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Protein

Metallothionein-2A

Gene

MT2A

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi5Divalent metal cation; cluster BBy similarity1
Metal bindingi7Divalent metal cation; cluster BBy similarity1
Metal bindingi13Divalent metal cation; cluster BBy similarity1
Metal bindingi15Divalent metal cation; cluster BBy similarity1
Metal bindingi19Divalent metal cation; cluster BBy similarity1
Metal bindingi21Divalent metal cation; cluster BBy similarity1
Metal bindingi24Divalent metal cation; cluster BBy similarity1
Metal bindingi26Divalent metal cation; cluster BBy similarity1
Metal bindingi29Divalent metal cation; cluster BBy similarity1
Metal bindingi33Divalent metal cation; cluster ABy similarity1
Metal bindingi34Divalent metal cation; cluster ABy similarity1
Metal bindingi36Divalent metal cation; cluster ABy similarity1
Metal bindingi37Divalent metal cation; cluster ABy similarity1
Metal bindingi41Divalent metal cation; cluster ABy similarity1
Metal bindingi44Divalent metal cation; cluster ABy similarity1
Metal bindingi48Divalent metal cation; cluster ABy similarity1
Metal bindingi50Divalent metal cation; cluster ABy similarity1
Metal bindingi57Divalent metal cation; cluster ABy similarity1
Metal bindingi59Divalent metal cation; cluster ABy similarity1
Metal bindingi60Divalent metal cation; cluster ABy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandMetal-binding, Metal-thiolate cluster

Names & Taxonomyi

Protein namesi
Recommended name:
Metallothionein-2A
Short name:
MT-2A
Alternative name(s):
Metallothionein-IIA
Short name:
MT-IIA
Gene namesi
Name:MT2A
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Chromosome 6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001972131 – 61Metallothionein-2AAdd BLAST61

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei58PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP79379
PeptideAtlasiP79379
PRIDEiP79379

Expressioni

Gene expression databases

BgeeiENSSSCG00000030300
GenevisibleiP79379 SS

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000022537

Structurei

3D structure databases

ProteinModelPortaliP79379
SMRiP79379
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 29BetaAdd BLAST29
Regioni30 – 61AlphaAdd BLAST32

Domaini

Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines.

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410JFS1 Eukaryota
ENOG41113QR LUCA
GeneTreeiENSGT00730000110883
HOVERGENiHBG009063
InParanoidiP79379
KOiK14739
OMAiCNCAGSC
TreeFamiTF336054

Family and domain databases

Gene3Di4.10.10.10, 1 hit
InterProiView protein in InterPro
IPR003019 Metalthion
IPR017854 Metalthion_dom_sf
IPR023587 Metalthion_dom_sf_vert
IPR000006 Metalthion_vert
IPR018064 Metalthion_vert_metal_BS
PANTHERiPTHR23299 PTHR23299, 1 hit
PfamiView protein in Pfam
PF00131 Metallothio, 1 hit
PRINTSiPR00860 MTVERTEBRATE
SUPFAMiSSF57868 SSF57868, 1 hit
PROSITEiView protein in PROSITE
PS00203 METALLOTHIONEIN_VRT, 1 hit

Sequencei

Sequence statusi: Complete.

P79379-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPNCSCAAG GSCTCAGSCK CKDCKCTSCK KSCCSCCPVG CAKCAQGCIC
60
KGASDKCSCC A
Length:61
Mass (Da):5,970
Last modified:May 1, 1997 - v1
Checksum:i6E1F7C54F430A1D3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB000794 mRNA Translation: BAA19183.1
RefSeqiXP_003355856.1, XM_003355808.3
UniGeneiSsc.15640

Genome annotation databases

EnsembliENSSSCT00000029059; ENSSSCP00000022537; ENSSSCG00000030300
GeneIDi396827
KEGGissc:396827

Similar proteinsi

Entry informationi

Entry nameiMT2A_PIG
AccessioniPrimary (citable) accession number: P79379
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: May 1, 1997
Last modified: April 25, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health