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P79376 (MT1C_PIG) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Metallothionein-1C

Short name=MT-1C
Alternative name(s):
Metallothionein-IC
Short name=MT-IC
Gene names
Name:MT1C
OrganismSus scrofa (Pig) [Reference proteome]
Taxonomic identifier9823 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus

Protein attributes

Sequence length61 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.

Subunit structure

Monomer By similarity.

Domain

Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines.

Sequence similarities

Belongs to the metallothionein superfamily. Type 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 6161Metallothionein-1C
PRO_0000197209

Regions

Region1 – 2929Beta
Region30 – 6132Alpha

Sites

Metal binding51Divalent metal cation; cluster B By similarity
Metal binding71Divalent metal cation; cluster B By similarity
Metal binding131Divalent metal cation; cluster B By similarity
Metal binding151Divalent metal cation; cluster B By similarity
Metal binding191Divalent metal cation; cluster B By similarity
Metal binding211Divalent metal cation; cluster B By similarity
Metal binding241Divalent metal cation; cluster B By similarity
Metal binding261Divalent metal cation; cluster B By similarity
Metal binding291Divalent metal cation; cluster B By similarity
Metal binding331Divalent metal cation; cluster A By similarity
Metal binding341Divalent metal cation; cluster A By similarity
Metal binding361Divalent metal cation; cluster A By similarity
Metal binding371Divalent metal cation; cluster A By similarity
Metal binding411Divalent metal cation; cluster A By similarity
Metal binding441Divalent metal cation; cluster A By similarity
Metal binding481Divalent metal cation; cluster A By similarity
Metal binding501Divalent metal cation; cluster A By similarity
Metal binding571Divalent metal cation; cluster A By similarity
Metal binding591Divalent metal cation; cluster A By similarity
Metal binding601Divalent metal cation; cluster A By similarity

Amino acid modifications

Modified residue11N-acetylmethionine By similarity

Sequences

Sequence LengthMass (Da)Tools
P79376 [UniParc].

Last modified May 1, 1997. Version 1.
Checksum: 4F5543119BDD3A4F

FASTA615,959
        10         20         30         40         50         60 
MDPNCSCSTG GSCSCAGSCT CKACRCTSCK KSCCSCCPAG CARCAQGCIC KGASDKCSCC 


A 

« Hide

References

[1]"Multiple isoforms of metallothionein are expressed in the porcine liver."
Huang M.-C., Pan P.K., Zheng T.F., Chen N.C., Peng J.Y., Huang P.C.
Gene 211:49-55(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Liver.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB000788 mRNA. Translation: BAA19178.1.
UniGeneSsc.15694.
Ssc.9079.

3D structure databases

ProteinModelPortalP79376.
SMRP79376. Positions 1-61.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG009063.

Family and domain databases

Gene3D4.10.10.10. 1 hit.
InterProIPR017854. Metalthion_dom.
IPR023587. Metalthion_dom_vert.
IPR003019. Metalthion_sfam_euk.
IPR000006. Metalthion_vert.
IPR018064. Metalthion_vert_metal_BS.
[Graphical view]
PANTHERPTHR23299. PTHR23299. 1 hit.
PfamPF00131. Metallothio. 1 hit.
[Graphical view]
PRINTSPR00860. MTVERTEBRATE.
SUPFAMSSF57868. SSF57868. 1 hit.
PROSITEPS00203. METALLOTHIONEIN_VRT. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMT1C_PIG
AccessionPrimary (citable) accession number: P79376
Entry history
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: May 1, 1997
Last modified: October 16, 2013
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Metallothioneins

Classification of metallothioneins and list of entries