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P79379

- MT2A_PIG

UniProt

P79379 - MT2A_PIG

Protein

Metallothionein-2A

Gene

MT2A

Organism
Sus scrofa (Pig)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
  1. Functioni

    Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi5 – 51Divalent metal cation; cluster BBy similarity
    Metal bindingi7 – 71Divalent metal cation; cluster BBy similarity
    Metal bindingi13 – 131Divalent metal cation; cluster BBy similarity
    Metal bindingi15 – 151Divalent metal cation; cluster BBy similarity
    Metal bindingi19 – 191Divalent metal cation; cluster BBy similarity
    Metal bindingi21 – 211Divalent metal cation; cluster BBy similarity
    Metal bindingi24 – 241Divalent metal cation; cluster BBy similarity
    Metal bindingi26 – 261Divalent metal cation; cluster BBy similarity
    Metal bindingi29 – 291Divalent metal cation; cluster BBy similarity
    Metal bindingi33 – 331Divalent metal cation; cluster ABy similarity
    Metal bindingi34 – 341Divalent metal cation; cluster ABy similarity
    Metal bindingi36 – 361Divalent metal cation; cluster ABy similarity
    Metal bindingi37 – 371Divalent metal cation; cluster ABy similarity
    Metal bindingi41 – 411Divalent metal cation; cluster ABy similarity
    Metal bindingi44 – 441Divalent metal cation; cluster ABy similarity
    Metal bindingi48 – 481Divalent metal cation; cluster ABy similarity
    Metal bindingi50 – 501Divalent metal cation; cluster ABy similarity
    Metal bindingi57 – 571Divalent metal cation; cluster ABy similarity
    Metal bindingi59 – 591Divalent metal cation; cluster ABy similarity
    Metal bindingi60 – 601Divalent metal cation; cluster ABy similarity

    GO - Molecular functioni

    1. zinc ion binding Source: UniProtKB

    GO - Biological processi

    1. cellular response to zinc ion Source: UniProtKB
    2. negative regulation of growth Source: UniProtKB

    Keywords - Ligandi

    Metal-binding, Metal-thiolate cluster

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Metallothionein-2A
    Short name:
    MT-2A
    Alternative name(s):
    Metallothionein-IIA
    Short name:
    MT-IIA
    Gene namesi
    Name:MT2A
    OrganismiSus scrofa (Pig)
    Taxonomic identifieri9823 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
    ProteomesiUP000008227: Chromosome 6

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. nucleus Source: UniProtKB
    3. perinuclear region of cytoplasm Source: UniProtKB

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 6161Metallothionein-2APRO_0000197213Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionineBy similarity

    Keywords - PTMi

    Acetylation

    Interactioni

    Subunit structurei

    Monomer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP79379.
    SMRiP79379. Positions 1-61.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 2929BetaAdd
    BLAST
    Regioni30 – 6132AlphaAdd
    BLAST

    Domaini

    Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines.

    Sequence similaritiesi

    Phylogenomic databases

    GeneTreeiENSGT00730000110883.
    HOVERGENiHBG009063.
    KOiK14739.
    OMAiNCAGSCK.
    TreeFamiTF336054.

    Family and domain databases

    Gene3Di4.10.10.10. 1 hit.
    InterProiIPR017854. Metalthion_dom.
    IPR023587. Metalthion_dom_vert.
    IPR003019. Metalthion_sfam_euk.
    IPR000006. Metalthion_vert.
    IPR018064. Metalthion_vert_metal_BS.
    [Graphical view]
    PANTHERiPTHR23299. PTHR23299. 1 hit.
    PfamiPF00131. Metallothio. 1 hit.
    [Graphical view]
    PRINTSiPR00860. MTVERTEBRATE.
    SUPFAMiSSF57868. SSF57868. 1 hit.
    PROSITEiPS00203. METALLOTHIONEIN_VRT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P79379-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDPNCSCAAG GSCTCAGSCK CKDCKCTSCK KSCCSCCPVG CAKCAQGCIC   50
    KGASDKCSCC A 61
    Length:61
    Mass (Da):5,970
    Last modified:May 1, 1997 - v1
    Checksum:i6E1F7C54F430A1D3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB000794 mRNA. Translation: BAA19183.1.
    RefSeqiXP_003355856.1. XM_003355808.2.
    UniGeneiSsc.15640.

    Genome annotation databases

    EnsembliENSSSCT00000029059; ENSSSCP00000022537; ENSSSCG00000030300.
    GeneIDi396827.
    KEGGissc:396827.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB000794 mRNA. Translation: BAA19183.1 .
    RefSeqi XP_003355856.1. XM_003355808.2.
    UniGenei Ssc.15640.

    3D structure databases

    ProteinModelPortali P79379.
    SMRi P79379. Positions 1-61.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSSSCT00000029059 ; ENSSSCP00000022537 ; ENSSSCG00000030300 .
    GeneIDi 396827.
    KEGGi ssc:396827.

    Organism-specific databases

    CTDi 396827.

    Phylogenomic databases

    GeneTreei ENSGT00730000110883.
    HOVERGENi HBG009063.
    KOi K14739.
    OMAi NCAGSCK.
    TreeFami TF336054.

    Family and domain databases

    Gene3Di 4.10.10.10. 1 hit.
    InterProi IPR017854. Metalthion_dom.
    IPR023587. Metalthion_dom_vert.
    IPR003019. Metalthion_sfam_euk.
    IPR000006. Metalthion_vert.
    IPR018064. Metalthion_vert_metal_BS.
    [Graphical view ]
    PANTHERi PTHR23299. PTHR23299. 1 hit.
    Pfami PF00131. Metallothio. 1 hit.
    [Graphical view ]
    PRINTSi PR00860. MTVERTEBRATE.
    SUPFAMi SSF57868. SSF57868. 1 hit.
    PROSITEi PS00203. METALLOTHIONEIN_VRT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Multiple isoforms of metallothionein are expressed in the porcine liver."
      Huang M.-C., Pan P.K., Zheng T.F., Chen N.C., Peng J.Y., Huang P.C.
      Gene 211:49-55(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Liver.

    Entry informationi

    Entry nameiMT2A_PIG
    AccessioniPrimary (citable) accession number: P79379
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 26, 2001
    Last sequence update: May 1, 1997
    Last modified: October 1, 2014
    This is version 77 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Metallothioneins
      Classification of metallothioneins and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3