRDLE DGGLERKFSL
360 370 380 390 400
DELLTVIMLY WTTGTITSSQ RFYKENLGQG VMANKHEAIK VHVPTGFAAF
410 420 430 440 450
PSEVLHCPEK WVKNKYPKLI SYSYMARGGH FAAFEEPELL AQDIRKFMGL

LEQQ
Length:454
Mass (Da):52,394
Last modified:May 1, 1997 - v1
Checksum:iBF3D34884565E092
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB000883 mRNA Translation: BAA19200.1
RefSeqiNP_999520.1, NM_214355.1
XP_005653835.1, XM_005653778.1
XP_005653836.1, XM_005653779.1
XP_005653837.1, XM_005653780.1
XP_005653838.1, XM_005653781.2
XP_005653839.1, XM_005653782.1
XP_005653840.1, XM_005653783.1
XP_013833722.1, XM_013978268.1
UniGeneiSsc.53710

Genome annotation databases

GeneIDi397639
KEGGissc:397639

Similar proteinsi

Entry informationi

Entry nameiHYEP_PIG
AccessioniPrimary (citable) accession number: P79381
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: May 1, 1997
Last modified: April 25, 2018
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

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