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P79379

- MT2A_PIG

UniProt

P79379 - MT2A_PIG

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Protein

Metallothionein-2A

Gene

MT2A

Organism
Sus scrofa (Pig)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi

Functioni

Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi5 – 51Divalent metal cation; cluster BBy similarity
Metal bindingi7 – 71Divalent metal cation; cluster BBy similarity
Metal bindingi13 – 131Divalent metal cation; cluster BBy similarity
Metal bindingi15 – 151Divalent metal cation; cluster BBy similarity
Metal bindingi19 – 191Divalent metal cation; cluster BBy similarity
Metal bindingi21 – 211Divalent metal cation; cluster BBy similarity
Metal bindingi24 – 241Divalent metal cation; cluster BBy similarity
Metal bindingi26 – 261Divalent metal cation; cluster BBy similarity
Metal bindingi29 – 291Divalent metal cation; cluster BBy similarity
Metal bindingi33 – 331Divalent metal cation; cluster ABy similarity
Metal bindingi34 – 341Divalent metal cation; cluster ABy similarity
Metal bindingi36 – 361Divalent metal cation; cluster ABy similarity
Metal bindingi37 – 371Divalent metal cation; cluster ABy similarity
Metal bindingi41 – 411Divalent metal cation; cluster ABy similarity
Metal bindingi44 – 441Divalent metal cation; cluster ABy similarity
Metal bindingi48 – 481Divalent metal cation; cluster ABy similarity
Metal bindingi50 – 501Divalent metal cation; cluster ABy similarity
Metal bindingi57 – 571Divalent metal cation; cluster ABy similarity
Metal bindingi59 – 591Divalent metal cation; cluster ABy similarity
Metal bindingi60 – 601Divalent metal cation; cluster ABy similarity

GO - Molecular functioni

  1. zinc ion binding Source: UniProtKB

GO - Biological processi

  1. cellular response to cadmium ion Source: Ensembl
  2. cellular response to copper ion Source: Ensembl
  3. cellular response to vascular endothelial growth factor stimulus Source: Ensembl
  4. cellular response to zinc ion Source: UniProtKB
  5. cellular zinc ion homeostasis Source: Ensembl
  6. detoxification of copper ion Source: Ensembl
  7. negative regulation of growth Source: UniProtKB
  8. nitric oxide mediated signal transduction Source: Ensembl
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Metal-thiolate cluster

Names & Taxonomyi

Protein namesi
Recommended name:
Metallothionein-2A
Short name:
MT-2A
Alternative name(s):
Metallothionein-IIA
Short name:
MT-IIA
Gene namesi
Name:MT2A
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
ProteomesiUP000008227: Chromosome 6

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. nucleus Source: UniProtKB
  3. perinuclear region of cytoplasm Source: UniProtKB
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 6161Metallothionein-2APRO_0000197213Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity

Keywords - PTMi

Acetylation

Interactioni

Subunit structurei

Monomer.By similarity

Structurei

3D structure databases

ProteinModelPortaliP79379.
SMRiP79379. Positions 1-61.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 2929BetaAdd
BLAST
Regioni30 – 6132AlphaAdd
BLAST

Domaini

Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines.

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00730000110883.
HOVERGENiHBG009063.
InParanoidiP79379.
KOiK14739.
OMAiNCAGSCK.
TreeFamiTF336054.

Family and domain databases

Gene3Di4.10.10.10. 1 hit.
InterProiIPR017854. Metalthion_dom.
IPR023587. Metalthion_dom_vert.
IPR003019. Metalthion_sfam_euk.
IPR000006. Metalthion_vert.
IPR018064. Metalthion_vert_metal_BS.
[Graphical view]
PANTHERiPTHR23299. PTHR23299. 1 hit.
PfamiPF00131. Metallothio. 1 hit.
[Graphical view]
PRINTSiPR00860. MTVERTEBRATE.
SUPFAMiSSF57868. SSF57868. 1 hit.
PROSITEiPS00203. METALLOTHIONEIN_VRT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P79379-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDPNCSCAAG GSCTCAGSCK CKDCKCTSCK KSCCSCCPVG CAKCAQGCIC
60
KGASDKCSCC A
Length:61
Mass (Da):5,970
Last modified:May 1, 1997 - v1
Checksum:i6E1F7C54F430A1D3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB000794 mRNA. Translation: BAA19183.1.
RefSeqiXP_003355856.1. XM_003355808.2.
UniGeneiSsc.15640.

Genome annotation databases

EnsembliENSSSCT00000029059; ENSSSCP00000022537; ENSSSCG00000030300.
GeneIDi396827.
KEGGissc:396827.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB000794 mRNA. Translation: BAA19183.1 .
RefSeqi XP_003355856.1. XM_003355808.2.
UniGenei Ssc.15640.

3D structure databases

ProteinModelPortali P79379.
SMRi P79379. Positions 1-61.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSSSCT00000029059 ; ENSSSCP00000022537 ; ENSSSCG00000030300 .
GeneIDi 396827.
KEGGi ssc:396827.

Organism-specific databases

CTDi 396827.

Phylogenomic databases

GeneTreei ENSGT00730000110883.
HOVERGENi HBG009063.
InParanoidi P79379.
KOi K14739.
OMAi NCAGSCK.
TreeFami TF336054.

Family and domain databases

Gene3Di 4.10.10.10. 1 hit.
InterProi IPR017854. Metalthion_dom.
IPR023587. Metalthion_dom_vert.
IPR003019. Metalthion_sfam_euk.
IPR000006. Metalthion_vert.
IPR018064. Metalthion_vert_metal_BS.
[Graphical view ]
PANTHERi PTHR23299. PTHR23299. 1 hit.
Pfami PF00131. Metallothio. 1 hit.
[Graphical view ]
PRINTSi PR00860. MTVERTEBRATE.
SUPFAMi SSF57868. SSF57868. 1 hit.
PROSITEi PS00203. METALLOTHIONEIN_VRT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Multiple isoforms of metallothionein are expressed in the porcine liver."
    Huang M.-C., Pan P.K., Zheng T.F., Chen N.C., Peng J.Y., Huang P.C.
    Gene 211:49-55(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.

Entry informationi

Entry nameiMT2A_PIG
AccessioniPrimary (citable) accession number: P79379
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: May 1, 1997
Last modified: October 29, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Metallothioneins
    Classification of metallothioneins and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3