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Protein

Epoxide hydrolase 1

Gene

EPHX1

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water.By similarity

Catalytic activityi

Cis-stilbene oxide + H2O = (+)-(1R,2R)-1,2-diphenylethane-1,2-diol.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Aromatic hydrocarbons catabolism, Detoxification

Protein family/group databases

ESTHERisussc-hyep. Epoxide_hydrolase.
MEROPSiS33.971.

Names & Taxonomyi

Protein namesi
Recommended name:
Epoxide hydrolase 1 (EC:3.3.2.9)
Alternative name(s):
Epoxide hydratase
Microsomal epoxide hydrolase
Gene namesi
Name:EPHX1
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
ProteomesiUP000008227 Componenti: Chromosome 10

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei2 – 2019Helical; Signal-anchorSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 454454Epoxide hydrolase 1PRO_0000080857Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei294 – 2941Dimethylated arginine; alternateBy similarity
Modified residuei294 – 2941Omega-N-methylated arginine; alternateBy similarity

Keywords - PTMi

Methylation

Proteomic databases

PaxDbiP79381.
PRIDEiP79381.

Expressioni

Gene expression databases

GenevisibleiP79381. SS.

Interactioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000011571.

Structurei

3D structure databases

ProteinModelPortaliP79381.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S33 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0596.
GeneTreeiENSGT00390000002210.
HOGENOMiHOG000132894.
HOVERGENiHBG002366.
InParanoidiP79381.
KOiK01253.
OMAiMANKHEA.
OrthoDBiEOG7B5WZH.
TreeFamiTF313813.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR000073. AB_hydrolase_1.
IPR000639. Epox_hydrolase-like.
IPR010497. Epoxide_hydro_N.
IPR016292. Epoxide_hydrolase.
[Graphical view]
PfamiPF00561. Abhydrolase_1. 1 hit.
PF06441. EHN. 1 hit.
[Graphical view]
PIRSFiPIRSF001112. Epoxide_hydrolase. 1 hit.
PRINTSiPR00412. EPOXHYDRLASE.
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Complete.

P79381-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWLEILLASV LGFVIYWFVS KDKEETLLLG DGWWGPGSRP AAAEDESIRP
60 70 80 90 100
FKVETSDEEI NDLHQRIEKF RLTPPLEDSR FHYGFNSNYL KKIISYWRNT
110 120 130 140 150
FDWRKQVEVL NKYPHFKTKI EGLDIHFIHV KPPQLPSGRT AKPLLMVHGW
160 170 180 190 200
PGCFYEFYKI IPLLTDPKNH GLSDEHVFEV ICPSIPGYGF SEASSKKGFN
210 220 230 240 250
SVAAARIFYK LMLRLGFQEF YLQGGDWGSL ICTNMAQLVP SHVKGLHLNV
260 270 280 290 300
ALVLRNVYTL TFFLGRRLGR LFGYTERDLE LLYPFKKTFY TLMRESGYMH
310 320 330 340 350
IQSTKPDTVG CALNDSPVGL AAYILEKFST WTNEEFRDLE DGGLERKFSL
360 370 380 390 400
DELLTVIMLY WTTGTITSSQ RFYKENLGQG VMANKHEAIK VHVPTGFAAF
410 420 430 440 450
PSEVLHCPEK WVKNKYPKLI SYSYMARGGH FAAFEEPELL AQDIRKFMGL

LEQQ
Length:454
Mass (Da):52,394
Last modified:May 1, 1997 - v1
Checksum:iBF3D34884565E092
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB000883 mRNA. Translation: BAA19200.1.
RefSeqiNP_999520.1. NM_214355.1.
XP_005653835.1. XM_005653778.1.
XP_005653836.1. XM_005653779.1.
XP_005653837.1. XM_005653780.1.
XP_005653838.1. XM_005653781.1.
XP_005653839.1. XM_005653782.1.
XP_005653840.1. XM_005653783.1.
UniGeneiSsc.53710.

Genome annotation databases

EnsembliENSSSCT00000011875; ENSSSCP00000011571; ENSSSCG00000010853.
GeneIDi397639.
KEGGissc:397639.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB000883 mRNA. Translation: BAA19200.1.
RefSeqiNP_999520.1. NM_214355.1.
XP_005653835.1. XM_005653778.1.
XP_005653836.1. XM_005653779.1.
XP_005653837.1. XM_005653780.1.
XP_005653838.1. XM_005653781.1.
XP_005653839.1. XM_005653782.1.
XP_005653840.1. XM_005653783.1.
UniGeneiSsc.53710.

3D structure databases

ProteinModelPortaliP79381.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000011571.

Protein family/group databases

ESTHERisussc-hyep. Epoxide_hydrolase.
MEROPSiS33.971.

Proteomic databases

PaxDbiP79381.
PRIDEiP79381.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSSSCT00000011875; ENSSSCP00000011571; ENSSSCG00000010853.
GeneIDi397639.
KEGGissc:397639.

Organism-specific databases

CTDi2052.

Phylogenomic databases

eggNOGiCOG0596.
GeneTreeiENSGT00390000002210.
HOGENOMiHOG000132894.
HOVERGENiHBG002366.
InParanoidiP79381.
KOiK01253.
OMAiMANKHEA.
OrthoDBiEOG7B5WZH.
TreeFamiTF313813.

Gene expression databases

GenevisibleiP79381. SS.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR000073. AB_hydrolase_1.
IPR000639. Epox_hydrolase-like.
IPR010497. Epoxide_hydro_N.
IPR016292. Epoxide_hydrolase.
[Graphical view]
PfamiPF00561. Abhydrolase_1. 1 hit.
PF06441. EHN. 1 hit.
[Graphical view]
PIRSFiPIRSF001112. Epoxide_hydrolase. 1 hit.
PRINTSiPR00412. EPOXHYDRLASE.
SUPFAMiSSF53474. SSF53474. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Cloning of the pig epoxide hydrolase gene."
    Kawakami K., Kimura M., Suzuki H., Hamasima N.
    Submitted (FEB-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiHYEP_PIG
AccessioniPrimary (citable) accession number: P79381
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: May 1, 1997
Last modified: July 22, 2015
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.