P79376 (MT1C_PIG) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Metallothionein-1C
Short name=MT-1C

Alternative name(s):
Metallothionein-IC
Short name=MT-IC

Gene names

Name:

MT1C

Organism

Sus scrofa (Pig) [Reference proteome]

Taxonomic identifier

9823 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Laurasiatheria › Cetartiodactyla › Suina › Suidae › Sus

Protein attributes

Sequence length	61 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.
Subunit structure	Monomer By similarity.
Domain	Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines.
Sequence similarities	Belongs to the metallothionein superfamily. Type 1 family.

Ontologies

Keywords
Ligand	Metal-binding Metal-thiolate cluster
PTM	Acetylation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cellular response to zinc ion Inferred from sequence or structural similarity. Source: UniProtKB negative regulation of growth Inferred from sequence or structural similarity. Source: UniProtKB
Cellular_component	nucleus Inferred from sequence or structural similarity. Source: UniProtKB perinuclear region of cytoplasm Inferred from sequence or structural similarity. Source: UniProtKB
Molecular_function	zinc ion binding Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 61	61	Metallothionein-1C		PRO_0000197209
Regions
	Region	1 – 29	29	Beta
	Region	30 – 61	32	Alpha
Sites
	Metal binding	5	1	Divalent metal cation; cluster B By similarity
	Metal binding	7	1	Divalent metal cation; cluster B By similarity
	Metal binding	13	1	Divalent metal cation; cluster B By similarity
	Metal binding	15	1	Divalent metal cation; cluster B By similarity
	Metal binding	19	1	Divalent metal cation; cluster B By similarity
	Metal binding	21	1	Divalent metal cation; cluster B By similarity
	Metal binding	24	1	Divalent metal cation; cluster B By similarity
	Metal binding	26	1	Divalent metal cation; cluster B By similarity
	Metal binding	29	1	Divalent metal cation; cluster B By similarity
	Metal binding	33	1	Divalent metal cation; cluster A By similarity
	Metal binding	34	1	Divalent metal cation; cluster A By similarity
	Metal binding	36	1	Divalent metal cation; cluster A By similarity
	Metal binding	37	1	Divalent metal cation; cluster A By similarity
	Metal binding	41	1	Divalent metal cation; cluster A By similarity
	Metal binding	44	1	Divalent metal cation; cluster A By similarity
	Metal binding	48	1	Divalent metal cation; cluster A By similarity
	Metal binding	50	1	Divalent metal cation; cluster A By similarity
	Metal binding	57	1	Divalent metal cation; cluster A By similarity
	Metal binding	59	1	Divalent metal cation; cluster A By similarity
	Metal binding	60	1	Divalent metal cation; cluster A By similarity
Amino acid modifications
	Modified residue	1	1	N-acetylmethionine By similarity

Sequences

	Sequence		Length	Mass (Da)
	P79376 [UniParc]. Last modified May 1, 1997. Version 1. Checksum: 4F5543119BDD3A4F	FASTA	61	5,959
	10 20 30 40 50 60 MDPNCSCSTG GSCSCAGSCT CKACRCTSCK KSCCSCCPAG CARCAQGCIC KGASDKCSCC A

References

[1]	"Multiple isoforms of metallothionein are expressed in the porcine liver." Huang M.-C., Pan P.K., Zheng T.F., Chen N.C., Peng J.Y., Huang P.C. Gene 211:49-55(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Liver.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB000788 mRNA. Translation: BAA19178.1.
UniGene	Ssc.15694. Ssc.9079.
3D structure databases
ProteinModelPortal	P79376.
SMR	P79376. Positions 1-61.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOVERGEN	HBG009063.
Family and domain databases
Gene3D	4.10.10.10. 1 hit.
InterPro	IPR017854. Metalthion_dom. IPR023587. Metalthion_dom_vert. IPR003019. Metalthion_sfam_euk. IPR000006. Metalthion_vert. IPR018064. Metalthion_vert_metal_BS. [Graphical view]
PANTHER	PTHR23299. PTHR23299. 1 hit.
Pfam	PF00131. Metallothio. 1 hit. [Graphical view]
PRINTS	PR00860. MTVERTEBRATE.
SUPFAM	SSF57868. Metallothionein_sfam. 1 hit.
PROSITE	PS00203. METALLOTHIONEIN_VRT. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MT1C_PIG

Accession

Primary (citable) accession number: P79376

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 26, 2001
Last sequence update:	May 1, 1997
Last modified:	April 3, 2013
This is version 66 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program